scholarly journals Dawn- and dusk-phased circadian transcription rhythms coordinate anabolic and catabolic functions in Neurospora

BMC Biology ◽  
2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Cigdem Sancar ◽  
Gencer Sancar ◽  
Nati Ha ◽  
François Cesbron ◽  
Michael Brunner
Keyword(s):  
Circadian Transcription

scholarly journals Shank3 Modulates Sleep and Expression of Circadian Transcription Factors

2018 ◽  
Author(s):  
Ashley M. Ingiosi ◽  
Taylor Wintler ◽  
Hannah Schoch ◽  
Kristan G. Singletary ◽  
Dario Righelli ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factors ◽  
Molecular Mechanisms ◽  
Sleep Problems ◽  
Wheel Running ◽  
The United States ◽  
Autism Spectrum ◽  
Wheel Running Activity ◽  
Falling Asleep ◽  
Circadian Transcription

AbstractAutism Spectrum Disorder (ASD) is the most prevalent neurodevelopmental disorder in the United States and often co-presents with sleep problems. Sleep problems in ASD predict the severity of ASD core diagnostic symptoms and have a considerable impact on the quality of life of caregivers. Little is known, however, about the underlying molecular mechanisms. We investigated the role of Shank3, a high confidence ASD gene candidate, in sleep architecture and regulation. We show that mice lacking exon 21 of Shank3 have problems falling asleep even when sleepy. Using RNA-seq we show that sleep deprivation increases the differences in gene expression between mutants and wild types, downregulating circadian transcription factors Per3, Dec2, Hlf, Tef, and Reverbα. Shank3 mutants also have trouble regulating wheel-running activity in constant darkness. Overall our study shows that Shank3 is an important modulator of sleep and clock gene expression.

scholarly journals Wild-Type Circadian Rhythmicity Is Dependent on Closely Spaced E Boxes in the Drosophila timelessPromoter

2001 ◽  
Vol 21 (4) ◽  
pp. 1207-1217 ◽  
Author(s):  
Michael J. McDonald ◽  
Michael Rosbash ◽  
Patrick Emery
Keyword(s):  
Transcription Factor ◽  
Transcriptional Regulation ◽  
Locomotor Activity ◽  
Circadian Rhythms ◽  
High Amplitude ◽  
Wild Type ◽  
Activity Rhythms ◽  
E Box ◽  
E Boxes ◽  
Circadian Transcription

ABSTRACT Transcriptional regulation plays an important role inDrosophila melanogaster circadian rhythms. The period promoter has been well studied, but the timeless promoter has not been analyzed in detail. Mutagenesis of the canonical E box in the timelesspromoter reduces but does not eliminate timeless mRNA cycling or locomotor activity rhythms. This is because there are at least two other cis-acting elements close to the canonical E box, which can also be transactivated by the circadian transcription factor dCLOCK. These E-box-like sequences cooperate with the canonical E-box element to promote high-amplitude transcription, which is necessary for wild-type rhythmicity.

scholarly journals Clock-dependent chromatin topology modulates circadian transcription and behavior

2018 ◽  
Vol 32 (5-6) ◽  
pp. 347-358 ◽  
Author(s):  
Jérôme Mermet ◽  
Jake Yeung ◽  
Clémence Hurni ◽  
Daniel Mauvoisin ◽  
Kyle Gustafson ◽  
...  
Keyword(s):  
And Behavior ◽  
Circadian Transcription

scholarly journals Demyelination Regulates the Circadian Transcription Factor BMAL1 to Signal Adult Neural Stem Cells to Initiate Oligodendrogenesis

Cell Reports ◽  
2020 ◽  
Vol 33 (7) ◽  
pp. 108394
Author(s):  
Suihong Huang ◽  
Ming Ho Choi ◽  
Hao Huang ◽  
Xin Wang ◽  
Yu Chen Chang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Transcription Factor ◽  
Neural Stem Cells ◽  
Adult Neural Stem Cells ◽  
Circadian Transcription

scholarly journals Preferential Inhibition of BMAL2-CLOCK Activity by PER2 Reemphasizes Its Negative Role and a Positive Role of BMAL2 in the Circadian Transcription

2009 ◽  
Vol 284 (37) ◽  
pp. 25149-25159 ◽  
Author(s):  
Momoko Sasaki ◽  
Hikari Yoshitane ◽  
Ngoc-Hien Du ◽  
Toshiyuki Okano ◽  
Yoshitaka Fukada
Keyword(s):  
Positive Role ◽  
Negative Role ◽  
Circadian Transcription

scholarly journals The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

Cell ◽  
2002 ◽  
Vol 110 (2) ◽  
pp. 251-260 ◽  
Author(s):  
Nicolas Preitner ◽  
Francesca Damiola ◽  
Luis-Lopez-Molina ◽  
Joszef Zakany ◽  
Denis Duboule ◽  
...  
Keyword(s):  
Nuclear Receptor ◽  
Circadian Oscillator ◽  
Orphan Nuclear Receptor ◽  
Circadian Transcription

scholarly journals Circadian Transcription Contributes to Core Period Determination in Drosophila

PLoS Biology ◽  
2008 ◽  
Vol 6 (5) ◽  
pp. e119 ◽  
Author(s):  
Sebastian Kadener ◽  
Jerome S Menet ◽  
Rebecca Schoer ◽  
Michael Rosbash
Keyword(s):  
Circadian Transcription
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