scholarly journals Arterial Spin Labeling Cerebral Perfusion Changes in Chronic Tinnitus With Tension-Type Headache

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhen-Gui Xu ◽  
Jin-Jing Xu ◽  
Jinghua Hu ◽  
Yuanqing Wu ◽  
Dan Wang
Keyword(s):  
Arterial Spin Labeling ◽  
Superior Temporal Gyrus ◽  
Spin Labeling ◽  
Tension Type Headache ◽  
Perfusion Magnetic Resonance Imaging ◽  
Chronic Tinnitus ◽  
Healthy Controls ◽  
Tinnitus Distress ◽  
Type Headache ◽  
The Right

Purpose: Tinnitus is along with tension-type headache that will influence the cerebral blood flow (CBF) and accelerate the tinnitus severity. However, the potential associations between tension-type headache and tinnitus is still unknown. The current study will explore whether abnormal CBF exists in tinnitus patients and examine the effects of headache on CBF in tinnitus patients.Materials and Methods: Resting-state perfusion magnetic resonance imaging was performed in 40 chronic tinnitus patients and 50 healthy controls using pseudocontinuous arterial spin labeling. Regions with CBF differences between tinnitus patients and healthy controls were investigated. The effects of headache on tinnitus for CBF changes were further explored. Correlation analyses revealed the relationship between CBF values and tinnitus distress as well as CBF values and headache degree.Results: Relative to healthy controls, chronic tinnitus showed decreased CBF, mainly in right superior temporal gyrus (STG), left middle frontal gyrus (MFG), and left superior frontal gyrus (SFG); the CBF in the right STG and the left MFG was negatively correlated with THQ scores (r = −0.553, p = 0.001; r = −0.399, p = 0.017). We also observed a significant effect of headache on tinnitus for CBF in the right STG. Furthermore, the headache degree was correlated positively with tinnitus distress (r = 0.594, p = 0.020).Conclusion: Decreased CBF in auditory and prefrontal cortex was observed in chronic tinnitus patients. Headache may accelerate CBF reductions in tinnitus, which may form the basis for the neurological mechanism in chronic tinnitus with tension-type headache.

scholarly journals Cerebral Blood Flow and Its Connectivity Deficits in Mild Traumatic Brain Injury at the Acute Stage

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Fengfang Li ◽  
Liyan Lu ◽  
Song’an Shang ◽  
Huiyou Chen ◽  
Peng Wang ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Impairment ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Perfusion Magnetic Resonance Imaging ◽  
The Right

Objective. The influence of cognitive impairment after mild traumatic brain injury (mTBI) on cerebral vascular perfusion has been widely concerned, yet the resting-state cerebral blood flow (CBF) connectivity alterations based on arterial spin labeling (ASL) in mild traumatic brain injury (mTBI) remain unclear. This study investigated region CBF and CBF connectivity features in acute mTBI patients, as well as the associations between CBF changes and cognitive impairment. Materials and Methods. Forty-five acute mTBI patients and 42 health controls underwent pseudocontinuous arterial spin labeling (pCASL) perfusion magnetic resonance imaging (MRI). The alterations in regional CBF and relationship between the CBF changes and cognitive impairment were detected. The ASL-CBF connectivity of the brain regions with regional CBF significant differences was also compared between two groups. Neuropsychological tests covered seven cognitive domains. Associations between the CBF changes and cognitive impairment were further investigated. Results. Compared with the healthy controls, the acute mTBI patients exhibited increased CBF in the bilateral inferior temporal gyrus (ITG) and decreased CBF in the right middle frontal gyrus (MFG), the bilateral superior frontal gyrus (SFG), and the right cerebellum posterior lobe (CPL). In the mTBI patients, significant correlations were identified between the CBF changes and cognitive impairment. Importantly, the acute mTBI patients exhibited CBF disconnections between the right CPL and right fusiform gyrus (FG) as well as bilateral ITG, between the left SFG and left middle occipital gyrus (MOG), and between the right SFG and right FG as well as right parahippocampal gyrus. Conclusion. Our results suggest that acute mTBI patients exhibit both regional CBF abnormalities and CBF connectivity deficits, which may underlie the cognitive impairment of the acute mTBI patients.

scholarly journals Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Yu-Chen Chen ◽  
Jian Zhang ◽  
Xiao-Wei Li ◽  
Wenqing Xia ◽  
Xu Feng ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Brain Activity ◽  
Inferior Frontal Gyrus ◽  
Resting State Fmri ◽  
Brain Regions ◽  
Chronic Tinnitus ◽  
Healthy Controls ◽  
Tinnitus Distress ◽  
The Right

Objective. Subjective tinnitus is hypothesized to arise from aberrant neural activity; however, its neural bases are poorly understood. To identify aberrant neural networks involved in chronic tinnitus, we compared the resting-state functional magnetic resonance imaging (fMRI) patterns of tinnitus patients and healthy controls.Materials and Methods. Resting-state fMRI measurements were obtained from a group of chronic tinnitus patients (n=29) with normal hearing and well-matched healthy controls (n=30). Regional homogeneity (ReHo) analysis and functional connectivity analysis were used to identify abnormal brain activity; these abnormalities were compared to tinnitus distress.Results. Relative to healthy controls, tinnitus patients had significant greater ReHo values in several brain regions including the bilateral anterior insula (AI), left inferior frontal gyrus, and right supramarginal gyrus. Furthermore, the left AI showed enhanced functional connectivity with the left middle frontal gyrus (MFG), while the right AI had enhanced functional connectivity with the right MFG; these measures were positively correlated with Tinnitus Handicap Questionnaires (r=0.459,P=0.012andr=0.479,P=0.009, resp.).Conclusions. Chronic tinnitus patients showed abnormal intra- and interregional synchronization in several resting-state cerebral networks; these abnormalities were correlated with clinical tinnitus distress. These results suggest that tinnitus distress is exacerbated by attention networks that focus on internally generated phantom sounds.

scholarly journals Aberrant cerebral blood flow in tinnitus patients with migraine: a perfusion functional MRI study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Zhen-Gui Xu ◽  
Jin-Jing Xu ◽  
Yu-Chen Chen ◽  
Jinghua Hu ◽  
Yuanqing Wu ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Sex Education ◽  
Arterial Spin Labeling ◽  
Superior Temporal Gyrus ◽  
Chronic Tinnitus ◽  
Functional Magnetic Resonance ◽  
Hearing Thresholds ◽  
Tinnitus Distress ◽  
Mri Study

Abstract Purpose Migraine is often accompanied with chronic tinnitus that will affect the cerebral blood flow (CBF) and exacerbate the tinnitus distress. However, the potential relationship between migraine and tinnitus remains unclear. This study will investigate whether aberrant CBF patterns exist in migraine patients with tinnitus and examine the influence of migraine on CBF alterations in chronic tinnitus. Materials and methods Participants included chronic tinnitus patients (n = 45) and non-tinnitus controls (n = 50), matched for age, sex, education, and hearing thresholds. CBF images were collected and analyzed using arterial spin labeling (ASL) perfusion functional magnetic resonance imaging (fMRI). Regions with major CBF differences between tinnitus patients and non-tinnitus controls were first detected. The effects of migraine on tinnitus for CBF alterations were further examined. Correlation analyses illustrated the association between CBF values and tinnitus severity as well as between CBF and severity of migraine. Results Compared with non-tinnitus controls, chronic tinnitus patients without migraine exhibited decreased CBF, primarily in right superior temporal gyrus (STG), bilateral middle frontal gyrus (MFG), and left superior frontal gyrus (SFG); decreased CBF in these regions was correlated with tinnitus distress. There was a significant effect of migraine on tinnitus for CBF in right STG and MFG. Moreover, the severity of migraine correlated negatively with CBF in tinnitus patients. Conclusions Chronic tinnitus patients exhibited reduced CBF in the auditory and prefrontal cortex. Migraine may facilitate a CBF decrease in the setting of tinnitus, which may underlie the neuropathological mechanisms of chronic tinnitus comorbid with migraine.

scholarly journals Headache is associated with aberrant cerebral blood flow in chronic tinnitus revealed by perfusion functional MRI

2020 ◽  
Author(s):  
Yu-Chen Chen ◽  
Jinghua Hu ◽  
Jinluan Cui ◽  
Song’an Shang ◽  
Wei Yong ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Sex Education ◽  
Arterial Spin Labeling ◽  
Superior Temporal Gyrus ◽  
Chronic Tinnitus ◽  
Significant Interaction Effect ◽  
Hearing Thresholds ◽  
Tinnitus Distress ◽  
Headache Symptom

Abstract Background: Chronic tinnitus is often accompanied with headache symptom that will affect the cerebral blood flow (CBF) and exacerbate the tinnitus distress. However, the potential relationship between headache and tinnitus remains unclear. This study will investigate whether aberrant CBF patterns exist in chronic tinnitus patients and examine the influence of headache on CBF alterations in chronic tinnitus. Methods: Participants included chronic tinnitus patients (n=45) and non-tinnitus controls (n=50), matched for age, sex, education, and hearing thresholds. CBF images were collected and analyzed using arterial spin labeling (ASL) perfusion functional magnetic resonance imaging (fMRI). Regions with major CBF differences between tinnitus patients and non-tinnitus controls were first detected. The interaction effects between headache and tinnitus for CBF alterations were further examined. Correlation analyses illustrated the association between CBF values and tinnitus severity as well as between CBF and degree of headache.Results: Compared with non-tinnitus controls, chronic tinnitus patients exhibited decreased CBF, primarily in right superior temporal gyrus (STG), bilateral middle frontal gyrus (MFG), and left superior frontal gyrus (SFG); decreased CBF in these regions was correlated with tinnitus distress. There was a significant interaction effect between headache and tinnitus for CBF in right STG and MFG. Moreover, the degree of headache correlated negatively with CBF in tinnitus patients.Conclusions: Chronic tinnitus patients exhibited reduced CBF in the auditory and prefrontal cortex. Headache may facilitate a CBF decrease in the setting of tinnitus, which may underlie the neuropathological mechanisms of chronic tinnitus comorbid with headache.

Frontotemporal resting state hypoperfusion in patients with major depression - a study using arterial spin labeling

2011 ◽  
Vol 26 (S2) ◽  
pp. 961-961 ◽  
Author(s):  
S. Walther ◽  
O. Höfle ◽  
A. Federspiel ◽  
H. Horn ◽  
W. Strik ◽  
...  
Keyword(s):  
Major Depression ◽  
Arterial Spin Labeling ◽  
Superior Temporal Gyrus ◽  
Spin Labeling ◽  
Depression Score ◽  
Middle Temporal Gyrus ◽  
Neural Function ◽  
Precentral Gyrus ◽  
The Right ◽  
Left Middle

IntroductionMajor depression is associated with altered neural function in frontal and limbic areas.ObjectivesThe findings have been inconsistent, especially those derived from cerebral blood flow (CBF) measures.AimsTo identify differences in regional CBF between patients and controls using arterial spin labeling (ASL) at rest.Methods20 patients with major depression and 20 matched healthy controls were scanned in the morning with a pCASL-sequence at a 3 T Siemens scanner. Mean Hamilton Depression Score (21 item version) was 26.2 ± 5.7 for patients, mean Beck Depression Inventory scores were 28.9 ± 8.9. Mean age did not differ between groups (39.6 vs. 44.4 years). Whole brain voxelwise T-Tests were correct for multiple comparisons using a False Discovery Rate of q < 0.05.ResultsMean global resting CBF was not different between groups (66.1 vs. 63.0 ml/100 mg/min, T = 0.95, p = 0.35). FDR correction at q < 0.05 led to a T-value threshold of 3.71 (p < 0.001) for group comparison. Hypoperfusion in patients was detected in left middle temporal gyrus, left middle frontal gyrus, right precentral gyrus. Hyperperfusion in patients was seen in the right superior temporal gyrus.ConclusionsASL revealed frontotemporal hypoperfusion in patients with major depression. This is in line with previous work and the current concept of depression. However, we were unable to replicate hyperperfusion in limibic areas.

Assessment of Pain Modulatory and Somatosensory Profiles in Chronic Tension-Type Headache Patients

Pain Medicine ◽  
2021 ◽  
Author(s):  
Fernando G Exposto ◽  
Karina H Bendixen ◽  
Malin Ernberg ◽  
Flemming W Bach ◽  
Peter Svensson
Keyword(s):  
Pain Catastrophizing ◽  
Tension Type Headache ◽  
Pain Modulation ◽  
Normative Values ◽  
Healthy Controls ◽  
Single Session ◽  
Chronic Tension Type Headache ◽  
Type Headache ◽  
Underlying Pathophysiology

Abstract Objective The aim of this study was to thoroughly phenotype a group of chronic tension-type headache (CTTH) patients. Methods Fifteen CTTH patients diagnosed according to the International Classification of Headache Disorders–3 and 15 healthy controls were included in this study. Furthermore, 70 healthy controls were included to establish normative values. Quantitative sensory testing (QST), including temporal summation of pain (TSP), conditioned pain modulation (CPM), and psychological and sleep variables, was assessed in a single session. TSP and CPM were then combined to build pain modulation profiles (PMP) for each individual. Results No difference was found between groups for PMP, TSP, and CPM. However, 10 CTTH patients showed a pronociceptive PMP, with 8 related to a deficient CPM and 2 to both a deficient CPM and increased TSP. Increased cold detection thresholds were the most common sensory disturbance found in CTTH patients. Significant differences were seen between groups for pain catastrophizing, depression, and sleep quality although not all patient’s scores were above the clinically meaningful cutoffs. Conclusions In summary, CTTH patients presented with different PMP. These PMP may be related to increased TSP, deficient CPM, alterations in thermal detection that may be related to autonomic dysregulation, or a combination of all three. Overall, this suggests that due to their heterogeneous pathophysiology, CTTH patients should be managed according to their underlying pathophysiology and not with a one-size-fits-all approach.

scholarly journals Hypoconnectivity networks in schizophrenia patients: a voxelwise meta-analysis of rs-fMRI

2021 ◽  
Author(s):  
Silvia Ruiz-Torras ◽  
Oscar Fernández-Vazquez ◽  
Cristina Cañete-Massé ◽  
Maribel Peró-Cebollero ◽  
Joan Guàrdia-Olmos
Keyword(s):  
Brain Connectivity ◽  
Meta Analysis ◽  
Superior Temporal Gyrus ◽  
Interesting Case ◽  
Control Group ◽  
Precentral Gyrus ◽  
Healthy Controls ◽  
Health States ◽  
The Right ◽  
Work Done

Abstract In the last few years, the field of brain connectivity has focused on identifying biomarkers to describe different health states and to discriminate between patients and healthy controls through the characterization of brain networks. A particularly interesting case, because of the symptoms' severity, is the work done with samples of patients diagnosed with schizophrenia. This meta-analysis aims to identify connectivity networks with different activation patterns between people diagnosed with schizophrenia and healthy controls. Therefore, we collected primary studies exploring whole brain connectivity by functional magnetic resonance imaging at rest in patients with schizophrenia compared to healthy people. Thus, we identified 25 high-quality studies that included a total of 1285 people with schizophrenia and 1279 healthy controls. The results indicate hypoactivation in the right precentral gyrus and in the left superior temporal gyrus of people with schizophrenia compared with the control group. These regions have been linked to deficits in gesticulation and the experience of auditory hallucinations in people with schizophrenia. A study of heterogeneity demonstrated that the effect size was influenced by the sample size and type of analysis. These results imply new contributions to the knowledge, diagnosis, and treatment of schizophrenia both clinically and in research.

scholarly journals Regional homogeneity alterations in multi-frequency bands in tension-type headache: a resting-state fMRI study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Shuxian Zhang ◽  
Huayun Li ◽  
Qinyan Xu ◽  
Chao Wang ◽  
Xue Li ◽  
...  
Keyword(s):  
Frequency Band ◽  
Neural Activity ◽  
Tension Type Headache ◽  
Regional Homogeneity ◽  
Group Differences ◽  
Superior Frontal Gyrus ◽  
Frequency Bands ◽  
Spontaneous Neural Activity ◽  
Type Headache ◽  
The Right

Abstract Objectives In this study, we aimed to investigate the spontaneous neural activity in the conventional frequency band (0.01−0.08 Hz) and two sub-frequency bands (slow-4: 0.027–0.073 Hz, and slow-5: 0.01–0.027 Hz) in tension-type headache (TTH) patients with regional homogeneity (ReHo) analyses. Methods Thirty-eight TTH patients and thirty-eight healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (RS-fMRI) scanning to investigate abnormal spontaneous neural activity using ReHo analysis in conventional frequency band (0.01−0.08 Hz) and two sub-frequency bands (slow-4: 0.027–0.073 Hz and slow-5: 0.01–0.027 Hz). Results In comparison with the HC group, patients with TTH exhibited ReHo increases in the right medial superior frontal gyrus in the conventional frequency band (0.01−0.08 Hz). The between group differences in the slow-5 band (0.01–0.027 Hz) highly resembled the differences in the conventional frequency band (0.01−0.08 Hz); even the voxels with increased ReHo were spatially more extensive, including the right medial superior frontal gyrus and the middle frontal gyrus. In contrast, no region showed significant between-group differences in the slow-4 band (0.027–0.073 Hz). The correlation analyses showed no correlation between the ReHo values in TTH patients and VAS scores, course of disease and number of seizures per month in conventional band (0.01−0.08 Hz), slow-4 band (0.027–0.073 Hz), as well as in slow-5 band (0.01–0.027 Hz). Conclusions The results showed that the superior frontal gyrus and middle frontal gyrus were involved in the integration and processing of pain signals. In addition, the abnormal spontaneous neural activity in TTH patients was frequency-specific. Namely, slow-5 band (0.01–0.027 Hz) might contain additional useful information in comparison to slow-4 band (0.027−0.073 Hz). This preliminary exploration might provide an objective imaging basis for the understanding of the pathophysiological mechanism of TTH.

Arterial spin labeling magnetic resonance imaging at short post-labeling delay reflects cerebral perfusion pressure verified by oxygen-15-positron emission tomography in cerebrovascular steno-occlusive disease

2020 ◽  
pp. 028418512091711
Author(s):  
Hiroshi Itagaki ◽  
Yasuaki Kokubo ◽  
Kanako Kawanami ◽  
Shinji Sato ◽  
Yuki Yamada ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Arterial Spin Labeling ◽  
Cerebral Perfusion ◽  
Perfusion Pressure ◽  
Spin Labeling ◽  
Occlusive Disease ◽  
Resonance Imaging ◽  
Arterial Transit Time ◽  
The Right

Background Arterial transit time correction by data acquisition with multiple post-labeling delays (PLDs) or relatively long PLDs is expected to obtain more accurate imaging in cases of the cerebrovascular steno-occlusive disease. However, there have so far been no reports describing the significance of arterial spin labeling (ASL) images at short PLDs regarding the evaluation of cerebral circulation in ischemic cerebrovascular disease. Purpose To clarify the role of short-PLD ASL in cerebrovascular steno-occlusive disease. Material and Methods Fifty-three patients with cerebrovascular steno-occlusive disease were included in this study. All patients underwent ASL magnetic resonance imaging and 15O-PET within two days of each modality. To compare the ASL findings with each parameter of PET, the right-to-left (R/L) ratio, defined as the right middle cerebral artery (MCA) value/left MCA value, was calculated. Results There is a significant correlation between the ASL images at a short PLD and the ratio of cerebral blood flow and cerebral blood volume by 15O-PET, which may accurately reflect the cerebral perfusion pressure. A receiver operating characteristic curve analysis indicated that ASL images at PLD 1000 and 1500 ms were more accurate than at PLD 2000–3000 ms for the detection of a ≥10% change in the PET cerebral blood flow. Conclusion ASL images at shorter PLDs may be useful at least as a screening modality to detect the changes in the cerebral circulation in cerebrovascular steno-occlusive disease. We must evaluate ASL images at multiple PLDs while considering the arterial transit time of each case at present.

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