scholarly journals Does ganciclovir exert retinal toxicity after multiple continuous intravitreal injections?

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Feng Hu ◽  
Ya Ma ◽  
Xiaoyan Peng
Keyword(s):  
Visual Acuity ◽  
Capillary Density ◽  
Acute Retinal Necrosis ◽  
Case Presentation ◽  
Visual Damage ◽  
Retinal Capillary ◽  
Single Flash ◽  
Interdigitation Zone ◽  
Anatomical Outcomes ◽  
Flash Response

Abstract Background The objective of this study is to report a case of acute retinal necrosis in which abnormalities in visual function did not correspond to retinal anatomical outcomes. Case presentation A 39-year-old female diagnosed with acute retinal necrosis underwent repeated (nine rounds) intravitreal ganciclovir injection (3 mg/0.1 ml) into the left eye, one injection every 2 weeks. During the therapy, the patient noticed her visual acuity declining gradually. The best corrected visual acuity in the left eye was 20/33. The visual field showed massive visual damage. There was no posterior necrotizing involvement, no macular edema or exudation, and only slight abnormity of the interdigitation zone in the fovea area was visible on OCT. Angio-OCT revealed normal capillary density of three retinal capillary and choriocapillaris layers. The visually evoked potential was normal. The photopic single-flash response showed a declined amplitude of a-wave and b-wave. The amplitudes of photopic 30 Hz flicker were decreased. Multifocal electroretinography revealed macular dysfunction. Conclusion Ganciclovir-associated photoreceptor damage may induce abnormalities in retinal function in response to multiple continuous intravitreal ganciclovir injections at a relatively high dosage (3 mg/0.1 ml).

scholarly journals Relationship between retinal capillary vessel density of OCT angiography and intraocular pressure in pig

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mihyun Choi ◽  
Seong-Woo Kim ◽  
Somin Ahn ◽  
Thi Que Anh Vu ◽  
Cheolmin Yun ◽  
...  
Keyword(s):  
Capillary Density ◽  
Vessel Density ◽  
Retinal Blood Flow ◽  
Vascular Plexus ◽  
Retinal Capillary ◽  
Capillary Plexus ◽  
Ocular Pressure ◽  
Retinal Artery ◽  
The Mean ◽  
Iop Elevation

AbstractThe purpose of this study was to evaluate density change in the retinal capillary plexus during intra ocular pressure (IOP) elevation in vitrectomized pigs’ eyes using optical coherence tomography angiography (OCTA). Eight eyes of eight micro pigs received vitrectomy and the IOP was controlled from 15 mmHg (baseline) to 105 mmHg in 15 mmHg increments using a vented-gas forced-infusion system, and then decreased back to normal IOP (recovery state). The spectral-domain OCTA device was set to scan an area of 8.8 × 4.4 mm (30° × 15°) above the optic nerve head for each IOP. The relative vessel density (rVAD) compared to baseline was determined for the total retinal blood flow (RBF) which included major retinal artery and venous vessels, radial peripapillary capillaries (RPCs), superficial (SVP), intermediate (IVP), and deep vascular plexus (DVP). The mean rVAD was 0.890 in RBF, 0.826 in RPCs, 0.817 in SVP, 0.819 in IVP, and 0.794 in DVP at 30 mmHg. While the rVAD of RBF and RPCs decreased to 0.504 and 0.541 at 45 mmHg, the SVP, IVP, and DVP decreased to 0.433, 0.359, and 0.345, respectively. When IOP was normalized, the rVAD was recovered in all layers and the VAD of RBF, IVP, and DVP were higher than baseline (P = 0.040, 0.019, and 0.019, respectively). Retinal capillary density deterioration in each layer was found from 30 mmHg using an OCTA system which showed excellent depth-resolved segmentation of retinal capillary layers even at higher IOPs. Reduction in VAD showed full recovery after IOP normalization.

To the question of retinal detachment in cytomegalovirus uveitis in HIV-infected patients: treatment outcomes

2021 ◽  
pp. 17-19
Author(s):  
T.D. Sizova ◽  
◽  
V.M. Khokkanen ◽  
F.O. Kasymov ◽  
E.V. Boyko ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Retinal Detachment ◽  
Hiv Infection ◽  
Vision Loss ◽  
Acute Retinal Necrosis ◽  
Study Group ◽  
Ophthalmological Examination ◽  
Complex Treatment ◽  
Key Words Cytomegalovirus ◽  
Common Causes

Cytomegalovirus uveitis (CMV-uveitis) is one of the most common causes of vision loss in HIV-infected patients. The purpose is to characterize the clinical features of the course of retinal detachment in HIV infection. Material and methods. The study group included 29 patients, 34 eyes (9 men and 20 women). All patients underwent a standard routine ophthalmological examination. To confirm the diagnosis, an ultrasound of the eyeball was performed. Results. The following forms of retinal detachment were identified: acute retinal necrosis, regmatogenic and traction detachment. In 50% of cases, the disease occurred as acute retinal necrosis of CMV-etiology. Visual acuity in the group of patients with operated retinal detachment became significantly lower after complex treatment. Conclusions. CMV-uveitis has a chronic sluggish course, despite multicomponent treatment. Key words: cytomegalovirus, uveitis, HIV, HIV-infection, AIDS, retinal detachment.

scholarly journals Corneal Perforation after Nd:YAG Capsulotomy: A Case Report and Literature Review

2019 ◽  
Vol 10 (1) ◽  
pp. 111-115 ◽  
Author(s):  
Maroun Khreish ◽  
Rana Hanna ◽  
Liron Berkovitz ◽  
Beatrice Tiosano
Keyword(s):  
Visual Acuity ◽  
Acute Onset ◽  
Systemic Scleroderma ◽  
Posterior Capsular Opacification ◽  
Corneal Perforation ◽  
Blurred Vision ◽  
Case Presentation ◽  
Corrected Visual Acuity ◽  
Nd:Yag Laser Capsulotomy ◽  
Corneal Laceration

Background: Nd:YAG capsulotomy is the treatment of choice for posterior capsular opacification after cataract surgery. We report a case of corneal perforation following Nd:YAG capsulotomy in a patient with systemic scleroderma. Case Presentation: A 69-year-old woman presented with acute onset of blurred vision 2 weeks following Nd:YAG laser capsulotomy for posterior subcapsular opacification. On examination, her best-corrected visual acuity was 1/120, and bio-microscopy revealed a central full-thickness corneal laceration. Conservative treatment consisted of topical ocular antibiotics, cycloplegics, hypotensive drops and a soft therapeutic contact lens. Her final visual acuity improved to 6/18 with resolution of the corneal laceration. Conclusion: The possibility of corneal perforation after Nd-YAG capsulotomy in patients with systemic scleroderma and connective tissue disease should be borne in mind when treating such patients.

scholarly journals Lower retinal capillary density in minimal cognitive impairment among older Latinx adults

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Bright S. Ashimatey ◽  
Lina M. D'Orazio ◽  
Samantha J. Ma ◽  
Kay Jann ◽  
Xuejuan Jiang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Capillary Density ◽  
Retinal Capillary

scholarly journals Photodynamic Therapy for Juxtapapillary Retinal Capillary Hemangioma

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Panagiotis G. Mitropoulos ◽  
Irini P. Chatziralli ◽  
Vasileios G. Peponis ◽  
Vasileia A. Tsiotra ◽  
Efstratios A. Parikakis
Keyword(s):  
Visual Acuity ◽  
Photodynamic Therapy ◽  
Optic Disc ◽  
Anterior Segment ◽  
Capillary Hemangioma ◽  
Treatment Modalities ◽  
Inferior Margin ◽  
Retinal Capillary ◽  
Retinal Capillary Hemangioma ◽  
The Right

Various treatment modalities have been described for retinal capillary hemangioma. Our purpose is to present a case of juxtapapillary retinal capillary hemangioma treated with photodynamic therapy. A 69-year-old woman with no previous ocular history presented with blurred vision and photopsias in the right eye three months ago. At presentation, her best corrected visual acuity was 6/9 in the right eye and 6/6 in the left eye. The anterior segment was totally normal and IOP was normal in both eyes as well. Dilated fundoscopy revealed a yellowish, well-circumscribed, elevated area with blood vessels, on the inferior margin of the right optic disc, as optic disc edema. Fluorescein angiography and angiogram with indocyanine green confirmed the diagnosis of juxtapapillary retinal capillary hemangioma. The patient was treated with photodynamic therapy with verteporfin and three months later her visual acuity was 6/7.5 in the right eye, while the lesion was slightly smaller. These findings remained stable at the one-year follow-up. In conclusion, photodynamic therapy offers promising anatomical and functional results for juxtapapillary retinal capillary hemangioma, providing visual acuity improvement or even stabilization and restriction of enlargement of the lesion.

scholarly journals IMPROVEMENT OF LEUKEMIC RETINOPATHY AFTER LEUKAPHERESIS IN CHRONIC MYELOGENOUS LEUKEMIA WITH LEUKOSTASIS

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Ruchyta Ranti ◽  
Sauli Ari Widjaja ◽  
Wimbo Sasono ◽  
Muhammad Firmansjah ◽  
Ima Yustiarini ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Chronic Myelogenous Leukemia ◽  
Visual Disturbance ◽  
Myelogenous Leukemia ◽  
Laboratory Examination ◽  
Retinal Hemorrhages ◽  
Case Presentation ◽  
Retinal Blood Vessels ◽  
Wbc Count ◽  
The Right

ABSTRACT Introduction: to report a case of bilateral leukemic retinopathy due to leukostasis that was successfully managed by leukapheresis. Case Presentation: 31-year-old male with mild visual disturbance was referred to ophthalmology department. He suffered from Chronic Myelogenous Leukemia (CML) with white blood cell (WBC) count 533.900/microL. He was started on hydroxyurea, allopurinol, and once leukapheresis. Ophthalmologic evaluation revealed visual acuity of 4/4 in the right eye and 4/6,3 in the left eye. Funduscopy examination showed the presence of bilateral papilledema, venous engorgement, tortuosity, and retinal hemorrhages. Then this patient continued with second leukapheresis. Result: Visual acuity, laboratory examination, and funduscopic finding was evaluated. His visual acuity was improved, papilledema and retinal blood vessels abnormality had markedly reduced concurring with the patient’s hematological remission. Decreasing WBC count after leukapheresis has improved blood flow that reflected from the retinal findings and visual acuity improvement. Conclusion: Leukapheresis treatment is sufficient to improved clinical condition for leukemic retinopathy caused by CML with leukostasis. Keywords: chronic myelogenous leukemia (CML), hyperleukocytosis, leukostasis, leukemic retinopathy

scholarly journals Nd:YAG Laser Hyaloidotomy for Treatment of Subhyaloid Hemorrhage in Pregnancy

2020 ◽  
Author(s):  
Mojtaba Abrishami ◽  
Nasser Shoeibi ◽  
Hamid Reza Heidarzadeh ◽  
Ghodsieh Zamani
Keyword(s):  
Visual Acuity ◽  
Nd:Yag Laser ◽  
Pregnant Patient ◽  
Visual Recovery ◽  
Case Presentation ◽  
Hand Motion ◽  
Valsalva Retinopathy ◽  
Eye Examination ◽  
In Pregnancy ◽  
Subhyaloid Hemorrhage

Abstract Purpose: To report a pregnant patient with impaired vision due to macular involvement of valsalva retinopathy associated with subhyaloid hemorrhage, who was effectively treated with Nd:YAG laser hyaloidotomy and led to successful visual recovery.Case presentation: A thirty-year-old pregnant woman at 36-week gestational age was referred due to suddenly decreased visual acuity in her left eye following a severe vomiting. Left eye examination showed a dense large subhyaloid hemorrhage in front of macula extending from superior to inferior arcade with a clear media. With the diagnosis of subhyaloid hemorrhage she underwent Nd:YAG laser hyaloidotomy and visual acuity improved from hand motion to 20/20 after one week.Conclusion: In this report, Nd:YAG laser hyaloidotomy was shown to be effective and safe in treatment of dense subhyaloid hemorrhage in pregnant patients with Valsalva retinopathy.

scholarly journals Vogt-Koyanagi-Harada Disease Following COVID-19 Infection

2021 ◽  
pp. 804-808
Author(s):  
Juan B. Yepez ◽  
Felipe A. Murati ◽  
Michele Petitto ◽  
Jazmin De Yepez ◽  
Jose M. Galue ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Optic Nerve ◽  
Plexiform Layer ◽  
Visual Disturbance ◽  
Ocular Pain ◽  
Ocular Movements ◽  
Interdigitation Zone ◽  
The Right ◽  
Retinal Folds

A 29-year-old female presented to the emergency clinic with gradual visual disturbance in both eyes for 15 days duration, accompanied by bilateral tinnitus, and ocular pain that increased with ocular movements. One month prior to presentation, the patient had tested positive for severe acute respiratory syndrome coronavirus-2 but without complications. Visual acuity was 20/100 in the right eye and 20/300 in the left eye. Funduscopy demonstrated optic nerve swelling, radial nerve fiber striation disruption, and bilateral retinal folds. Optical coherence tomography showed serous (bacillary) retinal detachment and multifocal areas of hyper-reflective changes in the inner and outer plexiform layer with inner nuclear layer thickening and disruption of the interdigitation zone bilaterally. We present a case of incomplete Vogt-Koyanagi-Harada disease following COVID-19 infection.

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