scholarly journals Outdoor air pollution, exhaled 8-isoprostane and current asthma in adults: the EGEA study

2018 ◽  
Vol 51 (4) ◽  
pp. 1702036 ◽  
Author(s):  
Anaïs Havet ◽  
Farid Zerimech ◽  
Margaux Sanchez ◽  
Valérie Siroux ◽  
Nicole Le Moual ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Air Pollution ◽  
Road Traffic ◽  
Outdoor Air ◽  
Pollution Effects ◽  
Cross Sectional ◽  
Current Asthma ◽  
Outdoor Air Pollution ◽  
French Case ◽  
Familial Dependence

Associations between outdoor air pollution and asthma in adults are still scarce, and the underlying biological mechanisms are poorly understood. Our aim was to study the associations between 1) long-term exposure to outdoor air pollution and current asthma, 2) exhaled 8-isoprostane (8-iso; a biomarker related to oxidative stress) and current asthma, and 3) outdoor air pollution and exhaled 8-iso.Cross-sectional analyses were conducted in 608 adults (39% with current asthma) from the first follow-up of the French case–control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Data on nitrogen dioxide, nitrogen oxides, particulate matter with a diameter ≤10 and ≤2.5 µm (PM10 and PM2.5), road traffic, and ozone (O3) were from ESCAPE (European Study of Cohorts for Air Pollution Effects) and IFEN (French Institute for the Environment) assessments. Models took account of city and familial dependence.The risk of current asthma increased with traffic intensity (adjusted (a)OR 1.09 (95% CI 1.00–1.18) per 5000 vehicles per day), with O3 exposure (aOR 2.04 (95% CI 1.27–3.29) per 10 µg·m−3) and with exhaled 8-iso concentration (aOR 1.50 (95% CI 1.06–2.12) per 1 pg·mL−1). Among participants without asthma, exhaled 8-iso concentration increased with PM2.5 exposure (adjusted (a)β 0.23 (95% CI 0.005–0.46) per 5 µg·m−3), and decreased with O3 and O3-summer exposures (aβ −0.20 (95% CI −0.39– −0.01) and aβ −0.52 (95% CI −0.77– −0.26) per 10 µg·m−3, respectively).Our results add new insights into a potential role of oxidative stress in the associations between outdoor air pollution and asthma in adults.

scholarly journals Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Anaïs Havet ◽  
Zhen Li ◽  
Farid Zerimech ◽  
Margaux Sanchez ◽  
Valérie Siroux ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Air Pollution ◽  
Mediation Analysis ◽  
Road Traffic ◽  
Persistent Asthma ◽  
Total Effect ◽  
Outdoor Air ◽  
Outdoor Air Pollution ◽  
Positive Direct

Abstract Background Evidences that oxidative stress plays a role in the associations between outdoor air pollution and asthma are growing. We aimed to study the role of plasma fluorescent oxidation products levels (FlOPs; an oxidative stress-related biomarker), as potential mediators, in the associations between outdoor air pollution and persistent asthma. Methods Analyses were conducted in 204 adult asthmatics followed up in the French case-control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Persistent asthma was defined as having current asthma at EGEA2 (baseline, 2003–2007) and EGEA3 (follow-up, 2011–2013). Exposures to nitrogen dioxide, nitrogen oxides, road traffic, particulate matter with a diameter ≤ 10 μm (PM10) and ≤ 2.5 μm were estimated by ESCAPE models (2009–2010), and ozone (O3) by IFEN models (2004). We used a mediation analysis to assess the mediated effect by FlOPs levels and the interaction between FlOPs levels and air pollution. Results FlOPs levels increased with PM10 and O3 (adjusted β = 0.04 (95%CI 0.001–0.08), aβ = 0.04 (95%CI 0.009–0.07) per 10 μg/m3, respectively), and the risk of persistent asthma increased with FlOPs levels (aOR = 1.81 (95%CI 1.08–3.02)). The risk of persistent asthma decreased with exposures to NO2, NOx and PM2.5 (aOR ranging from 0.62 to 0.94), and increased with exposures to PM10, O3, O3-summer and road traffic, the greater effect being observed for O3 (aOR = 1.78, 95% CI 0.73–4.37, per 10 μg/m3). Using mediation analysis, we observed a positive total effect (aOR = 2.16, 95%CI 0.70–11.9), a positive direct effect of O3 on persistent asthma (OR = 1.68, 95%CI 0.57–7.25), and a positive indirect effect mediated by FIOPs levels (aOR = 1.28 (95%CI 1.01–2.29)) accounting for 41% of the total effect. Conclusions Our results add insights on the role of oxidative stress in the association between air pollution and persistent asthma.

scholarly journals Outdoor Air Pollution and Depression in Canada: A Population-Based Cross-Sectional Study from 2011 to 2016

2021 ◽  
Vol 18 (5) ◽  
pp. 2450
Author(s):  
Ashley K. Dores ◽  
Gordon H. Fick ◽  
Frank P. MacMaster ◽  
Jeanne V. A. Williams ◽  
Andrew G. M. Bulloch ◽  
...  
Keyword(s):  
Air Pollution ◽  
Fine Particulate Matter ◽  
Canadian Community Health Survey ◽  
Population Based ◽  
Cross Sectional Study ◽  
Future Research ◽  
Outdoor Air ◽  
Cross Sectional ◽  
Outdoor Air Pollution ◽  
Environmental Health Research

To assess whether exposure to increased levels of outdoor air pollution is associated with psychological depression, six annual iterations of the Canadian Community Health Survey (n ≈ 127,050) were used to estimate the prevalence of a major depressive episode (2011–2014) or severity of depressive symptoms (2015–2016). Survey data were linked with outdoor air pollution data obtained from the Canadian Urban Environmental Health Research Consortium, with outdoor air pollution represented by fine particulate matter ≤2.5 micrometers (μm) in diameter (PM2.5), ozone (O3), sulfur dioxide (SO2), and nitrogen dioxide (NO2). Log-binomial models were used to estimate the association between outdoor air pollution and depression, and included adjustment for age, sex, marital status, income, education, employment status, urban versus rural households, cigarette smoking, and chronic illness. No evidence of associations for either depression outcomes were found. Given the generally low levels of outdoor air pollution in Canada, these findings should be generalized with caution. It is possible that a meaningful association with major depression may be observed in regions of the world where the levels of outdoor air pollution are greater, or during high pollution events over brief time intervals. Future research is needed to replicate these findings and to further investigate these associations in other regions and populations.

scholarly journals Cross-sectional and longitudinal analyses of outdoor air pollution exposure and cognitive function in UK Biobank

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Breda Cullen ◽  
Danielle Newby ◽  
Duncan Lee ◽  
Donald M. Lyall ◽  
Alejo J. Nevado-Holgado ◽  
...  
Keyword(s):  
Air Pollution ◽  
Cognitive Function ◽  
Longitudinal Analyses ◽  
Uk Biobank ◽  
Outdoor Air ◽  
Cross Sectional ◽  
Outdoor Air Pollution ◽  
Air Pollution Exposure ◽  
Pollution Exposure

scholarly journals Ocular surface symptoms among individuals exposed to ambient levels of traffic derived air pollution – a cross-sectional study

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 2167
Author(s):  
Nabin Paudel ◽  
Sanjeev Adhikari ◽  
Sarina Manandhar ◽  
Ashesh Acharya ◽  
Ajit Thakur ◽  
...  
Keyword(s):  
Air Pollution ◽  
Police Officers ◽  
Ocular Surface ◽  
Tear Film ◽  
Cross Sectional Study ◽  
Outdoor Air ◽  
Ocular Surface Disease Index ◽  
Cross Sectional ◽  
Traffic Police ◽  
Outdoor Air Pollution

Background: The ocular surface is separated by a thin layer of tear film from outdoor air pollutants making individuals exposed to outdoor air pollution prone to various ocular surface disorders. The aim of this study was to determine the magnitude of ocular surface disorders symptoms among traffic police officers of Kathmandu, Nepal. Methods: Two hundred traffic police officers working at different traffic police office branches of Kathmandu, Nepal were invited to the police headquarters for eye and vision examination. Among them, 91 individuals (95% males) completed the ocular surface disease index (OSDI) questionnaire and underwent Schirmer’s I tear test. Results: Symptoms of ocular surface disorders were reported by over 80% of the individuals. Approximately two fifths of the individuals (38%) reported severe symptoms.  Only 17% of the individuals’ tear secretion was found to be below normal using the Schirmer’s tear test.  There was no association between the OSDI score and Schirmer’s tear test scores (r = 0.008, p = 0.94). A weak but significant relationship was observed between the OSDI score and job duration (r=0.21,p = 0.04). Individual exposed to outdoor air pollution for more than 10 years had higher odds of reporting ocular surface complaints as compared to those who were exposed for less than 10 years (OR = 3.94, p = 0.02). Conclusion: Ocular surface disorder symptoms are common among traffic police officers of Kathmandu, Nepal. The duration of exposure appears to significantly contribute to the increased symptoms in this vulnerable population.

scholarly journals Ocular surface symptoms among individuals exposed to ambient levels of traffic derived air pollution – a cross-sectional study

F1000Research ◽  
2018 ◽  
Vol 6 ◽  
pp. 2167 ◽  
Author(s):  
Nabin Paudel ◽  
Sanjeev Adhikari ◽  
Sarina Manandhar ◽  
Ashesh Acharya ◽  
Ajit Thakur ◽  
...  
Keyword(s):  
Air Pollution ◽  
Police Officers ◽  
Ocular Surface ◽  
Tear Film ◽  
Outdoor Air ◽  
Ocular Surface Disease Index ◽  
Cross Sectional ◽  
Traffic Police ◽  
Outdoor Air Pollution ◽  
Exposed Population

Background: The ocular surface is separated by a thin layer of tear film from outdoor air pollutants making individuals exposed to outdoor air pollution prone to various ocular surface disorders. The aim of this study was to determine the magnitude of ocular surface disorders symptoms among traffic police officers of Kathmandu, Nepal. Methods: Two hundred traffic police officers working at different traffic police office branches of Kathmandu, Nepal were invited to the police headquarters for eye and vision examination. Among them, 91 individuals (95% males) completed the ocular surface disease index (OSDI) questionnaire and underwent Schirmer’s I tear test. Results: Symptoms of ocular surface disorders were reported by over 80% of the individuals. Approximately two-fifths of the individuals (38%) reported severe symptoms.  Only 17% of the individuals’ tear secretion was found to be below normal using the Schirmer’s tear test. No significant association was observed between the OSDI score and Schirmer’s tear test scores (r = 0.008, p = 0.94). A weak but significant relationship was observed between the OSDI score and job duration (r=0.21,p = 0.04). Individual exposed to outdoor air pollution for more than 10 years had higher odds of reporting ocular surface complaints as compared to those who were exposed for less than 10 years (OR = 3.94, p = 0.02). Conclusion: Ocular surface disorder symptoms are common among traffic police officers of Kathmandu, Nepal. The duration of exposure appears to significantly contribute to the increased symptoms in this exposed population.

Sign in / Sign up

Export Citation Format

Share Document