scholarly journals Assessment of β-human-derived chorionic gonadotrophic hormone (βhCG) and pregnancy-associated plasma protein A (PAPP-A) levels as predictive factors of preeclampsia in the first trimester among Iranian women: a cohort study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Maryam Honarjoo ◽  
Shahnaz Kohan ◽  
Elahe Zarean ◽  
Mohammad Javad Tarrahi
Keyword(s):  
Cohort Study ◽  
Plasma Protein ◽  
Predictive Factors ◽  
Protein A ◽  
First Trimester ◽  
Health Centers ◽  
Screening Tests ◽  
Iranian Women ◽  
First Trimester Of Pregnancy ◽  
Low Levels

Abstract Background Preeclampsia (PE) is a leading cause of maternal and perinatal mortality. There are controversial findings regarding the prediction of PE through the assessment of the Pregnancy-Associated Plasma Protein A (PAPP-A) and β-Human-Derived Chorionic Gonadotrophic hormone (βhCG) levels in the first trimester of pregnancy. Therefore, this cohort study was conducted to evaluate of PAPP-A and βhCG levels as predictive factors for PE development in the first trimester among Iranian women. Methods In this cohort study, a total of 4605 volunteer Primigravida and Multigravida women were selected by the census from 16 randomly selected Health Centers in Isfahan, Iran, from July 2016 to June 2018. Eligible pregnant women participated in the study had already undergone fetal anomalies screening tests between 11 + 0 and 13 + 6 weeks of pregnancy and their PAPP-A and βhCG biomarkers were adjusted to the Multiples of the Median (MOM). MOM PAPP-A <  0.4 and MOM βhCG > 3 were considered abnormal. The samples were followed up until delivery. The biomarkers’ levels were compared in the two groups of women with and without PE and Relative risk (RR) and odds ratio (OR) of PE calculated. Results In the PE group, the mean MOM PAPP-A was significantly lower (1 vs. 1.09 with P = 0.006) and MOM βhCG was significantly higher (1.51 vs. 1.14 with P = 0.001) than the group without PE. RR and OR for PE in subjects with MOM PAPP-A <  0.4 were reported as follows: RR = 2.49, (p = 0.001) and OR = 2.09, (p = 0.001). RR and OR for PE in subjects with MOM βhCG > 3 were also reported as follows: RR = 4.02, (p = 0.001) and OR = 5.65, (p = 0.001). Adjusted OR for MOM PAPP-A <  0.4 and MOM βhCG > 3 was obtained as follows: OR = 2.09 (P = 0.001) and OR = 5.65 (P = 0.001), respectively. Conclusion The results of the study showed that the high levels of βhCG would cause 5.65 times increase and the low levels of PAPP-A would cause 2.09 times increase in the chance of developing PE.

The association between pre-pregnancy obesity and screening results of depression for all trimesters of pregnancy, postpartum and 1 year after birth: a cohort study

2018 ◽  
Vol 46 (1) ◽  
pp. 87-95 ◽  
Author(s):  
Hanieh Salehi-Pourmehr ◽  
Sakineh Mohammad-Alizadeh ◽  
Nayyer Jafarilar-Agdam ◽  
Somayyeh Rafiee ◽  
Azizeh Farshbaf-Khalili
Keyword(s):  
Cohort Study ◽  
Depression Scale ◽  
First Trimester ◽  
Normal Weight ◽  
Health Centers ◽  
Obese Women ◽  
Third Trimester ◽  
Chi Square ◽  
First Trimester Of Pregnancy ◽  
The Relationship

AbstractObjective:To determine the relationship between pre-pregnancy obesity and screening results of gestational and post-delivery depression in women referred to the health centers of Tabriz, Iran.Methods:In this cohort study, 62 and 245 pregnant women with class 2–3 obesity [body mass index (BMI)≥35 kg/m2] and normal-weight (BMI 18.5–24.9 kg/m2) were enrolled, respectively, in the first trimester of pregnancy from December 2012 to January 2016. For matching of groups, nulliparous and multiparous mothers aged 18–35 years were selected with the ratio of 1:4 in obese and normal BMI groups from the same recruitment center and to controlling the confounder factors, inclusion criteria were considered. The Edinburgh Postnatal Depression Scale (EPDS) was completed in five time points, the first, second, third trimester of pregnancy, 6–8 weeks and 12 months after delivery. Independentt-test, Mann-Whitney, chi-square, Fisher’s exact tests and multivariate logistic and linear regression adjusted for confounders were used. P<0.05 was considered as statistically significant.Results:Based on the EPDS, 12.7% of normal weight women in first, 13.5% in second, 10.2% in third trimester of pregnancy, 7.8% in 6–8 weeks of postpartum and 10.6% in 1 year after delivery screened positive for depression. This proportion was greater in class 2–3 obese women (32.3%, 33.3%, 28.8% in trimesters of pregnancy and 35.4%, 19.4% in postpartum period, respectively) (P<0.05). The results of multivariate logistic regression adjusted for confounding factors showed that the risk of depression in the first trimester of pregnancy for class 2–3 obesity was 3.25-fold greater than normal weight group [adjusted odds ratio (aOR) 3.25, 95% confidence interval (CI) 1.68–6.28]. This risk was 3.29-fold in the second (aOR 3.29, 95% CI 1.67–6.47), 4-folds in the third trimester (aOR 4.003, 95% CI 1.84–8.70 for third), 7.5-fold in the 6–8 weeks of postpartum (aOR 7.46, 95% CI 3.30–16.89) and 1.83-fold (aOR 7.46, 95% CI 3.30–16.89) for 1 year after birth.Conclusions:Pre-pregnancy obesity was associated with probability of gestational and post-delivery depression. Therefore, training and planning to conduct required interventions to resolve obesity seem be helpful in this regard.

Low maternal pregnancy-associated plasma protein A during the first trimester of pregnancy and pregnancy outcomes

2016 ◽  
Vol 136 (1) ◽  
pp. 76-82 ◽  
Author(s):  
Marja Kaijomaa ◽  
Leena Rahkonen ◽  
Veli-Matti Ulander ◽  
Esa Hämäläinen ◽  
Henrik Alfthan ◽  
...  
Keyword(s):  
Plasma Protein ◽  
Pregnancy Outcomes ◽  
Protein A ◽  
First Trimester ◽  
First Trimester Of Pregnancy

Development of a Radioimmunoassay for Pregnancy-Associated Plasma Protein A and Establishment of Normal Levels in the First Trimester of Pregnancy

1983 ◽  
Vol 20 (1) ◽  
pp. 26-30 ◽  
Author(s):  
F Anthony ◽  
G M Masson ◽  
P J Wood
Keyword(s):  
Plasma Protein ◽  
Protein A ◽  
First Trimester ◽  
Serum Samples ◽  
Double Antibody ◽  
Normal Ranges ◽  
Antibody Method ◽  
First Trimester Of Pregnancy

An accelerated double antibody method has been developed for the radioimmunoassay of pregnancy-associated plasma protein A (PAPP-A) in serum. The workable range for the assay was 0·04–1·8 mg/l of serum. PAPP-A levels were determined in single serum samples from 110 women with prospective normal pregnancies of between 7 and 14 weeks' gestation. The level of pregnancy specific β1 glycoprotein (SP1) was also measured in these samples and normal ranges for PAPP-A and SP1 were constructed from the results obtained.

Sign in / Sign up

Export Citation Format

Share Document