Respiratory Syncytial Virus Consortium in Europe (RESCEU) Birth Cohort Study: Defining the Burden of Infant Respiratory Syncytial Virus Disease in Europe

Abstract Background Respiratory syncytial virus (RSV) causes significant morbidity and mortality in infants worldwide. Although prematurity and cardiopulmonary disease are risk factors for severe disease, the majority of infants hospitalized with RSV are previously healthy. Various vaccines and therapeutics are under development and expected to be available in the near future. To inform the use of these new vaccines and therapeutics, it is necessary to determine the burden of RSV disease in Europe. We will prospectively follow-up a birth cohort to obtain incidence data on RSV acute respiratory tract infection (ARTI). Methods Multicenter prospective study of a birth cohort consisting of 10 000 healthy infants, recruited during 3 consecutive years. RSV associated hospitalization in the first year of life will be determined by questionnaires and hospital chart reviews. A nested cohort of 1000 infants will be actively followed. In case of ARTI, a respiratory sample will be collected for RSV molecular diagnosis. Results The primary outcome is the incidence rate of RSV-associated hospitalization in the first year of life. In the active cohort the primary outcome is RSV associated ARTI and MA-ARTI. Conclusions We will provide key information to fill the gaps in knowledge about the burden of RSV disease in healthy infants. Clinical Trials Registration NCT03627572.

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Respiratory Syncytial Virus Epidemiology in a Birth Cohort from Kilifi District, Kenya: Infection during the First Year of Life

The Journal of Infectious Diseases ◽

10.1086/425040 ◽

2004 ◽

Vol 190 (10) ◽

pp. 1828-1832 ◽

Cited By ~ 53

Author(s):

D. James Nokes ◽

Emelda A. Okiro ◽

Mwanajuma Ngama ◽

Lisa J. White ◽

Rachel Ochola ◽

...

Keyword(s):

Respiratory Syncytial Virus ◽

Birth Cohort ◽

First Year ◽

Syncytial Virus ◽

First Year Of Life

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Breastfeeding, maternal asthma and wheezing in the first year of life: a longitudinal birth cohort study

European Respiratory Journal ◽

10.1183/13993003.02019-2016 ◽

2017 ◽

Vol 49 (5) ◽

pp. 1602019 ◽

Cited By ~ 19

Author(s):

Meghan B. Azad ◽

Lorena Vehling ◽

Zihang Lu ◽

David Dai ◽

Padmaja Subbarao ◽

...

Keyword(s):

Birth Cohort ◽

Respiratory Health ◽

Birth Cohort Study ◽

P Value ◽

First Year ◽

Dependent Manner ◽

Complementary Foods ◽

Adjusted Rate ◽

First Year Of Life ◽

The Impact

The impact of breastfeeding on respiratory health is uncertain, particularly when the mother has asthma. We examined the association of breastfeeding and wheezing in the first year of life.We studied 2773 infants from the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort. Caregivers reported on infant feeding and wheezing episodes at 3, 6 and 12 months. Breastfeeding was classified as exclusive, partial (supplemented with formula or complementary foods) or none.Overall, 21% of mothers had asthma, 46% breastfed for at least 12 months and 21% of infants experienced wheezing. Among mothers with asthma, breastfeeding was inversely associated with infant wheezing, independent of maternal smoking, education and other risk factors (adjusted rate ratio (aRR) 0.52; 95% CI 0.35–0.77 for ≥12 versus <6 months breastfeeding). Compared with no breastfeeding at 6 months, wheezing was reduced by 62% with exclusive breastfeeding (aRR 0.38; 95% CI 0.20–0.71) and by 37% with partial breastfeeding supplemented with complementary foods (aRR 0.63; 95% CI 0.43–0.93); however, breastfeeding was not significantly protective when supplemented with formula (aRR 0.89; 95% CI 0.61–1.30). Associations were not significant in the absence of maternal asthma (p-value for interaction <0.01).Breastfeeding appears to confer protection against wheezing in a dose-dependent manner among infants born to mothers with asthma.

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Anthropometry at birth and at age of routine vaccination to predict mortality in the first year of life: A birth cohort study in BukinaFaso

PLoS ONE ◽

10.1371/journal.pone.0213523 ◽

2019 ◽

Vol 14 (3) ◽

pp. e0213523 ◽

Cited By ~ 8

Author(s):

Martha Mwangome ◽

Moses Ngari ◽

Paluku Bwahere ◽

Patrick Kabore ◽

Marie McGrath ◽

...

Keyword(s):

Cohort Study ◽

Birth Cohort ◽

Routine Vaccination ◽

Birth Cohort Study ◽

First Year ◽

First Year Of Life

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Fcγ Receptor IIa (FCGR2A) Polymorphism Is Associated With Severe Respiratory Syncytial Virus Disease in Argentinian Infants

Frontiers in Cellular and Infection Microbiology ◽

10.3389/fcimb.2020.607348 ◽

2020 ◽

Vol 10 ◽

Author(s):

María Pía Holgado ◽

Silvina Raiden ◽

Inés Sananez ◽

Vanesa Seery ◽

Leonardo De Lillo ◽

...

Keyword(s):

Respiratory Syncytial Virus ◽

Virus Disease ◽

Severe Disease ◽

Critical Role ◽

Fcγ Receptor ◽

Factors Associated ◽

Severe Group ◽

Rsv Infection ◽

Syncytial Virus ◽

The Relationship

BackgroundMost patients with respiratory syncytial virus (RSV) infection requiring hospitalization have no risk factors for severe disease. Genetic variation in the receptor for the Fc portion of IgG (FcγR) determines their affinity for IgG subclasses driving innate and adaptive antiviral immunity. We investigated the relationship between FcγRIIa-H131R polymorphism and RSV disease.MethodsBlood samples were collected from 182 infants ≤24-month-old (50 uninfected, 114 RSV-infected with moderate course and 18 suffering severe disease). FcγRIIa-H131R SNP genotypic frequencies (HH, HR, RR) and anti-RSV IgG1, IgG2 and IgG3 levels were studied.ResultsGenotypic frequencies for FcγRIIa-H131R SNP were comparable between uninfected and RSV-infected infants. In contrast, we found a significant higher frequency of HH genotype in severe RSV-infected children compared to moderate patients. Among severe group, HH infants presented more factors associated to severity than HR or RR patients did. Furthermore, compared to moderate RSV-infected infants, severe patients showed higher levels of anti-RSV IgG1 and IgG3.ConclusionsWe found an association between an FcγRIIa (H131) polymorphism and severe RSV disease, which points towards a critical role for interactions between FcγRs and immune complexes in RSV pathogenesis. This genetic factor could also predict the worse outcome and identify those infants at risk during hospitalization.

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Breastfeeding and Infant Eczema in the First Year of Life in the KOALA Birth Cohort Study: A Risk Period-Specific Analysis

PEDIATRICS ◽

10.1542/peds.2006-0772 ◽

2007 ◽

Vol 119 (1) ◽

pp. e137-e141 ◽

Cited By ~ 22

Author(s):

B. E. P. Snijders ◽

C. Thijs ◽

I. Kummeling ◽

J. Penders ◽

P. A. van den Brandt

Keyword(s):

Cohort Study ◽

Birth Cohort ◽

Birth Cohort Study ◽

First Year ◽

Specific Analysis ◽

Risk Period ◽

First Year Of Life ◽

Infant Eczema

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749. Healthcare Utilization After Hospitalization for Respiratory Syncytial Virus or Unspecified Bronchiolitis in the First Year of Life

Open Forum Infectious Diseases ◽

10.1093/ofid/ofy210.756 ◽

2018 ◽

Vol 5 (suppl_1) ◽

pp. S268-S269

Author(s):

Joel Ledbetter ◽

Lance Brannman ◽

Sally Wade ◽

David Diakun ◽

Tara Gonzales ◽

...

Keyword(s):

Respiratory Syncytial Virus ◽

Healthcare Utilization ◽

Healthcare Resource Utilization ◽

Urgent Care ◽

First Year ◽

Chi Squared ◽

Ed Visits ◽

Syncytial Virus ◽

First Year Of Life

Abstract Background Respiratory syncytial virus (RSV) is the leading cause of infant hospitalizations and risk varies by gestational age (GA). Healthcare utilization following early hospitalizations caused by RSV (RSVH) or unspecified bronchiolitis (UBH) is not well understood. This study examined healthcare resource utilization (HRU) across GA categories within 12 months after an initial RSVH or UBH occurring in the first year of life. Methods Infants born July 1, 2009 to June 30, 2015 were identified in the MarketScan Commercial (COM) and Multistate Medicaid (MED) databases and assigned to GA categories using DRG and ICD codes and to an initial hospitalization cohort using inpatient claim diagnosis codes (RSVH, UBH without RSVH, or COMP [a comparator without RSVH or UBH]). Index dates (first admission dates for hospitalized infants) were assigned to COMP infants using times from birth to index dates among RSVH infants. HRU (hospitalizations, outpatient pharmacy fills, and visits for emergency department [ED], urgent care, wellness, other office or outpatient) excluded index hospitalizations and was assessed from 14 days post-index (or discharge if later) through 12 months post-index. Results were propensity score weighted to balance pre-index characteristics (age, sex, region, GA, birth hospitalization characteristics) across cohorts. Proportions were compared with chi-squared tests. Results Among all infants (all GA categories combined), the proportions of RSVH and UBH cohorts with follow-up hospitalizations or ED visits were greater (P < 0.05) than COMP (hospitalizations: COM +5.8%, +9.3%; MED +9.1%, +12.0%; ED visits: COM +15.8%, +16.2%; MED +14.4%, +17.1%). Follow-up hospitalizations in COM and MED and ED visits in COM declined with greater GA (Figures 1 and 2). HRU in other categories (fills, visits) was significantly (P < 0.05) greater among RSVH or UBH infants relative to COMP for nearly all GA categories in both COM and MED. Conclusion Infants hospitalized for RSV or UB in their first year of life had greater use of inpatient and outpatient resources in the 12 months following their initial hospitalizations compared with nonhospitalized infants. Inpatient care during follow-up was greatest among infants born at earlier GA. Funded by AstraZeneca Disclosures J. Ledbetter, AstraZeneca: Speaker’s Bureau, Speaker honorarium. L. Brannman, AstraZeneca: Employee, Salary and Stocks. S. Wade, Wade Outcomes Research and Consulting: Employee, Salary. D. Diakun, Truven Health Analytics, an IBM Company: Employee, Salary. T. Gonzales, AstraZeneca: Employee, Salary and Stocks. A. Kong, Truven Health Analytics, an IBM Company: Employee, Salary.

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