scholarly journals Functional connectivity and quality of life in young adults with cerebral palsy: a feasibility study

BMC Neurology ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Diana Tajik-Parvinchi ◽  
◽  
Andrew Davis ◽  
Sophia Roth ◽  
Peter Rosenbaum ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Young Adults ◽  
Cerebral Palsy ◽  
Functional Connectivity ◽  
Feasibility Study ◽  
Resting State ◽  
Quality Data ◽  
Gross Motor ◽  
Good Quality Data

Abstract Background Cerebral Palsy (CP) is a group of disorders that affect the development of movement and posture. CP results from injuries to the immature brain during the prenatal, perinatal, or postnatal stage of development. Neuroimaging research in CP has focused on the structural changes of the brain during early development, but little is known about brain’s structural and functional changes during late adolescence and early adulthood, a period in time when individuals experience major changes as they transition into adulthood. The work reported here served as a feasibility study within a larger program of research (MyStory Study). We aimed to determine whether it would be feasible to scan and obtain good quality data without the use of sedation during a resting state condition for functional connectivity (FC) analyses in young adults with CP. Second, we aimed to identify the FC pattern(s) that are associated with depressive mood ratings, indices of pain and fatigue, and quality of life in this group. Methods Resting state functional images were collected from 9 young people with CP (18–29 years). We applied a stringent head motion correction and quality control methods following preprocessing. Results We were able to scan and obtain good quality data without the use of sedation from this group of young individuals with CP who demonstrated a range of gross motor ability. The functional connectivity networks of interest were identified in the data using standard seed regions. Our analyses further revealed that higher well-being scores were associated with higher levels of FC between the Medial Pre-Frontal Cortex and the right Lateral Parietal regions, which are implicated in prosocial and emotion regulations skills. The implications of this association are discussed. Conclusion The findings of the present study demonstrate that it is feasible to conduct resting state functional connectivity in young adults with CP with different gross motor abilities without the use of sedation. Our results also highlight a neural circuitry that is associated with the self-report of quality of life and emotion regulation. These findings identify these regions/circuitries as important seeds for further investigations into mental health and wellbeing in CP.

scholarly journals Determinants of participation and quality of life of young adults with cerebral palsy: longitudinal approach and comparison with the general population – SPARCLE 3 study protocol

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Catherine Arnaud ◽  
Carine Duffaut ◽  
Jérôme Fauconnier ◽  
Silke Schmidt ◽  
Kate Himmelmann ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Young Adults ◽  
Cerebral Palsy ◽  
Young People ◽  
General Population ◽  
Transition Period ◽  
Well Being ◽  
Personal Factors ◽  
The Impact

Abstract Background Effective inclusion in society for young people with disabilities is increasingly seen as generating opportunities for self-development, and improving well-being. However, significant barriers remain in the vast majority of activities meaningful for young adults. Research argues that various personal (disabilities, health) and environmental (access to the resources needed, accessible environment, discrimination, lack of personal economic independence) factors contribute to limited participation. However, previous studies conducted in young people with cerebral palsy (CP) mainly investigated the transition period to adulthood, and did not fully consider the whole range of impairment severity profiles or environmental barriers. In this study, we will use the follow-up of the SPARCLE cohort and a comparison group from the general population (1) to investigate the impact of the environment on participation and quality of life of young adults with CP, (2) to determine predictors of a successful young adulthood in educational, professional, health and social fields, (3) to compare quality of life and frequency of participation in social, work and recreational activities with the general population, (4) to document on participation and quality of life in those with severe disabilities. Methods The SPARCLE3 study has a combined longitudinal and cross-sectional design. Young adults with CP aged 22 to 27 years in 6 European regions previously enrolled in the SPARCLE cohort or newly recruited will be invited to self-complete a comprehensive set of questionnaires exploring participation (daily life and discretionary activities), health-related quality of life, body function, personal factors (health, personal resources), and contextual factors (availability of needed environmental items, family environment, services provision) during home visits supervised by trained researchers. Proxy-reports or adapted questionnaires will be used for those with the most severe impairments. The recruitment of a large group from the general population (online survey) will enable to identify life areas where the discrepancies between young people with CP and their able-bodied peers are the most significant. Discussion This study will help identify to what extent disabilities and barriers in environment negatively affect participation and quality of life, and how previous valued experiences during childhood or adolescence might modulate these effects.

Quality of life in young adults with cerebral palsy

2016 ◽  
Vol 9 (4) ◽  
pp. 673-681 ◽  
Author(s):  
Benran Jiang ◽  
Janet Walstab ◽  
Susan M. Reid ◽  
Elise Davis ◽  
Dinah Reddihough
Keyword(s):  
Quality Of Life ◽  
Young Adults ◽  
Cerebral Palsy

scholarly journals Caregiver-reported health-related quality of life of children with cerebral palsy and their families and its association with gross motor function: A South Indian study

2016 ◽  
Vol 07 (02) ◽  
pp. 223-227 ◽  
Author(s):  
S. Surender ◽  
Vykuntaraju K. Gowda ◽  
K. S. Sanjay ◽  
G. V. Basavaraja ◽  
Naveen Benakappa ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cerebral Palsy ◽  
Motor Function ◽  
Classification System ◽  
Health Related Quality ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Related Quality ◽  
Health Related

ABSTRACT Introduction: In children, health-related quality of life (HRQOL) includes parental impact and family functioning along with concepts of illness, functional status, mental health, and comfort. We are focusing on the impact of cerebral palsy (CP) on children’s HRQOL and their families, and its relationship with gross motor dysfunction. Subjects and Methods: CP children aged 3–10 years under regular neurology follow-up were enrolled. The HRQOL and motor severity were prospectively assessed using lifestyle assessment questionnaire-CP and gross motor function classification systems, respectively. Results: One hundred children participated in this study. Thirty-three percent of children had good, 22% had mildly affected, whereas 45% had moderately to severely affected HRQOL. A significant association is present between gross motor function classification system and HRQOL. Conclusion: HRQOL in CP and their caregivers is highly impaired. The degree of impairment is associated with physical independence, mobility, clinical burden, and social integration dimensions. Therapies targeting these dimensions and associated comorbidities will improve the HRQOL. Gross motor function classification system is a good indicator of HRQOL.

scholarly journals Functionality, school participation and quality of life of schoolchildren with cerebral palsy

2020 ◽  
Vol 33 ◽  
Author(s):  
Afonso Rodrigues Tavares Netto ◽  
Carine Carolina Wiesiolek ◽  
Patrícia Meireles Brito ◽  
Gabriela Adelino da Rocha ◽  
Rayanne Maria Farias Tavares ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cerebral Palsy ◽  
Motor Function ◽  
Motor Performance ◽  
Life Questionnaire ◽  
Gross Motor ◽  
Gross Motor Function ◽  
School Participation ◽  
Study Population

Abstract Introduction: The quality of life (QoL) of schoolchildren with cerebral palsy (CP) should be evaluated considering the functional variability of the child with CP with an extended view on functionality in the school context and the determinants of QoL. Objective: to evaluate the school participation and the QoL of schoolchildren with CP in Recife's municipal public network, as well as to analyze the influence of GMFCS levels and motor performance on these variables in the study population. Method: This is an exploratory observational study whose evaluation model was structured based on the International Classification of Functioning, Disability and Health (CIF). Children with CP were classified in the Gross Motor Function Classification System (GMFCS) and evaluated according to Gross Motor Function Measure-88 (GMFM-88). The School Function Assessment (SFA) and the Quality of Life Questionnaire for Cerebral Palsy (CPQOL-Caregiver) were answered by teachers and mothers, respectively. Results: In the study population, the higher the GMFCS level, the lower the participation and the lower the independence in school activities, aspects that add to the QoL construct, mainly with less functionality, less emotional well-being and self-esteem, and lower family health. Conclusion: GMFCS levels and motor performance of schoolchildren with CP can affect school participation and QoL, and it is important to consider each child's individual and contextual factors. These results can help the development of functional, care, inclusion and pedagogical strategies for students with CP.

Clinical response of Abhaya Ghrita and procedure based therapy on Gross Motor Functions in children with Cerebral Palsy : An Open Label, Randomized Clinical Trial

2019 ◽  
Vol 4 (04) ◽  
Author(s):  
Sonam . ◽  
Mahapatra Arun Kumar ◽  
Rajagopala Shrikrishna
Keyword(s):  
Quality Of Life ◽  
Cerebral Palsy ◽  
Birth Weight ◽  
Motor Function ◽  
Gross Motor ◽  
Live Births ◽  
Gross Motor Function ◽  
Children With Cerebral Palsy ◽  
History Of

Introduction - Cerebral Palsy (CP) being the leading cause of disability in children is a symptom complex, whichv has worldwide incidence of 2.1/1000 live births, and for India it is 3/1000 live births. In Ayurveda, the cerebral palsy can be correlated with various conditions due to Vata predominance. There is no satisfactory criterion in managing this condition is developed till date. The present study is planned with Abhaya Ghrita and procedure based therapy to provide possible improvement in gross motor function of children with cerebral palsy and thereby improving their quality of life. Material and Methods - A Trial was conducted at a tertiary health care setting to evaluate the clinical efficacy of Ayurvedic Intervention (Abhaya Ghrita and procedure based therapy Udvartana, Sarvanga Abhyanga, Nadi Sweda and Matra Basti). Diagnosed children of cerebral palsy, aged 1-12 years of either gender were selected. The scale gross motor function manual (GMFM) and Cerebral Palsy quality of life (CP-QOL) were used for assessment. Results - Total 20 patients were registered in the present study. 70% patients were below 8 years of age with clear male predominance comprised of 85% of the total sample size. As per the birth history of the patients 15% were preterm, home delivery was present in 20%. 45% and 10% were Low birth weight (LBW) and Very Low birth weight (VLBW) after birth respectively. History of delayed cry was present in 80% cases. 45% required Hospitalization and 65% were subjected to Resuscitation and need of incubator just after birth was present in 25% patients. Discussion - Gross Motor Function scale has shown significant improvement in motor activities like lying and rolling, sitting and total score with pandlt;0.001, on crawling and kneeling and standing with pandlt;0.01 and on walking and running with pandlt;0.02. The CP-QOL has also shown significant results on health and family and friends component. Conclusion - Thus, it may be concluded that the Ayurveda approach is effective in improving the gross motor function and quality of life of children with cerebral palsy.

Impact of Hippotherapy on Gross Motor Function and Quality of Life in Children with Bilateral Cerebral Palsy: A Randomized Open-Label Crossover Study

2018 ◽  
Vol 49 (03) ◽  
pp. 185-192 ◽  
Author(s):  
Ute Deutz ◽  
Nicole Heussen ◽  
Katharina Weigt-Usinger ◽  
Steffen Leiz ◽  
Christa Raabe ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cerebral Palsy ◽  
Motor Function ◽  
Spastic Cerebral Palsy ◽  
Psychosocial Burden ◽  
Open Label ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Group Data

AbstractThis study investigated the effect of hippotherapy on gross motor function (Gross Motor Function Measure [GMFM]-66, GMFM dimension E and D) and quality of life (Child Health Questionnaire [CHQ 28], KIDSCREEN-27 parental versions) in children with bilateral spastic cerebral palsy. Seventy-three children (age: 9.1 ± 3.3 years; male = 44; GMFCS levels II = 27; III = 17; IV = 29) were randomized to an early (n = 35) or late (n = 38) treatment group. Data from 66 probands were available for further analysis. Probands received hippotherapy once to twice weekly during a period of 16 to 20 weeks (mean: 17 treatments) in a crossover approach. Whereas no significant changes were found for total GMFM scores and quality of life parameters, a significant increase in GMFM dimension E was found. Children terminating the study early showed lower mean psychosocial quality of life scores than children who completed the whole study (CHQ-28 “psychosocial dimension”; KIDSCREEN-27 “mood and emotional dimension”). Our data are in line with previous reports and suggest that hippotherapy shows distinct therapeutic strengths with regard to promoting upright stand and gait in children with cerebral palsy. Children with higher psychosocial burden of disease may need special support to get access to and benefit from intensified physiotherapy programs.

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