scholarly journals Validation and minimum important difference of the UCSD Shortness of Breath Questionnaire in fibrotic interstitial lung disease

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Tao Chen ◽  
Amy Po Yu Tsai ◽  
Seo Am Hur ◽  
Alyson W. Wong ◽  
Mohsen Sadatsafavi ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Internal Consistency ◽  
Shortness Of Breath ◽  
Minimum Important Difference ◽  
Domain Specific ◽  
St George's Respiratory Questionnaire ◽  
High Level ◽  
The University ◽  
Eq Vas

Abstract Rationale The University of California, San Diego Shortness of Breath Questionnaire (UCSDSOBQ) is a frequently used domain-specific dyspnea questionnaire; however, there is little information available regarding its use and minimum important difference (MID) in fibrotic interstitial lung disease (ILD). We aimed to describe the key performance characteristics of the UCSDSOBQ in this population. Methods UCSDSOBQ scores and selected anchors were measured in 1933 patients from the prospective multi-center Canadian Registry for Pulmonary Fibrosis. Anchors included the St. George’s Respiratory Questionnaire (SGRQ), European Quality of Life 5 Dimensions 5 Levels questionnaire (EQ-5D-5L) and EQ visual analogue scale (EQ-VAS), percent-predicted forced vital capacity (FVC%), diffusing capacity of the lung for carbon monoxide (DLCO%), and 6-min walk distance (6MWD). Concurrent validity, internal consistency, ceiling and floor effects, and responsiveness were assessed, followed by estimation of the MID by anchor-based (linear regression) and distribution-based methods (standard error of measurement). Results The UCSDSOBQ had a high level of internal consistency (Cronbach’s alpha = 0.97), no obvious floor or ceiling effect, strong correlations with SGRQ, EQ-5D-5L, and EQ-VAS (|r| > 0.5), and moderate correlations with FVC%, DLCO%, and 6MWD (0.3 < |r| < 0.5). The MID estimate for UCSDSOBQ was 5 points (1–8) for the anchor-based method, and 4.5 points for the distribution-based method. Conclusion This study demonstrates the validity of UCSDSOBQ in a large and heterogeneous population of patients with fibrotic ILD, and provides a robust MID estimate of 5–8 points.

scholarly journals Validation and minimum important difference of the UCSD shortness of breath questionnaire in fibrotic interstitial lung disease

2021 ◽  
Author(s):  
Tao Chen ◽  
Amy Po Yu Tsai ◽  
Seo Am Hur ◽  
Alyson W. Wong ◽  
Mohsen Sadatsafavi ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Internal Consistency ◽  
Shortness Of Breath ◽  
Minimum Important Difference ◽  
Domain Specific ◽  
St George's Respiratory Questionnaire ◽  
High Level ◽  
The University ◽  
Eq Vas

Abstract Rationale: The University of California, San Diego Shortness of Breath Questionnaire (UCSDSOBQ) is a frequently used domain-specific dyspnea questionnaire; however, there is little information available regarding its use and minimum important difference (MID) in fibrotic interstitial lung disease (ILD). We aimed to describe the key performance characteristics of the UCSDSOBQ in this population. Methods: UCSDSOBQ scores and selected anchors were measured in 1933 patients from the prospective multi-center Canadian Registry for Pulmonary Fibrosis. Anchors included the St. George’s Respiratory Questionnaire (SGRQ), European Quality of Life 5 Dimensions 5 Levels questionnaire (EQ-5D-5L) and EQ visual analogue scale (EQ-VAS), percent-predicted forced vital capacity (FVC%), diffusing capacity of the lung for carbon monoxide (DLCO%), and 6-minute walk distance (6MWD). Concurrent validity, internal consistency, ceiling and floor effects, and responsiveness were assessed, followed by estimation of the MID by anchor-based (linear regression) and distribution-based methods (standard error of measurement). Results: The UCSDSOBQ had a high level of internal consistency (Cronbach’s alpha=0.97), no obvious floor or ceiling effect, strong correlations with SGRQ, EQ-5D-5L, and EQ-VAS (|r|>0.5), and moderate correlations with FVC%, DLCO%, and 6MWD (0.3<|r|<0.5). The MID estimate for UCSDSOBQ was 5 points (1-8) for the anchor-based method, and 4.5 points for the distribution-based method. Conclusion: This study demonstrates the validity of UCSDSOBQ in a large and heterogeneous population of patients with fibrotic ILD, and provides a robust MID estimate of 5 to 8 points.

Minimum important difference of the EQ-5D-5L and EQ-VAS in fibrotic interstitial lung disease

Thorax ◽  
2020 ◽  
Vol 76 (1) ◽  
pp. 37-43
Author(s):  
Amy Po Yu Tsai ◽  
Seo Am Hur ◽  
Alyson Wong ◽  
Mohsen Safavi ◽  
Deborah Assayag ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Interstitial Lung Disease ◽  
Pulmonary Fibrosis ◽  
Lung Disease ◽  
Minimum Important Difference ◽  
Quality Of Life Questionnaires ◽  
Life Years ◽  
Patient Reported ◽  
Eq Vas

RationaleThe European Quality of Life 5-Dimensions 5-Levels questionnaire (EQ-5D-5L) is a multidimensional patient-reported questionnaire that supports calculation of quality-adjusted life-years. Our objectives were to demonstrate feasibility of use and to calculate the minimum important difference (MID) of the EQ-5D-5L and its associated visual analogue scale (EQ-VAS) in patients with fibrotic interstitial lung disease (ILD).MethodsPatients who completed the EQ-5D-5L were identified from the prospective multicentre CAnadian REgistry for Pulmonary Fibrosis. Validity, internal consistency and responsiveness of the EQ-5D-5L were assessed, followed by calculation of the MID for the EQ-5D-5L and EQ-VAS. Anchor-based methods used an unadjusted linear regression against pulmonary function tests (PFTs) and dyspnoea and other quality of life questionnaires. Distribution-based method used one-half SD and SE measurement (SEM) calculations.Results1816 patients were analysed, including 472 (26%) with idiopathic pulmonary fibrosis. EQ-5D-5L scores were strongly correlated with the dyspnoea and other quality of life questionnaires and weakly associated with PFTs. The estimated MID for EQ-5D-5L ranged from 0.0050 to 0.054 and from 0.078 to 0.095 for the anchor-based and distribution-based methods, respectively. The MID for EQ-VAS ranged from 0.5 to 5.0 and from 8.0 to 9.7 for the anchor-based and distribution-based methods. Findings were similar across ILD subtypes, sex and age.ConclusionWe used a large and diverse cohort of patients with a variety of fibrotic ILD subtypes to suggest validity and MID of both the EQ-5D-5L and EQ-VAS. These findings will assist in designing future clinical trials and supporting cost-effectiveness analyses of potential treatments for patients with fibrotic ILD.

Dino Lab

2021 ◽  
pp. 395-428
Author(s):  
Kirsten R. Butcher ◽  
Madlyn Runburg ◽  
Roger Altizer
Keyword(s):  
Critical Thinking ◽  
Student Centered ◽  
History Museum ◽  
University Of Utah ◽  
Domain Specific ◽  
Simulation Based ◽  
Teachers And Students ◽  
Specific Rule ◽  
High Level ◽  
The University

Dino Lab is a serious game designed to explore the potential of using games in scientific domains to support critical thinking. Through collaborations with educators and scientists at the Natural History Museum of Utah (NHMU), game designers and learning scientists at the University of Utah, and Title I middle school teachers and students, the authors have developed a beta version of Dino Lab that supports critical thinking through engagement in a simulation-based game. Dino Lab is organized around four key game stages that incorporate high-level goals, domain-specific rule algorithms that govern legal plays and resulting outcomes, embedded reflection questions, and built-in motivational features. Initial play testing has shown positive results, with students highly engaged in strategic game play. Overall, results suggest that games that support critical thinking have strong potential as student-centered, authentic activities that facilitate domain-based engagement and strategic analysis.

scholarly journals Psychometric validation of the needs assessment tool: progressive disease in interstitial lung disease

Thorax ◽  
2017 ◽  
Vol 73 (9) ◽  
pp. 880-883 ◽  
Author(s):  
Miriam J Johnson ◽  
Armita Jamali ◽  
Joy Ross ◽  
Caroline Fairhurst ◽  
Jason Boland ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Needs Assessment ◽  
Assessment Tool ◽  
Clinical Effectiveness ◽  
Psychometric Validation ◽  
Care Needs ◽  
Carer Support ◽  
St George's Respiratory Questionnaire ◽  
Test Retest Reliability

The inter-rater/test–retest reliability and construct validity of a palliative care needs assessment tool in interstitial lung disease (NAT:PD-ILD) were tested using NAT:PD-ILD-guided video-recorded consultations, and NAT:PD-ILD-guided consultations, and patient and carer-report outcomes (St George’s Respiratory Questionnaire (SGRQ)-ILD, Carer Strain Index (CSI)/Carer Support Needs Assessment Tool (CSNAT)). 11/16 items reached at least fair inter-rater agreement; 5 items reached at least moderate test–retest agreement. 4/6 patient constructs demonstrated agreement with SGRQ-I scores (Kendall’s tau-b, 0.24–20.36; P<0.05). 4/7 carer constructs agreed with the CSI/CSNAT items (kappa, 0.23–20.53). The NAT:PD-ILD is reliable and valid. Clinical effectiveness and implementation are to be evaluated.

Further Validation of a Subtle Racism Scale in South Africa

1993 ◽  
Vol 23 (3) ◽  
pp. 116-119 ◽  
Author(s):  
John Duckitt
Keyword(s):  
South Africa ◽  
South African ◽  
Internal Consistency ◽  
White Students ◽  
Strong Correlation ◽  
Subtle Racism ◽  
Preliminary Validation ◽  
Self Reports ◽  
High Level ◽  
The University

Obvious and transparent measures of traditional racism no longer appear to adequately assess anti-black prejudice in more sophisticated samples. This, together with a growing tendency for traditional measures to elicit antagonistic responses from subjects, led in an earlier study to the development and preliminary validation of a South African subtle racism (SR) scale. The current research used a new sample, in which the use of traditional measures of anti-black racism would have been very difficult, to cross-validate the SR scale. It also extended the validation of the SR scale by investigating its association with self-reports of actual interracial behaviour. The findings from 303 white students at the University of the Witwatersrand showed a high level of internal consistency on the SR scale, and a strong correlation with an interracial behavioural intention scale. These findings as well as significant correlations with self-reported interracial behaviour support the validity of the SR scale. Contrary to earlier thinking, the findings also indicate a very powerful relationship between anti-black prejudice and authoritarianism.

scholarly journals Peripheral blood leucocyte telomere length is associated with progression of interstitial lung disease in systemic sclerosis

Thorax ◽  
2021 ◽  
pp. thoraxjnl-2020-215918
Author(s):  
Shuo Liu ◽  
Melody P Chung ◽  
Brett Ley ◽  
Sarah French ◽  
Brett M Elicker ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Telomere Length ◽  
San Francisco ◽  
Longitudinal Analysis ◽  
Peripheral Blood ◽  
Peripheral Blood Leucocyte ◽  
Increased Risk ◽  
The University

BackgroundPeripheral blood leucocyte telomere length (PBL-TL) is associated with outcomes in patients with idiopathic pulmonary fibrosis. Whether PBL-TL is associated with progression of systemic sclerosis-associated interstitial lung disease (SSc-ILD) is unknown.MethodsA retrospective observational cohort study was performed using prospectively collected data from 213 patients with SSc followed at the University of California San Francisco (UCSF) Scleroderma Center. PBL-TL was measured by quantitative PCR of DNA isolated from peripheral blood. Associations between PBL-TL and pulmonary function test trends in patients with SSc-ILD were assessed by longitudinal analysis using Generalised Linear Mixed Models. Findings were validated in a cohort of 61 patients with SSc-ILD enrolled in the Stanford University Scleroderma Center database.ResultsPatients with UCSF SSc with ILD were found to have shorter PBL-TL compared with those without ILD (6554±671 base pairs (bp) vs 6782±698 bp, p=0.01). Shorter PBL-TL was associated with the presence of ILD (adjusted OR 2.1 per 1000 bp TL decrease, 95% CI [1.25 to 3.70], p=0.006). PBL-TL was shorter in patients with SSc-ILD lacking SSc-specific autoantibodies compared with seropositive subjects (6237±647 bp vs 6651±653 bp, p=0.004). Shorter PBL-TL was associated with increased risk for lung function deterioration with an average of 67 mL greater loss in per year for every 1000 bp decrease in PBL-TL in the combined SSc-ILD cohorts (longitudinal analysis, adjusted model: 95% CI −104 mL to −33 mL, p<0.001).ConclusionsThese findings suggest that telomere dysfunction may be associated with SSc-ILD progression and that PBL-TL measurement may be useful for stratifying risk for SSc-ILD progression.

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