scholarly journals Effects of dietary supplementation with a standardized aqueous extract of Terminalia chebula fruit (AyuFlex®) on joint mobility, comfort, and functional capacity in healthy overweight subjects: a randomized placebo-controlled clinical trial

Author(s):  
H. L. Lopez ◽  
S. M. Habowski ◽  
J. E. Sandrock ◽  
B. Raub ◽  
A. Kedia ◽  
...  
2019 ◽  
Vol 30 ◽  
pp. 100935
Author(s):  
Pouran Andarkhor ◽  
Amir Sadeghi ◽  
Mahmood Khodadoost ◽  
Mohammad Kamalinejad ◽  
Latif Gachkar ◽  
...  

2017 ◽  
Vol 40 (19) ◽  
pp. 2318-2324 ◽  
Author(s):  
Carolina Marciela Herpich ◽  
Ernesto Cesar Pinto Leal-Junior ◽  
Cid Andre Fidelis de Paula Gomes ◽  
Igor Phillip dos Santos Gloria ◽  
Ana Paula Amaral ◽  
...  

2015 ◽  
Vol 21 (3) ◽  
pp. 141-146 ◽  
Author(s):  
Mohammadali Kamali ◽  
Hamid Tavakoli ◽  
Mahmoud Khodadoost ◽  
Hamed Daghaghzadeh ◽  
Mohammad Kamalinejad ◽  
...  

2015 ◽  
Vol 66 (2-3) ◽  
pp. 117-124 ◽  
Author(s):  
Mohsen Taghizadeh ◽  
Mohammad Reza Memarzadeh ◽  
Zatollah Asemi ◽  
Ahmad Esmaillzadeh

Background: The current study was performed to determine the effects of cumin cyminum L. intake on weight loss and metabolic profiles among overweight subjects. Methods: This randomized double-blind placebo-controlled clinical trial was conducted among 78 overweight subjects (male, n = 18; female, n = 60) aged 18-60 years old. Participants were randomly assigned into three groups to receive: (1) cumin cyminum L. capsule (n = 26); (2) orlistat120 capsule (n = 26) and (3) placebo (n = 26) three times a day for 8 weeks. Anthropometric measures and fasting blood samples were taken at baseline and after 8 weeks of intervention. Results: Consumption of the Cuminum cyminum L. and orlistat120 resulted in a similar significant decrease in weight (-1.1 ± 1.2 and -0.9 ± 1.5 vs. 0.2 ± 1.5 kg, respectively, p = 0.002) and BMI (-0.4 ± 0.5 and -0.4 ± 0.6 vs. 0.1 ± 0.6 kg/m2, respectively, p = 0.003) compared with placebo. In addition, taking Cuminum cyminum L., compared with orlistat and placebo, led to a significant reduction in serum insulin levels (-1.4 ± 4.5 vs. 1.3 ± 3.3 and 0.3 ± 2.2 µIU/ml, respectively, p = 0.02), HOMA-B (-5.4 ± 18.9 vs. 5.8 ± 13.3 and 1.0 ± 11.0, respectively, p = 0.02) and a significant rise in QUICKI (0.01 ± 0.01 vs. -0.005 ± 0.01 and -0.004 ± 0.01, respectively, p = 0.02). Conclusion: Taking cumin cyminum L. for eight weeks among overweight subjects had the same effects of orlistat120 on weight and BMI and beneficial effects on insulin metabolism compared with orlistat120 and placebo.


Author(s):  
Christian Schmidt ◽  
Sebastian Bernert ◽  
Matthias Sing ◽  
Sandra Fahrenkrog ◽  
Dominika Urbanski-Rini ◽  
...  

Abstract Background and Aim The management of chronic low back pain is a persisting challenge for multidisciplinary biopsychosocial rehabilitation (MBR). A promising approach to improve the effectiveness is better individual tailoring of the therapeutic minutes to the impairment. We designed a questionnaire-based algorithm to identify individual risk profiles, which allows physicians and patients to decide upon the kind and amount of suitable and adequate therapeutic components of MBR. Our aim was to test whether the algorithm leads to a shift in the therapeutic components depending on the impairment, which should significantly increase the functional capacity of the rehabilitants 6 months after the end of rehabilitation. Methods Between January and November 2016, a controlled clinical trial with a sequential arrangement of study groups and 3 measurement time points (start of rehabilitation, end of rehabilitation and 6-month follow-up) was conducted. The control group (CG) passed through the standard inpatient MBR. In the intervention group (IG)the MBR components were matched to the individual risk-profiles determined via a new algorithm. The shift of therapeutic minutes is displayed via boxplots. The primary outcome was statistically tested by applying an analysis of covariance. All secondary outcomes are presented descriptively. Results Of 169 patients in total, 85 were assigned to the CG and 84 to the IG. Complete data concerning the primary outcome were available for 76 (89.4%) patients in the CG and 75 (89.3%) patients in the IG. Compared to the CG, the boxplots for the IG show a better fit of therapeutic minutes according to the impairments. For example, in the IG, the mean value of psychological therapies was about 120 min if they were impaired and 44.3 min if not. In contrast, impaired tested patients of the CG shown mean values of those therapies of about 96.6 min and 50.6 min if not. The baseline adjusted mean difference in functional capacity was significantly (p=0.047) improved by 4.4 points (95% CI: 0.063–8.465) in favor of the IG. . Main limitation is lack of randomization. In order to avoid inadequate therapy recommendations, the physician had the decision-making authority over the therapies. Conclusion The application of the developed algorithm for individual adaptation of the MBR increases the effectiveness of rehabilitation in terms of functional capacity.


Author(s):  
Pedro J. Benito ◽  
Bricia López-Plaza ◽  
Laura M. Bermejo ◽  
Ana B. Peinado ◽  
Rocío Cupeiro ◽  
...  

Studies with overweight people are a priority in order to observe the effect of the timing of intervention on pre-obesity people. The aim was to compare different physical activity programs plus an individualized hypocaloric diet on body composition in overweight subjects. A randomized controlled clinical trial was carried out in overweight adults with no history of relevant illness. Primary outcome was total fat mass (TFM). Participants were allocated into four activity programs with equal intensity and volume of exercise for 22 weeks: strength training (S), endurance training (E), strength + endurance training (SE), and ‘adhering to physical activity recommendations’ (C). Participants followed a diet with 25% less energy (50%–55% carbohydrates, 30%–35% fat) measured by accelerometer. Variables were assessed at baseline and at the end of the intervention. Body composition was measured by dual-energy X-ray absorptiometry. One hundred nineteen from 205 subjects were randomized in the four exercise groups (S = 30/E = 30/SE = 30/C = 29) and 84 participants (36 men/48 women) ended the intervention (S = 19/E = 25/SE = 22/C = 18). At the end of the experiment, all groups except C increased their total physical activity (S = 1159 ± 1740; E = 1625 ± 1790; SE = 1699 ± 2516; C = 724 ± 1979 MET-min/week). Using an ANOVA-test, improvements were observed in body weight (S = −4.6 ± 4.5; E = −6.6 ± 4.6; SE = −8.5 ± 2.8; C = −6.1 ± 5.6 kg, p = 0.059) and TFM (S = −4.24 ± 2.02; E = −4.74 ± 2.96; SE = −6.74 ± 3.27; C = −3.94 ± 4.18%; p < 0.05). The main conclusion was that there were no adverse events. Strength and endurance training with a balanced, individualized hypocaloric diet was the most effective at reducing weight loss and fat mass in overweight subjects. Trial registration: NCT01116856.


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