scholarly journals Aberrant cerebral blood flow in tinnitus patients with migraine: a perfusion functional MRI study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Zhen-Gui Xu ◽  
Jin-Jing Xu ◽  
Yu-Chen Chen ◽  
Jinghua Hu ◽  
Yuanqing Wu ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Sex Education ◽  
Arterial Spin Labeling ◽  
Superior Temporal Gyrus ◽  
Chronic Tinnitus ◽  
Functional Magnetic Resonance ◽  
Hearing Thresholds ◽  
Tinnitus Distress ◽  
Mri Study

Abstract Purpose Migraine is often accompanied with chronic tinnitus that will affect the cerebral blood flow (CBF) and exacerbate the tinnitus distress. However, the potential relationship between migraine and tinnitus remains unclear. This study will investigate whether aberrant CBF patterns exist in migraine patients with tinnitus and examine the influence of migraine on CBF alterations in chronic tinnitus. Materials and methods Participants included chronic tinnitus patients (n = 45) and non-tinnitus controls (n = 50), matched for age, sex, education, and hearing thresholds. CBF images were collected and analyzed using arterial spin labeling (ASL) perfusion functional magnetic resonance imaging (fMRI). Regions with major CBF differences between tinnitus patients and non-tinnitus controls were first detected. The effects of migraine on tinnitus for CBF alterations were further examined. Correlation analyses illustrated the association between CBF values and tinnitus severity as well as between CBF and severity of migraine. Results Compared with non-tinnitus controls, chronic tinnitus patients without migraine exhibited decreased CBF, primarily in right superior temporal gyrus (STG), bilateral middle frontal gyrus (MFG), and left superior frontal gyrus (SFG); decreased CBF in these regions was correlated with tinnitus distress. There was a significant effect of migraine on tinnitus for CBF in right STG and MFG. Moreover, the severity of migraine correlated negatively with CBF in tinnitus patients. Conclusions Chronic tinnitus patients exhibited reduced CBF in the auditory and prefrontal cortex. Migraine may facilitate a CBF decrease in the setting of tinnitus, which may underlie the neuropathological mechanisms of chronic tinnitus comorbid with migraine.

scholarly journals Headache is associated with aberrant cerebral blood flow in chronic tinnitus revealed by perfusion functional MRI

2020 ◽  
Author(s):  
Yu-Chen Chen ◽  
Jinghua Hu ◽  
Jinluan Cui ◽  
Song’an Shang ◽  
Wei Yong ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Sex Education ◽  
Arterial Spin Labeling ◽  
Superior Temporal Gyrus ◽  
Chronic Tinnitus ◽  
Significant Interaction Effect ◽  
Hearing Thresholds ◽  
Tinnitus Distress ◽  
Headache Symptom

Abstract Background: Chronic tinnitus is often accompanied with headache symptom that will affect the cerebral blood flow (CBF) and exacerbate the tinnitus distress. However, the potential relationship between headache and tinnitus remains unclear. This study will investigate whether aberrant CBF patterns exist in chronic tinnitus patients and examine the influence of headache on CBF alterations in chronic tinnitus. Methods: Participants included chronic tinnitus patients (n=45) and non-tinnitus controls (n=50), matched for age, sex, education, and hearing thresholds. CBF images were collected and analyzed using arterial spin labeling (ASL) perfusion functional magnetic resonance imaging (fMRI). Regions with major CBF differences between tinnitus patients and non-tinnitus controls were first detected. The interaction effects between headache and tinnitus for CBF alterations were further examined. Correlation analyses illustrated the association between CBF values and tinnitus severity as well as between CBF and degree of headache.Results: Compared with non-tinnitus controls, chronic tinnitus patients exhibited decreased CBF, primarily in right superior temporal gyrus (STG), bilateral middle frontal gyrus (MFG), and left superior frontal gyrus (SFG); decreased CBF in these regions was correlated with tinnitus distress. There was a significant interaction effect between headache and tinnitus for CBF in right STG and MFG. Moreover, the degree of headache correlated negatively with CBF in tinnitus patients.Conclusions: Chronic tinnitus patients exhibited reduced CBF in the auditory and prefrontal cortex. Headache may facilitate a CBF decrease in the setting of tinnitus, which may underlie the neuropathological mechanisms of chronic tinnitus comorbid with headache.

scholarly journals Bolus Arrival Time and Cerebral Blood Flow Responses to Hypercarbia

2014 ◽  
Vol 34 (7) ◽  
pp. 1243-1252 ◽  
Author(s):  
Manus J Donahue ◽  
Carlos C Faraco ◽  
Megan K Strother ◽  
Michael A Chappell ◽  
Swati Rane ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Arrival Time ◽  
Cerebrovascular Reactivity ◽  
Functional Magnetic Resonance ◽  
Parietal Lobes ◽  
Experimental Parameters ◽  
Repetition Time ◽  
Bolus Arrival Time

The purpose of this study was to evaluate how cerebral blood flow and bolus arrival time (BAT) measures derived from arterial spin labeling (ASL) MRI data change for different hypercarbic gas stimuli. Pseudocontinuous ASL (pCASL) was applied (3.0T; spatial resolution = 4 × 4 × 7 mm 3 ; repetition time/echo time ( TR/TE) = 3,600/11 ms) sequentially in healthy volunteers ( n = 12; age = 30±4 years) for separate experiments in which (i) normocarbic normoxia (i.e., room air), hypercarbic normoxia (i.e., 5% CO2/21% O2/74% N2), and hypercarbic hyperoxia (i.e., carbogen: 5% CO2/95% O2) gas was administered (12 L/minute). Cerebral blood flow and BAT changes were quantified using models that account for macrovascular signal and partial volume effects in all gray matter and regionally in cerebellar, temporal, occipital, frontal, and parietal lobes. Regional reductions in BAT of 4.6% to 7.7% and 3.3% to 6.6% were found in response to hypercarbic normoxia and hypercarbic hyperoxia, respectively. Cerebral blood flow increased by 8.2% to 27.8% and 3.5% to 19.8% for hypercarbic normoxia and hypercarbic hyperoxia, respectively. These findings indicate that changes in BAT values may bias functional ASL data and thus should be considered when choosing appropriate experimental parameters in calibrated functional magnetic resonance imaging or ASL cerebrovascular reactivity experiments that use hypercarbic gas stimuli.

Abnormalities of cerebral blood flow in multiple sclerosis: A pseudocontinuous arterial spin labeling MRI study

2013 ◽  
Vol 31 (6) ◽  
pp. 990-995 ◽  
Author(s):  
Miho Ota ◽  
Noriko Sato ◽  
Yasuhiro Nakata ◽  
Kimiteru Ito ◽  
Kouhei Kamiya ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Mri Study

P2-252: Cerebral blood flow changes in early Alzheimer's disease: A high-field arterial spin labeling perfusion MRI study

2012 ◽  
Vol 8 (4S_Part_9) ◽  
pp. P350-P350
Author(s):  
Xiaowei Song ◽  
Chen Wei ◽  
Ryan D'Arcy ◽  
Steven Beyea ◽  
Careesa Liu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
High Field ◽  
Spin Labeling ◽  
Perfusion Mri ◽  
Flow Changes ◽  
Early Alzheimer’S Disease ◽  
Mri Study

scholarly journals Arterial Spin Labeling Cerebral Perfusion Changes in Chronic Tinnitus With Tension-Type Headache

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhen-Gui Xu ◽  
Jin-Jing Xu ◽  
Jinghua Hu ◽  
Yuanqing Wu ◽  
Dan Wang
Keyword(s):  
Arterial Spin Labeling ◽  
Superior Temporal Gyrus ◽  
Spin Labeling ◽  
Tension Type Headache ◽  
Perfusion Magnetic Resonance Imaging ◽  
Chronic Tinnitus ◽  
Healthy Controls ◽  
Tinnitus Distress ◽  
Type Headache ◽  
The Right

Purpose: Tinnitus is along with tension-type headache that will influence the cerebral blood flow (CBF) and accelerate the tinnitus severity. However, the potential associations between tension-type headache and tinnitus is still unknown. The current study will explore whether abnormal CBF exists in tinnitus patients and examine the effects of headache on CBF in tinnitus patients.Materials and Methods: Resting-state perfusion magnetic resonance imaging was performed in 40 chronic tinnitus patients and 50 healthy controls using pseudocontinuous arterial spin labeling. Regions with CBF differences between tinnitus patients and healthy controls were investigated. The effects of headache on tinnitus for CBF changes were further explored. Correlation analyses revealed the relationship between CBF values and tinnitus distress as well as CBF values and headache degree.Results: Relative to healthy controls, chronic tinnitus showed decreased CBF, mainly in right superior temporal gyrus (STG), left middle frontal gyrus (MFG), and left superior frontal gyrus (SFG); the CBF in the right STG and the left MFG was negatively correlated with THQ scores (r = −0.553, p = 0.001; r = −0.399, p = 0.017). We also observed a significant effect of headache on tinnitus for CBF in the right STG. Furthermore, the headache degree was correlated positively with tinnitus distress (r = 0.594, p = 0.020).Conclusion: Decreased CBF in auditory and prefrontal cortex was observed in chronic tinnitus patients. Headache may accelerate CBF reductions in tinnitus, which may form the basis for the neurological mechanism in chronic tinnitus with tension-type headache.

scholarly journals Quantitative Functional Magnetic Resonance Imaging of Brain Activity Using Bolus-Tracking Arterial Spin Labeling

2010 ◽  
Vol 30 (5) ◽  
pp. 913-922 ◽  
Author(s):  
Michael E Kelly ◽  
Christoph W Blau ◽  
Karen M Griffin ◽  
Oliviero L Gobbo ◽  
James FX Jones ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Resting State ◽  
Arterial Spin Labeling ◽  
Cerebral Blood Volume ◽  
Spin Labeling ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Perfusion Coefficient

Blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) is the most widely used method for mapping neural activity in the brain. The interpretation of altered BOLD signals is problematic when cerebral blood flow (CBF) or cerebral blood volume change because of aging and/or neurodegenerative diseases. In this study, a recently developed quantitative arterial spin labeling (ASL) approach, bolus-tracking ASL (btASL), was applied to an fMRI experiment in the rat brain. The mean transit time (MTT), capillary transit time (CTT), relative cerebral blood volume of labeled water (rCBVlw), relative cerebral blood flow (rCBF), and perfusion coefficient in the forelimb region of the somatosensory cortex were quantified during neuronal activation and in the resting state. The average MTT and CTT were 1.939±0.175 and 1.606±0.106 secs, respectively, in the resting state. Both times decreased significantly to 1.616±0.207 and 1.305±0.201 secs, respectively, during activation. The rCBVlw, rCBF, and perfusion coefficient increased on average by a factor of 1.123±0.006, 1.353±0.078, and 1.479±0.148, respectively, during activation. In contrast to BOLD techniques, btASL yields physiologically relevant indices of the functional hyperemia that accompanies neuronal activation.

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