scholarly journals The evolving landscape of sex-based differences in lung cancer: a distinct disease in women

2022 ◽  
Vol 31 (163) ◽  
pp. 210100
Author(s):  
Meera Ragavan ◽  
Manali I. Patel
Keyword(s):  
Lung Cancer ◽  
Lung Cancer Risk ◽  
Incidence Rates ◽  
Mortality Benefit ◽  
Ongoing Research ◽  
Screening Guidelines ◽  
The World ◽  
Distinct Disease ◽  
Changing Demographics ◽  
Current Screening

In stark contrast to a few decades ago when lung cancer was predominantly a disease of men who smoke, incidence rates of lung cancer in women are now comparable to or higher than those in men and are rising alarmingly in many parts of the world. Women face a unique set of risk factors for lung cancer compared to men. These include exogenous exposures including radon, prior radiation, and fumes from indoor cooking materials such as coal, in addition to endogenous exposures such as oestrogen and distinct genetic polymorphisms. Current screening guidelines only address tobacco use and likely underrepresent lung cancer risk in women. Women were also not well represented in some of the landmark prospective studies that led to the development of current screening guidelines. Women diagnosed with lung cancer have a clear mortality benefit compared to men even when other clinical and demographic characteristics are accounted for. However, there may be sex-based differences in outcomes and side effects of systemic therapy, particularly with chemotherapy and immunotherapy. Ongoing research is needed to better investigate these differences to address the rapidly changing demographics of lung cancer worldwide.

scholarly journals Low-dose radiation therapy: a treatment for pneumonia resulting from COVID-19

2021 ◽  
pp. 1-4
Author(s):  
Hamid Ghaznavi ◽  
Farideh Elahimanesh ◽  
Jamil Abdolmohammadi ◽  
Meysam Mirzaie ◽  
Sadegh Ghaderi
Keyword(s):  
Lung Cancer ◽  
Radiation Therapy ◽  
Low Dose ◽  
Distress Syndrome ◽  
Lung Cancer Risk ◽  
Low Dose Radiation ◽  
The World ◽  
Dose Radiation

Abstract Background: The Coronavirus disease 2019 (COVID-19) is spreading rapidly throughout the world. Lung is the primary organ which the COVID-19 virus affects and leads to pneumonia, an acute respiratory distress syndrome. COVID-19 infects the lower respiratory system, and the lung’s response to this infection is recruiting macrophages and monocytes leading to inflammation, this response causes widespread damage to the lung’s airways. Aim: The purpose of this study is to review studies of using low-dose radiation as a treatment for the inflammation of the tissue and pneumonia resulting from COVID-19. These studies were compared with the risk of developing lung cancer during performed dose for the treatment of COVID-19 in radiation therapy. Materials and methods: Our study focused on in vitro, in vivo and clinical reports of using low-dose radiation for the treatment of inflammation, pneumonia and COVID-19. The risk of lung cancer resulting from suggested dose in these studies was also evaluated. Conclusion: From the review of articles, we have found that low-dose radiation can lead to improvement in inflammation in different line cells and animals; in addition, it has been effective in treating inflammation and pneumonia caused by COVID-19 in human up to 80%. Since suggested doses do not remarkably increase the lung cancer risk, low-dose radiation can be an adjuvant treatment for COVID-19 patients.

Effects of NAT2 Polymorphism on Lung Cancer Risk, and the Interaction Between Smoking and NAT2: A Meta-analysis

2020 ◽  
Author(s):  
Ke Zhu ◽  
Aiqun Xu ◽  
Binbin Zhang ◽  
Pulin Li ◽  
Huihui Jiang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Subgroup Analysis ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Sufficient Evidence ◽  
Crude Odds Ratio ◽  
Common Cancer ◽  
The World ◽  
Nat2 Polymorphism

Abstract Background Lung cancer is the most common cancer in the world, and cancer death is mainly caused by lung cancer. At present, the etiology and pathogenesis of lung cancer are not clear. N-acetyltransferase 2 (NAT2) is an enzyme found in the lungs, colon, breast, prostate, and liver. NAT2 is polymorphic and can metabolize carcinogens from tobacco smoke. At present, many studies have explored the effects of NAT2 polymorphism on lung cancer, but we found inconsistent results. Methods We conducted a research of 19 published studies, involving 4,130 patients and 6,057 controls, to more accurately assess the effects of NAT2 polymorphism on lung cancer risk and to investigate whether smoking is associated. We used STATA software to analyze the extracted data and used STATA for subgroup analysis, sensitivity analysis, and to perform publication bias tests. To determine the correlation, we used the crude odds ratio (ORs) with 95% confidence interval (CIs). Results From the major results, we found that there was no significant correlation between NAT2 polymorphism and lung cancer (OR = 1.00, 95% CI: 0.84–1.19, I² = 63.3%, P < 0.001 for heterogeneity). We also found no significant results in stratified analyses of smoking, ethnicity, gender, and source of controls. However, we learned from the subgroup analysis that the lung cancer risk in NAT2 patients with intermediate-slow acetylation may be increased (OR = 1.83, 95% CI: 1.22–2.73, I² = 39.6%, P = 0.191 for heterogeneity). Conclusions This research showed that no sufficient evidence was found to prove the effect of NAT2 polymorphism on lung cancer risk; however the increased acetylation capacity of NAT2 might reduce the risk of lung cancer.

scholarly journals Epidemiological Study of Lung Cancer Incidence in Lebanon

Medicina ◽  
2019 ◽  
Vol 55 (6) ◽  
pp. 217 ◽  
Author(s):  
Hamza A. Salhab ◽  
Mohamad Y. Fares ◽  
Hussein H. Khachfe ◽  
Hassan M. Khachfe
Keyword(s):  
Lung Cancer ◽  
Incidence Rate ◽  
Cancer Incidence ◽  
Incidence Rates ◽  
Lung Cancer Incidence ◽  
Cancer Incidence Rate ◽  
Mena Region ◽  
Mena Countries ◽  
Common Cancer ◽  
The World

Background and Objectives: Lung cancer (LC) is the most common cancer in the world. Developing countries in the Middle East and North Africa (MENA) region, including Lebanon, have witnessed a great increase in the incidence rates of this disease. The aim of our study is to investigate the incidence rates of lung cancer in Lebanon from 2005 to 2015 and to compare these rates to other countries from the MENA region and other regions of the world. Material and Methods: Lung cancer data for the years 2005–2015 were collected from the National Cancer Registry of Lebanon and stratified by gender and age group. Age-specific and age-standardized incidence rates were calculated and analyzed using joinpoint regression. Age-standardized incidence rates to the world population (ASR(w)) for other countries were obtained from two online databases. Results: Lung cancer ranked as the second most common cancer in Lebanon and accounted for 9.2% of all newly diagnosed cancers. Lung cancer ASR(w) showed a significantly increasing trend over the period studied for males and females. Lung cancer ASR(w) among males in Lebanon came second after Malta when compared to other MENA countries, but it was among the lowest when compared to non-MENA countries. For females, Lebanon ranked first when compared to other MENA countries but was among the lowest when compared to countries in other regions of the world. The lung cancer incidence rate increased with age in both sexes and 89.2% of patients were 50 years of age or older. Conclusion: Lebanon has the highest incidence of LC in females and the second highest for males in the MENA region. The lung cancer incidence rate is on the rise and older age groups are much more burdened by this disease than the young ones. Several risk factors, particularly smoking, play a role in increased LC incidence among the Lebanese population.

scholarly journals Disparities of National Lung Cancer Screening Guidelines in the US Population

2020 ◽  
Vol 112 (11) ◽  
pp. 1136-1142 ◽  
Author(s):  
Summer S Han ◽  
Eric Chow ◽  
Kevin ten Haaf ◽  
Iakovos Toumazis ◽  
Pianpian Cao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lung Cancer ◽  
Cancer Screening ◽  
Cancer Risk ◽  
Prediction Models ◽  
Lung Cancer Risk ◽  
Task Force ◽  
Lung Cancer Screening ◽  
Smoking History ◽  
Screening Guidelines

Abstract Background Current US Preventive Services Task Force (USPSTF) lung cancer screening guidelines are based on smoking history and age (55–80 years). These guidelines may miss those at higher risk, even at lower exposures of smoking or younger ages, because of other risk factors such as race, family history, or comorbidity. In this study, we characterized the demographic and clinical profiles of those selected by risk-based screening criteria but were missed by USPSTF guidelines in younger (50–54 years) and older (71–80 years) age groups. Methods We used data from the National Health Interview Survey, the CISNET Smoking History Generator, and results of logistic prediction models to simulate lifetime lung cancer risk-factor data for 100 000 individuals in the 1950–1960 birth cohorts. We calculated age-specific 6-year lung cancer risk for each individual from ages 50 to 90 years using the PLCOm2012 model and evaluated age-specific screening eligibility by USPSTF guidelines and by risk-based criteria (varying thresholds between 1.3% and 2.5%). Results In the 1950 birth cohort, 5.4% would have been ineligible for screening by USPSTF criteria in their younger ages but eligible based on risk-based criteria. Similarly, 10.4% of the cohort would be ineligible for screening by USPSTF in older ages. Notably, high proportions of blacks were ineligible for screening by USPSTF criteria at younger (15.6%) and older (14.2%) ages, which were statistically significantly greater than those of whites (4.8% and 10.8%, respectively; P &lt; .001). Similar results were observed with other risk thresholds and for the 1960 cohort. Conclusions Further consideration is needed to incorporate comprehensive risk factors, including race and ethnicity, into lung cancer screening to reduce potential racial disparities.

Early Mortality in Patients with Lung Cancer: Risk Factors for Death within 30 Days or 60 Days of Initial Diagnosis

2019 ◽  
Author(s):  
A Tufman ◽  
S Schneiderbauer ◽  
D Kauffmann-Guerrero ◽  
F Manapov ◽  
C Schneider ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Early Mortality ◽  
Initial Diagnosis ◽  
Cancer Risk Factors

Sonic Movements – Spatial Reflexivity

Somatechnics ◽  
2014 ◽  
Vol 4 (1) ◽  
pp. 133-148
Author(s):  
Johanna Hällsten
Keyword(s):  
Alarm System ◽  
Edo Period ◽  
Public Places ◽  
Ongoing Research ◽  
Site Specific ◽  
Rural Environments ◽  
The World ◽  
Architectural Structures ◽  
Sonic Environment ◽  
Sonic Structures

This article aims to investigate the creation of space and sound in artistic and architectural fields, with particular emphasis on the notions of interval and duration in the production and experience of soundscapes. The discussion arises out of an ongoing research project concerning sonic structures in public places, in which Japanese uguisubari ([Formula: see text]) – ‘nightingale flooring’, an alarm system from the Edo period) plays a key role in developing new kinds of site-specific and location-responsive sonic architectural structures for urban and rural environments. This paper takes uguisubari as its frame for investigating and evaluating how sounds create a space (however temporary), and how that sound in turn is created through movement. It thus seeks to unpick aspects of the reciprocal and performative act in which participant and the space engage through movement, whilst creating a sonic environment that permeates, defines and composes the boundaries of this space. The article will develop a framework for these kinds of works through a discussion on walking, movement, soundscape and somatechnical aspects of our experience of the world, drawing upon the work of Merleau-Ponty, Bergson and the Japanese concept of Ma (space-time).

LUNG CANCER RISK INDUCED BY RESIDENTIAL RADON IN CLUJ AND ALBA COUNTIES, ROMANIA

2013 ◽  
Vol 12 (6) ◽  
pp. 1281-1285 ◽  
Author(s):  
Tiberius Dicu ◽  
Doina Todea ◽  
Constantin Cosma ◽  
Loredana Rosca ◽  
Alexandra Cucos Dinu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Residential Radon
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