scholarly journals Circulating retinol binding protein 4 levels in coronary artery disease: a systematic review and meta-analysis

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Hengying Chen ◽  
Jiaying Zhang ◽  
Jiayu Lai ◽  
Yingyu Zhou ◽  
Xiaoping Lin ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Random Effects ◽  
Meta Analysis ◽  
Case Control ◽  
Retinol Binding Protein ◽  
Random Effects Model ◽  
Case Control Studies ◽  
Retinol Binding Protein 4 ◽  
Artery Disease

Abstract Background Retinol binding protein 4 (RBP4) has been proposed to play a role in the pathophysiology of coronary artery disease (CAD), but previous findings on the association of RBP4 levels with CAD are inconsistent. Methods A meta-analysis based on observational studies was conducted to evaluate the association between circulating RBP4 levels and CAD. Databases including PubMed, Web of Science, Embase, Google Scholar and ClinicalTrials.gov database were searched for eligible studies published up to 12 July 2021. Standard mean differences (SMDs) with 95% confidence intervals (CIs) were calculated using the inverse variance heterogeneity (IVhet) and random-effects model for data with moderate and high heterogeneity (I2 > 30%) and data with low heterogeneity were analysed using a fixed-effects model (I2 ≤ 30%). Moreover, a bias-adjusted quality-effects model was generated, and the prediction interval was also calculated under the random-effects model. Results Two nested case-control studies, one cohort study and twelve case–control studies with a total of 7111 participants were included. Circulating RBP4 levels in patients with CAD were comparable to those in the controls under the IVhet model (SMD: 0.25, 95% CI: − 0.29-0.79, I2: 96.00%). The quality-effects model produced consistent results. However, the association turned to be significant under the random-effect model (SMD: 0.46, 95% CI: 0.17–0.75, I2: 96.00%), whereas the 95% predictive interval (PI) included null values (95% PI: − 0.82-1.74). Subgroup analyses illustrated a positive relationship between CAD and RBP4 levels in patients with complications (SMD: 1.34, 95% CI: 0.38–2.29, I2: 96.00%). The meta-regression analysis revealed that the mean BMI of patients (P = 0.03) and complication status (P = 0.01) influenced the variation in SMD. Conclusions There was low-quality evidence that patients with CAD exhibited similar circulating RBP4 levels compared with controls, and high inter-study heterogeneity was also observed. Thus, RBP4 might not be a potential risk factor for CAD. Comparisons among different subtypes of RBP4 with larger sample size are needed in the future.

scholarly journals Significant association between the endothelial lipase gene 584C/T polymorphism and coronary artery disease risk

2020 ◽  
Vol 40 (9) ◽  
Author(s):  
Yue-e Wu ◽  
Lan Ma ◽  
Hao Zhang ◽  
Xin-ran Chen ◽  
Xin-yi Xu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Disease Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Endothelial Lipase ◽  
Case Control Studies ◽  
Lipase Gene ◽  
Comparison Model ◽  
Artery Disease

Abstract Several studies have investigated a potential association between the endothelial lipase gene (LIPG) 584C/T polymorphism and susceptibility to coronary artery disease (CAD), but a uniform conclusion is yet to be reached. To better evaluate the true relationship between the LIPG 584C/T polymorphism and the risk of CAD, a meta-analysis of 14 case–control studies with 9731 subjects was performed. Relevant articles published through August 2020 were searched in the CNKI, PubMed, Embase and Web of Science databases. Thirteen articles, including 14 eligible case–control studies with 4025 cases and 5706 controls, were enrolled in the present meta-analysis. The Newcastle–Ottawa Scale (NOS) scores of the case–control studies ranged from 6 to 8. The pooled results indicated that there is a significant association between the LIPG 584C/T polymorphism and CAD in the homozygote comparison model and the allelic comparison model. Subgroup analyses revealed that the LIPG 584C/T mutation significantly decreased the risk of CAD in the subgroups of African, CAD, hospital-based (HB), and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) populations in some genetic models. No publication bias was found in our meta-analysis, which certifies the robustness of the current meta-analysis. Trial sequential analysis (TSA) also confirmed the stability of our results. The results of our meta-analysis indicate that the LIPG 584C/T polymorphism plays a protective role in the incidence of CAD. More high-quality case–control studies on various ethnicities are needed to confirm our results.

Association between apolipoprotein E polymorphisms and premature coronary artery disease: a meta-analysis

2017 ◽  
Vol 55 (2) ◽  
Author(s):  
Qiong Rui Zhao ◽  
Yu Ying Lei ◽  
Juan Li ◽  
Nan Jiang ◽  
Jing Pu Shi
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Apolipoprotein E ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Case Control ◽  
Premature Coronary Artery Disease ◽  
Case Control Studies ◽  
Relevant Case ◽  
Artery Disease

AbstractBackground:Although several studies have explored the genetic polymorphisms of apolipoprotein E (Methods:All relevant case-control studies and cohort studies published in Chinese or English prior to March 2016 were searched for in electronic databases. Detailed information concerning each piece of literature was independently extracted by two researchers. We used STATA11.0 to process all data and to determine the pooled odds ratio (OR). Altogether, four genetic models were applied to calculate OR and 95% confidence interval (CI): (1)Results:Eighteen studies concerningConclusions:Our investigation supported the fact that the

Association of C47T polymorphism in SOD2 gene with coronary artery disease: a case–control study and a meta-analysis

2011 ◽  
Vol 39 (5) ◽  
pp. 5269-5276 ◽  
Author(s):  
Changwei Tian ◽  
Tongtao Liu ◽  
Shengxia Fang ◽  
Xunbo Du ◽  
Chongqi Jia
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Artery Disease ◽  
Control Study

scholarly journals Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies

2010 ◽  
Vol 56 (19) ◽  
pp. 1552-1563 ◽  
Author(s):  
Themistocles L. Assimes ◽  
Hilma Hólm ◽  
Sekar Kathiresan ◽  
Muredach P. Reilly ◽  
Gudmar Thorleifsson ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Case Control ◽  
Case Control Studies ◽  
Artery Disease

scholarly journals Clinical Significance of Resistin Expression in Osteoarthritis: A Meta-Analysis

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Xiao-Chuan Li ◽  
Feng Tian ◽  
Fei Wang
Keyword(s):  
Systematic Review ◽  
Random Effects ◽  
Meta Analysis ◽  
Case Control ◽  
Random Effects Model ◽  
Dutch Population ◽  
Review Of Literature ◽  
Case Control Studies ◽  
Stratified Analysis ◽  
Human Resistin

Background. The objective of this study was to conduct a systematic review of literature evaluating human resistin expression as a diagnostic factor in osteoarthritis development and to quantify the overall diagnostic effect.Method. Relevant studies were identified and evaluated for quality through multiple search strategies. Studies analyzing resistin expression in the development of OA were eligible for inclusion. Data from eligible studies were extracted and included into the meta-analysis using a random-effects model.Results. Four case-control studies consisting of a total of 375 OA patients and 214 controls as well as three sex-stratified analyses composed of 53 males and 104 females were incorporated into our meta-analysis. Our results revealed that resistin levels were significantly higher in male OA subjects and OA patients overall. Country-stratified analysis yielded significantly different estimates in resistin levels between male OA subjects and female OA subjects in the Canadian subgroup but not among the French and USA subgroups. Based on the resistin levels in OA cases and controls, resistin levels were heightened in OA patients in the Dutch population.Conclusion. These results support the hypothesis that high expression of resistin represents a significant and reproducible marker of poor progression in OA patients, especially in males.

scholarly journals Retinol Binding Protein 4 Levels relate to the presence and severity of coronary artery disease

2021 ◽  
Author(s):  
Gokay Nar ◽  
Sara Cetin Sanlialp ◽  
Rukiye Nar
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Serum Retinol ◽  
Retinol Binding Protein 4 ◽  
Coronary Syndrome ◽  
Artery Disease ◽  
The Relationship

Background: The prevous studies has showed that serum retinol binding protein 4 (RBP4) levels increased in metobolic disorders which are closely associated with cardiovascular dieases (CVD).  However the human studies investigating the role of RBP4 in CVD are conflicted. Therefore, we aimed to evaluate the relationship between RBP4 and the presence and the severity of coronary artery disease (CAD) in this study. Methods: 55 patients with presenting acute coronary syndrome (ACS) and 43 control subjects who had various cardiovascular risk factors with normal coronary artery on coronary angiography were included in this study.The serum RBP4 concentrations were measured using ELISA method and clinically and anatomically score models were used to asses the severity of coronary lesion. Results: Serum RBP4 level was significantly higher in patients with ACS compared to the controls (68.40 ± 47.94 mg/L vs. 49.46 ± 13.64 mg/L; p = 0.014).  RBP4 was correlated with GENSINI and SYNTAX I score (r = 0,286 p=0,034; r = 0.403 p = 0.002 respectively). However, there was no relationship between RBP4 and GRACE score. Conclusion: Patients with ACS had increased serum RBP4 levels and its high levels were correlated with CAD severity.

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