The role of self-regulating abilities in long-term weight loss in severely obese children and adolescents undergoing intensive combined lifestyle interventions (HELIOS); rationale, design and methods

Abstract Background Current adult studies suggest that uric acid (UA) is associated with body fat, but the relationship in obese children is unclear. Thus, we aim to evaluate the association between uric acid and body composition of obese children. Methods A total of 79 obese children were included in this study, and 52 children (34 boys and 18 girls) underwent a 6-week weight loss camp, including 34 boys and 18 girls. Six-week weight-loss interventions were performed on all participants through aerobic exercise and appropriate dietary control. Laboratory tests and body composition were collected before and after the intervention. Results Before the intervention, correlation analysis demonstrated that uric acid was positively correlated with height, weight, body mass index (BMI), waist circumference, hip circumference, fat mass (FM), and free fat mass (FFM) with adjusting for age and gender (P < 0.05). After 6 weeks of intervention, the participants gained 3.12 ± 0.85 cm in height, body fat percentage decreased by 7.23 ± 1.97%, and lost 10.30 ± 2.83 kg in weight. Univariate and multivariate analysis indicated that uric acid at baseline was associated with FM reduction during weight loss (P < 0.05). Conclusions This study is the first report that uric acid is associated with BMI and FM, and may play an important role in the reduction of FM during weight loss in obese children and adolescents. The interaction between UA and adiposity factors and its underlying mechanisms need to be further explored. Trial registration This study was registered in Clinical Trials.gov (NCT03490448) and approved by the Ethics Committee of Xinhua Hospital, Shanghai Jiao Tong University School of Medicine.

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Increased Oxidative Stress in Prepubertal Severely Obese Children: Effect of a Dietary Restriction-Weight Loss Program

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2004-2178 ◽

2005 ◽

Vol 90 (5) ◽

pp. 2653-2658 ◽

Cited By ~ 66

Author(s):

Angelika Mohn ◽

Mariangela Catino ◽

Rita Capanna ◽

Cosimo Giannini ◽

Maria Marcovecchio ◽

...

Keyword(s):

Oxidative Stress ◽

Weight Loss ◽

Dietary Restriction ◽

Weight Loss Program ◽

Obese Children ◽

Severely Obese

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Telemedical Coaching Improves Long-Term Weight Loss in Overweight Persons: A Randomized Controlled Trial

International Journal of Telemedicine and Applications ◽

10.1155/2018/7530602 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

Kerstin Kempf ◽

Martin Röhling ◽

Monika Stichert ◽

Gabriele Fischer ◽

Elke Boschem ◽

...

Keyword(s):

Health Care ◽

Weight Loss ◽

Occupational Health ◽

Care Setting ◽

Health Care Setting ◽

Control Group ◽

Lifestyle Interventions ◽

Occupational Health Care ◽

Weight Losses

Background. Lifestyle interventions have shown to be effective when continuous personal support was provided. However, there is lack of knowledge whether a telemedical-approach with personal coaching contributes to long-term weight losses in overweight employees. We, therefore, tested the hypothesis that telemedical-based lifestyle interventions accompanied with telemedical coaching lead to larger weight losses in overweight persons in an occupational health care setting. Methods. Overweight employees (n=180) with a body mass index (BMI) of >27 kg/m2 were randomized into either a telemedical (TM) group (n=61), a telemedical coaching (TMC) group (n=58), or a control group (n=61). Both intervention groups were equipped with scales and pedometers automatically transferring the data into a personalized online portal, which could be monitored from participants and coaches. Participants of the TMC group received additionally one motivational care call per week by mental coaches to discuss the current data (current weight and steps) and achieving goals such as a healthy lifestyle or weight reduction. The control group remained in routine care. Clinical and anthropometric data were determined after the 12-week intervention. Additionally, weight change was followed up after 12 months. Results. Participants of TMC (-3.1 ± 4.8 kg, p<0.0001) and TM group (-1.9 ± 4.0 kg; p=0.0012) significantly reduced weight and sustained it during the 1-year follow-up, while the control group showed no change. Compared to the control group only weight loss in the TMC group was significantly different (p<0.001) after 12 months. TMC and TM group also reduced BMI, waist circumference, and LDL cholesterol. Moreover, TMC group improved additionally systolic and diastolic blood pressure, total cholesterol, HDL cholesterol, and HbA1c. Conclusions. Telemedical devices in combination with telemedical coaching lead to significant long-term weight reductions in overweight persons in an occupational health care setting. This study is registered with NCT01868763, ClinicalTrials.gov.

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Customized Nutritional Intervention to Improve Body Composition, Macronutrient Intake, and Nutritional Behavior in Moderate to Severe Obese Children and Adolescents (P21-063-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz041.p21-063-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Jieun Kim ◽

YoonMyung Kim ◽

Kyung-Hee Park ◽

Han Byul Jang ◽

Hye-Ja Lee ◽

...

Keyword(s):

Body Composition ◽

Children And Adolescents ◽

Body Fat ◽

Nutritional Intervention ◽

Care Process ◽

Evidence Based ◽

Macronutrient Intake ◽

Obese Children ◽

Nutritional Behavior ◽

Severely Obese

Abstract Objectives Evidence-based customized nutritional interventions are required for effective treatment of moderately-severely obese children and adolescents. Methods Eligible participants who agreed to participate in the intervention program provided informed consent. Customized nutritional intervention was implemented for each participant based on a nutrition care process (NCP) model. Sociodemographic assessment, anthropometrics, biochemical data, health- and dietary-related behaviors, and dietary intake of the study subjects were assessed at baseline and follow-up. All participants engaged in 30-minute nutritional sessions on a monthly basis. Results One hundred three [mean age: 12.4 years, severely obese: n = 69(67%)] children and adolescents were assessed at baseline. After 16 weeks, there were significant improvements in body composition [BMI (−0.8 ± 0.9, P < 0.05), BMI z-score (−0.3 ± 0.2, P < 0.001), body fat (kg) (−1.3 ± 2.1, P < 0.05), and body fat (%)(−1.5 ± 1.9, P < 0.05)] as well as macronutrient intake [total energy intake (kcal)(−563.7 ± 656.8, P < 0.05), energy (%)(−26.5 ± 30.0, P < 0.05) and fat (g)(−28.3 ± 40.6, P < 0.05)] in the adherent group than the non-adherent group. The stage of change according to the transtheoretical model (TTM) was higher in both groups after the intervention (P < 0.001). Conclusions Our customized nutritional intervention resulted in improvements in body composition, macronutrient intake, and nutritional behavior in adherent moderately-severely obese children and adolescents. These results highlight the positive effects of an evidence-based approach as a multidisciplinary intervention for people-centered nutritional care and weight management. Funding Sources This study was funded by Korea Centers for Disease Control and Prevention Grant 2015-ER6401-00.

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