scholarly journals CD44 enhances invasion of basal-like breast cancer cells by upregulating serine protease and collagen-degrading enzymatic expression and activity

2012 ◽  
Vol 14 (3) ◽  
Author(s):  
Nicola Montgomery ◽  
Ashleigh Hill ◽  
Suzanne McFarlane ◽  
Jessica Neisen ◽  
Anthony O'Grady ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Serine Protease ◽  
Breast Cancer Cells ◽  
Basal Like Breast Cancer ◽  
Enzymatic Expression ◽  
Expression And Activity

scholarly journals Correction: MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Yubao Wang ◽  
Young-Mi Li ◽  
Lukas Baitsch ◽  
Alan Huang ◽  
Yi Xiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Mitotic Progression ◽  
Basal Like Breast Cancer

scholarly journals α-Tubulin Acetylation Elevated in Metastatic and Basal-like Breast Cancer Cells Promotes Microtentacle Formation, Adhesion, and Invasive Migration

2014 ◽  
Vol 75 (1) ◽  
pp. 203-215 ◽  
Author(s):  
Amanda E. Boggs ◽  
Michele I. Vitolo ◽  
Rebecca A. Whipple ◽  
Monica S. Charpentier ◽  
Olga G. Goloubeva ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Tubulin Acetylation ◽  
Basal Like Breast Cancer

scholarly journals A homeobox protein, NKX6.1, up-regulates interleukin-6 expression for cell growth in basal-like breast cancer cells

2016 ◽  
Vol 343 (2) ◽  
pp. 177-189 ◽  
Author(s):  
Wenzhao Li ◽  
Junji Itou ◽  
Sunao Tanaka ◽  
Tomomi Nishimura ◽  
Fumiaki Sato ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Interleukin 6 ◽  
Breast Cancer Cells ◽  
Basal Like Breast Cancer ◽  
Homeobox Protein

scholarly journals Aberrant ALOX5 Activation Correlates with HER2 Status and Mediates Breast Cancer Biological Activities through Multiple Mechanisms

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Xiao Zhou ◽  
Yi Jiang ◽  
Qiuyun Li ◽  
Zhen Huang ◽  
Huawei Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Biological Activities ◽  
Critical Role ◽  
Her2 Overexpression ◽  
Her2 Positive ◽  
Mesenchymal Transition ◽  
And Migration ◽  
Expression And Activity

Arachidonate lipoxygenases (ALOX) have been implicated in playing a critical role in tumorigenesis, development, and metastasis. We previously reported that ALOX12 is involved in breast cancer chemoresistance. In this study, we demonstrate that the ALOX5 activation correlates with the HER2 expression and mediates breast cancer growth and migration. We found that the ALOX5 expression and activity were upregulated in breast cancer patients, particularly in those tissues with HER2-positive. ALOX5 upregulation was also observed in HER2-positive breast cancer cells. In contrast, HER2 inhibition led to decreased expression and activity of ALOX5 but not ALOX5AP, suggesting that HER2 specifically regulates the ALOX5 expression and activity in breast cancer cells. We further demonstrated that ALOX5 is important for breast cancer biological activities with the predominant roles in growth and migration, likely through RhoA, focal adhesion, and PI3K/Akt/mTOR signaling but not epithelial mesenchymal transition (EMT). Our work is the first to report a correlation between the ALOX5 activity and HER2 overexpression in breast cancer. Our findings also highlight the therapeutic value of inhibiting ALOX5 in breast cancer, particularly those patients with the HER2 overexpression.

scholarly journals Selective Effects of Thioridazine on Self-Renewal of Basal-Like Breast Cancer Cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Matthew Tegowski ◽  
Cheng Fan ◽  
Albert S. Baldwin
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cells ◽  
Cell Types ◽  
Breast Cancer Cell Lines ◽  
Breast Cancers ◽  
Self Renewal ◽  
Basal Like Breast Cancer

AbstractSeveral recent publications demonstrated that DRD2-targeting antipsychotics such as thioridazine induce proliferation arrest and apoptosis in diverse cancer cell types including those derived from brain, lung, colon, and breast. While most studies show that 10–20 µM thioridazine leads to reduced proliferation or increased apoptosis, here we show that lower doses of thioridazine (1–2 µM) target the self-renewal of basal-like breast cancer cells, but not breast cancer cells of other subtypes. We also show that all breast cancer cell lines tested express DRD2 mRNA and protein, regardless of thioridazine sensitivity. Further, DRD2 stimulation with quinpirole, a DRD2 agonist, promotes self-renewal, even in cell lines in which thioridazine does not inhibit self-renewal. This suggests that DRD2 is capable of promoting self-renewal in these cell lines, but that it is not active. Further, we show that dopamine can be detected in human and mouse breast tumor samples. This observation suggests that dopamine receptors may be activated in breast cancers, and is the first time to our knowledge that dopamine has been directly detected in human breast tumors, which could inform future investigation into DRD2 as a therapeutic target for breast cancer.

scholarly journals Serine Protease PRSS23 Is Upregulated by Estrogen Receptor α and Associated with Proliferation of Breast Cancer Cells

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e30397 ◽  
Author(s):  
Hau-Shien Chan ◽  
Shing-Jyh Chang ◽  
Tao-Yeuan Wang ◽  
Hung-Ju Ko ◽  
Yu-Chih Lin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Serine Protease ◽  
Breast Cancer Cells ◽  
Estrogen Receptor Α
Sign in / Sign up

Export Citation Format

Share Document