Hemodynamics changes induced by volume expansion measured by PiCCO® system: the post-expansion effect

Diabetic nephropathy is global problem with several drugs into trial without much success the current article highlights the role of thiazolidinedione’s in diabetic nephropathy by scrutinizing and reconnoitring the cellular and intracellular mechanism and shielding action and the role of peroxisome proliferator-activated gamma receptors (PPARγ) receptors. Not only anti-diabetic action but renal protective effect with evidence based study has been highlighted. PPAR γ-is versatile target having numerous benefits and mainly preventing fibrosis in diabetic experimental model and some clinical case report yet, the benefits are not up to mark, since renal failure itself causes volume expansion and the thiazolidinedione’s (TZDs) also preserve salt and water and lead to congestive heart failure which constraints its clinical application. Dual activators and balaglitazone selective PPAR modulator are having upcoming potential for treatment of diabetic nephropathy. Further detail investigation on such drug is needed to explore. However adverse effect like heart failure, osteoporosis and volume expansion effect over-rides the beneficial effect thus limiting its clinical use of currently available TZDs.

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The liquid volume expansion effect as a simple thermodynamic criterion in cholesterol micronization by supercritical assisted atomization

Chemical Engineering Science ◽

10.1016/j.ces.2012.02.046 ◽

2012 ◽

Vol 75 ◽

pp. 38-48 ◽

Cited By ~ 5

Author(s):

Qi Wang ◽

Yi-Xin Guan ◽

Shan-Jing Yao ◽

Zi-Qiang Zhu

Keyword(s):

Volume Expansion ◽

Liquid Volume ◽

Thermodynamic Criterion ◽

Expansion Effect

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Glue Embolization of the Giant Aneurysm by Reducing Thrombosis-Induced Volume Expansion Effect

Journal of the Korean Society of Radiology ◽

10.3348/jksr.2015.72.4.300 ◽

2015 ◽

Vol 72 (4) ◽

pp. 300 ◽

Cited By ~ 1

Author(s):

Yoo Kyung Yeom ◽

Dae Chul Suh

Keyword(s):

Volume Expansion ◽

Giant Aneurysm ◽

Glue Embolization ◽

Expansion Effect

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Steel slag aggregate concrete filled-in FRP tubes: Volume expansion effect and axial compressive behaviour

Construction and Building Materials ◽

10.1016/j.conbuildmat.2021.125961 ◽

2022 ◽

Vol 318 ◽

pp. 125961

Author(s):

Peng Feng ◽

Zhiyuan Li ◽

Shanbao Zhang ◽

Jia-Qi Yang

Keyword(s):

Volume Expansion ◽

Steel Slag ◽

Aggregate Concrete ◽

Compressive Behaviour ◽

Frp Tubes ◽

Expansion Effect

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Radiation Damage Studies with the HVEM

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100096655 ◽

1972 ◽

Vol 30 ◽

pp. 680-681

Author(s):

J. J. Laidler ◽

B. Mastel

Keyword(s):

Radiation Damage ◽

Stainless Steels ◽

Volume Expansion ◽

Austenitic Stainless Steels ◽

Test Facility ◽

Fast Breeder Reactors ◽

Breeder Reactors ◽

Under Construction ◽

Development Laboratory ◽

Insight Into

One of the major materials problems encountered in the development of fast breeder reactors for commercial power generation is the phenomenon of swelling in core structural components and fuel cladding. This volume expansion, which is due to the retention of lattice vacancies by agglomeration into large polyhedral clusters (voids), may amount to ten percent or greater at goal fluences in some austenitic stainless steels. From a design standpoint, this is an undesirable situation, and it is necessary to obtain experimental confirmation that such excessive volume expansion will not occur in materials selected for core applications in the Fast Flux Test Facility, the prototypic LMFBR now under construction at the Hanford Engineering Development Laboratory (HEDL). The HEDL JEM-1000 1 MeV electron microscope is being used to provide an insight into trends of radiation damage accumulation in stainless steels, since it is possible to produce atom displacements at an accelerated rate with 1 MeV electrons, while the specimen is under continuous observation.

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