Intra-observer and inter-observer repeatability of ocular surface interferometer in measuring lipid layer thickness

Purpose: To compare the lipid layer thickness (LLT), meibomian gland (MG) dropouts, and blinking pattern determined by the analysis of images acquired from the LipiView® II (LVII) and the IDRA® Ocular surface analyzer. Methods: A cross-sectional single-visit observational study was conducted. The LLT (minimum, maximum, and average), percentages of MG dropouts, and partial blink rates (PBR) were taken from both eyes of 47 participants using LVII and IDRA. Both devices were used to image the inferior eyelid of each participant in a random order. Results: Forty-seven participants (mean age 56.77 ± 14.47 (21–79) years, 66% female) completed the study. There was no significant difference in LLT between the two devices. A significant difference in percentages of MG dropouts was obtained between the LVII (36.51 ± 17.53) and the IDRA (45.36 ± 21.87), p = 0.003). There was also a significant difference in PBR between the LVII (0.51 ± 0.37) and the IDRA (0.23 ± 0.27), p < 0.001). Conclusion: No significant difference in LLT was obtained between LVII and IDRA. IDRA had a significantly lesser percentage of MG dropout and a higher PBR compared to LVII. These results indicate that these devices should not be used interchangeably for the evaluation of MG dropouts and PBR.

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Correlation Analysis of Tear Film Lipid Layer Thickness and Ocular Surface Disease Index

Journal of the Korean Ophthalmological Society ◽

10.3341/jkos.2017.58.7.788 ◽

2017 ◽

Vol 58 (7) ◽

pp. 788 ◽

Cited By ~ 3

Author(s):

Rae Young Kim ◽

Kyung Sun Na ◽

Yu Li Park ◽

Hyun Seung Kim

Keyword(s):

Correlation Analysis ◽

Layer Thickness ◽

Ocular Surface ◽

Tear Film ◽

Disease Index ◽

Ocular Surface Disease ◽

Lipid Layer ◽

Ocular Surface Disease Index

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Correlation of the retinopathy degree with the change of ocular surface and corneal nerve in patients with type 2 diabetes mellitus

International Journal of Ophthalmology ◽

10.18240/ijo.2021.05.17 ◽

2021 ◽

Vol 14 (5) ◽

pp. 750-758

Author(s):

Jia-Xin Han ◽

◽

Huan-Huan Liang ◽

Jian-Xin Guo ◽

◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Nerve Fiber ◽

Layer Thickness ◽

Ocular Surface ◽

Lipid Layer ◽

Corneal Nerve

AIM: To investigate the change of ocular surface and corneal nerve and their correlation in patients suffering from type 2 diabetes mellitus under different degrees of retinopathy. METHODS: Totally 129 type 2 diabetes mellitus patients (257 eyes) were included. They were divided into three groups: no diabetic retinopathy (NDR) group (33 cases, 66 eyes), non-proliferative diabetic retinopathy (NPDR) group (32 cases, 64 eyes), and proliferative diabetic retinopathy (PDR) group (34 cases, 67 eyes). Healthy normal individuals were enrolled as controls (30 cases, 60 eyes). Ocular Surface Disease Index (OSDI) questionnaire was completed by all subjects, and dry eye analyzer was applied to examine tear meniscus height (TMH), first tear break-up time (FTBUT), average tear break-up time (ATBUT), tear film lipid layer thickness classification, and meibomian gland loss (MGL) score. Corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), corneal nerve fiber length (CNFL), and corneal nerve fiber tortuosity (CNFT) were examined by in vivo confocal microscopy (IVCM). The differences and correlation among these parameters were analyzed. RESULTS: Total OSDI score, TMH, FTBUT, ATBUT, tear film lipid layer thickness, MGL score, CNFD, CNBD, CNFL, and CNFT were statistically different among the four groups (P<0.05). In NDR group, CNFL was positively correlated with TMH (r=0.493, both P<0.01) and ATBUT (r=0.437, P<0.05). CNFL in NPDR group was positively correlated with TMH (r=0.642, P<0.01) and ATBUT (r=0.6, P<0.01). CNFL in PDR group was positively correlated with TMH (r=0.364, P<0.05) and ATBUT (r=0.589, P<0.01), with low negative correlation with MGL score (r=-0.331, P<0.05). CONCLUSION: With the progression of diabetic retinopathy, TMH, BUT, lipid layer thickness, CNFL, CNFD, and CNBD gradually decreased, while total OSDI score, MGL score, and CNFT increased. CNFL is correlated with TMH and ATBUT in diabetic patients.

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Evaluation of Tear Film Lipid Layer Thickness Measurements Obtained Using an Ocular Surface Interferometer in Nasolacrimal Duct Obstruction Patients

Korean Journal of Ophthalmology ◽

10.3341/kjo.2018.0012 ◽

2018 ◽

Vol 32 (6) ◽

pp. 445 ◽

Cited By ~ 3

Author(s):

Sang Min Lee ◽

Sok Joong Chung ◽

Helen Lew

Keyword(s):

Layer Thickness ◽

Ocular Surface ◽

Tear Film ◽

Nasolacrimal Duct ◽

Nasolacrimal Duct Obstruction ◽

Lipid Layer ◽

Duct Obstruction ◽

Thickness Measurements

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A preliminary investigation into the relationship between ocular surface temperature and lipid layer thickness

Contact Lens and Anterior Eye ◽

10.1016/j.clae.2009.06.004 ◽

2009 ◽

Vol 32 (4) ◽

pp. 177-180 ◽

Cited By ~ 10

Author(s):

Maria Jesus Giraldez ◽

Shehzad A. Naroo ◽

Carlos Garcia Resua

Keyword(s):

Surface Temperature ◽

Layer Thickness ◽

Ocular Surface ◽

Preliminary Investigation ◽

Lipid Layer ◽

The Relationship

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Evaluation of Changes in Tear Film Lipid Layer Thickness Using Ocular Surface Interferometer after Artificial Tear Application

Journal of the Korean Ophthalmological Society ◽

10.3341/jkos.2016.57.12.1857 ◽

2016 ◽

Vol 57 (12) ◽

pp. 1857

Author(s):

Seo Hee Kim ◽

Si Yoon Park ◽

Yong Woo Ji ◽

Kyoung Yul Seo ◽

Eung Kweon Kim ◽

...

Keyword(s):

Layer Thickness ◽

Ocular Surface ◽

Tear Film ◽

Lipid Layer ◽

Artificial Tear

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Effect of Transcutaneous Upper Eyelid Blepharoplasty on Blink Parameters and Lipid Layer Thickness

Frontiers in Medicine ◽

10.3389/fmed.2021.732041 ◽

2021 ◽

Vol 8 ◽

Author(s):

Siyi Zhang ◽

Yan Yan ◽

Yang Lu ◽

Yixiong Zhou ◽

Yao Fu

Keyword(s):

Layer Thickness ◽

Postoperative Period ◽

Ocular Surface ◽

Early Postoperative Period ◽

Palpebral Fissure ◽

Blink Rate ◽

Lipid Layer ◽

Ocular Surface Disease Index ◽

Upper Eyelid ◽

Surface Parameters

Purpose: This study aimed to investigate the effect of transcutaneous upper eyelid blepharoplasty on lipid layer thickness (LLT) and blink parameters in young women during the early postoperative period.Methods: This prospective study included 110 eyes of 55 young female patients (age range, 19–31 years) who underwent transcutaneous upper eyelid blepharoplasty. The LLT and blink parameters measured using a LipiView interferometer were recorded before the surgery and 1 week and 1 month after the surgery. Ocular Surface Disease Index (OSDI) score, noninvasive tear film breakup time (NITBUT), and palpebral fissure height (PFH) measurements were also performed at each time point.Results: The number of blinks significantly decreased (P < 0.001), and the number of partial blinks and partial blink rate (PBR) significantly increased 1 week after the surgery (P = 0.002 and P < 0.001); they all returned to baseline in 1 month. The LLT and OSDI score increased significantly 1 week and 1 month after the surgery (P < 0.001 and P < 0.001). A significant increase in the NITBUT and a significant decrease in the PFH were observed 1 week after the surgery (P < 0.001 and P < 0.001), and the values returned to baseline 1 month after the surgery. No clinical correlation was found between blink parameters and ocular surface parameters.Conclusions: Transcutaneous upper eyelid blepharoplasty led to a change in blink parameters and ocular surface parameters during the early postoperative period. However, this influence was temporary, and the transitory change in blink parameters had no effects on the ocular surface environment.

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