Disseminated Talaromyces marneffei infection presenting as multiple intestinal perforations and diffuse hepatic granulomatous inflammation in an infant with STAT3 mutation: a case report

Background: Recurrent episodes of isolated pericardial effusion due to tuberculosis, leading to reduced Left Ventricle Ejection Fraction (LVEF), are uncommon. Methods: This is a case report of a previously healthy 32-years old male with tuberculous induced pericardial effusion as isolated manifestation. The only known exposure of tuberculosis was a brother with whom the patient did not have physical contact during the last year. The pericardial effusion repeatedly appeared after being drained a total of three times. Due to recurrent episodes of pericardial effusion, severe thickening of the pericardium, pericardial adherences and increasing affection on the heart, pericardiectomy was ultimately performed. Results: Biochemical examination, chest X-ray, computed tomography of thorax and abdomen and cytology report did not reveal any signs of malignancy, connective tissue disease or other infections including extra-pulmonary/pulmonary tuberculosis. However, the pericardial biopsy was Polymerase Chain Reaction positive (PCR) for tuberculosis DNA and showed granulomatous inflammation with necrosis. After 6 months anti-tuberculous therapy, biochemical parameters, LVEF and the clinical condition of the patient were normalized. Conclusion: Tuberculosis can be difficult to diagnose when it only manifests as pericardial effusion especially if the time for exposure is long before the appearance of symptoms and admission.

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A diffuse granulomatous inflammation secondary to a trauma of hand: a case report.

Radiology Case Reports ◽

10.1016/j.radcr.2021.05.040 ◽

2021 ◽

Vol 16 (8) ◽

pp. 2256-2260

Author(s):

Sui Zheng ◽

Jiagang Wang ◽

Zhongyuan Ji

Keyword(s):

Case Report ◽

Granulomatous Inflammation

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Tuberculous Pachymeningitis Presenting as a Diffused Dural Thickening in a Patient with Chronic Headache and Recurrent Neurological Abnormalities for More than a Decade: A Case Report and a Review of the Literature

Case Reports in Infectious Diseases ◽

10.1155/2018/3012034 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5

Author(s):

C. L. Fonseka ◽

T. E. Kanakkahewa ◽

S. D. A. L. Singhapura ◽

J. S. Hewavithana ◽

L. P. Kolambage ◽

...

Keyword(s):

Case Report ◽

Chronic Headache ◽

Facial Nerve Palsy ◽

Extrapulmonary Tuberculosis ◽

Granulomatous Inflammation ◽

Mantoux Test ◽

Resonance Imaging ◽

Neurological Signs ◽

Neurological Abnormalities ◽

Contrast Enhanced

Background. Tuberculous pachymeningitis is a rare form of extrapulmonary tuberculosis usually suspected from the detection of thickening of the dura in contrast-enhanced magnetic resonance imaging. Progressive nature of the disease can lead to chronic headache with focal neurological signs due to compression from the thickened dura. Case Report. We report a 40-year-old female who presented with chronic headache over a decade associated with recurrent neurological abnormalities including optic neuritis, hemisensory loss, migraine, facial nerve palsy, and recurrent vertigo. Although there was an initial perceived response to steroids, the patient had a subsequent progressive course. On investigations, she was found to have a diffused dural thickening on contrast MRI with a strongly positive Mantoux test with caseating necrotizing granulomatous inflammation on dural histology. With initiation of antituberculous medication with steroids, the patient markedly improved, and the medication for tuberculosis was continued for a year with good response. Conclusion. Primary tuberculous pachymeningitis should be suspected in a patient complaining of prolonged headache with focal neurological signs when MRI evidence of dural thickening is detected, and another focus of tuberculosis was not found. Prompt suspicion with image-guided dural biopsy for histology would help to confirm the diagnosis.

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Canine Hepatitis Associated with Intrahepatic Bacteria in Three Dogs

Journal of the American Animal Hospital Association ◽

10.5326/jaaha-ms-6492 ◽

2018 ◽

Vol 54 (1) ◽

pp. 65-70 ◽

Cited By ~ 3

Author(s):

Joon Im ◽

Derek P. Burney ◽

Sean P. McDonough ◽

Brigid Nicholson ◽

Adam Eatroff ◽

...

Keyword(s):

In Situ Hybridization ◽

Case Report ◽

Fluorescence In Situ Hybridization ◽

Antimicrobial Therapy ◽

Granulomatous Inflammation ◽

Formalin Fixed Paraffin ◽

Formalin Fixed Paraffin Embedded ◽

Hematoxylin And Eosin ◽

Formalin Fixed

ABSTRACT This case report describes the detection of intrahepatic bacteria in formalin-fixed paraffin-embedded histopathological sections from three dogs with neutrophilic, pyogranulomatous, or lymphoplasmacytic hepatitis and cholangiohepatitis. In each of these cases, eubacterial fluorescence in situ hybridization enabled colocalization of intrahepatic bacteria with neutrophilic and granulomatous inflammation in samples that were negative for bacteria when evaluated by routine hematoxylin and eosin histopathology augmented with histochemical stains. Positive responses to antimicrobial therapy were observed in of 2 out of 2 patients that were treated with antimicrobials. These findings suggest that eubacterial fluorescence in situ hybridization analysis of formalin-fixed paraffin-embedded histopathological sections is more sensitive than conventional histochemical stains for the diagnosis of bacteria-associated canine hepatitis.

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Management of Enteroatmospheric Fistula and Floating Ileostomy: Would Eaken Wound Pouch Be the Answer? A Case Report

American Journal of Surgical Case Reports ◽

10.31487/j.ajscr.2020.03.05 ◽

2020 ◽

pp. 1-2

Author(s):

Abdirahaman Nuno ◽

A. Sinha ◽

Abdirahaman Nuno ◽

Mokhtar Eltair

Keyword(s):

Inflammatory Bowel Disease ◽

Case Report ◽

Rare Case ◽

Open Abdomen ◽

Granulomatous Inflammation ◽

Multidisciplinary Care ◽

Abdominal Tuberculosis ◽

Abdominal Sepsis ◽

Enteroatmospheric Fistula ◽

Inflammatory Bowel

Enterocutaneous and enteroatmospheric fistulas are the most challenging complications of abdominal sepsis to deal with a high mortality. This is even more challenging with a stoma in an open abdomen. In the setting of chronic granulomatous inflammation like abdominal tuberculosis or inflammatory bowel disease, recovery is prolonged and management involves multidisciplinary care. We present a rare case that was a complication of tuberculous peritonitis.

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Caseating Tuberculous Lymphadenitis- A Case Report

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i41b32342 ◽

2021 ◽

pp. 37-40

Author(s):

Mayur B. Wanjari ◽

Deeplata Mendhe ◽

Pratibha Wankhede ◽

Sagar Alwadkar

Keyword(s):

Case Report ◽

Lymph Node ◽

Granulomatous Inflammation ◽

Neck Region ◽

Needle Aspiration ◽

Tuberculous Lymphadenitis ◽

Submandibular Region ◽

Hiv Test ◽

Painful Sensation ◽

Loss Of Appetite

Introduction: Tuberculosis lymphadenitis (or tuberculous adenitis) is the most common type of infection with tuberculosis that occurs outside of the respiratory system. Tuberculosis lymphadenitis is a chronic condition caused by Mycobacterium tuberculosis in the granulomatous inflammation of the lymph node caused by caseated necrosis. The number of people who contact tuberculosis is estimated at 8 million per year, and about 3 million people die from tuberculosis in the world. Presentation of Case: In this case report we delineate the case of a female patient, 26-year-old, she had some pain and lymph node swelling in her right submandibular region since from 4 months and was diagnosed as right Caseating Tuberculous Lymphadenitis, associated with the cervical (neck) region, who was immunocompetent and HIV test negative, with a history of recurring fever, weight loss, loss of appetite for the last 4 months. On physical examination, she had swelling approximately 3×3 cm in the right submandibular region and a hard mass and painful sensation were noticed in her right submandibular region. On Fine needle aspiration cytology of submandibular lymph node reveals Caseating Tuberculous Lymphadenitis. this is extremely rare in immunocompetent individuals.

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