The association between pre-pregnancy obesity and screening results of depression for all trimesters of pregnancy, postpartum and 1 year after birth: a cohort study

2018 ◽  
Vol 46 (1) ◽  
pp. 87-95 ◽  
Author(s):  
Hanieh Salehi-Pourmehr ◽  
Sakineh Mohammad-Alizadeh ◽  
Nayyer Jafarilar-Agdam ◽  
Somayyeh Rafiee ◽  
Azizeh Farshbaf-Khalili
Keyword(s):  
Cohort Study ◽  
Depression Scale ◽  
First Trimester ◽  
Normal Weight ◽  
Health Centers ◽  
Obese Women ◽  
Third Trimester ◽  
Chi Square ◽  
First Trimester Of Pregnancy ◽  
The Relationship

AbstractObjective:To determine the relationship between pre-pregnancy obesity and screening results of gestational and post-delivery depression in women referred to the health centers of Tabriz, Iran.Methods:In this cohort study, 62 and 245 pregnant women with class 2–3 obesity [body mass index (BMI)≥35 kg/m2] and normal-weight (BMI 18.5–24.9 kg/m2) were enrolled, respectively, in the first trimester of pregnancy from December 2012 to January 2016. For matching of groups, nulliparous and multiparous mothers aged 18–35 years were selected with the ratio of 1:4 in obese and normal BMI groups from the same recruitment center and to controlling the confounder factors, inclusion criteria were considered. The Edinburgh Postnatal Depression Scale (EPDS) was completed in five time points, the first, second, third trimester of pregnancy, 6–8 weeks and 12 months after delivery. Independentt-test, Mann-Whitney, chi-square, Fisher’s exact tests and multivariate logistic and linear regression adjusted for confounders were used. P<0.05 was considered as statistically significant.Results:Based on the EPDS, 12.7% of normal weight women in first, 13.5% in second, 10.2% in third trimester of pregnancy, 7.8% in 6–8 weeks of postpartum and 10.6% in 1 year after delivery screened positive for depression. This proportion was greater in class 2–3 obese women (32.3%, 33.3%, 28.8% in trimesters of pregnancy and 35.4%, 19.4% in postpartum period, respectively) (P<0.05). The results of multivariate logistic regression adjusted for confounding factors showed that the risk of depression in the first trimester of pregnancy for class 2–3 obesity was 3.25-fold greater than normal weight group [adjusted odds ratio (aOR) 3.25, 95% confidence interval (CI) 1.68–6.28]. This risk was 3.29-fold in the second (aOR 3.29, 95% CI 1.67–6.47), 4-folds in the third trimester (aOR 4.003, 95% CI 1.84–8.70 for third), 7.5-fold in the 6–8 weeks of postpartum (aOR 7.46, 95% CI 3.30–16.89) and 1.83-fold (aOR 7.46, 95% CI 3.30–16.89) for 1 year after birth.Conclusions:Pre-pregnancy obesity was associated with probability of gestational and post-delivery depression. Therefore, training and planning to conduct required interventions to resolve obesity seem be helpful in this regard.

scholarly journals Assessment of β-human-derived chorionic gonadotrophic hormone (βhCG) and pregnancy-associated plasma protein A (PAPP-A) levels as predictive factors of preeclampsia in the first trimester among Iranian women: a cohort study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Maryam Honarjoo ◽  
Shahnaz Kohan ◽  
Elahe Zarean ◽  
Mohammad Javad Tarrahi
Keyword(s):  
Cohort Study ◽  
Plasma Protein ◽  
Predictive Factors ◽  
Protein A ◽  
First Trimester ◽  
Health Centers ◽  
Screening Tests ◽  
Iranian Women ◽  
First Trimester Of Pregnancy ◽  
Low Levels

Abstract Background Preeclampsia (PE) is a leading cause of maternal and perinatal mortality. There are controversial findings regarding the prediction of PE through the assessment of the Pregnancy-Associated Plasma Protein A (PAPP-A) and β-Human-Derived Chorionic Gonadotrophic hormone (βhCG) levels in the first trimester of pregnancy. Therefore, this cohort study was conducted to evaluate of PAPP-A and βhCG levels as predictive factors for PE development in the first trimester among Iranian women. Methods In this cohort study, a total of 4605 volunteer Primigravida and Multigravida women were selected by the census from 16 randomly selected Health Centers in Isfahan, Iran, from July 2016 to June 2018. Eligible pregnant women participated in the study had already undergone fetal anomalies screening tests between 11 + 0 and 13 + 6 weeks of pregnancy and their PAPP-A and βhCG biomarkers were adjusted to the Multiples of the Median (MOM). MOM PAPP-A <  0.4 and MOM βhCG > 3 were considered abnormal. The samples were followed up until delivery. The biomarkers’ levels were compared in the two groups of women with and without PE and Relative risk (RR) and odds ratio (OR) of PE calculated. Results In the PE group, the mean MOM PAPP-A was significantly lower (1 vs. 1.09 with P = 0.006) and MOM βhCG was significantly higher (1.51 vs. 1.14 with P = 0.001) than the group without PE. RR and OR for PE in subjects with MOM PAPP-A <  0.4 were reported as follows: RR = 2.49, (p = 0.001) and OR = 2.09, (p = 0.001). RR and OR for PE in subjects with MOM βhCG > 3 were also reported as follows: RR = 4.02, (p = 0.001) and OR = 5.65, (p = 0.001). Adjusted OR for MOM PAPP-A <  0.4 and MOM βhCG > 3 was obtained as follows: OR = 2.09 (P = 0.001) and OR = 5.65 (P = 0.001), respectively. Conclusion The results of the study showed that the high levels of βhCG would cause 5.65 times increase and the low levels of PAPP-A would cause 2.09 times increase in the chance of developing PE.

scholarly journals FREKUENSI PEMERIKSAAN ANC BERHUBUNGAN DENGAN PREEKLAMPSIA

2021 ◽  
Vol 7 (1) ◽  
pp. 14
Author(s):  
Lina fiitriani Lina fiitriani ◽  
Ros Diana
Keyword(s):  
Data Collection ◽  
First Trimester ◽  
Bivariate Analysis ◽  
Second Trimester ◽  
Third Trimester ◽  
Chi Square ◽  
Cross Sectional ◽  
Normal Duration ◽  
The Relationship ◽  
Duration Of Pregnancy

The gestation period starts from conception until the birth of the fetus. The normal duration of pregnancy is 280 days (40 weeks or 9 months and 7 days) counting from the first day of the last menstruation. Pregnancy is divided into 3, the first trimester starts from conception until 3 months, the second trimester starts from the fourth month to 6 months, the third trimester is from the seventh month to 9 months. Preeclampsia is a disease characterized by hypertension, proteinuria and edema that occurs during pregnancy. or up to 48 hours postpartum. This study aims to determine the frequency of ANC examinations with preeclamptic. The research method used was analytic survey research design with a cross sectional approach. Data collection techniques. Data collection in this study used a questionnaire sheet. The technique used in this study was purposive sampling. The data analysis used was univariate and bivariate analysis and the statistical test used was Chi Square. The significance of the relationship between the two variables is p = 0.000, p = 0.002 <α 0.05, this means that Ha is accepted and Ho is rejected, so there is a relationship between the frequency of ANC examinations and preeclamptic

Adiponectin and leptin as first trimester markers for gestational diabetes mellitus: a cohort study

2017 ◽  
Vol 55 (11) ◽  
Author(s):  
Ida Näslund Thagaard ◽  
Lone Krebs ◽  
Jens-Christian Holm ◽  
Theis Lange ◽  
Torben Larsen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Cohort Study ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
First Trimester ◽  
Normal Weight ◽  
Obese Women ◽  
Obesity Epidemic ◽  
Trimester Screening ◽  
Severely Obese

AbstractBackground:Gestational diabetes mellitus (GDM) is increasing partly due to the obesity epidemic. Adipocytokines have thus been suggested as first trimester screening markers for GDM. In this study we explore the associations between body mass index (BMI) and serum concentrations of adiponectin, leptin, and the adiponectin/leptin ratio. Furthermore, we investigate whether these markers can improve the ability to screen for GDM in the first trimester.Methods:A cohort study in which serum adiponectin and leptin were measured between gestational weeks 6+0 and 14+0 in 2590 pregnant women, categorized into normal weight, moderately obese, or severely obese.Results:Lower concentrations of adiponectin were associated with GDM in all BMI groups; the association was more pronounced in BMI<35 kg/mConclusions:Low adiponectin measured in the first trimester is associated with the development of GDM; higher BMI was associated with lower performance of adiponectin, though this was insignificant. Leptin had an inverse relationship with GDM in severely obese women and did not improve the ability to predict GDM.

scholarly journals Hyperleptinemia as a Prognostic Factor for Preeclampsia: a Cohort Study

2012 ◽  
Vol 55 (4) ◽  
pp. 165-171 ◽  
Author(s):  
Hugo Mendieta Zerón ◽  
Verónica Jackeline García Solorio ◽  
Pamela Montserrat Nava Díaz ◽  
Adriana Garduño Alanís ◽  
Jonnathan Guadalupe Santillán Benítez ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Area Under The Curve ◽  
Roc Curves ◽  
Serum Levels ◽  
First Trimester ◽  
Normal Weight ◽  
Second Trimester ◽  
Obese Women ◽  
A Value ◽  
First Trimester Of Pregnancy

Introduction: Leptin is an adipokine which has a direct relationship to obesity. Our aim was to measure this hormone in pregnant women at three months intervals throughout their pregnancies to determine the serum value of those who developed preeclampsia. Material and Methods: We followed 19 women (median age 24.8 ± 5.7 years) with pre-gestational Body Mass Index (BMI) less than 25 kg/m2, 21 (median age 26.1 ± 4.6 years) with BMI higher than 25 kg/m2 and 16 (median age 30.9 ± 5.8 years) with Gestational Diabetes Mellitus (GDM) (median age 30.9 ± 5.8 years), recruited in the 1st trimester of pregnancy. Serum levels of leptin were measured with radioimmunoassay (RIA) technique. Results: In the first trimester of pregnancy leptin levels showed statistically significant differences between normal weight and overweight-obese women (p < 0.001), diabetic women (p < 0.05) and the subgroup of preeclamptic women (p < 0.001). For those women with PGBMI ≥ 40 kg/m2 and leptin ≥ 40 ng/ml in the second trimester, the Odds Ratio (OR) to develop preeclampsia was of 47.95% CI (4.1–527.2). Analyzing leptin values with ROC curves, the greatest area under the curve (AUC) was for leptin in the second trimester (0.773, CI: 0.634–0.911). Conclusion: Women with morbid obesity (BMI ≥ 40 kg/m2) had significantly higher levels of serum leptin (p < 0.01) and a value of 40 ng/ml of this hormone seems to be predictive of developing preeclampsia in this group of patients.

Relationship between Gravidity and Severity of Emesis Gravidarum in Trimester I Pregnant Women at PMB Fatimatu Zahrok Midwifery Care, Kediri, East Java

2020 ◽  
Author(s):  
Rahma Kusuma Dewi ◽  
◽  
Halimatus Saidah ◽  
Keyword(s):  
Pregnant Women ◽  
First Trimester ◽  
Cross Sectional Study ◽  
Nausea And Vomiting ◽  
Chi Square ◽  
Cross Sectional ◽  
Midwifery Care ◽  
First Trimester Pregnancy ◽  
First Trimester Of Pregnancy ◽  
The Relationship

ABSTRACT Background: Emesis gravidarum or nausea and vomiting has commonly occurred during pregnancy. However, excessive nausea and vomiting in early pregnancy have a potentially adverse effect on pregnancy outcomes. This study aimed to investigate the relationship between gravidity and severity of emesis gravidarum in women with first-trimester of pregnancy at PMB Fatimatu Zahrok Midwifery Care, Kediri, East Java. Subjects and Method: This was a cross-sectional study conducted at PMB Fatimatu Zahrok Midwifery Care, Kediri, East Java, from July to August 2020. A sample of 32 women with first-trimester of pregnancy was selected for this study. The dependent variable was severity of emesis gravidarum categorized into mild to moderate and severe. The independent variable was the number of gravidities categorized into primigravida and multigravida. The data were collected using questionnaire. The data were analyzed by chi-square. Results: Multigravida reduced the severity of emesis gravidarum (OR= 0.14; 95% CI= 0.02 to 0.85; p= 0.034). Conclusion: Multigravida reduces the severity of emesis gravidarum in women with first-trimester pregnancy. Keywords: emesis gravidarum, first trimester, gravidity, severity, pregnant women Correspondence: Rahma Kusuma Dewi. Faculty of Health Sciences, Universitas Kadiri. Jl. Selomangleng No 1, Kediri, East Java. Email: [email protected]. Mobile: +6281229440101. DOI: https://doi.org/10.26911/the7thicph.03.77

Correlations Between the Values of Maternal Glycemia from the Last Trimester of Pregnancy and Fetal Birth Weight

2013 ◽  
Vol 20 (3) ◽  
pp. 259-265
Author(s):  
Monica Vereş ◽  
Aurel Babeş ◽  
Szidonia Lacziko
Keyword(s):  
First Trimester ◽  
Mean Value ◽  
Fetal Macrosomia ◽  
Entire Group ◽  
Third Trimester ◽  
The Third ◽  
Group I ◽  
Fetal Birth Weight ◽  
First Trimester Of Pregnancy ◽  
The Mean

Abstract Background and aims: Gestational diabetes represents a form of diabetes diagnosed during pregnancy that is not clearly overt diabetes. In the last trimester of gestation the growth of fetoplacental unit takes place, thus maternal hyperglycemia will determine an increased transplacental passage, hyperinsulinemia and fetal macrosomia. The aim of our study was that o analyzing the effect of maternal glycemia from the last trimester of pregnancy over fetal weight. Material and method: We run an observational study on a group of 46 pregnant women taken into evidence from the first trimester of pregnancy, separated in two groups according to blood glucose determined in the third trimester (before birth): group I normoglycemic and group II with hyperglycemia (>92mg/dl). Results: The mean value of third trimester glycemia for the entire group was of 87.13±22.03. The mean value of the glycemia determined in the third trimester of pregnancy was higher in the second group (109.17 mg/dl) in comparison to the first group (74.,21 mg/dl). The ROC curve for third trimester glycemia as fetal macrosomia appreciation test has an AUC of 0.517. Conclusions: Glycemia determined in the last trimester of pregnancy cannot be used alone as the predictive factor for fetal macrosomia.

scholarly journals Hair cortisol levels in pregnancy as a possible determinant of fetal sex: a longitudinal study

2021 ◽  
pp. 1-6
Author(s):  
Borja Romero-Gonzalez ◽  
Jose A. Puertas-Gonzalez ◽  
Raquel Gonzalez-Perez ◽  
Marta Davila ◽  
Maria Isabel Peralta-Ramirez
Keyword(s):  
Low Birthweight ◽  
First Trimester ◽  
Hair Cortisol ◽  
Negative Results ◽  
Stress Vulnerability ◽  
Biological Stress ◽  
First Trimester Of Pregnancy ◽  
Prenatal Distress ◽  
Cortisol Levels ◽  
The Relationship

Abstract Stress during pregnancy has been widely studied and associated to different variables, usually with negative results for the health of the mother and the newborn, such as having a higher risk of suffering postpartum depression, premature birth, obstetrics complications or low birthweight, among others. However, there are not many lines of research that study the role that the sex of the baby plays on this specific stress and vice versa. Thus, the main objective was to analyse the relationship between the sex of the offspring and the stress of the mothers in the first trimester of pregnancy. In order to achieve this, 108 women had their biological stress measured (trough hair cortisol levels) and psychological stress evaluated (the Prenatal Distress Questionnaire (PSS), the Perceived Stress Scale (PDQ) and the Stress Vulnerability Inventory (IVE)). The results revealed significant differences in maternal hair cortisol levels in the first trimester based on the sex of the baby they had given birth to (t = −2.04; P < 0.05): the concentration of the hormone was higher if the baby was a girl (164.36:54.45-284.87 pg/mg) than if it was a boy (101.13:37.95-193.56 pg/mg). These findings show that the sex of the future baby could be conditioned, among many other variables, by the mother´s stress levels during conception and first weeks of pregnancy. Further research is needed in this area to support our findings.

scholarly journals Excessive daytime sleepiness in the elderly: association with cardiovascular risk, obesity and depression

2013 ◽  
Vol 16 (4) ◽  
pp. 872-879 ◽  
Author(s):  
Johnnatas Mikael Lopes ◽  
Fábio Galvão Dantas ◽  
Jovany Luis Alves de Medeiros
Keyword(s):  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
The Elderly ◽  
Cardiovascular Dysfunction ◽  
Chi Square ◽  
Chi Square Test ◽  
The Relationship ◽  
Health Districts

OBJECTIVE: To observe the relationship between Excessive Daytime Sleepiness (EDS) and the presence of risk factors for cardiovascular dysfunction, depression and obesity in the elderly. METHODS: We interviewed 168 elderly from the community of Campina Grande, Paraíba. They were selected according to health districts in the period of 2010. We used the Epworth Sleepiness Scale to diagnose excessive daytime sleepiness (> 10 points); waist circumference for the risk of cardiovascular dysfunction (> 94 or > 80 cm); Geriatric Depression Scale for depression (>10 points) and body mass index for obesity (> 25 kg/m2). Association analysis was performed by the Chi-square test adjusted for sex and age group, adopting α < 0.05. RESULTS: One hundred and sixty eight elderly individuals with mean age of 72.34 ± 7.8 years old participated in this study, being 122 (72.6%) women. EDS was identified in 53 (31.5%) of them; depression, in 72 (42.9%); overweight/obesity, in 95 (64.46%); and risk of cardiovascular dysfunction, in 129 (79.6%). Depressed men (78.6%, p = 0.0005) and risk of cardiovascular dysfunction (57.1%, p = 0.02) were more prone to EDS. In women, only obesity was related to sleepiness (42.1%, p = 0.01). Only those aged between 70 - 79 years old showed association between sleepiness and obesity. CONCLUSION: It was found that obesity for women, and depression and cardiovascular dysfunction risking for men were associated with EDS in the elderly. The variable sex is a confusion condition for the association with sleepiness.

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