Effect of intrauterine injection of human chorionic gonadotropin before embryo transfer on clinical pregnancy rates from in vitro fertilisation cycles: a prospective study

IntroductionA trial or mock embryo transfer (ET) may influence pregnancy rates and it performed prior to ET allows the clinician to assess the uterine cavity and the utero-cervical angle. The aim of this study is to compare the consistency of the type of ET in mock ET with real ET.Material & MethodsA retrospective comparative analysis of patients who underwent in vitro fertilization or ICSI cycle from January 2014 to December 2014 in Halim Fertility Center was done. The type of transfer was divided into two groups: ‘easy’ or ‘difficult’. An easy ET was defined as a transfer that occurred without the use of manipulation or other instrumentation and difficult ET was considered when additional instrumentation was required.ResultsFrom the study, 103 patients who underwent Mock-ET, we found 58 patients (56.3%) with easy ET and 45 patients (43.7%) with difficult ET, which with hard catheter ET in 17 patients (16.5%), with osfander assistance in 20 patients (19.4%) and with stylet in 8 patients (7,8%). 58 patients with Easy Mock ET group were entirely easy real ET (100%) and 45 patients with difficult Mock ET group also entirely were difficult real ET (100%). The Statistical analysis shows no significant difference between the mock ET and real ET groups (p>0,05). In easy real ET, clinical pregnancy rates were 32.8% and in difficult real ET, clinical pregnancy rates were 26.7% with no significant difference between the groups (p>0,05).Conclusion:Mock ET prior to the treatment cycle is consistent with real ET.

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Effects of human chorionic gonadotropin intrauterine injection on oocyte retrieval day on assisted reproductive techniques outcomes: An RCT

International Journal of Reproductive BioMedicine ◽

10.18502/ijrm.v19i9.9709 ◽

2021 ◽

pp. 773-780

Author(s):

Robabe Hosseinisadat ◽

Lida Saeed ◽

Sareh Ashourzadeh ◽

Sedigheh Safar Heidari ◽

Victoria Habibzadeh

Keyword(s):

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Oocyte Retrieval ◽

Pregnancy Rates ◽

Clinical Pregnancy ◽

Assisted Reproductive Techniques ◽

Control Group ◽

Case Group ◽

Reproductive Techniques ◽

Clinical Pregnancy Rates

Background: Several mediators play an important role in implantation. One of these mediators is human chorionic gonadotropin (HCG). Objective: To evaluate the effects of HCG intrauterine injection on the day of oocyte retrieval on the result of assisted reproductive techniques (ART). Materials and Methods: In this randomized clinical trial study, 126 women who were referred to Afzalipour Infertility Center between December 2018 to December 2019 undergoing in vitro fertilization/intracytoplasmic sperm injection cycles were enrolled and assigned to two groups of: a case (n = 62) and a control group (n = 64). The protocols for both groups were the same; except that the case group was injected with the protocols for both groups were the same, except that the case group was injected with 1000 IU of HCG into uterine cavity following the oocyte puncture, while no medication was administered to the control group. The implantation rate, chemical pregnancy, clinical pregnancy, and abortion rates were compared between the two groups. Results: Positive chemical pregnancy was seen in 15 (27.3%) cases of the case group and 14 (25.5%) of the control group. No significant difference was seen in the chemical and clinical pregnancy rates between the groups. The abortion rate was higher in the control group but that was not significant. Conclusion: A 1000 IU of HCG intrauterine injection after oocyte retrieval does not improve implantation, chemical or clinical pregnancy rates in ART cycles. Further studies are needed to clearly understand the role of HCG intrauterine injection in the day of oocyte retrieval in ART outcomes. Key words: Oocyte retrieval, Chorionic gonadotropin, Pregnancy, Assisted reproductive techniques.

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Do intrauterine injection of human chorionic gonadotropin (hCG) before embryo transfer increases implantation and pregnancy rates in patients undergoing in vitro fertilization?

Fertility and Sterility ◽

10.1016/j.fertnstert.2013.07.1082 ◽

2013 ◽

Vol 100 (3) ◽

pp. S289 ◽

Cited By ~ 3

Author(s):

M.M. Rebolloso ◽

J.C. Rosales De Leon ◽

P. Galache Vega ◽

R. Santos-Haliscak ◽

P. Diaz-Spindola ◽

...

Keyword(s):

In Vitro Fertilization ◽

Embryo Transfer ◽

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Pregnancy Rates ◽

Vitro Fertilization ◽

Implantation And Pregnancy Rates

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The Non-linear Association Between Serum Level of Anti-M�llerian Hormone and in vitro Fertilisation Outcome

Revista de Chimie ◽

10.37358/rc.19.9.7556 ◽

2019 ◽

Vol 70 (9) ◽

pp. 3392-3398

Author(s):

Dragos Nicolae Albu ◽

Alice Ioana Albu ◽

Gabriel Octavian Olaru ◽

Romina Marina Sima ◽

Adrian Neacsu ◽

...

Keyword(s):

Serum Level ◽

Negative Impact ◽

Fertilization Rate ◽

Pregnancy Rates ◽

Clinical Pregnancy ◽

In Vitro Fertilisation ◽

Fertilisation Rate ◽

Clinical Pregnancy Rates ◽

Age Independent

Aim of the study was to analyse the relationship between Anti-M�llerian Hormone (AMH) serum level and in vitro fertilisation (IVF) with and without intra-cytoplasmic sperm injection (ICSI) outcome. We performed a retrospective study which included 1073 patients (mean age 34.68�4.28 years, mean body mass index 22.7�15.65 kg/m2) who performed IVF or IVF/ICSI between January 2013 and December 2016.We found that AMH serum level was age-independent positively related with oocytes (beta=0.329, p[0.0001) and zygotes number (beta=0.248, p[0.0001) and negatively correlated with fertilization rate (beta=-0.108, p=0.001). In multivariate regression, after adjustment for confounders, only oocytes number, but not AMH serum level, was associated with zygotes number (beta=0.814, p[0.0001) and fertilisation rate (beta=- 0.133, p=0.001). Patients with AMH in the range 1.1-5 ng/mL had significantly higher biochemical (65.3% versus 56.6%, p=0.009) and clinical pregnancy rates (57.7% versus 49.2%, p=0.014) in comparison with patients with AMH below 1.1 ng/mL and higher clinical pregnancy rates in comparison with patients with AMH above 7 ng/mL (57.7% versus 44%, p=0.011). Logistic regression analysis showed that AMH was positively associated with biochemical (OR 1.19, p=0.003) and clinical pregnancy (OR 1.16, p=0.009) independently of age and number of good embryos transferred in patients with AMH below 5 ng/mL. In turn, when only patients with normal ovarian reserve were analysed (AMH above 1.1 ng/mL), we found an age-independent negative association between AMH and clinical pregnancy (OR 0.93, p=0.014). AMH serum level is associated with both quantitative response (oocytes number) and qualitative parameters (pregnancy rate) during IVF/ICSI. We also found a bimodal relationship between AMH and pregnancy rates, which were positively associated in patients with AMH below 5 ng/mL, although higher AMH values seem to have a negative impact on pregnancy chances.

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