Ginsenoside Rh1 potentiates dexamethasone’s anti-inflammatory effects for chronic inflammatory disease by reversing dexamethasone-induced resistance

AbstractAtherosclerotic vascular disease and its related complications are the major cause of mortality in Western societies. Atherosclerosis is a chronic inflammatory disease of the arterial wall triggered by traditional and nontraditional risk factors and mediated by inflammatory and immune responses. Recent clinical trials provided compelling evidence corroborating that atherosclerosis is an inflammatory disease and demonstrated efficacy of anti-inflammatory interventions in reducing cardiovascular events and mortality. Traditional risk factors drive vascular inflammation, further justifying the instrumental role of intensified risk factor management in attenuating and preventing atherosclerotic disease and complications. Promising therapeutic approaches specifically related to inhibition of inflammation span traditional anti-inflammatory drugs, specific immunomodulation, and development of vaccination against atherosclerotic disease. Here, we review the inflammatory component in atherogenesis, the available evidence from clinical trials evaluating efficacy of therapeutic anti-inflammatory interventions in patients with high cardiovascular risk, and discuss potential future targets for anti-inflammatory or immune modulatory treatment in atherosclerotic cardiovascular disease.

Download Full-text

Millet shell polyphenols prevent atherosclerosis by protecting gut barrier and remodeling gut microbiota in ApoE-/- mice

Food & Function ◽

10.1039/d1fo00991e ◽

2021 ◽

Author(s):

Fengming Liu ◽

Shuhua Shan ◽

Hanqing Li ◽

Jiangying Shi ◽

Ruilin Hao ◽

...

Keyword(s):

Cardiovascular Disease ◽

Gut Microbiota ◽

Inflammatory Disease ◽

Chronic Inflammatory Disease ◽

Gut Barrier ◽

Anti Inflammatory ◽

Inflammatory Effect

Atherosclerosis, the major cause of cardiovascular disease, is a chronic inflammatory disease. The anti-inflammatory effect of certain polyphenols have been recognized. Active polyphenols were extracted from millet shell (MSP)，and the...

Download Full-text

Therapeutic glucocorticoids prevent local and systemic bone loss in the TNF-tg model of chronic inflammatory disease

Endocrine Abstracts ◽

10.1530/endoabs.59.oc5.6 ◽

2018 ◽

Author(s):

Chloe Fenton ◽

Syeda Fareed ◽

Amy Naylor ◽

Dominika Nanus ◽

Mark Cooper ◽

...

Keyword(s):

Bone Loss ◽

Inflammatory Disease ◽

Chronic Inflammatory Disease ◽

Systemic Bone Loss

Download Full-text

Acute and Chronic Inflammatory Disease, Lifestyle and Treatment Response

Case Medical Research ◽

10.31525/ct1-nct04193020 ◽

2019 ◽

Author(s):

Keyword(s):

Treatment Response ◽

Inflammatory Disease ◽

Chronic Inflammatory Disease

Download Full-text

Assessment of biochemical determinants in Multiple Sclerosis patients following the oral administration of β-D-Mannuronic acid [M2000]

Current Drug Discovery Technologies ◽

10.2174/1570163817999200918104333 ◽

2020 ◽

Vol 17 ◽

Author(s):

Mohamad Reza Nikouei Moghaddam ◽

Monireh Movahedi ◽

Maryam Bananej ◽

Soheil Najafi ◽

Nahid Beladi Moghadam ◽

...

Keyword(s):

Multiple Sclerosis ◽

Uric Acid ◽

Vitamin D3 ◽

Chronic Inflammatory Disease ◽

Toxic Effects ◽

Control Group ◽

Therapeutic Effects ◽

Mannuronic Acid ◽

Anti Inflammatory ◽

Multiple Sclerosis Patients

Background: Multiple sclerosis is an autoimmune chronic inflammatory disease of the central nervous system that can lead to some serious disabilities. Despite using various immunomodulatory and anti-inflammatory drugs that have therapeutic effects, they cannot reduce its progression completely, and have some unwanted side effects too. The immunomodulatory and anti-inflammatory effects of the β-D-Mannuronic acid [M2000] have been proven in several surveys, and the present research was designed to determine its toxicity and therapeutic effects in MS patients. Methods: This study was performed on 15 MS patients who took 25 mg/kg/day the oral form of the β-D-Mannuronic acid for six months, and 15 healthy people as a control group. Serum levels of Urea, Creatinine, GGT, Vitamin D3, Uric acid, and Anti-Phospholipids were compared to evaluate the therapeutic and possible toxic effects of this drug after this period. Results: Non- toxic effects through the study of Urea, Creatinine, GGT, and non-significant changes in Uric acid and AntiPhospholipids levels, besides a significant rise in Vitamin, D3 levels in the M2000 treated cases were found. Conclusions: Our results suggested that β-D-Mannuronic acid is a safe drug and has no toxicity when administered orally and also has some therapeutic effects in MS patients.

Download Full-text

A Critical Review on Tamaka Shwasa (Bronchial Asthma) - An Ayurvedic View

Journal of Ayurveda and Integrated Medical Sciences (JAIMS) ◽

10.21760/jaims.v2i3.8236 ◽

2017 ◽

Vol 2 (3) ◽

Author(s):

Sandip R. Baheti ◽

Deepa Sharma ◽

Saroj Devi ◽

Amit Rai

Keyword(s):

Bronchial Asthma ◽

Inflammatory Disease ◽

Critical Review ◽

Modern Science ◽

Modern Medicine ◽

Chronic Inflammatory Disease ◽

The Body ◽

Natural Immunity ◽

Shortness Of Breath ◽

Asthma Symptoms

Difficulty in breathing or shortness of breath may be simply termed as Shwasa (Asthma), As per Ayurveda, Shwasa is mainly caused by the Vata and Kapha Doshas. Shwasa is broadly classified into five types in Maha Shwasa (Dyspnoea major), Urdhawa Shwasa (Expiratory Dyspnoea), Chinna Shwasa (Chyne-stroke respiration), Kshudra Shwasa (Dyspnoea minor), Tamaka Shwasa (Bronchial Asthma). In modern science Tamaka Shwasa can be correlated with Asthma, Asthma which is a chronic inflammatory disease of airway. In modern medicine there is no cure for Asthma, symptoms can typically be improved. In Ayurveda, Asthma can be effectively and safely manage the condition without inducing any drug dependency where Pachakarma procedures and use of internal medication detoxifies the body, provides nutrition and increases the elasticity of lung tissue it also develops natural immunity of the body thus decreasing episodic recurrence of the disease.

Download Full-text

Intermammary Hidradenitis Suppurativa: Considerations on a Unique Presentation

Skin Appendage Disorders ◽

10.1159/000514363 ◽

2021 ◽

pp. 1-4

Author(s):

Ana Luísa João ◽

Nélia Cunha ◽

Joana Cabete

Keyword(s):

Surgical Approach ◽

Inflammatory Disease ◽

Pilonidal Sinus ◽

Hidradenitis Suppurativa ◽

Chronic Inflammatory Disease ◽

Pilonidal Sinus Disease ◽

Sinus Disease ◽

Case Presentation ◽

Overweight Women

Introduction: Hidradenitis suppurativa (HS) is a potentially disabling chronic inflammatory disease. The intermammary location, not clearly specified in the usual phenotypic classifications, entails significant functional and cosmetic compromise. Case Presentation: Eleven cases of predominantly intermammary disease with multiple fistulization and disfiguring scarring were observed at our Department between January 2016 and March 2020. They were young (mean age = 22 years) obese or overweight women, in which the medical-surgical approach has led to variable results. Discussion/Conclusion: Intermammary HS possibly represents a unique phenotypic presentation, likely to be fistulizing and severe. We believe that anatomo-functional considerations, which can be paralleled to pilonidal sinus disease, contribute to its pathophysiology and striking appearance, and further emphasize the importance of multidisciplinary endeavor to reduce the morbidity associated with this seemingly overlooked location.

Download Full-text