scholarly journals Association between multiple sclerosis and epilepsy: large population-based record-linkage studies

BMC Neurology ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Alexander N Allen ◽  
Olena O Seminog ◽  
Michael J Goldacre
Keyword(s):  
Multiple Sclerosis ◽  
Record Linkage ◽  
Large Population ◽  
Population Based ◽  
Linkage Studies

Dietary inflammatory index and risk of multiple sclerosis: Findings from a large population-based incident case–control study

2020 ◽  
Vol 39 (11) ◽  
pp. 3402-3407 ◽  
Author(s):  
Ibrahim Abdollahpour ◽  
Dejan Jakimovski ◽  
Nitin Shivappa ◽  
James R. Hébert ◽  
Farhad Vahid ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Case Control Study ◽  
Large Population ◽  
Population Based ◽  
Case Control ◽  
Dietary Inflammatory Index ◽  
Incident Case ◽  
Inflammatory Index ◽  
Control Study

Multiple sclerosis presenting as a pure psychiatric disorder

1993 ◽  
Vol 23 (4) ◽  
pp. 909-914 ◽  
Author(s):  
Keren Skegg
Keyword(s):  
Multiple Sclerosis ◽  
Psychiatric Disorder ◽  
Diagnostic Criteria ◽  
Large Population ◽  
Population Based ◽  
Population Based Study ◽  
Mental Symptoms

SynopsisUsing strict diagnostic criteria, 91 patients with multiple sclerosis (MS) were identified in a defined population of 112000. Of these patients, 29 were found to have been referred to a psychiatrist at least once. Their psychiatric records were searched for cases of MS presenting as a pure psychiatric disorder. Only 18 of the 30 psychiatric referrals before the diagnosis of MS involved purely mental symptoms, and there was no reason to suppose most of them to be related to MS. This study highlighted the problem of how to define a true psychiatric presentation of MS. The uncovering of two likely candidates among a population-based sample of 91 supported the existence of such a phenomenon, but it was concluded that the only way to ascertain how often purely mental symptoms might be the first manifestation of MS would be to conduct a large population-based study with controls.

Temporal trends in multiple sclerosis prevalence and incidence in a large population

Neurology ◽  
2018 ◽  
Vol 90 (16) ◽  
pp. e1435-e1441 ◽  
Author(s):  
Dalia L. Rotstein ◽  
Hong Chen ◽  
Andrew S. Wilton ◽  
Jeffrey C. Kwong ◽  
Ruth Ann Marrie ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Sex Ratio ◽  
Media Coverage ◽  
Latitudinal Gradient ◽  
Large Population ◽  
Temporal Trends ◽  
Delayed Diagnosis ◽  
Population Based ◽  
Incidence Rates ◽  
Health Administrative Data

ObjectiveWe sought to better understand the reasons for increasing prevalence of multiple sclerosis (MS) by studying prevalence in relation to incidence, mortality rates, sex ratio, and geographic distribution of cases.MethodsWe identified MS cases from 1996 to 2013 in Ontario, Canada, by applying a validated algorithm to health administrative data. We calculated age- and sex-standardized prevalence and incidence rates for the province and by census division. Incidence and prevalence sex ratios for women to men were computed.ResultsThe prevalence of MS increased by 69% from 1.57 (95% confidence interval [CI]: 1.54–1.59) per 1,000 in 1996 (n = 12,155) to 2.65 (95% CI: 2.62–2.68) in 2013 (n = 28,192). Incidence remained relatively stable except for a spike in 2010, followed by a subsequent decline in 2011–2013, particularly among young people and men. Mortality decreased by 33% from 26.7 (95% CI: 23.5–30.3) per 1,000 to 18.0 (95% CI: 16.4–19.8) per 1,000. The incidence sex ratio was stable from 1996 to 2009, then declined in 2010, with partial rebound by 2013. MS prevalence and incidence showed no consistent association with latitude.ConclusionIn this large, population-based MS cohort, we found stable incidence and increasing prevalence of MS; the latter largely reflected declining mortality. A spike in incidence in 2010 among younger patients and men at a time of widespread media coverage of MS suggests that these groups may be vulnerable to delayed diagnosis. We did not find a latitudinal gradient; however, most Ontarians live between the 42nd and 46th parallels, reducing our ability to detect an effect of latitude.

Determinants of Homonym and Synonym Rates of Record Linkage in Disease Registration

1996 ◽  
Vol 35 (01) ◽  
pp. 19-24 ◽  
Author(s):  
I. Schmidtmann ◽  
H. Brenner
Keyword(s):  
Quality Assessment ◽  
Record Linkage ◽  
Population Based ◽  
The Other ◽  
Linkage Studies ◽  
Discriminating Power ◽  
Number Of Patients ◽  
Disease Registries ◽  
The One

AbstractReliable record linkage is an essential component of the quality of population-based disease registration. Quality assessment of disease registries should, therefore, include quantitative approaches to describe the extent of record-linkage errors. The homonym and synonym rates have been proposed for this purpose. The homonym rate quantifies the proportion of distinct patients excluded from registration due to erroneous linkage with other patients. The synonym rate quantifies the proportion of unrecognized duplicate notifications on patients already registered in the registry. This paper provides an algebraic assessment of the determinants of both rates. It is shown how the homonym and the synonym rate are determined by the discriminating power provided by the personal identifiers and the record linkage procedure on the one hand and the specific circumstances of disease registration on the other hand, such as the number of patients in the registry or the number of notifications per case. All these factors should be taken into account when reporting and interpreting results of record-linkage studies, particularly if comparisons are made between the performance of record-linkage procedures in different environments.

scholarly journals Risk of Schizophrenia and Bipolar Disorder in Patients With Multiple Sclerosis: Record-Linkage Studies

2020 ◽  
Vol 11 ◽  
Author(s):  
Ute-Christiane Meier ◽  
Sreeram V. Ramagopalan ◽  
Michael J. Goldacre ◽  
Raph Goldacre
Keyword(s):  
Multiple Sclerosis ◽  
Bipolar Disorder ◽  
Record Linkage ◽  
Linkage Studies

scholarly journals ‘Links2HealthierBubs’ cohort study: protocol for a record linkage study on the safety, uptake and effectiveness of influenza and pertussis vaccines among pregnant Australian women

BMJ Open ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. e030277 ◽  
Author(s):  
Mohinder Sarna ◽  
Ross Andrews ◽  
Hannah Moore ◽  
Michael J Binks ◽  
Lisa McHugh ◽  
...  
Keyword(s):  
Cohort Study ◽  
Record Linkage ◽  
Large Population ◽  
Population Level ◽  
Aboriginal Health ◽  
Population Based ◽  
Linkage Study ◽  
Outcome Data ◽  
Pertussis Infection ◽  
The Impact

IntroductionPregnant women and infants are at risk of severe influenza and pertussis infection. Inactivated influenza vaccine (IIV) and diphtheria-tetanus-acellular pertussis vaccine (dTpa) are recommended during pregnancy to protect both mothers and infants. In Australia, uptake is not routinely monitored but coverage appears sub-optimal. Evidence on the safety of combined antenatal IIV and dTpa is fragmented or deficient, and there remain knowledge gaps of population-level vaccine effectiveness. We aim to establish a large, population-based, multi-jurisdictional cohort of mother-infant pairs to measure the uptake, safety and effectiveness of antenatal IIV and dTpa vaccines in three Australian jurisdictions. This is a first step toward assessing the impact of antenatal vaccination programmes in Australia, which can then inform government policy with respect to future strategies in national vaccination programmes.Methods and analysis‘Links2HealthierBubs’ is an observational, population-based, retrospective cohort study established through probabilistic record linkage of administrative health data. The cohort includes births between 2012 and 2017 (~607 605 mother-infant pairs) in jurisdictions with population-level antenatal vaccination and health outcome data (Western Australia, Queensland and the Northern Territory). Perinatal data will be the reference frame to identify the cohort. Jurisdictional vaccination registers will identify antenatal vaccination status and the gestational timing of vaccination. Information on maternal, fetal and child health outcomes will be obtained from hospitalisation and emergency department records, notifiable diseases databases, developmental anomalies databases, birth and mortality registers.Ethics and disseminationEthical approval was obtained from the Western Australian Department of Health, Curtin University, the Menzies School of Health Research, the Royal Brisbane and Women’s Hospital, and the West Australian Aboriginal Health Ethics Committees. Research findings will be disseminated in peer-reviewed journals, at scientific meetings, and may be incorporated into communication materials for public health agencies and the public.

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