scholarly journals Should we care about Plasmodium vivax and HIV co-infection? A systematic review and a cases series from the Brazilian Amazon

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Paola López Del-Tejo ◽  
Nadia Cubas-Vega ◽  
Cecilia Caraballo-Guerra ◽  
Bernardo Maia da Silva ◽  
Jefferson da Silva Valente ◽  
...  
Keyword(s):  
Systematic Review ◽  
Plasmodium Vivax ◽  
Vivax Malaria ◽  
Tertiary Care ◽  
Case Series ◽  
Brazilian Amazon ◽  
Outcome Data ◽  
Malaria Episode ◽  
Tertiary Care Centre ◽  
Cross Sectional

Abstract Background Malaria and HIV are two important public health issues. However, evidence on HIV-Plasmodium vivax co-infection (HIV/PvCo) is scarce, with most of the available information related to Plasmodium falciparum on the African continent. It is unclear whether HIV can change the clinical course of vivax malaria and increase the risk of complications. In this study, a systematic review of HIV/PvCo studies was performed, and recent cases from the Brazilian Amazon were included. Methods Medical records from a tertiary care centre in the Western Brazilian Amazon (2009–2018) were reviewed to identify HIV/PvCo hospitalized patients. Demographic, clinical and laboratory characteristics and outcomes are reported. Also, a systematic review of published studies on HIV/PvCo was conducted. Metadata, number of HIV/PvCo cases, demographic, clinical, and outcome data were extracted. Results A total of 1,048 vivax malaria patients were hospitalized in the 10-year period; 21 (2.0%) were HIV/PvCo cases, of which 9 (42.9%) had AIDS-defining illnesses. This was the first malaria episode in 11 (52.4%) patients. Seven (33.3%) patients were unaware of their HIV status and were diagnosed on hospitalization. Severe malaria was diagnosed in 5 (23.8%) patients. One patient died. The systematic review search provided 17 articles (12 cross-sectional or longitudinal studies and 5 case report studies). A higher prevalence of studies involved cases in African and Asian countries (35.3 and 29.4%, respectively), and the prevalence of reported co-infections ranged from 0.1 to 60%. Conclusion Reports of HIV/PvCo are scarce in the literature, with only a few studies describing clinical and laboratory outcomes. Systematic screening for both co-infections is not routinely performed, and therefore the real prevalence of HIV/PvCo is unknown. This study showed a low prevalence of HIV/PvCo despite the high prevalence of malaria and HIV locally. Even though relatively small, this is the largest case series to describe HIV/PvCo.

scholarly journals Should we care about Plasmodium vivax and HIV co-infection? A systematic review and a cases series from the Brazilian Amazon

2020 ◽  
Author(s):  
Paola López Del-Tejo ◽  
Nadia Cubas-Vega ◽  
Cecilia Caraballo-Guerra ◽  
Bernardo Maia da Silva ◽  
Jefferson da Silva Valente ◽  
...  
Keyword(s):  
Systematic Review ◽  
Plasmodium Vivax ◽  
Vivax Malaria ◽  
Tertiary Care ◽  
Case Series ◽  
Brazilian Amazon ◽  
Outcome Data ◽  
Malaria Episode ◽  
Tertiary Care Centre ◽  
Cross Sectional

Abstract Background Malaria and HIV are two important public health issues. However, evidence on HIV-Plasmodium vivax co-infection (HIV/PvCo) is scarce, with most of the available information related to Plasmodium falciparum on the African continent. It is unclear whether HIV can change the clinical course of vivax malaria and increase the risk of complications. In this study, a systematic review of HIV/PvCo studies was performed, and recent cases from the Brazilian Amazon were included. Methods Medical records from a tertiary care centre in the Western Brazilian Amazon (2009-2018) were reviewed to identify HIV/PvCo hospitalized patients. Demographic, clinical and laboratory characteristics and outcomes are reported. Also, a systematic review of published studies on HIV/PvCo was conducted. Metadata, number of HIV/PvCo cases, demographic, clinical, and outcome data were extracted. Results A total of 1,048 vivax malaria patients were hospitalized in the 10-year period; 21 (2.0%) were HIV/PvCo cases, of which 9 (42.9%) had AIDS-defining illnesses. This was the first malaria episode in 11 (52.4%) patients. Seven (33.3%) patients were unaware of their HIV status and were diagnosed on hospitalization. Severe malaria was diagnosed in 5 (23.8%) patients. One patient died. The systematic review search provided 17 articles (12 cross-sectional or longitudinal studies and 5 case report studies). A higher prevalence of studies involved cases in African and Asian countries (35.3 and 29.4%, respectively), and the prevalence of reported co-infections ranged from 0.1 to 60%. Conclusion Reports of HIV/PvCo are scarce in the literature, with only a few studies describing clinical and laboratory outcomes. Systematic screening for both co-infections is not routinely performed, and therefore the real prevalence of HIV/PvCo is unknown. This study showed a low prevalence of HIV/PvCo despite the high prevalence of malaria and HIV locally. Even though relatively small, this is the largest case series to describe HIV/PvCo.

scholarly journals Should we care about Plasmodium vivax and HIV coinfection? A systematic review and a cases series from the Brazilian Amazon

2020 ◽  
Author(s):  
Paola López Del-Tejo ◽  
Nadia Cubas-Vega ◽  
Cecilia Caraballo-Guerra ◽  
Bernardo Maia da Silva ◽  
Jefferson da Silva Valente ◽  
...  
Keyword(s):  
Systematic Review ◽  
Plasmodium Vivax ◽  
Care Center ◽  
Tertiary Care ◽  
Case Series ◽  
Brazilian Amazon ◽  
Outcome Data ◽  
Malaria Episode ◽  
Cross Sectional ◽  
Systematic Screening

Abstract Background. Malaria and HIV are two important public health issues. However, evidence on HIV-Plasmodium vivax co-infection (HIV/PvCo) is scarce, with most of the available information related to P. falciparum on the African continent. It is unclear whether HIV can change the clinical course of Plasmodium vivax (Pv) malaria, and increase the risk of complications. In this study, we present a systematic review of the HIV/PvCo, and include recent cases from the Brazilian Amazon. Methods. Medical records from a tertiary care center in the Western Brazilian Amazon (2009 - 2018) were reviewed to identify HIV/PvCo hospitalized patients. Demographic, clinical and laboratory characteristics and outcomes are reported. We also performed a systematic review of published studies on HIV/PvCo. Metadata, number of HIV/PvCo cases, demographic, clinical, and outcome data were extracted. Results. A total of 1048 vivax malaria patients were hospitalized in the 10-year period; 21 (2.0%) were HIV/PvCo cases, of which nine (42.9%) had AIDS-defining illnesses. This was the first malaria episode in eleven (52.4%) patients. Seven (33.3%) patients were unaware of their HIV status and were diagnosed on hospitalization. Severe malaria was diagnosed in 5 (23.8%) patients. One patient died. The systematic review search provided 17 articles (12 cross-sectional or longitudinal studies and 5 case report studies). A higher prevalence of studies involved cases in African and Asian countries (35.3% and 29.4%, respectively), and the prevalence of reported co-infections ranged from 0.1 to 60%. Conclusion. Reports of HIV/PvCo are scarce in the literature, with only a few studies describing clinical and laboratory outcomes. Systematic screening for both co-infections is not routinely performed, and therefore, the real prevalence of HIV/PvCo is unknown. This study showed a low prevalence of HIV/PvCo, despite the high prevalence of malaria and HIV locally. Even though relatively small, this is the largest case series to describe HIV/PvCo.

scholarly journals Should We Care About Plasmodium Vivax and HIV Coinfection? A Systematic Review and a Cases Series From the Brazilian Amazon

2020 ◽  
Author(s):  
Paola López Del-Tejo ◽  
Nadia Cubas-Vega ◽  
Cecilia Caraballo-Guerra ◽  
Bernardo Maia da Silva ◽  
Jefferson da Silva Valente ◽  
...  
Keyword(s):  
Systematic Review ◽  
Plasmodium Vivax ◽  
Severe Malaria ◽  
Care Center ◽  
Tertiary Care ◽  
Case Series ◽  
Brazilian Amazon ◽  
African Region ◽  
Cross Sectional ◽  
Hiv Coinfection

Abstract Background. Malaria and HIV are two important public health issues. However, data on HIV-Plasmodium vivax co-infection (HIV/PvCo) is scarce, with most of the available data related to P. falciparum in the African region. It is unclear whether HIV can change the clinical course of Plasmodium vivax (Pv) malaria, and thereby increase the risk of complications. In this study, a systematic review of the HIV/PvCo is presented, including new cases from the Brazilian Amazon. Methods. Medical records from a tertiary care center in the Western Brazilian Amazon (2009 to 2018) were reviewed to identify HIV/PvCo hospitalized patients. Demographic, clinical and laboratory characteristics, and outcomes are reported. We also performed a systematic review of published studies on HIV/PvCo. Metadata, number of HIV/PvCo cases, demographic, clinical, and outcome data were extracted if available. Results. A total of 1048 vivax malaria patients were hospitalized in the 10-year period; 21 (2.0%) were HIV/PvCo cases, of which nine (42.9%) had AIDS-defining illnesses. For eleven (52.4%) patients, this was their first malaria infection. Seven (33.3%) patients were unaware of their HIV status and were diagnosed at hospitalization. Severe malaria criteria were found in 5 (23.8%) patients. One patient died. The systematic review provided 17 articles (12 cross-sectional or longitudinal studies and 5 case report studies). A higher prevalence of studies involved cases in African and Asian countries (35.3% and 29.4%, respectively), and the prevalence of reported co-infections ranged from 0.1 to 60%. Cases of severe malaria-HIV coinfection were not reported. Conclusion. Reports of HIV/PvCo are scarce in the literature, with only a few studies describing clinical and laboratory outcomes. Systematic screening for both co-infections are not performed, and therefore, a realistic prevalence of HIV/PvCo is absent. This study showed a low prevalence of HIV/PvCo, despite local malaria and HIV high prevalence. Even though relatively small, this is the largest case series to describe HIV/PvCo.

scholarly journals Clinical Profile of Concurrent Dengue Fever and Plasmodium vivax Malaria in the Brazilian Amazon: Case Series of 11 Hospitalized Patients

2012 ◽  
Vol 87 (6) ◽  
pp. 1119-1124 ◽  
Author(s):  
Belisa M. L. Magalhães ◽  
André M. Siqueira ◽  
Quique Bassat ◽  
Marcus V. G. Lacerda ◽  
Gisely C. Melo ◽  
...  
Keyword(s):  
Plasmodium Vivax ◽  
Dengue Fever ◽  
Vivax Malaria ◽  
Case Series ◽  
Brazilian Amazon ◽  
Hospitalized Patients ◽  
Clinical Profile ◽  
Plasmodium Vivax Malaria

scholarly journals Clinico-laboratory profile of severe Plasmodium vivax malaria in a tertiary care centre in Kolkata

2013 ◽  
Vol 3 (1) ◽  
pp. 53 ◽  
Author(s):  
Sayantan Ray ◽  
Manjari Saha ◽  
Debojyoti Sarkar ◽  
Arunansu Talukdar ◽  
Amitava Chakraborty
Keyword(s):  
Plasmodium Vivax ◽  
Vivax Malaria ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Plasmodium Vivax Malaria ◽  
Laboratory Profile

scholarly journals A menace to human health: rhino-orbital cerebral mucormycosis

2021 ◽  
Vol 8 (7) ◽  
pp. 3597
Author(s):  
Arvind Sharma ◽  
Aditi Bharti ◽  
Tej Pratap Singh ◽  
Richa Sharma
Keyword(s):  
Diabetes Mellitus ◽  
Corticosteroid Therapy ◽  
Fungal Infections ◽  
Severe Disease ◽  
Tertiary Care ◽  
Case Series ◽  
Care Centre ◽  
Contributing Factors ◽  
Tertiary Care Centre ◽  
Cross Sectional

Collate and interpret data on rhino-orbital-cerebral mucormycosis (ROCM) infections admitted at the tertiary care centre and investigate the common contributing factors leading to such infections and highlighting the relationship of this upsurge seen in patients infected with COVID-19. We conducted a cross-sectional study in Central India, in the period of eleven days (from 9 May to 18 May). A total of ten patients with ROCM was investigated, admitted to the separate ward for mucormycosis in the tertiary care centre. A self-pre-designed questionnaire was used for the evaluation. Verbal consent was obtained from the patients before the start of the study and also ensured the confidentiality of their respective details. Among ten of the patients, six patients were known cases of diabetes mellitus, two of the patients were diagnosed with diabetes mellitus after the initiation of corticosteroid therapy during their treatment and two of them were non-diabetic. All the patients in this case series were on corticosteroid therapy and on oxygen supplementation. Majority of the patients showing mild to moderate disease with unilateral symptoms, although only 10% showed the severe disease with bilateral eye involvement. It is evident that the poor or impaired immune functioning is the leading cause of the upsurge in mucormycosis cases. Therefore, early diagnosis and treatment of fungal infections can substantially reduce morbidity and mortality.

scholarly journals Severity of Plasmodium vivax Malaria in Karachi: a cross-sectional study

2012 ◽  
Vol 6 (09) ◽  
pp. 664-670 ◽  
Author(s):  
Amber Mehmood ◽  
Kiran Ejaz ◽  
Tauqeer Ahmed
Keyword(s):  
Plasmodium Vivax ◽  
Vivax Malaria ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Shock Index ◽  
Sectional Study ◽  
Cross Sectional ◽  
Number Of Patients ◽  
Plasmodium Vivax Malaria

Introduction: Plasmodium vivax malaria affects billions of people annually. This study aimed to note the presentations and complications and subsequently to identify the determinants of in-patient hospital care of P. vivax malaria patients presenting to a tertiary care hospital in Karachi, Pakistan. Severity of the shock was also assessed using a shock index. Methodology: This study descriptive cross-sectional study was conducted at the Emergency Department of Aga Khan University Hospital, Karachi. All adult patients with a positive P. vivax peripheral film and/or immunochromatography admitted through the department were studied during 2009. Data was entered and analyzed using SPSS version 16. Keeping the length of stay at a cut-off of 48 hours after admission, the independent Student-t test was applied. Level of significance was taken at 0.05. Results: A total of 97 patients were included in the study. Fever was the most common presentation. A significant number of patients had nonspecific complaints, but tachycardia, altered mental status, and adult respiratory distress syndrome were important findings. Mean shock index was 1 (SD 0.26). Common reasons for admission were thrombocytopenia and dehydration. Some patients were admitted for more than 48 hours. Complications included pneumonia and bleeding requiring platelet transfusion. Conclusion: This study highlights that the debilitating impact of P. vivax malaria remains high. Although the effects of severe vivax malaria can be contained through aggressive resuscitation and specific therapy, sensitivity and awareness of this complicated course must be highlighted among caregivers.

scholarly journals Sonographic Appearance of Different Presentations of Ascariasis in a Tertiary Care Centre in West Bengal - A Case Series and Review of Imaging Features

2021 ◽  
Vol 8 (18) ◽  
pp. 1206-1211
Author(s):  
Devpriyo Pal ◽  
Narayan Pandit
Keyword(s):  
Tertiary Care ◽  
Case Series ◽  
Imaging Features ◽  
Tertiary Care Centre ◽  
Ultrasound Technique ◽  
Cross Sectional ◽  
Characteristic Appearance ◽  
Abdominal Symptoms ◽  
Imaging Characteristics ◽  
Typical Appearance

BACKGROUND Ascariasis is a type of roundworm infestation caused by the helminth Ascaris lumbricoides. In spite of advancements in the diagnosis and management of ascariasis, it remains one of the commonest infections in the world, especially in the tropical and subtropical countries, causing both acute and chronic illnesses. Ultrasound offers a quick and non-invasive way to diagnose ascariasis of the intestine and hepatobiliary system. In this study we have described the imaging appearance of ascariasis through a series of cases and demonstrated key imaging characteristics according to location. METHODS This is an institution based observational and descriptive study. A cross-sectional study was conducted in the Department of Radiodiagnosis of North Bengal Medical College & Hospital for a period of 15 months (Oct 2018 - Jan 2020). This study was conducted among the patients who were referred to the Department of Radiodiagnosis for evaluation of abdominal symptoms. RESULTS Intestinal and extra-intestinal ascaris worms have a typical appearance which is easily identifiable in on ultrasound, but diagnostic confidence is affected by several factors related to the patient, worms and the ultrasound technique. CONCLUSIONS Ultrasound is a rapid, inexpensive and easily available modality with a high success rate in diagnosing ascariasis and its complications. It is important to be aware of the characteristic appearance of ascaris in the intestines and the hepatopancreato-biliary tree and it must be remembered that the typical appearance is grossly affected by several factors such as the number, whether living or not as well as the luminal distension of the organ. KEYWORDS Ultrasound, Ascariasis, Intestinal Obstruction, Cholecystitis, Cholangitis, Pancreatitis, Appendicitis

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