Prevalence and risk factors for vitamin D insufficiency and deficiency at birth and associated outcome

AbstractObjectiveWe quantified the prevalence of vitamin D status in 6–24-month-old underweight and normal-weight children and identified the socio-economic and dietary predictors for status.DesignCross-sectional, baseline data from a nutritional intervention study were analysed. Multinomial logistic regression was used to estimate the odds of being vitamin D deficient or insufficient with the reference being vitamin D sufficient.SettingUrban slum area of Mirpur field site, Dhaka, Bangladesh.SubjectsUnderweight (weight-for-age Z-score <−2·00) and normal-weight (weight-for-age Z-score ≥−1·00) children aged 6–24 months.ResultsAmong 468 underweight children, 23·1 % were sufficient, 42·3 % insufficient, 31·2 % deficient and 3·4 % severely vitamin D deficient. Among 445 normal-weight children, 14·8 % were sufficient, 39·6 % insufficient and 40·0 % deficient and 5·6 % severely deficient. With adjusted multinominal regression analysis, risk factors (OR (95 % CI)) for vitamin D deficiency in underweight children were: older age group (18–24 months old; 2·9 (1·5–5·7)); measurement of vitamin D status during winter (3·0 (1·4–6·4)) and spring (6·9 (3·0–16·1)); and maternal education (≥6 years of institutional education; 2·2 (1·0–4·9)). In normal-weight children, older age group (3·6 (1·2–10·6)) and living in the richest quintile (3·7 (1·1–12·5)) were found to be significantly associated with vitamin D insufficiency.ConclusionsThe study demonstrates a significant burden of vitamin D insufficiency and deficiency in both underweight and normal-weight children <2 years of age from an urban slum of Bangladesh. Identification of risk factors may help in mitigating the important burden in such children.

Download Full-text

Vitamin D insufficiency and risk of paclitaxel-induced peripheral neuropathy.

Journal of Clinical Oncology ◽

10.1200/jco.2019.37.15_suppl.e12027 ◽

2019 ◽

Vol 37 (15_suppl) ◽

pp. e12027-e12027

Author(s):

Theodore Salvatore Jennaro ◽

Ellen M. Lavoie Smith ◽

Kiran Vangipuram ◽

Kelley M. Kidwell ◽

Monika Leigh Burness ◽

...

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Vitamin D ◽

Metastatic Breast Cancer ◽

Peripheral Neuropathy ◽

Assessment Tool ◽

Metastatic Breast ◽

Vitamin D Insufficiency ◽

Primary Analysis ◽

Patient Reported

e12027 Background: Peripheral neuropathy (PN) is a severe, dose-limiting toxicity of paclitaxel that occurs in up to 25% of patients and can lead to permanent loss of balance and manual dexterity. Due to the lack of effective strategies for PN prevention or treatment, there is a critical need to identify predictive risk factors for paclitaxel-induced PN. Vitamin insufficiencies are known risk factors for PN in other disease states. However, the effect of vitamin insufficiency on paclitaxel-induced PN has not been adequately investigated. Methods: Baseline levels of vitamin D and other nutrients (vitamin B, homocysteine, folate) were measured, and PN was assessed weekly in an observational trial of patients receiving paclitaxel 80 mg/m2 for 12 weeks for non-metastatic breast cancer (NCT0233811). Nutrient levels were measured by Michigan Medicine and insufficiency defined by institutional standards (vitamin D insufficiency < 20 ng/mL). In the primary analysis, the maximum increase from baseline in the 8-item sensory subscale (ΔCIPN8) of the EORTC CIPN20, a validated patient-reported PN assessment tool, was compared in nutrient insufficient and sufficient patients. The effect of vitamin insufficiencies on PN-induced treatment disruptions (dose decrease, delay, or discontinuation) was conducted as a secondary analysis. Results: Only vitamin D insufficiency was identified in enough patients for analysis (15/37 = 41%). Vitamin D insufficient patients reported a greater mean (+/- SD) ΔCIPN8 (36.39 ±22.8) than vitamin D sufficient patients (16.29 ±16.3) (p = 0.003). However, the increase in treatment disruption for vitamin D insufficient patients was not significant (OR = 2.98, 95% CI [0.72, 12.34], p = 0.16). Conclusions: Paclitaxel-treated patients who were vitamin D insufficient at baseline had greater increases in patient-reported PN. If validated in larger studies, vitamin D insufficiency may be a clinically translatable, modifiable risk factor that can be used to prevent paclitaxel-induced PN in patients with non-metastatic breast cancer.

Download Full-text

Vitamin D is associated with the hypertriglyceridemic waist phenotype in Brazilian children

Journal of Public Health ◽

10.1093/pubmed/fdaa041 ◽

2020 ◽

Author(s):

Luana Cupertino Milagres ◽

Mariana De Santis Filgueiras ◽

Naruna Pereira Rocha ◽

Leidjaira Lopes Juvanhol ◽

Sylvia do Carmo Castro Franceschini ◽

...

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Cardiometabolic Risk ◽

Public Health Problem ◽

Vitamin D Insufficiency ◽

Cardiometabolic Risk Factors ◽

Cardiometabolic Health ◽

Biochemical Tests ◽

Hypertriglyceridemic Waist ◽

Hypertriglyceridemic Waist Phenotype

Abstract Background Prevalence of cardiometabolic risk factors is increasing and vitamin D insufficiency/deficiency has become a worldwide public health problem, even in tropical countries. Therefore, we identified the prevalence of hypertriglyceridemic waist phenotype (HWP) and evaluate its relationship with vitamin D insufficiency/deficiency. Methods A cross-sectional study with 378 children aged 8 and 9 enrolled in all urban schools in the city of Viçosa, MG, Brazil. Anthropometric measurements, body composition (dual energy X-ray absorptiometry), biochemical tests and clinical evaluation were performed. Poisson regression was used to analyze the association between vitamin D and HWP. Results Prevalence of HWP was 16.4%. This prevalence was higher among children with vitamin D insufficiency and deficiency and in those with a greater number of other cardiometabolic risk factors. Multiple regression analysis showed that children with vitamin D insufficiency and deficiency had, respectively, prevalence 85% (95% CI: 1.03–3.30) and 121% (95% CI: 1.11–4.45) higher of HWP than the vitamin D sufficiency group. Conclusion Vitamin D insuffiency and deficiency were associated with a higher prevalence of HWP among children, regardless of the presence of other cardiometabolic risk factors, indicating an additional risk of inadequate vitamin D status to cardiometabolic health in childhood.

Download Full-text

Vitamin D insufficiency prior to bariatric surgery: risk factors and a pilot treatment study

Clinical Endocrinology ◽

10.1111/j.1365-2265.2008.03470.x ◽

2009 ◽

Vol 71 (2) ◽

pp. 176-183 ◽

Cited By ~ 67

Author(s):

E. M. Stein ◽

G. Strain ◽

N. Sinha ◽

D. Ortiz ◽

A. Pomp ◽

...

Keyword(s):

Risk Factors ◽

Bariatric Surgery ◽

Vitamin D ◽

Vitamin D Insufficiency

Download Full-text

A Clinical Analysis of Vitamin D Status in Patients Before Spinal Surgery

International Surgery ◽

10.9738/intsurg-d-16-00102.1 ◽

2016 ◽

Vol 101 (7-8) ◽

pp. 367-374

Author(s):

Qingqing Li ◽

Jianwei Zhang ◽

Jian Chen ◽

Jin Fan ◽

Tao Jiang ◽

...

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Spinal Surgery ◽

Smoking Habit ◽

High Body Mass Index ◽

Clinical Analysis ◽

Vitamin D Insufficiency ◽

Vitamin D Status ◽

Factors Associated

The goal of this paper was to study preoperative concentrations of vitamin D in patients undergoing spinal surgery and analyze relevant risk factors associated with vitamin D deficiency. Vitamin D plays an important role in maintaining normal functions of skeletal muscles, and vitamin D insufficiency or deficiency may affect outcomes of spinal surgery patients. A retrospective analysis was conducted on 503 patients undergoing spinal surgery in the First Affiliated Hospital with Nanjing Medical University from September 2012 to October 2013. Preoperative concentrations of serum 25-hydroxyvitamin D [25(OH)D] were measured. Normal vitamin D was defined as a serum 25(OH)D level ≥ 32 ng/mL, vitamin D insufficiency as ≥20 and <32 ng/mL, and vitamin D deficiency as <20 ng/mL. Relevant risk factors associated with vitamin D insufficiency and deficiency were analyzed. In 503 spinal surgery patients, rate of vitamin D deficiency and insufficiency was 71.4% and 23.9%. Rate of vitamin D deficiency in female patients was significantly higher than that in male (P < 0.001). Rate of vitamin D deficiency in patients with high body mass index (P = 0.009) or patients with smoking habit (P < 0.001) was much higher than other patients. Multivariate analysis demonstrated that female (P < 0.001), smoking (P = 0.005), and winter (P = 0.001) were potential risk factors for vitamin D deficiency. Screening preoperative vitamin D status and relevant treatment should be reinforced in spine surgery patients.

Download Full-text

Prevalence and Risk Factors for Vitamin D Insufficiency Among Children With Epilepsy

Pediatric Neurology ◽

10.1016/j.pediatrneurol.2010.03.004 ◽

2010 ◽

Vol 42 (6) ◽

pp. 422-426 ◽

Cited By ~ 33

Author(s):

Renée A. Shellhaas ◽

Amanda K. Barks ◽

Sucheta M. Joshi

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Vitamin D Insufficiency

Download Full-text

Prevalence and Risk Factors of Hypovitaminosis D in Nigerian Children with Sickle Cell Anaemia

Annals of Health Research ◽

10.30442/ahr.0604-06-104 ◽

2020 ◽

Vol 6 (4) ◽

pp. 410-420

Author(s):

MO Adekunle ◽

OF Njokanma ◽

AU Solarin ◽

AO Dada ◽

BA Animasahun ◽

...

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Sickle Cell ◽

Sickle Cell Anaemia ◽

Age Groups ◽

Hypovitaminosis D ◽

Vitamin D Insufficiency ◽

Bone Diseases ◽

Number Of Children

Background: Vitamin D deficiency (VDD) has been linked to some acute and chronic bone disorders that commonly complicate sickle cell anaemia (SCA) in children. Some of these bone diseases include chronic pain, reduced bone density and fractures. Despite Nigeria having the highest number of children with SCA in the world, there is a paucity of data on vitamin D status and the associated risk factors in affected children. Objective: To determine the prevalence and risk factors for hypovitaminosis D in children with sickle cell anaemia in steady-state. Methods: A total of 174 children with sickle cell anaemia aged one to eighteen years were recruited at the Sickle Cell Foundation Centre, Lagos. Baseline sociodemographic, clinical, anthropometric and laboratory parameters (serum 25-hydroxyvitamin D, corrected serum calcium and alkaline phosphatase) were recorded. Results: The prevalence of vitamin D insufficiency and deficiency were 12.6 % and 72.5% respectively. Children below six years of age were less likely to have hypovitaminosis D compared to the older age groups (p = 0.017). The mean serum corrected calcium was lowest in subjects with vitamin D deficiency (p >0.001). Age and hypocalcaemia are independent predictors of hypovitaminosis D. Conclusion: There is a high prevalence of vitamin D deficiency among children with sickle cell anaemia. Children aged below six years and with those with hypocalcaemia had higher odds of hypovitaminosis D.

Download Full-text

Vitamin D Intake and Other Risk Factors for Vitamin D Insufficiency in Middle Eastern People Living in the UK: A Comparison of Cultural and Ethnic Groups

Ecology of Food and Nutrition ◽

10.1080/03670244.2012.706105 ◽

2013 ◽

Vol 52 (3) ◽

pp. 191-202 ◽

Cited By ~ 2

Author(s):

Wassan A. Ahmed ◽

Waleed Al-Murrani ◽

Victor Kuri ◽

Gail A. Rees

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Ethnic Groups ◽

Middle Eastern ◽

Vitamin D Insufficiency ◽

Vitamin D Intake ◽

The Uk

Download Full-text

Risk assessment for severe hypocalcemia requiring hospitalization with denosumab.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.6_suppl.115 ◽

2013 ◽

Vol 31 (6_suppl) ◽

pp. 115-115 ◽

Cited By ~ 1

Author(s):

Karen A. Autio ◽

Azeez Farooki ◽

Ilya Glezerman ◽

Amelia Chan ◽

Hallie C. Barr ◽

...

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Calcium Absorption ◽

Advanced Disease ◽

Vitamin D Insufficiency ◽

Castration Resistant Prostate Cancer ◽

Exact Test ◽

Symptomatic Hypocalcemia ◽

Potential Risk Factors ◽

Clinical Risks

115 Background: Skeletal-related events (SRE) pose clinical risks to patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) that can be mitigated with denosumab. Hypocalcemia is a side effect, however risk factors are not well described. Methods: An IRB waiver was obtained to review medical records for all mCRPC pts receiving denosumab at MSKCC between March-August 2011 for baseline labs, calcium (ca) and vitamin D nadirs, details of hospitalizations, concurrent therapies, and comorbidities. Comparisons between groups were made using Fisher’s exact test and the Wilcox rank sum test. Results: Nine of sixty pts (15%) treated with 1-2 doses of denosumab developed severe symptomatic hypocalcemia (median nadir 6.5 mg/dL) requiring hospitalization for intravenous (IV) ca replacement. Ca/Vitamin D was recommended to all pts. Ca recovered in 17 days in those who did return to baseline levels (n=5). However, four of nine (44%) pts required repeated hospitalizations for IV ca, never recovered to baseline ca levels, and died of advanced disease within 3 months. Median vitamin D 25-OH was 22.5 ng/ml for hospitalized pts, and PTH was 198 pg/ml at ca nadir. Conclusions: Denosumab was associated with severe hypocalcemia sufficient to require hospitalizations for IV ca replacement in 15% of pts with mCRPC. PSA, Ca, Alk Phos, and current chemotherapy were associated with severe hypocalcemia requiring hospitalization for IV ca. Clinicians are cautioned regarding potential risk factors including advanced disease, vitamin D insufficiency, and possibly comorbidities affecting calcium absorption. [Table: see text]

Download Full-text

Prevalence and Predictors of Vitamin D Deficiency and Insufficiency among Pregnant Rural Women in Bangladesh

Nutrients ◽

10.3390/nu13020449 ◽

2021 ◽

Vol 13 (2) ◽

pp. 449

Author(s):

Faruk Ahmed ◽

Hossein Khosravi-Boroujeni ◽

Moududur Rahman Khan ◽

Anjan Kumar Roy ◽

Rubhana Raqib

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Gestational Age ◽

First Trimester ◽

Vitamin D Insufficiency ◽

Vitamin D Status ◽

Vitamin A Status ◽

Associated Risk Factors

Although adequate vitamin D status during pregnancy is essential for maternal health and to prevent adverse pregnancy outcomes, limited data exist on vitamin D status and associated risk factors in pregnant rural Bangladeshi women. This study determined the prevalence of vitamin D deficiency and insufficiency, and identified associated risk factors, among these women. A total of 515 pregnant women from rural Bangladesh, gestational age ≤ 20 weeks, participated in this cross-sectional study. A separate logistic regression analysis was applied to determine the risk factors of vitamin D deficiency and insufficiency. Overall, 17.3% of the pregnant women had vitamin D deficiency [serum 25(OH)D concentration <30.0 nmol/L], and 47.2% had vitamin D insufficiency [serum 25(OH)D concentration between 30–<50 nmol/L]. The risk of vitamin D insufficiency was significantly higher among nulliparous pregnant women (OR: 2.72; 95% CI: 1.75–4.23), those in their first trimester (OR: 2.68; 95% CI: 1.39–5.19), anaemic women (OR: 1.53; 95% CI: 0.99–2.35; p = 0.056) and women whose husbands are farmers (OR: 2.06; 95% CI: 1.22–3.50). The risk of vitamin deficiency was significantly higher among younger pregnant women (<25 years; OR: 2.12; 95% CI: 1.06–4.21), nulliparous women (OR: 2.65; 95% CI: 1.34–5.25), women in their first trimester (OR: 2.55; 95% CI: 1.12–5.79) and those with sub-optimal vitamin A status (OR: 2.30; 95% CI: 1.28–4.11). In conclusion, hypovitaminosis D is highly prevalent among pregnant rural Bangladeshi women. Parity and gestational age are the common risk factors of vitamin D deficiency and insufficiency. A husband’s occupation and anaemia status might be important predictors of vitamin D insufficiency, while younger age and sub-optimal vitamin A status are risk factors for vitamin D deficiency in this population.

Download Full-text