scholarly journals Propolis volatile compounds: chemical diversity and biological activity: a review

2014 ◽  
Vol 8 (1) ◽  
Author(s):  
Vassya Bankova ◽  
Milena Popova ◽  
Boryana Trusheva
Marine Drugs ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. 335
Author(s):  
Xia Yan ◽  
Jing Liu ◽  
Xue Leng ◽  
Han Ouyang

Sinularia is one of the conspicuous soft coral species widely distributed in the world’s oceans at a depth of about 12 m. Secondary metabolites from the genus Sinularia show great chemical diversity. More than 700 secondary metabolites have been reported to date, including terpenoids, norterpenoids, steroids/steroidal glycosides, and other types. They showed a broad range of potent biological activities. There were detailed reviews on the terpenoids from Sinularia in 2013, and now, it still plays a vital role in the innovation of lead compounds for drug development. The structures, names, and pharmacological activities of compounds isolated from the genus Sinularia from 2013 to March 2021 are summarized in this review.


2017 ◽  
Vol 18 (5) ◽  
pp. 1081 ◽  
Author(s):  
Joyce da Silva ◽  
Rafaela da Trindade ◽  
Edith Moreira ◽  
José Maia ◽  
Noura Dosoky ◽  
...  

Biomolecules ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1155
Author(s):  
Jamile S. da Costa ◽  
Ellen de Nazaré S. da Cruz ◽  
William N. Setzer ◽  
Joyce Kelly do R. da Silva ◽  
José Guilherme S. Maia ◽  
...  

The Eugenia and Syzygium genera include approximately 1000 and 1800 species, respectively, and both belong to the Myrtaceae. Their species present economic and medicinal importance and pharmacological properties. Due to their chemical diversity and biological activity, we are reporting the essential oils of 48 species of these two genera, which grow in South America and found mainly in Brazil. Chemically, a total of 127 oil samples have been described and displayed a higher intraspecific and interspecific diversity for both Eugenia spp. and Syzygium spp., according to the site of collection or seasonality. The main volatile compounds were sesquiterpene hydrocarbons and oxygenated sesquiterpenes, mainly with caryophyllane and germacrane skeletons and monoterpenes of mostly the pinane type. The oils presented many biological activities, especially antimicrobial (antifungal and antibacterial), anticholinesterase, anticancer (breast, gastric, melanoma, prostate), antiprotozoal (Leishmania spp.), antioxidant, acaricidal, antinociceptive and anti-inflammatory. These studies can contribute to the rational and economic exploration of Eugenia and Syzygium species once they have been identified as potent natural and alternative sources to the production of new herbal medicines.


Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5386
Author(s):  
Shean-Yeaw Ng ◽  
Chin-Soon Phan ◽  
Takahiro Ishii ◽  
Takashi Kamada ◽  
Toshiyuki Hamada ◽  
...  

Members of the marine soft coral genus Xenia are rich in a diversity of diterpenes. A total of 199 terpenes consisting of 14 sesquiterpenes, 180 diterpenes, and 5 steroids have been reported to date. Xenicane diterpenes were reported to be the most common chemical skeleton biosynthesized by members of this genus. Most of the literature reported the chemical diversity of Xenia collected from the coral reefs in the South China Sea and the coastal waters of Taiwan. Although there was a brief review on the terpenoids of Xenia in 2015, the present review is a comprehensive overview of the structural diversity of secondary metabolites isolated from soft coral genus Xenia and their potent biological activity as reported between 1977 to 2019.


2015 ◽  
Vol 112 (34) ◽  
pp. E4717-E4725 ◽  
Author(s):  
Erin N. Heim ◽  
Jez L. Marston ◽  
Ross S. Federman ◽  
Anne P. B. Edwards ◽  
Alexander G. Karabadzhak ◽  
...  

We have constructed 26-amino acid transmembrane proteins that specifically transform cells but consist of only two different amino acids. Most proteins are long polymers of amino acids with 20 or more chemically distinct side-chains. The artificial transmembrane proteins reported here are the simplest known proteins with specific biological activity, consisting solely of an initiating methionine followed by specific sequences of leucines and isoleucines, two hydrophobic amino acids that differ only by the position of a methyl group. We designate these proteins containing leucine (L) and isoleucine (I) as LIL proteins. These proteins functionally interact with the transmembrane domain of the platelet-derived growth factor β-receptor and specifically activate the receptor to transform cells. Complete mutagenesis of these proteins identified individual amino acids required for activity, and a protein consisting solely of leucines, except for a single isoleucine at a particular position, transformed cells. These surprisingly simple proteins define the minimal chemical diversity sufficient to construct proteins with specific biological activity and change our view of what can constitute an active protein in a cellular context.


2016 ◽  
Vol 14 (1) ◽  
pp. e1600125 ◽  
Author(s):  
Yoro Tine ◽  
Abdoulaye Diop ◽  
William Diatta ◽  
Jean-Marie Desjobert ◽  
Cheikh Saad Bouh Boye ◽  
...  

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