Temporal trends of geographic variation in mortality following cancer diagnosis: a population-based study

ObjectiveAfter a decade of increase, the preterm birth (PTB) rate has declined in the USA since 2006, with the largest decline at late preterm (34–36 weeks). We described concomitant changes in gestational age-specific rates of neonatal mortality and morbidity following spontaneous and clinician-initiated PTB among singleton infants.Design, setting and participantsThis retrospective population-based study included 754 763 singleton births in Washington State, USA, 2004–2013, using data from birth certificates and hospitalisation records. PTB subtypes included preterm premature rupture of membranes (PPROM), spontaneous onset of labour and clinician-initiated delivery.Outcome measuresThe primary outcomes were neonatal mortality and a composite outcome including death or severe neonatal morbidity. Temporal trends in the outcomes and individual morbidities were assessed by PTB subtype. Logistic regression yielded adjusted odds ratios (AOR) per 1 year change in outcome and 95% CI.ResultsThe rate of PTB following PPROM and spontaneous labour declined, while clinician-initiated PTB increased (all p<0.01). Overall neonatal mortality remained unchanged (1.3%; AOR 0.99, CI 0.95 to 1.02), though gestational age-specific mortality following clinician-initiated PTB declined at 32–33 weeks (AOR 0.85, CI 0.74 to 0.97) and increased at 34–36 weeks (AOR 1.10, CI 1.01 to 1.20). The overall rate of the composite outcome increased (from 7.9% to 11.9%; AOR 1.06, CI 1.05 to 1.08). Among late preterm infants, combined mortality or severe morbidity increased following PPROM (AOR 1.13, CI 1.08 to 1.18), spontaneous labour (AOR 1.09, CI 1.06 to 1.13) and clinician-initiated delivery (AOR 1.10, CI 1.07 to 1.13). Neonatal sepsis rates increased among all preterm infants (AOR 1.09, CI 1.08 to 1.11).ConclusionsTiming of obstetric interventions is associated with infant health outcomes at preterm. The temporal decline in late PTB among singleton infants was associated with increased mortality among late preterm infants born following clinician-initiated delivery and increased combined mortality or severe morbidity among all late preterm infants, mainly due to increased rate of sepsis.

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Temporal Trends of Hypovitaminosis D: A Population-Based Study of Cases Under 19 Years of Age

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2019.12.723 ◽

2020 ◽

Vol 145 (2) ◽

pp. AB63

Author(s):

Alyssa Kerber ◽

Anna Kellund ◽

Amy Weaver ◽

Rachel Carlson ◽

Seema Kumar ◽

...

Keyword(s):

Temporal Trends ◽

Hypovitaminosis D ◽

Population Based ◽

Population Based Study

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Temporal trends of pancreatic ductal adenocarcinoma in young adults in the United States: A Population-Based Study

Clinics and Research in Hepatology and Gastroenterology ◽

10.1016/j.clinre.2019.07.001 ◽

2020 ◽

Vol 44 (2) ◽

pp. 204-210

Author(s):

Mohamed M. Gad ◽

Anas M. Saad ◽

Muneer J. Al-Husseini ◽

Youssef M. Abdel-Gawad ◽

Obai M. Alsalhani ◽

...

Keyword(s):

United States ◽

Young Adults ◽

Pancreatic Ductal Adenocarcinoma ◽

Temporal Trends ◽

The United States ◽

Population Based ◽

Ductal Adenocarcinoma ◽

Population Based Study

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A population-based study on temporal trends of five-year survival of patients with colon cancer by age group and gender in Bulgaria

European Journal of Cancer ◽

10.1016/s0959-8049(17)30640-8 ◽

2017 ◽

Vol 72 ◽

pp. S173-S174

Author(s):

D. Tashkova

Keyword(s):

Colon Cancer ◽

Temporal Trends ◽

Population Based ◽

Age Group ◽

Population Based Study ◽

And Gender

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Trends in vertebral augmentation for spinal fractures in myeloma patients: a 2002–2012 population-based study using a large national cancer registry

Journal of NeuroInterventional Surgery ◽

10.1136/neurintsurg-2017-013011 ◽

2017 ◽

Vol 10 (2) ◽

pp. 183-190 ◽

Cited By ~ 1

Author(s):

Falgun H Chokshi ◽

David H Howard ◽

Jeffrey G Jarvik ◽

Richard Duszak

Keyword(s):

Temporal Trends ◽

Spinal Fractures ◽

Sociodemographic Factors ◽

Spinal Fracture ◽

Population Based ◽

Vertebral Augmentation ◽

Population Based Study ◽

Black Patients ◽

The Impact ◽

Osteoporotic Spinal Fractures

PurposeTo evaluate temporal trends and factors associated with vertebral augmentation use in myeloma patients with spinal fractures from 2002 to 2012.MethodsThis retrospective cohort study used the Surveillance, Epidemiology and End Results (SEER)-Medicare claims database for 2002 through 2012. We included patients age ≥66 years with myeloma and spinal fractures. First, we evaluated receipt of vertebral augmentation. Second, multivariate logistic regression was used to assess the impact of sociodemographic factors, treatment facility type, and underlying comorbidities on the odds of undergoing vertebral augmentation.ResultsOf 4725 myeloma patients with spinal fractures, 653 underwent vertebral augmentation. Procedures increased initially from <1.7% in 2002 to 21.0% (109/520) in 2007, 18.6% (81/435) in 2008, 21.4% (109/509) in 2009, and 17.5% (76/435) in 2011. Patients with a spinal fracture before myeloma diagnosis were twice as likely to undergo vertebral augmentation as patients with fracture after myeloma diagnosis (OR 2.06, 95% CI 1.55 to 2.75). Black patients were half as likely to undergo vertebral augmentation as white patients (OR 0.48, 95% CI 0.34 to 0.68). Patients with 3–5 comorbidities (OR 0.78, 95% CI 0.64 to 0.96) and ≥6 comorbidities (OR 0.69, 95% CI 0.54 to 0.87) were less likely than patients with 0–2 comorbidities to undergo vertebral augmentation.ConclusionsVertebral augmentation for myeloma patients with spinal fractures peaked between 2007 and 2009 and then declined. Providers may have adopted vertebral augmentation in myeloma patients since its introduction, and potentially modified practice patterns following the publication of trials of vertebral augmentation in patients with osteoporotic spinal fractures.

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