scholarly journals Epidemiological characteristics and mortality risk factors among COVID-19 patients in Ardabil, Northwest of Iran

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Davoud Adham ◽  
Shahram Habibzadeh ◽  
Hassan Ghobadi ◽  
Shabnam Asghari Jajin ◽  
Abbas Abbasi-Ghahramanloo ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Multiple Model ◽  
Shortness Of Breath ◽  
Imaging Data ◽  
Demographic Information ◽  
Runny Nose ◽  
Data Registration ◽  
Northwestern Iran ◽  
Northwest Of Iran ◽  
Epidemiological Characteristics

Abstract Background Coronavirus disease highly contagious, is prevalent in all age and sex groups infecting the respiratory system. The present study seeks to investigate the epidemiology and effective factors in mortality of patients with COVID-19 in Ardabil province, northwestern Iran. Methods In a retrospective study, the hospitalized patients with laboratory-diagnosed COVID-19 between February to August 2020 were enrolled. The data registration portal was designated according to Iranian Ministry of Health and Medical Education guidelines. In this portal, demographic information, clinical presentation, laboratory and imaging data were registered for patients in all hospitals in the same format. The Hosmer-Lemeshow strategy was used for variable selection in a multiple model. Results Of the patients involved 2812(50.3%) were male and 150 (2.7%) had contact with a confirmed case of COVID-19 in the last 14 days. Pre-existing comorbidity was reported in 1310 (23.4%) patients. Of all patients, 477(8.5%) died due to COVID-19. the result of the multiple logistic regression model indicated that after adjusting for other factors, higher age (OR = 3.11), fever or chills (OR = 1.61), shortness of breath (OR = 1.82), fatigue (OR = 0.71), headache (OR = 0.64), runny nose (OR = 1.54), Skeletal muscle pain (OR = 1.53), hospitalization (OR = 5.66), and hospitalization in ICU (OR = 5.12) were associated with death. Conclusions Hospitalization had the strongest effect on mortality followed by hospitalization in ICU, and higher age. This study showed that having some extra-pulmonary symptoms in contrast with pulmonary symptoms can predict as good prognostic factors.

scholarly journals Epidemiological Characteristics and Mortality Risk Factors among COVID-19 Patients in Ardabil, Northwest of Iran

2021 ◽  
Author(s):  
Davoud Adham ◽  
Shahram Habibzadeh ◽  
Hassan Ghobadi ◽  
Shabnam Asghari jajin ◽  
Abbas Abbasi-Ghahramanloo ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Multiple Model ◽  
Shortness Of Breath ◽  
Imaging Data ◽  
Demographic Information ◽  
Runny Nose ◽  
Data Registration ◽  
Northwest Of Iran ◽  
Epidemiological Characteristics ◽  
Age And Sex

Abstract Background: Coronavirus disease highly contagious, is prevalent in all age and sex groups infecting the respiratory system. The present study seeks to investigate the epidemiology and effective factors in mortality of patients with COVID-19 in Ardabil province, northwestern of Iran.Methods: In a retrospective study, the hospitalized patients with laboratory diagnosed COVID-19 between February to August, 2020 were enrolled. Data registration portal was designated according to WHO recommendation. In this portal, demographic information, clinical presentation, laboratorial and imaging data were registered for patients in all hospitals in the same format. The Hosmer-Lemeshow guideline was used for variable selection in a multiple model.Results: Of the patients involved 2812(50.3%) were male and 150 (2.7%) had a contact with a confirmed case of COVID-19 in the last 14 days. Pre-existing morbidity was reported in 1310 (23.4%) patients. Of all patients 477(8.5%) died due to COVID 19. The hospitalization in ICU had significant correlation with fever or chills, shortness of breath, aches and pains, runny nose and chest pain.Conclusions: Hospitalization had the strongest effect on mortality followed by hospitalization in ICU, and higher age. This study showed that having some symptoms like aches and pains and headache can serve as preventive factors of mortality.

scholarly journals A Systematic Review of Characteristics Associated with COVID-19 in Children with Typical Presentation and with Multisystem Inflammatory Syndrome

2021 ◽  
Vol 18 (16) ◽  
pp. 8269
Author(s):  
Jeffrey Kornitzer ◽  
Jacklyn Johnson ◽  
Max Yang ◽  
Keith W. Pecor ◽  
Nicholas Cohen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Sore Throat ◽  
Literature Search ◽  
Clinical Presentation ◽  
Pediatric Population ◽  
Chinese Language ◽  
Clinical Information ◽  
Shortness Of Breath ◽  
Global Pandemic ◽  
Inflammatory Syndrome

Setting off a global pandemic, coronavirus disease 2019 (COVID-19) has been marked by a heterogeneous clinical presentation that runs the gamut from asymptomatic to severe and fatal. Although less lethal in children than adults, COVID-19 has nonetheless afflicted the pediatric population. This systematic review used clinical information from published literature to assess the spectrum of COVID-19 presentation in children, with special emphasis on characteristics associated with multisystem inflammatory syndrome (MIS-C). An electronic literature search for English and Chinese language articles in COVIDSeer, MEDLINE, and PubMed from 1 January 2020 through 1 March 2021 returned 579 records, of which 54 were included for full evaluation. Out of the total 4811 patients, 543 (11.29%) exhibited MIS-C. The most common symptoms across all children were fever and sore throat. Children presenting with MIS-C were less likely to exhibit sore throat and respiratory symptoms (i.e., cough, shortness of breath) compared to children without MIS-C. Inflammatory (e.g., rash, fever, and weakness) and gastrointestinal (e.g., nausea/vomiting and diarrhea) symptoms were present to a greater extent in children with both COVID-19 and MIS-C, suggesting that children testing positive for COVID-19 and exhibiting such symptoms should be evaluated for MIS-C.

scholarly journals Airbag pneumonitis: a report and discussion of a new clinical entity

CJEM ◽  
2007 ◽  
Vol 9 (06) ◽  
pp. 470-473 ◽  
Author(s):  
Jaelyn M. Caudle ◽  
Robert Hawkes ◽  
Daniel W. Howes ◽  
Robert J. Brison
Keyword(s):  
Clinical Presentation ◽  
Motor Vehicle ◽  
Young Male ◽  
Motor Vehicle Crash ◽  
Clinical Entity ◽  
Shortness Of Breath ◽  
Pulmonary Infiltrates ◽  
Vehicle Crash ◽  
Chest Radiology ◽  
Airbag Deployment

ABSTRACT This report describes the occurrence of pneumonitis in a young male immediately after inhalation of aerosolized chemicals subsequent to motor vehicle airbag deployment. The clinical presentation was one of mild shortness of breath associated with bilateral alveolar infiltrates on chest radiology. Not previously described, this diagnosis should be considered in the differential of pulmonary infiltrates in motor vehicle crash patients.

scholarly journals Quantifying and correcting slide-to-slide variation in multiplexed immunofluorescence images

2021 ◽  
Author(s):  
Coleman R Harris ◽  
Eliot T McKinley ◽  
Joseph T Roland ◽  
Qi Liu ◽  
Martha J Shrubsole ◽  
...  
Keyword(s):  
Functional Data ◽  
Single Cell Analysis ◽  
Evaluation Criteria ◽  
Evaluation Framework ◽  
Complex Data ◽  
Imaging Data ◽  
Data Registration ◽  
Multiplexed Imaging ◽  
In Situ Methods ◽  
Clear Slide

The multiplexed imaging domain is a nascent single-cell analysis field with a complex data structure susceptible to technical variability that disrupts inference. These in situ methods are valuable in understanding cell-cell interactions, but few standardized processing steps or normalization techniques of multiplexed imaging data are available. We implement and compare data transformations and normalization algorithms in multiplexed imaging data. Our methods adapt the ComBat and functional data registration methods to remove slide effects in this domain, and we present an evaluation framework to compare the proposed approaches. We present clear slide-to-slide variation in the raw, unadjusted data, and show that many of the proposed normalization methods reduce this variation while preserving and improving the biological signal. Further, we find that dividing this data by its slide mean, and the functional data registration methods, perform the best under our proposed evaluation framework. In summary, this approach provides a foundation for better data quality and evaluation criteria in the multiplexed domain.

scholarly journals Vocal Cord Dysfunction: A Frequently Forgotten Entity

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
S. Campainha ◽  
C. Ribeiro ◽  
M. Guimarães ◽  
R. Lima
Keyword(s):  
Vocal Cord ◽  
Direct Observation ◽  
Clinical Presentation ◽  
Upper Airway ◽  
Vocal Cord Dysfunction ◽  
Shortness Of Breath ◽  
Vocal Cords ◽  
Variable Nature

Vocal cord dysfunction (VCD) is a disorder characterized by unintentional paradoxical adduction of the vocal cords, resulting in episodic shortness of breath, wheezing and stridor. Due to its clinical presentation, this entity is frequently mistaken for asthma. The diagnosis of VCD is made by direct observation of the upper airway by rhinolaryngoscopy, but due to the variable nature of this disorder the diagnosis can sometimes be challenging. We report the case of a 41-year old female referred to our Allergology clinics with the diagnosis of asthma. Thorough investigation revealed VCD as the cause of symptoms.

scholarly journals Post-acute sequelae of COVID-19 in a non-hospitalized cohort: results from the Arizona CoVHORT

2021 ◽  
Author(s):  
Melanie L Bell ◽  
Collin J Catalfamo ◽  
Leslie V. Farland ◽  
Kacey C Ernst ◽  
Elizabeth T Jacobs ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Severe Disease ◽  
Median Number ◽  
Population Based ◽  
Diverse Population ◽  
Shortness Of Breath ◽  
Persistent Symptoms ◽  
Estimate Prevalence ◽  
Hispanic White

AbstractClinical presentation, outcomes, and duration of COVID-19 has ranged dramatically. While some individuals recover quickly, others suffer from persistent symptoms, collectively known as post-acute sequelae of SAR-CoV-2 (PASC). Most PASC research has focused on hospitalized COVID-19 patients with moderate to severe disease. We used data from a diverse population-based cohort of Arizonans to estimate prevalence of various symptoms of PASC, defined as experiencing at least one symptom 30 days or longer. There were 303 non-hospitalized individuals with a positive lab-confirmed COVID-19 test who were followed for a median of 61 days (range 30-250). COVID-19 positive participants were mostly female (70%), non-Hispanic white (68%), and on average 44 years old. Prevalence of PASC at 30 days post-infection was 68.7% (95%CI 63.4, 73.9). The most common symptoms were fatigue (37.5%), shortness-of-breath (37.5%), brain fog (30.8%), and stress (30.8%). The median number of symptoms was 3 (range 1-20). Amongst 157 participants with longer follow-up (≥60 days), PASC prevalence was 77.1%.

scholarly journals Spironucleus muris and Eperythrozoon coccoides in Rodents from Northwestern Iran: Rare Infections

2019 ◽  
Author(s):  
Soudabeh Heidari ◽  
Mehdi Mohebali ◽  
Zabihollah Zarei ◽  
Mehdi Nateghpour ◽  
Afsaneh Motevalli-Haghi
Keyword(s):  
Light Microscopy ◽  
Systemic Risk ◽  
Crucial Role ◽  
Blood Smear ◽  
Domestic Animals ◽  
High Magnification ◽  
Rural Districts ◽  
Blood Smears ◽  
Northwestern Iran ◽  
Northwest Of Iran

Background: Rodents perform a crucial role in dispersal of zoonosis causes globally. We aimed to investigation about infection levels of parasitic agents in rodents’ population in Meshkinshahr areas, northwest of Iran from Apr to Sep 2014. Methods: Two hundred four rodents were trapped and anaesthetized. A sample of blood was collected via cardi­opuncture from each one. Thin and thick blood smears were prepared and stained with Giemsa. All stained smear were examined under light microscopy with high magnification by two expert microscopists. Every suspected uni­cellular observed were measured microscopically and compared with key references to diagnose. Results: Captured rodents were identified as three genera including Meriones persicus, Mus musculus, Cricetulus migraturius. Protozoa identified in this study were included of Spironucleus muris and Eperythrozoon coccoides, these parasites were observed in blood smear of 0.98% of rodents. S. muris and E. coccoides were seen in M. mus­culus and C. migraturius, respectively. Conclusion: The present study increases awareness about Eperythrozoonosis in rodents and its potential transmis­sion to domestic animals and even to human in rural districts in Iran. Moreover, the attack of Spironucleus on the mucus of colon and its systemic risk was confirmed

scholarly journals SARS-Cov-2: Epidemiological characteristics, clinical characteristics, diagnosis and prevention: A review of current knowledge

2021 ◽  
Vol 2 (2) ◽  
pp. 16-22
Author(s):  
Marina Fišeković-Kremić ◽  
Snežana Stojanović-Ristić
Keyword(s):  
Clinical Manifestation ◽  
Clinical Characteristics ◽  
Current Knowledge ◽  
Nasal Congestion ◽  
Clinical Manifestations ◽  
Diagnostic Procedures ◽  
X Rays ◽  
Runny Nose ◽  
Biochemical Analyses ◽  
Epidemiological Characteristics

The SARS-Cov-2 disease appeared in December 2019, when the new coronavirus was confirmed to be the cause of the disease. The objective of this article is to summarize previous research on the epidemiological characteristics, etiology, clinical characteristics, diagnosis, prevention, and control of the new SARS-Cov-2 infection. The SARS-Cov-2 virus belongs to the group of betacoronaviruses, which are single-stranded RNA viruses. The envelope has a crucial role in the pathogenicity of the virus. A viral infection can cause an excessive immune response in the patient, which is labeled as a "cytokine storm," and whose effect is extensive tissue damage. Three main routes of the transmission of the virus are: droplets, direct contact, aerosol. The incubation period is considered to be 1-14 days. The clinical manifestation ranges from asymptomatic, mild, to severe, and some cases end in death. The main clinical manifestations include fever, cough, and shortness of breath. Nasal congestion, a runny nose, a sore throat, headache, myalgia, diarrhea, loss of the sense of taste and/or smell have also been reported. The diagnostic procedures are the following: clinical manifestation, chest X-rays, biochemical analyses, epidemiological anamnesis. A positive nasopharyngeal or oropharyngeal swab (Ag test, and/or reverse transcription polymerase chain reaction (RT-PCR)) is used for etiological diagnosis. The SARS-Cov-2 infection has affected a large number of people and countries around the world. The application of preventive measures, early identification of infected persons, their isolation , and vaccination are currently the most effective mode in the battle against this virus. After the conclusion of the pandemic, it will be possible to estimate the health, social and economic impact of the virus.

scholarly journals Determine the Clinical Presentation and Outcomes of Thoracostomy in Children with Complicated Pneumonia

2021 ◽  
Vol 15 (6) ◽  
pp. 1463-1465
Author(s):  
S. U. Rehman ◽  
S. Khan ◽  
M. Anwar ◽  
A. Rafique ◽  
Z. I. Bhatti ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Chest Pain ◽  
Chest Tube ◽  
Clinical Presentation ◽  
Causative Factor ◽  
Paediatric Surgery ◽  
Shortness Of Breath ◽  
Effective Treatment Modality ◽  
The Common ◽  
Complicated Pneumonia

Objective: To examine the clinical presentation and outcomes of thoracostomy in patients presented with complicated pneumonia. Study Design: Descriptive/Observational Place and Duration of Study: Department of Paediatric Surgery, DHQ Teaching Hospital Sahiwal from 1st January 2019 to 31st December 2020. Methodology: Fifty patients of both genders with ages 0 to 12 years presented with complicated pneumonia were included. All the patients received chest tube intubation. Outcomes of thoracostomy were examined. Radiological examination was done. Results: Thirty eight (76%) patients were males while 24% were females. Majority of patients 64% were ages less than 5 years. Fever, cough, shortness of breath and chest pain were the common symptoms. Staphylococcus aureus was the most common causative factor found in 56% cases followed by streptococcus in 24% cases. 84% cases were successfully removed chest tube. Recollection found in 8% cases, pneumothorax found in 4% patients and 4% patients had pneumatocele. Conclusion: Chest tube intubation was the safe and effective treatment modality for complicated pneumonia with fewer rates of complications. Keywords: Complicated pneumonia, Thoracostomy, Empyema, Pneumothorax, Outcomes

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