Effects of early pregnancy BMI, mid-gestational weight gain, glucose and lipid levels in pregnancy on offspring’s birth weight and subcutaneous fat: a population-based cohort study

Abstract Objectives The aim of this study was to analyze the interaction between pre-pregnancy body mass index (PP BMI), gestational weight gain (GWG), and newborn outcomes among pregnant mothers in West Sumatera, Indonesia. Methods This VDPM cohort study was conducted from September 2017 to March 2018 in West Sumatra, Indonesia. We obtained 195 healthy mother-infant pairs. GWG status created by comparing PP BMI and GWG guidelines based on the World Health Organization (WHO). Newborn birth weight, birth length, and head circumference were taken immediately after delivery as pregnancy outcomes. SPSS version 20.0 was used to analyze bivariate and multivariate analysis to assess the interaction between PP BMI and gestational weight gain in pregnancy outcomes with adjusting potential confounders. A P-value less than 0.05 was considered as a significant association. Results Of the 195 mother-infant pairs (Mean 29.66 years) included in the main sample, Most of the mothers had 46.7% normal PP BMI with most of them had an inadequate GWG status during pregnancy with 53.3%. Adequate and excessive GWG statuses were 34.4% and 12.3%, respectively. There was a significant association between PP BMI and GWG (p < 0.01). This study had no interaction between PP BMI and GWG to the newborn outcomes (p > 0.05). Adverse newborn outcomes were not statistically significant among groups. However, mothers who had inadequate GWG status may have significant lower birth weight and head circumference compared to normal and excessive GWG status (p < 0.05). Conclusions This study had no interaction between PP BMI and GWG status to newborn outcomes. However, the GWG status associated with newborn outcomes in birth weight and head circumference level. Further prospective studies with a larger number are required to confirm this finding. Funding Sources Indonesian Danone Institute Foundation.

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Bump2Baby and Me: protocol for a randomised trial of mHealth coaching for healthy gestational weight gain and improved postnatal outcomes in high-risk women and their children

Trials ◽

10.1186/s13063-021-05892-4 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Sharleen L. O’Reilly ◽

Christy Burden ◽

Cristina Campoy ◽

Fionnuala M. McAuliffe ◽

Helena Teede ◽

...

Keyword(s):

Weight Gain ◽

High Risk ◽

Usual Care ◽

Gestational Weight Gain ◽

Early Pregnancy ◽

Evidence Based ◽

Non Communicable Diseases ◽

Gestational Weight ◽

Pregnancy And Postpartum ◽

In Pregnancy

Abstract Background Gestational diabetes (GDM) impacts 8–18% of pregnancies and greatly increases both maternal and child risk of developing non-communicable diseases such as type 2 diabetes and obesity. Whilst lifestyle interventions in pregnancy and postpartum reduce this risk, a research translation gap remains around delivering implementable interventions with adequate population penetration and participation. Impact Diabetes Bump2Baby is an implementation project of an evidence-based system of care for the prevention of overweight and obesity. Bump2Baby and Me is the multicentre randomised controlled trial investigating the effectiveness of a mHealth coaching programme in pregnancy and postpartum for women at high risk of developing GDM. Methods Eight hundred women will be recruited in early pregnancy from 4 clinical sites within Ireland, the UK, Spain, and Australia. Women will be screened for eligibility using the validated Monash GDM screening tool. Participants will be enrolled from 12 to 24 weeks’ gestation and randomised on a 1:1 basis into the intervention or control arm. Alongside usual care, the intervention involves mHealth coaching via a smartphone application, which uses a combination of synchronous and asynchronous video and text messaging, and allows for personalised support and goal setting with a trained health coach. The control arm receives usual care. All women and their children will be followed from early pregnancy until 12 months postpartum. The primary outcome will be a difference in maternal body mass index (BMI) of 0.8 kg/m2 at 12 months postpartum. Secondary maternal and infant outcomes include the development of GDM, gestational weight gain, pregnancy outcomes, improvements in diet, physical activity, sleep, and neonatal weight and infant growth patterns. The 5-year project is funded by the EU Commission Horizon 2020 and the Australian National Health and Medical Research Council. Ethical approval has been received. Discussion Previous interventions have not moved beyond tightly controlled efficacy trials into routine service delivery. This project aims to provide evidence-based, sustainable support that could be incorporated into usual care for women during pregnancy and postpartum. This study will contribute evidence to inform the early prevention of non-communicable diseases like obesity and diabetes in mothers and the next generation. Trial registration Australian New Zealand Clinical Trials Registry ACTRN12620001240932. Registered on 19 November 2020

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Gestational weight gain and delivery outcomes: A population‐based cohort study

Paediatric and Perinatal Epidemiology ◽

10.1111/ppe.12709 ◽

2020 ◽

Author(s):

Huiling Xu ◽

Elizabeth V. Arkema ◽

Sven Cnattingius ◽

Olof Stephansson ◽

Kari Johansson

Keyword(s):

Cohort Study ◽

Weight Gain ◽

Gestational Weight Gain ◽

Population Based ◽

Gestational Weight ◽

Delivery Outcomes

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The association between gestational weight gain and risk of stillbirth: a population-based cohort study

Annals of Epidemiology ◽

10.1016/j.annepidem.2017.09.006 ◽

2017 ◽

Vol 27 (10) ◽

pp. 638-644.e1 ◽

Cited By ~ 6

Author(s):

Ruofan Yao ◽

Bo Y. Park ◽

Sarah E. Foster ◽

Aaron B. Caughey

Keyword(s):

Cohort Study ◽

Weight Gain ◽

Gestational Weight Gain ◽

Population Based ◽

Gestational Weight

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Maternal Preconception Body Mass Index and Gestational Weight Gain: A Prospective Cohort Study Potentially to Prevent Low Birth Weight

Indian Journal of Public Health Research & Development ◽

10.5958/0976-5506.2017.00377.1 ◽

2017 ◽

Vol 8 (4) ◽

pp. 110 ◽

Cited By ~ 1

Author(s):

Asry Dwi Muqni ◽

Andi Imam Arundhana ◽

Abdul Razak Thaha ◽

Veni Hadju ◽

Nurhaedar Jafar

Keyword(s):

Body Mass Index ◽

Cohort Study ◽

Weight Gain ◽

Birth Weight ◽

Low Birth Weight ◽

Gestational Weight Gain ◽

Body Mass ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Gestational Weight

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Associations Between Pre-Pregnancy Body Mass Index, Gestational Weight Gain and Preterm Birth: a Cohort Study in Wuhan, China

10.21203/rs.3.rs-49045/v1 ◽

2020 ◽

Author(s):

Yiyang Guo ◽

Chao Xiong ◽

Aifen Zhou ◽

Ronghua Hu ◽

Rong Yang ◽

...

Keyword(s):

Cohort Study ◽

Weight Gain ◽

Preterm Birth ◽

Gestational Weight Gain ◽

Early Pregnancy ◽

Tracking System ◽

Normal Weight ◽

Elevated Risk ◽

Gestational Weight ◽

Increased Risk

Abstract Background Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity worldwide. Methods This cohort study was designed to investigate the associations between pre-pregnancy BMI, total gestational weight gain (GWG), and GWG during early pregnancy with PTB utilizing data of 83,096 Chinese women from the Maternal and Children Healthcare Information Tracking System of Wuhan, China. Results Women who were underweight, overweight or obese prior to pregnancy had an overall elevated risk of PTB, compared to their normal weight counterparts. Women with total GWG below the IOM recommendation had an increased risk of PTB compared to women who had GWG within the recommendation, whereas an increasing risk of PTB was observed asweekly early pregnancy GWGincreased. When stratified by subtypes of PTB, pre-pregnancy underweight was associated with higher risk of spontaneous PTB, and pre-pregnancy overweight /obese increased the risk of both spontaneous PTB and medically indicated PTB. Women with total GWG below the IOM recommendation had elevated risk for spontaneous PTB and PROM, and women with GWG above the recommendation had decreased risk for all three subtypes of PTB, whereas risk for the three subtypes of PTB increased along with increasing weekly GWG of early pregnancy. Conclusions Maternal underweight, overweight/obesity, total GWG, and GWG during early pregnancy should be considered in combination to reduce the risk of PTB, women should modify their weight gains during pregnancy according to the results.

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