scholarly journals The relationship between vitamin D and risk of atrial fibrillation: a dose-response analysis of observational studies

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Xiao Liu ◽  
Wei Wang ◽  
Zhaochong Tan ◽  
Xin Zhu ◽  
Menglu Liu ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Dose Response ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Cochrane Library ◽  
Response Analysis ◽  
Serum Vitamin D ◽  
The Relationship

Abstract Background The relationship between serum vitamin D and atrial fibrillation (AF) or postoperative atrial fibrillation (POAF) in patients undergoing coronary artery bypass graft (CABG) is still debated. It is also unclear whether there is a dose-response relationship between circulating vitamin D and the risk of AF or POAF. Methods The Cochrane Library, PubMed, and Embase databases were searched for relevant studies. We used a “one-stage approach” with a restricted cubic spline model to summarize the dose-specific relationships between serum vitamin D and AF. Relative risk (RR) was used to measure the effects in this meta-analysis. Results In total, 13 studies were included with a total of 6519 cases of AF among 74,885 participants. Vitamin D deficiency (< 20 ng/ml) was associated with increased risks of AF (RR: 1.23, 95% CI: 1.05–1.43). In the dose-response analysis, the summary RR for a 10 ng/ml increased in vitamin D was 0.88 (95% CI: 0.78–0.98) and there was no evidence of a non-linear association, Pnon-linearity = 0.86. In the age subgroup, high vitamin D (per 10 ng/ml increase) reduced the risk of AF in the older group (> 65 years) (RR = 0.68, 95% CI = 0.52–0.89) but not among young individuals (< 65 years) (RR = 0.87, 95% CI = 0.72–1.06). In addition, a strong association was found between a 10 ng/ml increased in vitamin D and POAF incident in the patient after CABG (RR: 0.44, 95% CI: 0.24–0.82). Conclusion Our dose-response meta-analysis suggested serum vitamin D deficiency was associated with an increased risk of AF in the general population and POAF in patients after CABG. Further studies are needed to explore the age difference in the association between serum vitamin D level and the risk of AF and whether vitamin D supplements will prevent AF. Trial registration This study has been registered with PROSPERO (International prospective register of systematic reviews)-registration number-CRD42019119258.

scholarly journals The relationship between preoperative serum vitamin D deficiency and postoperative atrial fibrillation: A systematic review and meta-analysis

2021 ◽  
Vol 13 (2) ◽  
pp. 102-108
Author(s):  
Mehran Rahimi ◽  
Mohammadreza Taban-Sadeghi ◽  
Leila Nikniaz ◽  
Fariba Pashazadeh
Keyword(s):  
Atrial Fibrillation ◽  
Systematic Review ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Postoperative Atrial Fibrillation ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Relationship

Postoperative atrial fibrillation (POAF) is the most common arrhythmia seen in the first days following cardiac surgeries. Recently, there is a growing discussion regarding the link between vitamin D deficiency and POAF development. This systematic review and meta-analysis of the observational studies aimed at evaluating the association between preoperative vitamin D deficiency and Postoperative atrial fibrillation. In this study, using PubMed, Scopus, Google Scholar, EMBASE, Web of Science, and Cochrane Libraries, we searched for records published before July 2020. Two reviewers screened for studies that examined the relationship between preoperative vitamin D levels and the generation of POAF. Data regarding study design, patient characteristics, definition of atrial fibrillation (AF) , type of surgery, vitamin D levels, and measurement methods were extracted. Five studies were included in the meta-analysis. Our primary analysis showed a significant relationship between preoperative levels of vitamin D and POAF development (mean differences (MD) = -2.851, 95% confidence interval (CI) =-5.506 to -0.195; P value 0.035). Our meta-analysis suggested serum vitamin D deficiency is associated with an increased risk of POAF development. Further large scale interventional studies are needed to explore whether vitamin D supplementation will prevent POAF.

The association between vitamin D levels and precocious puberty: a meta-analysis

2020 ◽  
Vol 33 (3) ◽  
pp. 427-429
Author(s):  
Shanshan Liu ◽  
Xun Zhu ◽  
Yuanxin Wang ◽  
Shoumeng Yan ◽  
Dong Li ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Precocious Puberty ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Comprehensive Search ◽  
Vitamin D Supplements ◽  
The Relationship

AbstractThe objective of this short communication was the relationship between vitamin D and precocious puberty (PP). In this study, a comprehensive search of multiple databases was performed to identify studies focused on the association between vitamin D deficiency and PP. Studies that compared serum vitamin D levels between patients with PP and controls were selected for the systematic meta-analysis. The main outcome was the mean difference in serum vitamin D levels between PP and controls. Vitamin D-deficient subjects were more likely to develop PP. Our findings suggest that PP may be linked to vitamin D deficiency. Thus, providing supplements of vitamin D to PP patients may improve their nutritional status and prevent diseases. But, the amount of vitamin D required is uncertain, so it is important to be careful when taking vitamin D supplements.

scholarly journals Association Between Vitamin D and Uric Acid in Adults: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 52 (10) ◽  
pp. 732-741
Author(s):  
Ronny Isnuwardana ◽  
Sanjeev Bijukchhe ◽  
Kunlawat Thadanipon ◽  
Atiporn Ingsathit ◽  
Ammarin Thakkinstian
Keyword(s):  
Vitamin D ◽  
Uric Acid ◽  
Vitamin D Deficiency ◽  
Serum Uric Acid ◽  
Serum Uric Acid Level ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Mean Difference ◽  
Serum Vitamin D ◽  
Bidirectional Association

AbstractAssociation between vitamin D and uric acid is complex and might be bidirectional. Our study aimed to determine the bidirectional association between vitamin D and uric acid in adults. Using MEDLINE via PubMed and Scopus, we systematically searched for observational or interventional studies in adults, which assessed the association between serum vitamin D and serum uric acid, extracted the data, and conducted analysis by direct and network meta-analysis. The present review included 32 studies, of which 21 had vitamin D as outcome and 11 had uric acid as outcome. Meta-analysis showed a significant pooled beta coefficient of serum uric acid level on serum 25(OH)D level from 3 studies of 0.512 (95% confidence interval: 0.199, 0.825) and a significant pooled odds ratio between vitamin D deficiency and hyperuricemia of 1.496 (1.141, 1.963). The pooled mean difference of serum 25(OH)D between groups with hyperuricemia and normouricemia was non-significant at 0.138 (−0.430, 0.707) ng/ml, and the pooled mean difference of serum uric acid between categories of 25(OH)D were also non-significant at 0.072 (−0.153, 0.298) mg/dl between deficiency and normal, 0.038 (−0.216, 0.292) mg/dl between insufficiency and normal, and 0.034 (−0.216, 0.283) mg/dl between deficiency and insufficiency. In conclusion, increasing serum uric acid might be associated with increasing 25(OH)D level, while vitamin D deficiency is associated with hyperuricemia. These reverse relationships should be further evaluated in a longitudinal study.

scholarly journals The relationship between serum vitamin D and fracture risk in the elderly: a meta-analysis

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Ning Wang ◽  
Yungang Chen ◽  
Jindou Ji ◽  
Jinlei Chang ◽  
Shengwen Yu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Fracture Risk ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
The Elderly ◽  
Serum Vitamin D ◽  
The Relationship

Relationship between vitamin D level and Bechcet’s disease activity: A systematic review and meta-analysis

2020 ◽  
Vol 90 (5-6) ◽  
pp. 527-534 ◽  
Author(s):  
Alireza Khabbazi ◽  
Morteza Ghojazadeh ◽  
Sakineh Hajebrahimi ◽  
Zeinab Nikniaz
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Healthy Controls ◽  
Behcet's Disease ◽  
Serum Vitamin D

Abstract. Aim: In the present study, the evidence about the association between vitamin D deficiency and Behcet’s disease activity was systematically reviewed and meta-analyzed. Method: We searched the English and Persian databases of Medline (Ovid), CINHAL, Scopus, Proquest, the Cochrane library and SID, IranDoc, Magiran, Iran Medex for articles published up until May 2018 with the keywords were related to serum vitamin D and active and inactive Behcet’s disease in adults. Meta-analysis was done using the CMA software. Results: A total of 138 titles were retrieved and reduced to 80 titles after deletion of duplicates and finally after close assessing of titles and abstracts eight eligible studies including a total of 939 participants were identified for systematic review and meta-analysis. According to the results of the meta-analysis, the pooled effect size of the differences in the serum level of vitamin D in patients with inactive Behçet’s Disease and healthy controls was [OR:−0.05; 95% CI:−2.05, 1.94; p = 0.95]. The serum vitamin D level was significantly lower in active patients compared with healthy controls [OR:1.21; 95%CI: −0.12, 2.31; p = 0.03]. The pooled effect size of the differences in the serum level of vitamin D in active and inactive Behçet’s Disease was [OR:−0.71; 95%CI: −1.41, −0.007; p = 0.04] Conclusion: There is an association between vitamin D deficiency and active Behçet’s Disease. Future studies investigating the association of vitamin D deficiency and Behçet’s Disease needs to involve following information: dietary intake of calcium and vitamin D, measuring of sun exposure, report of drug consumption and physical activity level.

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