scholarly journals Predictors associated with neurological recovery after anterior decompression with fusion for degenerative cervical myelopathy

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hiroyuki Inose ◽  
Takashi Hirai ◽  
Toshitaka Yoshii ◽  
Atsushi Kimura ◽  
Katsushi Takeshita ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Cervical Myelopathy ◽  
Recovery Rate ◽  
Regression Coefficient ◽  
Neurological Recovery ◽  
Stepwise Multiple Regression ◽  
Stepwise Multiple Regression Analysis ◽  
Anterior Decompression ◽  
Sf 36 ◽  
Degenerative Cervical Myelopathy

Abstract Background Anterior decompression with fusion (ADF) has often been performed for degenerative cervical myelopathy (DCM) in patients with poor cervical spine alignment and/or anterior cord compression. We aimed to identify clinical and radiological predictors associated with neurological recovery after ADF. Methods This post-hoc analysis from a prospective multicenter study included patients who were scheduled for ADF for DCM. The patients who received other surgeries (laminoplasty, posterior decompression and fusion) were excluded. The associations between baseline clinical and radiographic variables (age, sex, body mass index, etiology, cervical lordosis, range of motion, C7 slope, C2-7 sagittal vertical axis [SVA], thoracic kyphosis [TK], lumbar lordosis, sacral slope, SVA, pelvic tilt, T1 pelvic angle [TPA], the Japanese Orthopedic Association score for the assessment of cervical myelopathy [C-JOA], European Quality of Life Five Dimensions Scale [EQ-5D], Neck Disability Index [NDI], Physical Component Summary of the SF-36 [PCS], and Mental Component Summary of the SF-36) and the recovery rates as the outcome variables were investigated in the univariate regression analysis. Then, the independent predictors for increased recovery rates were evaluated using a stepwise multiple regression analysis. Results In total, 37 patients completed the 1 year follow-up. The recovery rate was significantly correlated with SVA (p = 0.001) and TPA (p = 0.03). Univariate regression analyses showed that age (Regression coefficient = − 0.92, p = 0.049), SVA (Regression coefficient  = − 0.57, p = 0.004) and PCS (Regression coefficient = 0.80, p = 0.03) score were significantly associated with recovery rate. Then, a stepwise multiple regression analysis identified the independent predictors of recovery rate after ADF as TK (p = 0.01), PCS (p = 0.03), and SVA (p = 0.03). According to this prediction model, the following equation was obtained: recovery rate = − 8.26 + 1.17 × (TK) − 0.45 × (SVA) + 0.85 × (PCS) (p = 0.002, R2 = 0.44). Conclusion Patients with lower TK, lower PCS score, and higher SVA were more likely to have poor neurological recovery after ADF. Therefore, patients with DCM and these predictors who undergo ADF should be warned about poor recovery and be required to provide adequate informed consent.

scholarly journals Predictors associated with neurological recovery after anterior decompression with fusion for degenerative cervical myelopathy

2021 ◽  
Author(s):  
Hiroyuki Inose ◽  
Takashi Hirai ◽  
Toshitaka Yoshii ◽  
Atsushi Kimura ◽  
Katsushi Takeshita ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Multiple Regression Analysis ◽  
Cervical Myelopathy ◽  
Recovery Rate ◽  
Neurological Recovery ◽  
Stepwise Multiple Regression ◽  
Stepwise Multiple Regression Analysis ◽  
Anterior Decompression ◽  
Sf 36 ◽  
Degenerative Cervical Myelopathy

Abstract Background: Anterior decompression with fusion (ADF) has often been performed for degenerative cervical myelopathy (DCM) in patients with poor cervical spine alignment and/or anterior cord compression. We aimed to identify clinical and radiological predictors associated with neurological recovery after ADF.Methods: This post-hoc analysis from a prospective multicenter study included patients who were scheduled for ADF for DCM. The patients who received other surgeries (laminoplasty, posterior decompression and fusion) were excluded. The associations between baseline clinical and radiographic variables (age, sex, body mass index, etiology, cervical lordosis, range of motion, C7 slope, C2-7 sagittal vertical axis [SVA], thoracic kyphosis [TK], lumbar lordosis, sacral slope, SVA, pelvic tilt, T1 pelvic angle [TPA], the Japanese Orthopedic Association score for the assessment of cervical myelopathy [C-JOA], European Quality of Life Five Dimensions Scale [EQ-5D], Neck Disability Index [NDI], Physical Component Summary of the SF-36 [PCS], and Mental Component Summary of the SF-36) and the recovery rates as the outcome variables were investigated in the univariate regression analysis. Then, the independent predictors for increased recovery rates were evaluated using a stepwise multiple regression analysis.Results: In total, 37 patients completed the 1-year follow-up. The recovery rate was significantly correlated with SVA (p = 0.001) and TPA (p = 0.03). Univariate regression analyses showed that age (r = -0.92, p = 0.049), SVA (r = -0.57, p = 0.004) and PCS (r = -0.80, p = 0.03) score were significantly associated with recovery rate. Then, a stepwise multiple regression analysis identified the independent predictors of recovery rate after ADF as TK (p = 0.01), PCS (p = 0.03), and SVA (p = 0.03). According to this prediction model, the following equation was obtained: recovery rate = –8.26 + 1.17 × (TK) – 0.45 × (SVA) + 0.85 × (PCS) (p = 0.002, R2 = 0.44).Conclusion: Patients with lower TK, lower PCS score, and higher SVA were more likely to have poor neurological recovery after ADF. Therefore, patients with DCM and these predictors who undergo ADF should be warned about poor recovery and be required to provide adequate informed consent.

scholarly journals Predictors associated with neurological recovery after anterior decompression with fusion for degenerative cervical myelopathy

2020 ◽  
Author(s):  
Hiroyuki Inose ◽  
Takashi Hirai ◽  
Toshitaka Yoshii ◽  
Atsushi Kimura ◽  
Katsushi Takeshita ◽  
...  
Keyword(s):  
Cervical Myelopathy ◽  
Recovery Rate ◽  
Neck Disability Index ◽  
Multiple Linear Regression Model ◽  
Vertical Axis ◽  
Neurological Recovery ◽  
Anterior Decompression ◽  
Sagittal Vertical Axis ◽  
Japanese Orthopedic Association ◽  
Degenerative Cervical Myelopathy

Abstract Background Anterior decompression with fusion (ADF) has often been performed for degenerative cervical myelopathy (DCM) in patients with poor cervical spine alignment and/or anterior cord compression. However, it is difficult to preoperatively predict the extent to which patients will experience postoperative neurological improvement. We aimed to identify predictors associated with neurological recovery after ADF in a retrospective study of prospectively collected data. Methods We prospectively enrolled patients who were scheduled for ADF for DCM. The associations of baseline variables with recovery rate were investigated using a multiple linear regression model. Results In total, 36 patients completed the 1-year follow-up. Regarding clinical outcomes, the Japanese Orthopedic Association score for the assessment of cervical myelopathy, European Quality of Life Five Dimensions Scale, Neck Disability Index, and Physical Component Summary of the SF-36 (PCS) scores improved postoperatively. The recovery rate was significantly correlated with the sagittal vertical axis (SVA) and T1 pelvic angle. Univariate regression analyses showed that the SVA and PCS score were significantly associated with recovery rate. Lastly, multiple regression analysis identified the independent predictors of recovery rate after ADF as thoracic kyphosis (TK), PCS, and SVA. According to this prediction model, the following equation was obtained: recovery rate = − 8.26 + 1.17 × (TK) – 0.45 × (SVA) + 0.85 × (PCS). Conclusion Patients with lower TK, lower PCS score, and higher SVA were more likely to have poor neurological recovery after ADF. Therefore, DCM patients with these predictors who undergo ADF might be cautioned about poor recovery and be required to provide adequate informed consent.

scholarly journals Cardiac Affection in Type 1 Diabetic Patients in Relation to Omentin

2015 ◽  
Vol 3 (4) ◽  
pp. 699-704 ◽  
Author(s):  
Soha M. Abd El Dayem ◽  
Ahmed A. Battah ◽  
Amal El Shehaby
Keyword(s):  
Type 1 Diabetes ◽  
Regression Analysis ◽  
Multiple Regression Analysis ◽  
Multiple Regression ◽  
Stepwise Multiple Regression ◽  
Cardiac Autonomic Neuropathy ◽  
Control Group ◽  
Diabetic Patients ◽  
Stepwise Multiple Regression Analysis

AIM: To evaluate cardiac affection in type 1 diabetes in relation to Omentin.PATIENTS AND METHODS: Sixty two diabetics and 30 volunteer of the same age and sex were included as a control group. Blood sample was taken for assessment of omentin and oxidized low density lipoprotein (OxLDL), glycosylated hemoglobin (HbA1) and lipid profile. Urine sample was taken for assessment of albumin/ creatinine ratio. 24 hour holter was also done. T-test, simple correlation followed by stepwise multiple regression analysis was used for analysis of data.RESULTS: Parameters of 24 hour holter were significantly lower in diabetics. Omentin was significantly lower, while OxLDL were significantly higher than controls. RMSSD, ST deviation and OxLDL were the parameters related to omentin by stepwise multiple regression analysis in diabetics.CONCLUSION: Diabetic patients had a cardiac autonomic neuropathy. A significant reduction of omentin and elevation OxLDL imply that they influence glucose metabolism in type 1 diabetes. Omentin had a significant relation to 24 hr holter which may reflect its role in cardiac affection. Omentin and OxLDL had a role in renal affection.

20 FACTORS THAT AFFECT PURITY AND YIELD OF BOVINE SEX-SORTED SPERM

2011 ◽  
Vol 23 (1) ◽  
pp. 116
Author(s):  
Y. Sakamoto ◽  
M. Ueda ◽  
S. Toda ◽  
H. Kimura
Keyword(s):  
Regression Analysis ◽  
Multiple Regression Analysis ◽  
Multiple Regression ◽  
Event Rate ◽  
Stepwise Multiple Regression ◽  
Stepwise Multiple Regression Analysis ◽  
Drive Frequency ◽  
Frequency Drop ◽  
Degree Of Separation ◽  
Holstein Bulls

The purposes of these studies were to examine the influence on the yield of sex-sorted sperm by the different size of sorting gate and to evaluate factors that affect the purity of sex-sorted sperm. As the sorting gate was expanded, so the yield of bovine sex-sorted sperm using flow cytometry was increased. At the same time, the purity of sex-sorted sperm became low. In addition, though the sorting gates were the same size, the purity of sex-sorted sperm differed among trials. These observations indicated the existence of factors that affect purity besides the size of sorting gate. To examine the yield of sex-sorted sperm, X-bearing sex-sorted sperm from 4 Holstein bulls were produced repeatedly 34 times by 3 flow cytometers. The sizes of sorting gates were fixed at 40–42%, 44%, and 46%. Each yield of sorting gate at 40–42%, at 44% and at 46% was compared. To evaluate factors that affect purity, X- or Y-bearing sex-sorted sperm were produced by one flow cytometer. These trials were repeated 160 times for the sorting of X-bearing sperm and 45 times for the sorting of Y-bearing sperm. Stepwise multiple regression analysis was used to analyse the relationships between the purity of sex-sorted sperm and the following sorting conditions, the percentage of oriented sperm, the percentage of dead sperm, degree of separation between X-bearing and Y-bearing sperm, the size of sorting gate, event rate, drop drive frequency, drop delay value and drop delay accuracy. The highest yield was acquired by sorting gate at 44%. The number of sex-sorted sperm was increased as sorting gate was expanded, however, the purity became low. The purities of the sperm by some trials using sorting gate at 46% were less than our acceptable lowest purity that was 90%. So that those sperm must be discarded. Therefore the yield of sorting gate at 44% was greater than sorting gate at 46%. Stepwise multiple regression analysis revealed that the factors for increasing purity of X-bearing sex-sorted sperm were the percentage of oriented sperm (P < 0.001), the degree of separation between X-bearing sperm and Y-bearing sperm (P < 0.001), the drop delay accuracy (P < 0.001), the event rate and the drop drive frequency, and the factor for decreasing purity of X-bearing sex-sorted sperm was the size of sorting gate (P < 0.001). On the other hand, the factors for increasing purity of Y-bearing sex-sorted sperm were the percentage of oriented sperm (P < 0.01), the degree of separation between X-bearing sperm and Y-bearing sperm (P < 0.01) and the event rate (P < 0.05), and the factor for decreasing purity of Y-bearing sex-sorted sperm was the size of sorting gate (P < 0.01). From these results, it can be concluded that the purity of sex-sorted sperm was not depend on simply by size of sorting gate but was more completely explained by other sorting conditions.

Influence of Obesity on Plasma Fructosamine Concentration

1992 ◽  
Vol 38 (11) ◽  
pp. 2190-2192 ◽  
Author(s):  
J Woo ◽  
C Cockram ◽  
E Lau ◽  
A Chan ◽  
R Swaminathan
Keyword(s):  
Body Mass Index ◽  
Regression Analysis ◽  
Glycemic Control ◽  
Multiple Regression Analysis ◽  
Multiple Regression ◽  
Body Mass ◽  
Total Protein ◽  
Stepwise Multiple Regression ◽  
Stepwise Multiple Regression Analysis ◽  
Chinese Community

Abstract The influence of obesity on plasma fructosamine concentration was studied in 68 diabetic and 1335 nondiabetic subjects from a Chinese community. Obese nondiabetic men (body mass index &gt; 25 kg/m2) had lower fructosamine concentrations than nonobese nondiabetic men (body mass index &lt; or = 25 kg/m2); the pattern was similar for diabetic women. Stepwise multiple-regression analysis showed that, apart from known factors (total protein, albumin, and indices of glycemic control), fructosamine was also associated with body mass index and plasma fasting triglycerides. However, the contribution of these were small except in diabetic women. We conclude that the effect of obesity on fructosamine is small.

PERCEIVED PARENTAL FAVORITISM AND SUICIDAL IDEATION IN HONG KONG ADOLESCENTS

2003 ◽  
Vol 31 (3) ◽  
pp. 245-251 ◽  
Author(s):  
Anton F. de Man ◽  
Iris N. Wong ◽  
Patrick W. L. Leung
Keyword(s):  
Regression Analysis ◽  
Hong Kong ◽  
Suicidal Ideation ◽  
Multiple Regression Analysis ◽  
Stepwise Multiple Regression ◽  
Stepwise Multiple Regression Analysis ◽  
Mothers And Fathers ◽  
Hong Kong Adolescents ◽  
And Control ◽  
The Relationship

Chinese adolescents from Hong Kong (N = 317) participated in a study of the relationship between perceived parental favoritism in terms of affection and control, and suicidal ideation. Correlation analyses showed that adolescents who believed that children in their families were treated differently in terms of affection and control by their mothers and fathers reported greater suicidal ideation; whether they personally were the favored or nonfavored children made no difference. Stepwise multiple regression analysis identified perceived differential maternal affection as the best predictor of suicidal ideation.

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