scholarly journals Soluble CD14 subtype (sCD14-ST) as biomarker in neonatal early-onset sepsis and late-onset sepsis: a systematic review and meta-analysis

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Iris van Maldeghem ◽  
Charlotte M. Nusman ◽  
Douwe H. Visser
Keyword(s):  
Systematic Review ◽  
Early Onset ◽  
Late Onset ◽  
Meta Analysis ◽  
Soluble Cd14 ◽  
Late Onset Sepsis ◽  
Early Onset Sepsis

NEONATAL SEPSIS AND IDENTIFICATION OF RISK FACTORS: STUDY IN AVBRH HOSPITAL SAWANGI

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Pramod P. Singhavi
Keyword(s):  
Risk Factors ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Late Onset ◽  
Signs And Symptoms ◽  
Premature Rupture ◽  
Maternal Risk ◽  
Late Onset Sepsis ◽  
Early Onset Sepsis ◽  
Meconium Stained Amniotic Fluid

Introduction: India has the highest incidence of clinical sepsis i.e.17,000/ 1,00,000 live births. In Neonatal sepsis septicaemia, pneumonia, meningitis, osteomyelitis, arthritis and urinary tract infections can be included. Mortality in the neonatal period each year account for 41% (3.6 million) of all deaths in children under 5 years and most of these deaths occur in low income countries and about one million of these deaths are due to infectious causes including neonatal sepsis, meningitis, and pneumonia. In early onset neonatal sepsis (EOS) Clinical features are non-specific and are inefficient for identifying neonates with early-onset sepsis. Culture results take up to 48 hours and may give false-positive or low-yield results because of the antenatal antibiotic exposure. Reviews of risk factors has been used globally to guide the development of management guidelines for neonatal sepsis, and it is similarly recommended that such evidence be used to inform guideline development for management of neonatal sepsis. Material and Methods: This study was carried out using institution based cross section study . The total number neonates admitted in the hospital in given study period was 644, of which 234 were diagnosed for neonatal sepsis by the treating pediatrician based on the signs and symptoms during admission. The data was collected: Sociodemographic characteristics; maternal information; and neonatal information for neonatal sepsis like neonatal age on admission, sex, gestational age, birth weight, crying immediately at birth, and resuscitation at birth. Results: Out of 644 neonates admitted 234 (36.34%) were diagnosed for neonatal sepsis by the paediatrician based on the signs and symptoms during admission. Of the 234 neonates, 189 (80.77%) infants were in the age range of 0 to 7 days (Early onset sepsis) while 45 (19.23%) were aged between 8 and 28 days (Late onset sepsis). Male to female ratio in our study was 53.8% and 46% respectively. Out of total 126 male neonates 91(72.2%) were having early onset sepsis while 35 (27.8%) were late onset type. Out of total 108 female neonates 89(82.4%) were having early onset sepsis while 19 (17.6%) were late onset type. Maternal risk factors were identified in 103(57.2%) of early onset sepsis cases while in late onset sepsis cases were 11(20.4%). Foul smelling liquor in early onset sepsis and in late onset sepsis was 10(5.56%) and 2 (3.70%) respectively. In early onset sepsis cases maternal UTI, Meconium stained amniotic fluid, Multipara and Premature rupture of membrane was seen in 21(11.67%), 19 (10.56%), 20(11.11%) and 33 (18.33%) cases respectively. In late onset sepsis cases maternal UTI, Meconium stained amniotic fluid, Multipara and Premature rupture of membrane was seen in 2 (3.70%), 1(1.85%), 3 (5.56%) and 3 (5.56%) cases respectively. Conclusion: Maternal risk identification may help in the early identification and empirical antibiotic treatment in neonatal sepsis and thus mortality and morbidity can be reduced.

scholarly journals Patient characteristics, Bacteriological profile & outcome of Neonatal Sepsis: A Hospital Based Study

2013 ◽  
Vol 2 (1) ◽  
pp. 49-54
Author(s):  
Nasim Jahan ◽  
Zabrul SM Haque ◽  
Md Abdul Mannan ◽  
Morsheda Akhter ◽  
Sabina Yasmin ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Late Onset ◽  
Female Ratio ◽  
Gram Negative ◽  
Common Pathogen ◽  
Late Onset Sepsis ◽  
Early Onset Sepsis

Neonatal sepsis is a major cause of mortality and morbidity in newborn. The spectrum of bacteria which causes neonatal sepsis varies in different parts of the world. The organisms responsible for early onset and late onset sepsis are different. The objective of the study was undertaken to determine the pattern of bacterial isolates responsible for early and late onset neonatal sepsis. A prospective descriptive study over the period of one year was conducted at the Department of Neonatal Intensive care unit of Ad-din Women’s Medical College and Hospital, Dhaka, Bangladesh.Organisms were isolated from 8.7% of collected blood samples. The male female ratio of culture proven sepsis was 1.7:1. More than half (52.8%) of the evaluated neonates were preterm. & 56.3% had low birth weight. The gram positive and gram negative bacteria accounted for 24.1% and 75.9% of the isolates respectively. Around three fourth of the neonates (75.8%) presented with early onset sepsis, while 24.2% presented with late onset sepsis. Acinetobacter was the most common pathogen both in early onset (70%) and late onset (30%) sepsis. Pseudomonas (89.4%) was the second most common pathogen in early onset sepsis. Total mortality rate was 5.7%. Pre term, low birth weight and gram negative sepsis contributes majority of mortality.Gram negative organism especially Acinetobacter found to be commonest cause of sepsis. Pseudomonas was second most common but contributed highest in late onset sepsis and neonatal death due to sepsis. DOI: http://dx.doi.org/10.3329/cbmj.v2i1.14184 Community Based Medical Journal Vol.2(1) 2013 49-54

scholarly journals Bacterial Isolates of Early Onset Neonatal Sepsis and Their Antibiotic Susceptibility Pattern

2018 ◽  
Vol 17 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Md Abdul Mannan ◽  
Shahed Iqbal ◽  
SM Rezaul Karim ◽  
Talim Uddin Ahmed ◽  
Md Hakimul Haque Khan ◽  
...  
Keyword(s):  
Neonatal Sepsis ◽  
Early Onset ◽  
Late Onset ◽  
Gram Positive ◽  
Gram Negative ◽  
E Coli ◽  
Late Onset Sepsis ◽  
Early Onset Sepsis ◽  
Sensitivity Pattern ◽  
Rule Out

Background: Neonatal infections are the commonest cause of neonatal mortality along with perinatal asphyxia and consequence of Prematurity and Low Birth Weight (LBW) in Bangladesh. Early Onset Neonatal Sepsis (EONS) is neonatal sepsis occurring within the first 72 hours of birth and it is much more fulminant and has a higher mortality than Late Onset Sepsis (LOS). Sepsis in neonate remains a significant cause of mortality and morbidity in developing countries. Changing bacterial flora and emergence of resistant strains adds to the problem. Thus, neonatal sepsis requires accurate and timely clinical and laboratory diagnosis and proper management for better outcome. The organisms responsible for Early Onset Sepsis (EOS) are different than Late Onset Sepsis (LOS). In this study an attempt has been made to know the positivity rate of EOS and profile of bacteria responsible for EOS and determine the antimicrobial sensitivity pattern that were investigated for rule out sepsis. Methods: This was a prospective observation single centre study over a period of nine months (January to September, 2017) conducted on neonates born at Ad-din Medical College Hospital (AMCH), Dhaka and subsequently admitted in Neonatal Intensive Care Unit (NICU) within 72 hours of birth that were investigated for rule out sepsis. Dual blood sample for cultures from separate area along with essential investigations were sent by collecting samples under aseptic precautions. Empirical antimicrobial therapy was started according to antimicrobial guidelines in the NICU. The blood cultures test were carried out by BD BACTEC automated blood culture system and susceptibility testing was done for all blood culture isolates according to the criteria of the National Committee for Clinical Laboratory Standards by disk diffusion method. Results: A total of 700 neonates were investigated to rule out sepsis and 5.43% neonates were found with culture proven sepsis in the study. The gram positive bacteria accounted for 71% and gram negative 29% of the total isolates. Out of total 38 isolates, Coagulase-Negative Staphylococci (CONS) (68.4%) was the commonest followed by Acinetobacter (18.4%) and E. coli (7.9%) was common culture isolates. Among the gram positive, CONS (96.3%) was commonest isolate and in gram negative Acinetobacter (63.6%) was the most prevalent bacteria followed by E.coli (27.3%). Gram positive isolate, especially CONS (68.4%) was the major culprit for the early onset sepsis. Among the commonly used antibiotics, the susceptibilities were remarkably low to Amikacin (16%) in comparison to Ampicillin (42%) Cefotaxime (45%) and moderately high to Gentamicin (58%) for both gram positive & gram negative isolates. All (100%) gram positive isolates were resistant to Amikacin. Majority of the gram positive showed low susceptibilities to Meropenem (22%) Ciprofloxacin (41%) Ampicillin (48%) & Oxacillin (48%) in comparison to Cefotaxime (52%) Levofloxacin (55%) Gentamicin (70%), Linezolid (70%) and Vancomycin (74%). 50% of Coagulase Negative Staphylococcus (CONS) were resistant to Methicillin/Oxacillin. The sensitivity pattern of majority of gram negative isolates showed high level of resistance to Piperacillin+Tazobacterm (9%) and Ampicillin (27%) Gentamicin (27%) Cefotaxime (27%) less sensitive to Ciprofloxacin (45%); moderately high to Levofloxacin (54%) & Amikacin (54%) and highly sensitive to Imipenem/Meropenem (73%) & Colistin (91%). Gentamicin (58%) and Levofloxacin (55%) were showed marginal superiority compared to Ampicillin (42%) and Cefotaxime (45%) for effective coverage of both. Conclusion: Present study indicated that gram positive species especially CONS continue to be the predominant causative organism followed by Acinetobacter and E. coli in gram negative species. The antibiotic susceptibility profile suggested that for a given cohort empiric (initial) choice of Ampicillin and Gentamicin in EOS. Routine bacterial surveillance and their sensitivity patterns must be an essential component of neonatal care Chatt Maa Shi Hosp Med Coll J; Vol.17 (1); Jan 2018; Page 3-8

Rückgang von Infektionen durch Streptokokken der Gruppe B bei Neugeborenen: Analyse von Krankenversicherungsdaten 2005 bis 2017

2020 ◽  
Vol 233 (01) ◽  
pp. 17-23
Author(s):  
Anna-Lisa Sorg ◽  
Viola Obermeier ◽  
Jakob Armann ◽  
Mathias Klemme ◽  
Rüdiger von Kries
Keyword(s):  
Early Onset ◽  
Late Onset ◽  
Late Onset Sepsis ◽  
Early Onset Sepsis ◽  
Icd 10

Zusammenfassung Hintergrund In der Leitlinie zur Prophylaxe der frühen Form (Early Onset Sepsis, EOS) der Neugeborenensepsis durch Streptokokken der Gruppe B (GBS) wird ein GBS Screening aller Schwangeren empfohlen. Dieses ist jedoch nicht Bestandteil der Mutterschaftsrichtlinien. Studienziel war die Überprüfung des zeitlichen Verlaufs der Infektionsrate im Zusammenhang mit dem GBS Screening. Methodik Krankenversicherungsdaten der Jahre 2005 bis 2017 von 313 385 BARMER versicherten Mutter-Kind Paaren wurden analysiert. Über die ICD-10 P36.0 wurde die jährliche Häufigkeit von GBS Infektionen bei Neugeborenen ermittelt. Als Surrogat für das GBS Screening wurde die ICD-10 B95.1 verwendet, welche bekannte positive mütterliche GBS Besiedelung beschreibt. Durch logistische Regressionsmodelle wurden die zeitliche Veränderungen des Erkrankungsrisikos von EOS bei Neugeborenen untersucht. Pearson-Korrelationskoeffizient wurde zur Bewertung des Zusammenhangs zwischen der zeitlichen Veränderung der Häufigkeit an EOS und dem Surrogatmarker für GBS Besiedelung verwendet. Ergebnisse Das Erkrankungsrisiko der EOS bei Neugeborenen hat jährlich um 9,3% abgenommen, gesamt über die Beobachtungsjahre um 72,0%, während für die Spätform LOS (Late Onset Sepsis) keine statistisch signifikante Veränderung beobachtet wurde. Diese Abnahme konnte nicht durch zeitliche Veränderungen bei Kaiserschnitten, Risikofaktoren oder Frühgeburten erklärt werden. Eine gleichzeitige Erhöhung des Anteils der Mütter mit bekanntem positivem GBS Status um den Faktor 3,5 korrelierte invers (r=− 0,75; p=0,002) mit der Inzidenz von EOS. Schlussfolgerung Die starke Abnahme der EOS in Deutschland bei unveränderter Inzidenz von LOS könnte durch eine zunehmende Umsetzung des Schwangerenscreenings erklärt werden.

scholarly journals Probiotics Prevent Late-Onset Sepsis in Human Milk-Fed, Very Low Birth Weight Preterm Infants: Systematic Review and Meta-Analysis

Nutrients ◽  
2017 ◽  
Vol 9 (8) ◽  
pp. 904 ◽  
Author(s):  
Arianna Aceti ◽  
Luca Maggio ◽  
Isadora Beghetti ◽  
Davide Gori ◽  
Giovanni Barone ◽  
...  
Keyword(s):  
Systematic Review ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Human Milk ◽  
Preterm Infants ◽  
Very Low Birth Weight ◽  
Late Onset ◽  
Meta Analysis ◽  
Late Onset Sepsis

scholarly journals Hubungan Sepsis Neonatorum dengan Berat Badan Lahir pada Bayi di RSUP Dr. M. Djamil Padang

2018 ◽  
Vol 7 (3) ◽  
pp. 405
Author(s):  
Putri Rahmawati ◽  
Mayetti Mayetti ◽  
Sukri Rahman
Keyword(s):  
Early Onset ◽  
Case Control Study ◽  
Late Onset ◽  
Case Control ◽  
Chi Square ◽  
Late Onset Sepsis ◽  
Early Onset Sepsis ◽  
Control Study

Sepsis neonatorum merupakan salah satu penyakit yang masih menjadi masalah utama pada neonatus saat ini, karena banyaknya faktor risiko yang belum dapat dicegah.Salah satu faktor risiko tersebut adalah berat badan lahir rendah atau lebih. Tujuan penelitian ini adalah menentukan hubungan sepsis neonatorum dengan berat badan lahir pada bayi di RSUP Dr. M. Djamil Padang. Jenis penelitian ini adalah analitik retrospektif dengan metode case control study. Populasi adalah seluruh neonatus yang mengalami sepsis neonatorum (kasus) dan yang tidak mengalami sepsis neonatorum (kontrol) yang diambil dari data rekam medik RSUP.Dr. M. Djamil Padang periode Januari 2014 sampai Juli 2016. Subjek penelitian adalah populasi dengan data rekam medik yang lengkap. Hasil penelitian diolah dengan uji Chi-square. Jumlah subjek penelitian adalah 162 orang yang terdiri dari 81 kasus dan 81 kontrol. Dari 81 neonatus yang mengalami sepsis neonatorum, 43 diantaranya mengalami sepsis dengan late onset sepsis, 38 dengan early onset sepsis, 25 dengan Berat Badan Lahir Rendah (BBLR) dan 56 tidak BBLR. Setelah dilakukan uji hubungan antara sepsis neonatorum dengan berat badan lahir menggunakan uji Chi-square didapatkan nilai p=0,601, OR=1,276, CI= 0,643-2,530. Simpulan studi ini ialah tidak terdapat hubungan yang bermakna antara sepsis neonatorum dengan berat badan lahir bayi. BBLR memiliki risiko yang lebih besar untuk mengalami sepsis daripada yang tidak BBLR.

scholarly journals Hubungan Sepsis Neonatorum dengan Berat Badan Lahir pada Bayi di RSUP Dr. M. Djamil Padang

2018 ◽  
Vol 7 (3) ◽  
pp. 405
Author(s):  
Putri Rahmawati ◽  
Mayetti Mayetti ◽  
Sukri Rahman
Keyword(s):  
Early Onset ◽  
Case Control Study ◽  
Late Onset ◽  
Case Control ◽  
Chi Square ◽  
Late Onset Sepsis ◽  
Early Onset Sepsis ◽  
Control Study

Sepsis neonatorum merupakan salah satu penyakit yang masih menjadi masalah utama pada neonatus saat ini, karena banyaknya faktor risiko yang belum dapat dicegah.Salah satu faktor risiko tersebut adalah berat badan lahir rendah atau lebih. Tujuan penelitian ini adalah menentukan hubungan sepsis neonatorum dengan berat badan lahir pada bayi di RSUP Dr. M. Djamil Padang. Jenis penelitian ini adalah analitik retrospektif dengan metode case control study. Populasi adalah seluruh neonatus yang mengalami sepsis neonatorum (kasus) dan yang tidak mengalami sepsis neonatorum (kontrol) yang diambil dari data rekam medik RSUP.Dr. M. Djamil Padang periode Januari 2014 sampai Juli 2016. Subjek penelitian adalah populasi dengan data rekam medik yang lengkap. Hasil penelitian diolah dengan uji Chi-square. Jumlah subjek penelitian adalah 162 orang yang terdiri dari 81 kasus dan 81 kontrol. Dari 81 neonatus yang mengalami sepsis neonatorum, 43 diantaranya mengalami sepsis dengan late onset sepsis, 38 dengan early onset sepsis, 25 dengan Berat Badan Lahir Rendah (BBLR) dan 56 tidak BBLR. Setelah dilakukan uji hubungan antara sepsis neonatorum dengan berat badan lahir menggunakan uji Chi-square didapatkan nilai p=0,601, OR=1,276, CI= 0,643-2,530. Simpulan studi ini ialah tidak terdapat hubungan yang bermakna antara sepsis neonatorum dengan berat badan lahir bayi. BBLR memiliki risiko yang lebih besar untuk mengalami sepsis daripada yang tidak BBLR.

Sign in / Sign up

Export Citation Format

Share Document