Thermo-responsive polymer encapsulated gold nanorods for single continuous wave laser-induced photodynamic/photothermal tumour therapy

AbstractOwing to strong and tunable surface plasmon resonance (SPR) effect and good biocompatibility, gold nanoparticles have been suggested to be a versatile platform for a broad range of biomedical applications. In this study, a new nanoplatform of thermo-responsive polymer encapsulated gold nanorods incorporating indocyanine green (ICG) was designed to couple the photothermal properties of gold nanorods (AuNRs) and the photodynamic properties of ICG to enhance the photodynamic/photothermal combination therapy (PDT/PTT). In addition to the significantly increased payload and enhancing photostability of ICG, the polymer shell in the nanoplatform also has thermo-responsive characteristics that can control the release of drugs at tumour sites upon the laser irradiation. On the basis of these improvements, the nanoplatform strongly increased drug aggregation at the tumour site and improved the photothermal/photodynamic therapeutic efficacy. These results suggest that this nanoplatform would be a great potential system for tumour imaging and antitumour therapy.

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Thermo-responsive Polymer Encapsulated Gold Nanorods for Single Continuous Wave Laser-induced Photodynamic/photothermal Tumour Therapy

10.21203/rs.3.rs-94362/v1 ◽

2020 ◽

Author(s):

Wei Li ◽

Beilei Gong ◽

Yuanbing Shen ◽

Huiyan Li ◽

Xiaojun Li ◽

...

Keyword(s):

Gold Nanorods ◽

Biomedical Applications ◽

Continuous Wave ◽

Continuous Wave Laser ◽

Tumour Site ◽

Polymer Shell ◽

Potential System ◽

Responsive Polymer ◽

Good Biocompatibility ◽

Spr Effect

Abstract Owing to strong and tunable surface plasmon resonance (SPR) effect and good biocompatibility, gold nanoparticles have been suggested to be a versatile platform for a broad range of biomedical applications. In this study, a new nanoplatform of thermo-responsive polymer encapsulated gold nanorods incorporating indocyanin green (ICG) was designed to couple the photothermal properties of gold nanorods (AuNRs) and the photodynamic properties of ICG to enhanc the photodynamic/photothermal combination therapy (PDT/PTT). in addition to the significantly increased payload and enhancing photostability of ICG , the polymer shell in the nanoplatform also has thermo-responsive characteristics that can control the release of drugs at tumour sites upon the laser irradiation. On the basis of these improvements, the nanoplatform strongly increased drug aggregation at the tumour site and improved the photothermal/photodynamic therapeutic efficacy. These results suggest that this nanoplatform would be a great potential system for tumour imaging and antitumour therapy.

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Thermo-Responsive Polymer Encapsulated Gold Nanorods for Single Continuous Wave Laser-Induced Photodynamic/ Photothermal Tumour Therapy

10.21203/rs.3.rs-41731/v1 ◽

2020 ◽

Author(s):

Beilei Gong ◽

Yuanbing Shen ◽

Huiyan Li ◽

Xiaojun Li ◽

Xia Huan ◽

...

Keyword(s):

Gold Nanorods ◽

Biomedical Applications ◽

Continuous Wave ◽

Continuous Wave Laser ◽

Tumour Imaging ◽

Tumour Site ◽

Polymer Shell ◽

Potential System ◽

Good Biocompatibility ◽

Spr Effect

Abstract Gold nanoparticles have been proven suggested to be a versatile platform for a broad range of biomedical applications owing to their strong and tunable surface plasmon resonance (SPR) effect and good biocompatibility. In this study, a new nanoplatform composed of thermo-responsivepolymer encapsulated gold nanorods incorporating ICG was designed to couple the photothermal properties of gold nanorods (AuNRs) and the photodynamic properties of ICG for enhanced photodynamic/photothermal combination therapy (PDT/PTT). For the nanoplatform, in addition to significantly increasing theICG payload with the additional benefit of enhancing ICG photostability, the polymer shell also has thermo-responsive characteristics, which can control the release of drugs at tumour sites afterlaser irradiation. On the basis of these improvements, the nanoplatform strongly increased drug aggregation at the tumour site and improvedthe photothermal/photodynamic therapeutic efficacy by inhibiting the growth of tumours in mice aftermild laser irradiation. These results suggest that thisnanoplatform is a great potential system for tumour imaging and antitumour therapy.

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Biomedical Applications: Single Continuous Wave Laser Induced Photodynamic/Plasmonic Photothermal Therapy Using Photosensitizer-Functionalized Gold Nanostars (Adv. Mater. 22/2013)

Advanced Materials ◽

10.1002/adma.201370142 ◽

2013 ◽

Vol 25 (22) ◽

pp. 3009-3009 ◽

Cited By ~ 10

Author(s):

Shouju Wang ◽

Peng Huang ◽

Liming Nie ◽

Ruijun Xing ◽

Dingbin Liu ◽

...

Keyword(s):

Photothermal Therapy ◽

Biomedical Applications ◽

Continuous Wave ◽

Continuous Wave Laser ◽

Gold Nanostars ◽

Wave Laser ◽

Plasmonic Photothermal Therapy

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1848: Revolix 70 Watt 2 Micron Continuous Wave Laser Vaporesection of the Prostate. Preliminary Results After a One Year Follow-Up

The Journal of Urology ◽

10.1016/s0022-5347(18)32021-4 ◽

2007 ◽

Vol 177 (4S) ◽

pp. 614-614

Author(s):

Thorsten Bach ◽

Thomas R.W. Herrmann ◽

Roman Ganzer ◽

Andreas J. Gross

Keyword(s):

Continuous Wave ◽

Continuous Wave Laser ◽

Preliminary Results ◽

Wave Laser ◽

One Year

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Graphene Integrated Hydrogels Based Biomaterials in Photothermal Biomedicine

Nanomaterials ◽

10.3390/nano11040906 ◽

2021 ◽

Vol 11 (4) ◽

pp. 906

Author(s):

Le Minh Tu Phan ◽

Thuy Anh Thu Vo ◽

Thi Xoan Hoang ◽

Sungbo Cho

Keyword(s):

Photothermal Therapy ◽

Biomedical Applications ◽

High Light ◽

Conversion Materials ◽

Potential Applications ◽

Good Biocompatibility ◽

Biomedical Field ◽

Hydrogel Composites ◽

Material Fabrication ◽

Biomedical Fields

Recently, photothermal therapy (PTT) has emerged as one of the most promising biomedical strategies for different areas in the biomedical field owing to its superior advantages, such as being noninvasive, target-specific and having fewer side effects. Graphene-based hydrogels (GGels), which have excellent mechanical and optical properties, high light-to-heat conversion efficiency and good biocompatibility, have been intensively exploited as potential photothermal conversion materials. This comprehensive review summarizes the current development of graphene-integrated hydrogel composites and their application in photothermal biomedicine. The latest advances in the synthesis strategies, unique properties and potential applications of photothermal-responsive GGel nanocomposites in biomedical fields are introduced in detail. This review aims to provide a better understanding of the current progress in GGel material fabrication, photothermal properties and potential PTT-based biomedical applications, thereby aiding in more research efforts to facilitate the further advancement of photothermal biomedicine.

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High-precision optical fiber pressure sensor using frequency-modulated continuous-wave laser interference

AIP Advances ◽

10.1063/5.0035643 ◽

2021 ◽

Vol 11 (2) ◽

pp. 025038

Author(s):

Lang Bai ◽

Gang Zheng ◽

Bin Sun ◽

Xiongxing Zhang ◽

Qiming Sheng ◽

...

Keyword(s):

Optical Fiber ◽

High Precision ◽

Pressure Sensor ◽

Continuous Wave ◽

Continuous Wave Laser ◽

Laser Interference ◽

Wave Laser

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Injectable keratin hydrogels as hemostatic and wound dressing materials

Biomaterials Science ◽

10.1039/d1bm00135c ◽

2021 ◽

Author(s):

Ao Tang ◽

Ying Li ◽

Yiqian Yao ◽

Xuexia Yang ◽

Zhangjun Cao ◽

...

Keyword(s):

Wound Dressing ◽

Biomedical Applications ◽

Injectable Hydrogels ◽

Good Biocompatibility ◽

Dressing Materials ◽

Administration Procedure ◽

Wound Dressing Materials

Injectable hydrogels hold promise in biomedical applications due to their noninvasive administration procedure, and capacity enabling the filling of irregularly shaped defects. Protein-based hydrogels provide features including good biocompatibility and...

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