Association between serum zinc levels and lung cancer: a meta-analysis of observational studies

Objective This meta-analysis was conducted to examine the possible association between serum zinc concentration and cervical cancer risk. Methods PubMed, WanFang, China National Knowledge Infrastructure, and SinoMed databases were searched for relevant articles published between January 1980 and September 2017. Results were combined using a random-effects model, and pooled standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated to compare serum zinc levels in patients with cervical cancer versus controls. Publication bias was evaluated using Begg’s funnel plot and Egger’s regression asymmetry test. Results Twelve articles regarding serum zinc levels and cervical cancer were included in this meta-analysis. Combined results showed that serum zinc levels in cervical cancer cases were significantly lower than in controls without cervical cancer (summary SMD –1.379, 95% CI –1.527, –1.231), with high heterogeneity ( I2 = 98.8%). Analysis of data stratified by geographic location showed a significant association between serum zinc levels and cervical cancer risk in Asian populations (summary SMD –1.391, 95% CI –1.543, –1.239). Conclusions Higher serum zinc levels may be a protective factor for cervical cancer in Asian women.

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Association between serum zinc levels and recurrent aphthous stomatitis: a meta-analysis with trial sequential analysis

Clinical Oral Investigations ◽

10.1007/s00784-020-03704-8 ◽

2021 ◽

Vol 25 (2) ◽

pp. 407-415

Author(s):

Sadeq A. Al-Maweri ◽

Esam Halboub ◽

Hesham Mohammed Al-Sharani ◽

Anas Shamala ◽

Ahlam Al-Kamel ◽

...

Keyword(s):

Sequential Analysis ◽

Meta Analysis ◽

Serum Zinc ◽

Recurrent Aphthous Stomatitis ◽

Aphthous Stomatitis ◽

Trial Sequential Analysis ◽

Zinc Levels ◽

Serum Zinc Levels

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Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta‐analysis

Dermatologic Therapy ◽

10.1111/dth.14252 ◽

2020 ◽

Vol 33 (6) ◽

Author(s):

Brittany E. Yee ◽

Phillip Richards ◽

Jennifer Y. Sui ◽

Amanda Fleming Marsch

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Acne Vulgaris ◽

Serum Zinc ◽

Zinc Treatment ◽

Zinc Levels ◽

Serum Zinc Levels

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Cord blood zinc status effects on pregnancy outcomes and its relation with maternal serum zinc levels: a systematic review and meta-analysis

World Journal of Pediatrics ◽

10.1007/s12519-019-00305-8 ◽

2019 ◽

Vol 16 (4) ◽

pp. 366-376 ◽

Cited By ~ 5

Author(s):

Sevginur Akdas ◽

Nuray Yazihan

Keyword(s):

Systematic Review ◽

Cord Blood ◽

Pregnancy Outcomes ◽

Meta Analysis ◽

Serum Zinc ◽

Maternal Serum ◽

Zinc Status ◽

Zinc Levels ◽

Blood Zinc ◽

Serum Zinc Levels

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Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials

BioMed Research International ◽

10.1155/2017/1024769 ◽

2017 ◽

Vol 2017 ◽

pp. 1-11 ◽

Cited By ~ 12

Author(s):

Ling-Jun Wang ◽

Ming-Qing Wang ◽

Rong Hu ◽

Yi Yang ◽

Yu-Sheng Huang ◽

...

Keyword(s):

Systematic Review ◽

Nutritional Status ◽

Subgroup Analysis ◽

Zinc Supplementation ◽

Meta Analysis ◽

Serum Zinc ◽

Maintenance Hemodialysis ◽

Randomized Controlled ◽

Zinc Levels ◽

Serum Zinc Levels

We aimed to examine the effects of zinc supplementation on nutritional status, lipid profile, and antioxidant and anti-inflammatory therapies in maintenance hemodialysis (MHD) patients. We performed a systematic review and meta-analysis of randomized, controlled clinical trials of zinc supplementation. Metaregression analyses were utilized to determine the cause of discrepancy. Begg and Egger tests were performed to assess publication bias. Subgroup analysis was utilized to investigate the effects of zinc supplementation in certain conditions. In the crude pooled results, we found that zinc supplementation resulted in higher serum zinc levels (weighted mean difference [WMD] = 28.489;P<0.001), higher dietary protein intake (WMD = 8.012;P<0.001), higher superoxide dismutase levels (WMD = 357.568;P=0.001), and lower levels of C-reactive protein (WMD = −8.618;P=0.015) and malondialdehyde (WMD = −1.275;P<0.001). The results showed no differences in lipid profile. In the metaregression analysis, we found that serum zinc levels correlated positively with intervention time (β=0.272;P=0.042) and varied greatly by ethnicity (P=0.023). Results from Begg and Egger tests showed that there was no significant bias in our meta-analysis (P>0.1). Results of subgroup analysis supported the above results. Our analysis shows that zinc supplementation may benefit the nutritional status of MHD patients and show a time-effect relationship.

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Significance of erythrocyte and serum zinc levels in lung cancer patients.

Haigan ◽

10.2482/haigan.30.513 ◽

1990 ◽

Vol 30 (4) ◽

pp. 513-520

Author(s):

Shoichi Inoue ◽

Osamu Nakajima ◽

Hiroshi Miyamoto ◽

Yoshikazu Kawakami ◽

Masami Ito

Keyword(s):

Lung Cancer ◽

Cancer Patients ◽

Serum Zinc ◽

Lung Cancer Patients ◽

Zinc Levels ◽

Serum Zinc Levels

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Association between Serum Zinc Levels and T-Cell Subsets in Patients with Lung Cancer

Tuberculosis and Respiratory Diseases ◽

10.4046/trd.1988.35.2.120 ◽

1988 ◽

Vol 35 (2) ◽

pp. 120-124

Author(s):

Sun Young Kim ◽

Jae Man Nam ◽

Kyoung Joo Rhee ◽

Kyung Sun Son

Keyword(s):

Lung Cancer ◽

T Cell ◽

Serum Zinc ◽

T Cell Subsets ◽

Zinc Levels ◽

Serum Zinc Levels

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The Relationship between Serum Zinc Level and Heart Failure: A Meta-Analysis

BioMed Research International ◽

10.1155/2018/2739014 ◽

2018 ◽

Vol 2018 ◽

pp. 1-9 ◽

Cited By ~ 2

Author(s):

Xuefang Yu ◽

Lei Huang ◽

Jinyan Zhao ◽

Zhuoqun Wang ◽

Wei Yao ◽

...

Keyword(s):

Heart Failure ◽

Subgroup Analysis ◽

Meta Analysis ◽

Serum Zinc ◽

Idiopathic Dilated Cardiomyopathy ◽

Case Control Studies ◽

Control Subjects ◽

Zinc Levels ◽

The Relationship ◽

Serum Zinc Levels

Zinc is essential for the maintenance of normal cellular structure and functions. Zinc dyshomeostasis can lead to many diseases, such as cardiovascular disease. However, there are conflicting reports on the relationship between serum zinc levels and heart failure (HF). The purpose of the present study is to explore the relationship between serum zinc levels and HF by using a meta-analysis approach. PubMed, Web of Science, and OVID databases were searched for reports on the association between serum zinc levels and HF until June 2016. 12 reports with 1453 subjects from 27 case-control studies were chosen for the meta-analysis. Overall, the pooled analysis indicated that patients with HF had lower zinc levels than the control subjects. Further subgroup analysis stratified by different geographic locations also showed that HF patients had lower zinc levels than the control subjects. In addition, subgroup analysis stratified by HF subgroups found that patients with idiopathic dilated cardiomyopathy (IDCM) had lower zinc levels than the control subjects, except for patients with ischemic cardiomyopathy (ICM). In conclusion, the results of the meta-analysis indicate that there is a significant association between low serum zinc levels and HF.

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