The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants' life: a systematic review

Abstract The early-life microbiome appears to be affected by mode of delivery, but this effect may depend on intrapartum antibiotic exposure. Here, we assess the effect of delivery mode on gut microbiota, independent of intrapartum antibiotics, by postponing routine antibiotic administration to mothers until after cord clamping in 74 vaginally delivered and 46 caesarean section born infants. The microbiota differs between caesarean section born and vaginally delivered infants over the first year of life, showing enrichment of Bifidobacterium spp., and reduction of Enterococcus and Klebsiella spp. in vaginally delivered infants. The microbiota composition at one week of life is associated with the number of respiratory infections over the first year. The taxa driving this association are more abundant in caesarean section born children, providing a possible link between mode of delivery and susceptibility to infectious outcomes.

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Microbiota development in early life mediates association between mode of delivery and vaccine responses

10.1101/2021.09.01.21262898 ◽

2021 ◽

Author(s):

Emma M. de Koff ◽

Debbie van Baarle ◽

Marlies A. van Houten ◽

Marta Reyman ◽

Guy A.M. Berbers ◽

...

Keyword(s):

Gut Microbiota ◽

Early Life ◽

Mode Of Delivery ◽

Microbial Community Composition ◽

First Year ◽

Vaccine Responses ◽

Childhood Vaccines ◽

First Year Of Life ◽

Immune Maturation ◽

Conjugate Vaccination

The gut microbiota in early life, when critical immune maturation takes place, may influence the immunogenicity of childhood vaccinations. We assessed the association between mode of delivery, gut microbiota development in the first year of life, and mucosal antigen-specific immunoglobulin G (IgG) responses against pneumococcal and meningococcal conjugate vaccination at ages 12 and 18 months, respectively, in a prospective birth cohort of 120 infants. Birth by natural delivery was associated with higher IgG responses against both vaccines, which for the anti-pneumococcal IgG response could be explained by a gut microbial community composition with high abundances of Bifidobacterium and Escherichia coli in the first weeks of life. High E. coli abundance in the same period was also associated with higher anti-meningococcal IgG responses. Our results suggest that associations between mode of delivery and antibody responses to routine childhood vaccines are mediated by gut microbiota development.

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Effective Parental intervention strategies to reduce screen time among preschool-aged children: A systematic review (Preprint)

10.2196/preprints.25774 ◽

2020 ◽

Author(s):

Diana Raj ◽

Halimatus Sakdiah Minhat ◽

Nor Afiah Mohd. Zulkefli ◽

Norliza Ahmad

Keyword(s):

Systematic Review ◽

Preschool Children ◽

Young Children ◽

Screen Time ◽

Mode Of Delivery ◽

Intervention Strategies ◽

Controlled Trials ◽

Cochrane Central Register ◽

Negative Consequences ◽

Parental Intervention

BACKGROUND The increasing screen time exposure among young children in general and the reported negative consequences associated with excessive ST, calls for focused strategies to reduce ST, especially among young children. OBJECTIVE This systematic review aimed to identify effective parental intervention strategies to reduce ST among preschool children. METHODS A total of five databases, namely Cochrane Central Register of Controlled Trials, CINAHL, Medline Complete, PubMed, and Scopus, were searched for randomised controlled trials that involved intervention strategies in ST reduction among preschool children. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines were used. RESULTS A total of nine studies were assessed. The results showed that besides providing knowledge and awareness regarding ST, having restrictive practices, offering alternative activities to parents, and removal of screen from child’s bedroom were the most common strategies used by studies that reported successful intervention. Intervention duration of between six to eight weeks was sufficient to produce ST reduction. Face-to-face method was the commonest mode of delivery. Theoretical constructs that aimed at increasing parental self-efficacy, listing outcome expectations, and offering reinforcement of strategies that targeted both the parents and home environment were beneficial in reducing ST. CONCLUSIONS By offering appropriate strategies to parents, a reduction in the amount of ST was observed among the children. Future intervention studies could benefit in exploring culturally adapted strategies, especially in developing countries. Trials of higher quality would also facilitate the drawing of conclusions in future research. CLINICALTRIAL PROSPERO No: CRD42020199398

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The experience of men who have sex with men in responding to and coping with HIV in the first year following a diagnosis: a systematic review of qualitative evidence

The JBI Database of Systematic Reviews and Implementation Reports ◽

10.11124/01938924-201109641-00002 ◽

2011 ◽

Vol 9 (Supplement) ◽

pp. 1-10

Author(s):

John McLuskey ◽

Catrin Evans ◽

Wendy Stanton ◽

Matthew Grundy-Bowers ◽

Fiona Bath-Hextall

Keyword(s):

Systematic Review ◽

First Year ◽

Qualitative Evidence ◽

Sex With Men ◽

And Coping

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Correction to: Clinical effects and gut microbiota changes of using probiotics, prebiotics or synbiotics in inflammatory bowel disease: a systematic review and meta-analysis

European Journal of Nutrition ◽

10.1007/s00394-021-02592-2 ◽

2021 ◽

Author(s):

Xiao-Feng Zhang ◽

Xiao-Xian Guan ◽

Yu-Jun Tang ◽

Jin-Feng Sun ◽

Xiao-Kai Wang ◽

...

Keyword(s):

Systematic Review ◽

Inflammatory Bowel Disease ◽

Gut Microbiota ◽

Bowel Disease ◽

Meta Analysis ◽

Clinical Effects ◽

Inflammatory Bowel

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Effect of gut microbiota modulation on feeding tolerance of enterally fed critically ill adult patients: a systematic review

Systematic Reviews ◽

10.1186/s13643-021-01633-5 ◽

2021 ◽

Vol 10 (1) ◽

Author(s):

Najmeh Seifi ◽

Ali Jafarzadeh Esfahani ◽

Alireza Sedaghat ◽

Reza Rezvani ◽

Majid Khadem-Rezaiyan ◽

...

Keyword(s):

Systematic Review ◽

Gut Microbiota ◽

Beneficial Effect ◽

Critically Ill ◽

Energy Intake ◽

Adult Patients ◽

Controlled Trials ◽

Cochrane Central Register ◽

Clinical Endpoints ◽

Feeding Tolerance

Abstract Purpose The objective of this systematic review was to evaluate the effect of pre-, pro-, and synbiotics on feeding tolerance of enterally fed critically ill adult patients. Methods MEDLINE, Science Direct, Web of Knowledge, and the Cochrane Central Register of Controlled Trials were searched up to November 2019. English language randomized controlled trials reporting the effect of pre, pro or synbiotics on the feeding tolerance of enterally fed critically ill adult patients were included. Results Overall, 15 papers were selected for review. Among six studies reporting the energy intake, only two studies showed significantly higher energy intake in the prebiotic-receiving groups. Among four RCTs reporting frequency or time to achieve the target calorie, only one found a significant effect of probiotics to reduce the time to achieve a target dose of calorie. About the prevalence or duration of diarrhea, 7 out of 12 RCTs reported a beneficial effect. All but one study found no beneficial effects for gut microbiota manipulation on clinical endpoints including length of stay (LOS) in hospital and intensive care unit (ICU). Conclusion It should be noticed that the heterogeneity in study designs, product format, and ICU patient populations makes it difficult to draw any general conclusion. Overall, it seems that pre, pro, or synbiotics have no significant beneficial effect on feeding tolerance and clinical endpoints in critically ill adults, but they may reduce the prevalence or duration of diarrhea.

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Levels of Predominant Intestinal Microorganisms in 1 Month-Old Full-Term Babies and Weight Gain During the First Year of Life

Nutrients ◽

10.3390/nu13072412 ◽

2021 ◽

Vol 13 (7) ◽

pp. 2412

Author(s):

Sonia González ◽

Marta Selma-Royo ◽

Silvia Arboleya ◽

Cecilia Martínez-Costa ◽

Gonzalo Solís ◽

...

Keyword(s):

Weight Gain ◽

Gut Microbiota ◽

Early Life ◽

Later Life ◽

Full Term ◽

First Year ◽

Term Infants ◽

Term Newborns ◽

Infant Weight Gain ◽

First Year Of Life

The early life gut microbiota has been reported to be involved in neonatal weight gain and later infant growth. Therefore, this early microbiota may constitute a target for the promotion of healthy neonatal growth and development with potential consequences for later life. Unfortunately, we are still far from understanding the association between neonatal microbiota and weight gain and growth. In this context, we evaluated the relationship between early microbiota and weight in a cohort of full-term infants. The absolute levels of specific fecal microorganisms were determined in 88 vaginally delivered and 36 C-section-delivered full-term newborns at 1 month of age and their growth up to 12 months of age. We observed statistically significant associations between the levels of some early life gut microbes and infant weight gain during the first year of life. Classifying the infants into tertiles according to their Staphylococcus levels at 1 month of age allowed us to observe a significantly lower weight at 12 months of life in the C-section-delivered infants from the highest tertile. Univariate and multivariate models pointed out associations between the levels of some fecal microorganisms at 1 month of age and weight gain at 6 and 12 months. Interestingly, these associations were different in vaginally and C-section-delivered babies. A significant direct association between Staphylococcus and weight gain at 1 month of life was observed in vaginally delivered babies, whereas in C-section-delivered infants, lower Bacteroides levels at 1 month were associated with higher later weight gain (at 6 and 12 months). Our results indicate an association between the gut microbiota and weight gain in early life and highlight potential microbial predictors for later weight gain.

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