scholarly journals Investigation of the high rates of extrapulmonary tuberculosis in Ethiopia reveals no single driving factor and minimal evidence for zoonotic transmission of Mycobacterium bovis infection

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Stefan Berg ◽  
Esther Schelling ◽  
Elena Hailu ◽  
Rebuma Firdessa ◽  
Balako Gumi ◽  
...  
2020 ◽  
Vol 155 (6) ◽  
Author(s):  
Alejandro Hernández-Solís ◽  
Maribel González-Villa ◽  
Raúl Cicero-Sabido ◽  
Heleodora González-González ◽  
Yesenia Colín-Muñoz ◽  
...  

2019 ◽  
Vol 23 (11) ◽  
pp. 1162-1170 ◽  
Author(s):  
S. Cadmus ◽  
V. Oluwatoyin Akinseye ◽  
D. van Soolingen

Zoonotic transmission of mycobacteria between humans and other animal species is an important aspect of the epidemiology of tuberculosis (TB) in regions of the world where the burden of the disease in humans and other animals is high. This is particularly important in areas in which sociocultural factors increase the possibility for interspecies transmission of different mycobacteria. Carrying out a review of the published literature involving laboratory-confirmed TB cases (by culture) and/or biochemical and molecular identification, we described the presence of Mycobacterium bovis and M. tuberculosis infections in humans and animals from 1975 to 2014. Overall, 1693 isolates of M. tuberculosis complex and other mycobacteria were identified and reported, of which 1131 represented M. tuberculosis, 286 represented M. bovis, 71 represented M. africanum, and 205 represented other mycobacteria. Importantly, 1.3% (15/1131) of the M. tuberculosis isolates reported were identified in cattle, while 8.0% (23/286) of the M. bovis isolates reported were isolated from humans. We suggest that representative sampling of TB cases in both hosts, studied by molecular identification tools, will help significantly in deciphering ongoing transmission between animals and humans in both directions and will enhance TB control in Nigeria.


Praxis ◽  
2019 ◽  
Vol 108 (15) ◽  
pp. 991-996
Author(s):  
Ngisi Masawa ◽  
Farida Bani ◽  
Robert Ndege

Abstract. Tuberculosis (TB) remains among the top 10 infectious diseases with highest mortality globally since the 1990s despite effective chemotherapy. Among 10 million patients that fell ill with tuberculosis in the year 2017, 36 % were undiagnosed or detected and not reported; the number goes as high as 55 % in Tanzania, showing that the diagnosis of TB is a big challenge in the developing countries. There have been great advancements in TB diagnostics with introduction of the molecular tests such as Xpert MTB/RIF, loop-mediated isothermal amplification, lipoarabinomannan urine strip test, and molecular line-probe assays. However, most of the hospitals in Tanzania still rely on the TB score chart in children, the WHO screening questions in adults, acid-fast bacilli and chest x-ray for the diagnosis of TB. Xpert MTB/RIF has been rolled-out but remains a challenge in settings where the samples for testing must be transported over many kilometers. Imaging by sonography – nowadays widely available even in rural settings of Tanzania – has been shown to be a useful tool in the diagnosis of extrapulmonary tuberculosis. Despite all the efforts and new diagnostics, 30–50 % of patients in high-burden TB countries are still empirically treated for tuberculosis. More efforts need to be placed if we are to reduce the death toll by 90 % until 2030.


2019 ◽  
Author(s):  
F Attig ◽  
SA Barth ◽  
M Kohlbach ◽  
W Baumgärtner ◽  
A Lehmbecker
Keyword(s):  

2019 ◽  
Vol 69 (10) ◽  
pp. 417 ◽  
Author(s):  
Irene Panero Pérez ◽  
Rafael San-Juan ◽  
Carla Eiriz Fernández ◽  
Daniel García Pérez ◽  
Igor Paredes ◽  
...  
Keyword(s):  

JMS SKIMS ◽  
2018 ◽  
Vol 21 (1) ◽  
pp. 11-16
Author(s):  
Abdul Ahad Wani ◽  
Javeed Iqbal Bhat ◽  
Muzafar Naik ◽  
Nisar Ahmed Dar ◽  
Syed Masood Ahmed

Background: India accounts for one-fourth of the global tuberculosis (TB) burden. Since the countrywide implementation of RNTCP, tuberculosis care has received renewed focus. Directly observed treatment short-term (DOTS) is a cornerstone of RNTCP program. Objective: To evaluate demographic profile, clinical presentation and outcome of TB in district Baramulla of North Kashmir. Methods:  A prospective study over a period of seven years in patients diagnosed with TB in district Baramulla of North Kashmir. Results: This study was conducted prospectively over seven years from March 2011 to February 2017. A total of 802 patients were enrolled in the study. Among them, there were a total of 638 adult patients and 164 paediatric patients with a male: female ratio of 1:0.99. Majority of patients belonged to rural areas of north Kashmir and had received no or elementary education. Pulmonary tuberculosis was diagnosed in 530 (66 %) patients and 272 (34%) patients were diagnosed as extrapulmonary tuberculosis. Sputum for AFB was important mode of diagnosis in our series and was positive in 525 (65%) our patients. Majority of patients presented with fever, weight loss, and night sweats. None of the patients had Acquired Immunodeficiency syndrome (AIDS). There was a consistent improvement in AFB isolation among TB patients over the study period. Majority of our patients were cured completely of disease Conclusion: Sputum positive pulmonary tuberculosis remains the most common presentation of tuberculosis in North Kashmir. There is a steady increase in the proportion of bacteriologically confirmed TB cases over the study period. Furthermore, DOTS treatment is successful in all forms of tuberculosis. JMS 2018;21(1):11-16


2003 ◽  
Author(s):  
Charles Thomas Parker ◽  
Dorothea Taylor ◽  
George M Garrity
Keyword(s):  

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