Eosinopenia in COPD patients with severe acute respiratory virus 2 (Sars-CoV-2) infection as a potential fatal outcome predictor

2021 ◽  
Author(s):  
Jane-Erica Paluero ◽  
Lemar Tokhi ◽  
Mihovil Roglic ◽  
Marina Labor
Keyword(s):  
Respiratory Virus ◽  
Fatal Outcome ◽  
Outcome Predictor ◽  
Copd Patients

scholarly journals The prevalence and clinical features of pulmonary embolism in patients with AE-COPD: A meta-analysis and systematic review

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0256480
Author(s):  
Xiaofang Fu ◽  
Yonghong Zhong ◽  
Wucheng Xu ◽  
Jiangang Ju ◽  
Min Yu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pulmonary Embolism ◽  
Confidence Intervals ◽  
Meta Analysis ◽  
Fatal Outcome ◽  
Cochrane Library ◽  
Chronic Obstructive ◽  
Risk Of Death ◽  
Copd Patients ◽  
Increased Risk

Background The prevalence of pulmonary embolism (PE) in the acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) is highly controversial. We conducted a systematic review and meta-analysis to summarize the epidemiology and characteristics of PE with AE-COPD for current studies. Methods We searched the PubMed, EMBASE, Cochrane Library and Web of Science databases for studies published prior to October 21, 2020. Pooled proportions with 95% confidence intervals (95% CIs) were calculated using a random effects model. Odds ratios (ORs) and mean differences (MDs) with 95% confidence intervals were used as effect measures for dichotomous and continuous variables, respectively. Results A total of 17 studies involving 3170 patients were included. The prevalence of PE and deep vein thrombosis (DVT) in AE-COPD patients was 17.2% (95% CI: 13.4%-21.3%) and 7.1% (95% CI: 3.7%-11.4%%), respectively. Dyspnea (OR = 6.77, 95% CI: 1.97–23.22), pleuritic chest pain (OR = 3.25, 95% CI: 2.06–5.12), lower limb asymmetry or edema (OR = 2.46, 95% CI:1.51–4.00), higher heart rates (MD = 20.51, 95% CI: 4.95–36.08), longer hospital stays (MD = 3.66, 95% CI: 3.01–4.31) were associated with the PE in the AE-COPD patients. Levels of D-dimer (MD = 1.51, 95% CI: 0.80–2.23), WBC counts (MD = 1.42, 95% CI: 0.14–2.70) were significantly higher and levels of PaO2 was lower (MD = -17.20, 95% CI: -33.94- -0.45, P<0.05) in the AE-COPD with PE group. The AE-COPD with PE group had increased risk of fatal outcome than the AE-COPD group (OR = 2.23, 95% CI: 1.43–3.50). Conclusions The prevalence of PE during AE-COPD varies considerably among the studies. AE-COPD patients with PE experienced an increased risk of death, especially among the ICU patients. Understanding the potential risk factors for PE may help clinicians identify AE-COPD patients at increased risk of PE. Prospero registration number CRD42021226568.

Oral and Oropharyngeal Sensory Function in Adults With Chronic Obstructive Pulmonary Disease

2020 ◽  
Vol 29 (2) ◽  
pp. 864-872
Author(s):  
Fernanda Borowsky da Rosa ◽  
Adriane Schmidt Pasqualoto ◽  
Catriona M. Steele ◽  
Renata Mancopes
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Oral Cavity ◽  
Pulmonary Disease ◽  
Thermal Sensation ◽  
Sensory Function ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Age Related ◽  
Copd Patients

Introduction The oral cavity and pharynx have a rich sensory system composed of specialized receptors. The integrity of oropharyngeal sensation is thought to be fundamental for safe and efficient swallowing. Chronic obstructive pulmonary disease (COPD) patients are at risk for oropharyngeal sensory impairment due to frequent use of inhaled medications and comorbidities including gastroesophageal reflux disease. Objective This study aimed to describe and compare oral and oropharyngeal sensory function measured using noninstrumental clinical methods in adults with COPD and healthy controls. Method Participants included 27 adults (18 men, nine women) with a diagnosis of COPD and a mean age of 66.56 years ( SD = 8.68). The control group comprised 11 healthy adults (five men, six women) with a mean age of 60.09 years ( SD = 11.57). Spirometry measures confirmed reduced functional expiratory volumes (% predicted) in the COPD patients compared to the control participants. All participants completed a case history interview and underwent clinical evaluation of oral and oropharyngeal sensation by a speech-language pathologist. The sensory evaluation explored the detection of tactile and temperature stimuli delivered by cotton swab to six locations in the oral cavity and two in the oropharynx as well as identification of the taste of stimuli administered in 5-ml boluses to the mouth. Analyses explored the frequencies of accurate responses regarding stimulus location, temperature and taste between groups, and between age groups (“≤ 65 years” and “> 65 years”) within the COPD cohort. Results We found significantly higher frequencies of reported use of inhaled medications ( p < .001) and xerostomia ( p = .003) in the COPD cohort. Oral cavity thermal sensation ( p = .009) was reduced in the COPD participants, and a significant age-related decline in gustatory sensation was found in the COPD group ( p = .018). Conclusion This study found that most of the measures of oral and oropharyngeal sensation remained intact in the COPD group. Oral thermal sensation was impaired in individuals with COPD, and reduced gustatory sensation was observed in the older COPD participants. Possible links between these results and the use of inhaled medication by individuals with COPD are discussed.

Many COPD Patients Have Both Anxiety and Depression

2005 ◽  
Vol 38 (7) ◽  
pp. 23
Author(s):  
DOUG BRUNK
Keyword(s):  
Anxiety And Depression ◽  
Copd Patients

P. aeruginosa Worse Among Hospitalized COPD Patients

2006 ◽  
Vol 39 (11) ◽  
pp. 62
Author(s):  
PATRICE WENDLING
Keyword(s):  
Copd Patients

Forced oscillation total respiratory resistance and spontaneous breathing lung resistance in COPD patients

1999 ◽  
Vol 14 (1) ◽  
pp. 172 ◽  
Author(s):  
R. Farré ◽  
R. Peslin ◽  
M. Rotger ◽  
J Barberá ◽  
D Navajas
Keyword(s):  
Spontaneous Breathing ◽  
Forced Oscillation ◽  
Respiratory Resistance ◽  
Copd Patients ◽  
Lung Resistance

Combo Therapy Cuts Mortality in COPD Patients

2006 ◽  
Vol 36 (22) ◽  
pp. 4
Author(s):  
BRUCE JANCIN
Keyword(s):  
Copd Patients

Improvement in Quality of Life (QoL) in COPD patients treated with Roflumilast as assessed by the Clinical COPD Questionnaire (CCQ)

Pneumologie ◽  
2013 ◽  
Vol 67 (S 01) ◽  
Author(s):  
P Kardos ◽  
TD Bethke ◽  
C Vogelmeier
Keyword(s):  
Quality Of Life ◽  
Copd Patients
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