scholarly journals Complete remission of Cdx-2 positive primary testicular carcinoid tumor: 10-years follow-up and literature review

BMC Urology ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Eugen Widmeier ◽  
Hannah Füllgraf ◽  
Cornelius F. Waller
Keyword(s):  
Complete Remission ◽  
Literature Review ◽  
Carcinoid Tumor ◽  
Unknown Origin ◽  
Distant Metastases ◽  
Metastatic Tumor ◽  
Carcinoid Tumors ◽  
Neuroendocrine Cells ◽  
Significant Past Medical History

Abstract Background The neuroendocrine cells can cause a variety of malignancies throughout the human body known as the neuroendocrine tumors (NETs) or carcinoid tumors. The primary testicular carcinoid tumor (PTCT) accounts for less than 1% of the testicular neoplasms and for only 0.2% of all carcinoid tumors representing already a very rare neoplastic entity. Here, we present a patient with a history of an exceptionally rare primary testicular carcinoid tumor, staining positive for Cdx-2 along with a literature review. Case presentation A 44-year old patient without significant past medical history was diagnosed in September 2009 with primary testicular carcinoid tumor, which was surprisingly staining positively for Cdx-2, too. At the time of the initial diagnosis the tumor was already showing histopathological infiltration of veins. DOTA-TATE-PET/CT imaging and endoscopy studies did not show any signs of distant metastases and in particular no gastrointestinal manifestation following no further medical indication for systemic chemotherapy. The continuous and close follow-up of the patient has reached a total of over 10 years at the time of publication remaining in complete remission. Conclusion The diagnosis of primary testicular carcinoid is based on histopathology. The detailed histopathologic assessment of biomarkers based on immunohistochemistry is very important for the classification and the prognosis of the primary testicular carcinoid tumor. Primary testicular carcinoid tumor with Cdx-2 positive stain outlines an exceptionally rare neoplastic entity without a consensus about general follow-up guidelines, requiring close clinical and imaging aftercare and consideration in Cdx-2 positive metastatic tumor of unknown origin.

scholarly journals Primary ovarian carcinoid tumor: a report of 4 cases

2017 ◽  
Vol 4 (8) ◽  
pp. 2826 ◽  
Author(s):  
H. Salhi ◽  
B. Laamouri ◽  
N. Boujelbène ◽  
J. B. Hassouna ◽  
T. Dhiab ◽  
...  
Keyword(s):  
Carcinoid Tumor ◽  
Radical Surgery ◽  
Cystic Teratoma ◽  
Surgical Excision ◽  
Clinical Results ◽  
Disease Recurrence ◽  
Carcinoid Tumors ◽  
Stage Iii ◽  
Pathological Findings

Ovarian carcinoid tumor is a rare neoplasm that account for 0.3% of all ovarian tumors. It is commonly seen in perimenopausal and postmenopausal women. The aim of this study is to investigate the clinical features and to evaluate the treatment of this rare tumor. The study reviewed retrospectively the clinical and pathological findings of 4 cases of primary OCT treated in Salah Azaiez Institute between 1994 and 2012. The median age was 50 years (ranging from 28 to 75 years). All the patients underwent radical surgery. Two patients had carcinoid tumors occurring in mature cystic teratoma. Three patients had stage I diseases, and one patient had stage III disease, this patient had adjuvant chemotherapy. The follow up median was 23 months. There was one case of bone and lung metastasis diagnosed in the patient who had stage III disease, fourteen months after the surgery but the patient died of her disease four month later. The other patients were alive without evidence of disease recurrence. Primary Ovarian carcinoid tumors are most of the time associated with good clinical results. Surgical excision of the tumor is usually sufficient treatment for most of the patients

Clinicopathologic characteristics that affect the treatment and recurrence of rectal carcinoid tumor in Korea.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 684-684
Author(s):  
Dong Ho Lee ◽  
Young Soo Park ◽  
Jae Jin Hwang ◽  
Hyun chae Jung
Keyword(s):  
Carcinoid Tumor ◽  
Endoscopic Resection ◽  
Carcinoid Tumors ◽  
Rectal Carcinoid ◽  
Resection Margins ◽  
Female Ratio ◽  
Rectal Carcinoid Tumor ◽  
Mean Size ◽  
The Mean

684 Background: The increase of colonoscopy procedures has led to an increase in the diagnosis of rectal carcinoid tumors. The aim of this study was to evaluate the clinical and pathological characteristics that affect the treatment and recurrence of rectal carcinoid tumors. Methods: Between 2003 and 2014, the medical records of patients with rectal carcinoid tumors were retrospectively reviewed. Patient and tumor characteristics, treatment and recurrence were analyzed. Results: The mean age was 51.7 ± 11.7 (range, 22-80 years) and the male to female ratio was 1:0.58. The mean tumor size was 8.7 ± 4.9 (3-27) mm. Four hundred-seven out of 424 patients were treated by endoscopy (mean size of tumor: 8.6 ± 3.6 mm) and 17 were treated by surgery (mean size of tumor: 12.5 ± 5.7 mm, p = 0.023). However, the histology showed that 87 patients treated by endoscopy had positive resection margins; 68 cases (16.0%) had a polypectomy and 19 cases (4.4%) had a endoscopic mucosal resection (p = 0.033). The mean follow-up duration was 29.1 ± 31.3 months, and there were five recurrences of rectal carcinoid tumors.All cases of recurrence of rectal carcinoid tumor were successfully re-treated by additional endoscopic resection. Conclusions: Endoscopic resection was an effective method for the treatment of rectal carcinoid tumors. Moreover, even for small rectal carcinoid tumors, follow-up examination should be performed to evaluate for tumor recurrence.The recurrence of rectal carcinoid tumor should be successfully controlled by additional endoscopic resection.

Primary Granulocytic Sarcoma:A Allo-Transplantation Case Report and Literature Review.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 4368-4368
Author(s):  
Xiaolin Li ◽  
Jie Fu ◽  
Yan Xue ◽  
Yang Yang ◽  
Yang Wang ◽  
...  
Keyword(s):  
Case Report ◽  
Complete Remission ◽  
Literature Review ◽  
Conflicts Of Interest ◽  
Granulocytic Sarcoma ◽  
Allogeneic Transplantation ◽  
Radical Operation ◽  
Matched Sibling ◽  
Granulocytic Leukemia

Abstract Abstract 4368 Objective To investigate the effect of allogeneic transplantation in treating primary granulocytic sarcoma. Methods We report the diagnosis and treatment of one patient with primary granulocytic sarcoma and review the related articles. Results Firstly appeared as one isolated tumor in breast, the disease was diagnosed by pathological methods with immunochemistry positive stain in MPO, CD68(KP-1) and bacteriolysis enzyme. After radical operation on sick breast, the patient was treated with four courses chemotherapy according to that of acute granulocytic leukemia,then followed by matched sibling transplantation. After 6 months follow-up, the patients is still in complete remission. Conclusion If having suitable donor, patient with primary granulocytic sarcoma shoud be treated with allogeneic transplantation. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Primary Carcinoid Tumor of the Testis: A Case Report and Review of the Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Rawad Abou Zahr ◽  
Khalil Chalhoub ◽  
Elias Mansour ◽  
Camil Chouairy ◽  
Georges Ghazal ◽  
...  
Keyword(s):  
Carcinoid Tumor ◽  
Malignant Potential ◽  
Carcinoid Tumors ◽  
Tumor Site ◽  
Review Of The Literature ◽  
Primary Tumor Site ◽  
Long Term Follow Up ◽  
Primary Carcinoid Tumor

Carcinoid tumors usually arise in the gastrointestinal tract. Immunocytohistochemical and radiologic studies are important in detecting the primary tumor site. Primary carcinoid tumors of the testis are particularly rare with a high malignant potential warranting long-term follow-up. We present the case of a primary carcinoid tumor of the testis with long-term surveillance.

scholarly journals Three Cases of Carcinoid in the Equine Nasal Cavity and Maxillary Sinuses: Histologic and Immunohistochemical Features

1996 ◽  
Vol 33 (1) ◽  
pp. 92-95 ◽  
Author(s):  
C. van Maanen ◽  
W. R. Klein ◽  
K. J. Dik ◽  
T. S. G. A. M. van den Ingh
Keyword(s):  
Nasal Cavity ◽  
Carcinoid Tumor ◽  
Nasal Mucosa ◽  
Chromogranin A ◽  
Neuron Specific Enolase ◽  
Carcinoid Tumors ◽  
Neuroendocrine Cells ◽  
Maxillary Sinuses

Three cases of carcinoid tumor in horses are described. The tumors originated from the maxillary sinuses and the retrobulbar region and caused exophthalmos. Histologically, they had a characteristic endocrine pattern and were argyrophilic with the Grimelius stain. All tumors contained reactivity for neuron-specific enolase and synaptophysin. Two of three tumors were reactive for both bovine and porcine chromogranin A. These immunohistochemical results confirm the neuroendocrine nature of these tumors. Neuroendocrine cells could not be detected in the nasal mucosa and maxillary sinuses of a normal horse; therefore, the origin of these carcinoid tumors remains obscure.

Symptomatology, localization and treatment of recurrent cervical carcinoma

1992 ◽  
Vol 2 (4) ◽  
pp. 179-188 ◽  
Author(s):  
D. J. Tinga ◽  
J. Bouma ◽  
H. Boonstra ◽  
J. G. Aalders
Keyword(s):  
Complete Remission ◽  
Tumor Recurrence ◽  
Lung Metastases ◽  
Distant Metastases ◽  
Primary Treatment ◽  
Vaginal Wall ◽  
Asymptomatic Stage ◽  
Permanent Remission ◽  
Vaginal Recurrence

In a group of 367 women treated for invasive carcinoma of the cervix tumor recurrence was discovered at an asymptomatic stage in 16 (23%) patients. The tumor recurrence was localized to the pelvis in 29 (41%) cases, in the vaginal wall in 3 (4%) cases, and 39 (55%) patients had distant metastases (with or without recurrent tumor in the pelvis). Curative treatment (surgery,n= 2; radiotherapy,n= 8) was applied in 5/29 (17%) patients whose recurrent disease was confined to the pelvis, in all 3 patients with vaginal recurrence and in 2/39 (5%) of the patients with distant metastases. Permanent remission (follow-up > 36 months) was observed in 2 patients with vaginal recurrence and in one with central recurrence. Temporary complete remission (mean 22 months, range 12–30 months) was observed in 3 patients (2 with central recurrence and one with vaginal recurrence). In 20 (69%) of the patients with central or locoregional recurrence, the primary treatment had been so radical (including adjuvant postoperative or full radiotherapy) that surgical treatment or radiotherapy of the recurrence was not considered possible or worthwhile; moreover, 4 of the patients were older than 80 years of age. In retrospect, exenterative treatment could have been considered in 14 patients (< 70 years) and based on 50% operability, could have led to a cure in 2 to 4 patients with tumor recurrence in the pelvis without distant metastases. Chemotherapy was applied to 10 patients, one of whom went into complete remission of lung metastases (follow-up 108 months).

scholarly journals Primary carcinoid of the ovary

2011 ◽  
Vol 68 (3) ◽  
pp. 274-276 ◽  
Author(s):  
Marina Djurovic ◽  
Svetozar Damjanovic ◽  
Svetislav Tatic ◽  
Marjan Micev ◽  
Aleksandar Cetkovic ◽  
...  
Keyword(s):  
Case Report ◽  
Carcinoid Tumor ◽  
Carcinoid Tumors ◽  
Ca 125 ◽  
Neuroendocrine Neoplasm ◽  
Neuroendocrine Neoplasms ◽  
Abdominal Ct ◽  
Long Term Follow Up

Background. Carcinoid tumors are distinct neuroendocrine neoplasms commonly located within the gastrointestinal tract and bronchopulmonary system. The aim of this case report was to present a patient with carcinoid tumor of the ovary as a less common form of this neoplasm. Case report. A 49 year old woman was admitted to the hospital with symptoms of diarrhea and abdominal pain and suspicion of neuroendocrine neoplasm, 4 month after bilateral salpingo-oophorectomy and total hysterectomy for ovarian tumor. Pathological diagnosis was typical for carcinoid tumor. At admission the patient had slightly eleveated levels of tumor marker CA 125 and highly elevated levels of 5- HIAA. Abdominal CT showed suspicious rest tumor in the pelvis. Relaparotomy was done and retroperitoneal fibrosis was found. Six months after the intervention the levels of 5-HIAA and CA 125 were normal, and NMR of the abdomen showed no signs of rest tumor. Conclusion. Carcinoid tumor of the ovary is rare form of ovarian tumors and less than 0.1% had malignant potential. Surgical therapy associated with a long-term follow up was the treatment of choice. Consideration of unusual sites of carcinoid tumors facilitates appropriate diagnosis and treatment.

scholarly journals Primary Mesenteric Carcinoid Tumor Presenting with Carcinoid Syndrome

2018 ◽  
Vol 12 (2) ◽  
pp. 396-401
Author(s):  
Oluwaseun Shogbesan ◽  
Abdullateef Abdulkareem ◽  
Binu Pappachen ◽  
John Altomare
Keyword(s):  
Carcinoid Tumor ◽  
Primary Tumor ◽  
Carcinoid Syndrome ◽  
The Body ◽  
Carcinoid Tumors ◽  
Neuroendocrine Cells ◽  
Neuroendocrine Neoplasms ◽  
Diverse Group ◽  
Poorly Differentiated ◽  
Well Differentiated

Neuroendocrine neoplasms (NENs) are a diverse group of tumors arising throughout the body with a common origin from neuroendocrine cells. Well-differentiated NENs, also known as neuroendocrine tumors (NETs), are generally indolent and are often found incidentally, while poorly differentiated tumors are more aggressive. Carcinoid tumors are NETs arising from the gastrointestinal tract and less commonly from the lungs, thymus, and kidneys. NETs in the mesentery arise from metastasis from primary tumor, and carcinoid syndrome in this setting results from concomitant metastasis to the liver. Primary mesenteric carcinoid tumors are very rare. We present a 64-year-old man with carcinoid syndrome from a mesenteric carcinoid tumor without evidence of liver metastasis or other primary tumor sites.

Role of Adjuvant Hysterectomy in Management of High-Risk Gestational Trophoblastic Neoplasia

2012 ◽  
Vol 22 (3) ◽  
pp. 509-514 ◽  
Author(s):  
Jing Fang ◽  
Shu Wang ◽  
Xiaobing Han ◽  
Ruifang An ◽  
Weimin Wang ◽  
...  
Keyword(s):  
High Risk ◽  
Complete Remission ◽  
Therapeutic Response ◽  
Distant Metastases ◽  
Initial Response ◽  
Gestational Trophoblastic Neoplasia ◽  
Pelvic Organs ◽  
Adjuvant Hysterectomy

ObjectivesThe objectives of the study were to investigate the role of and indications for adjuvant hysterectomy in patients with high-risk gestational trophoblastic neoplasia.MethodsWe retrospectively analyzed records of patients identified as having undergone adjuvant hysterectomy for high-risk gestational trophoblastic neoplasia at First Hospital of Xi’an Jiaotong University, Xi’an, China, between 1985 and 2005. Therapeutic response was defined as complete with normalization of human chorionic gonadotropin (hCG) concentration, partial response with a decrease of more than 50%, and no response with a decrease of 50% or less. Complete remission was defined as normal hCG at 3 consecutive weekly assays without clinical evidence of disease.ResultsA total of 21 patients (72.4%) showed an initial therapeutic response after surgery and 8 (27.6%) had no response. The initial therapeutic response was complete in 8 patients (27.6%) and partial in 13 (44.8%). During follow-up of 6 to 168 months, all 21 patients with an initial response and 2 of 8 patients without an initial response ultimately achieved complete remission (23 of 29 patients, 79.3%). Three patients (10.3%) had recurrence after primary remission; 2 patients (6.90%) died. Metastases outside of lungs or pelvic organs, number of metastases, presurgery chemoresistance to multidrug regimens, especially with 2 or more failed protocols, were considered possible reasons for decreased effectiveness of hysterectomy.ConclusionsOur study suggests that timely adjuvant hysterectomy is likely to benefit cautiously selected patients with high-risk gestational trophoblastic neoplasia. Although preoperative metastases limited to pelvic organs or lungs should not be considered an absolute contraindication, adjuvant hysterectomy should generally not be performed in the presence of distant metastases beyond the pelvic organs and lungs.

Pneumomediastinum: A Rare Presentation of Inflicted Injuries in Infants

2020 ◽  
Author(s):  
Adam Lee ◽  
Adam Bajinting ◽  
Abby Lunneen ◽  
Colleen M. Fitzpatrick ◽  
Gustavo A. Villalona
Keyword(s):  
Literature Review ◽  
Retrospective Review ◽  
Review Of The Literature ◽  
Rare Presentation ◽  
Spontaneous Pneumomediastinum ◽  
Nonaccidental Trauma ◽  
Comprehensive Literature Review ◽  
Healthy Infants ◽  
History Of

AbstractReports of incidental pneumomediastinum in infants secondary to inflicted trauma are limited. A retrospective review of infants with pneumomediastinum and history of inflicted trauma was performed. A comprehensive literature review was performed. Three infants presented with pneumomediastinum associated with inflicted trauma. Mean age was 4.6 weeks. All patients underwent diagnostic studies, as well as a standardized evaluation for nonaccidental trauma. All patients with pneumomediastinum were resolved at follow-up. Review of the literature identified other cases with similar presentations with related oropharyngeal injuries. Spontaneous pneumomediastinum in previously healthy infants may be associated with inflicted injuries. Clinicians should be aware of the possibility of an oropharyngeal perforation related to this presentation.

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