Association Between Serum Zinc Levels and the Risk of Parkinson’s Disease: a Meta-Analysis

2017 ◽  
Vol 179 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Hualei Sun ◽  
Xinxin Liu ◽  
Huina Ge ◽  
Teng Wang ◽  
Yan Wang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Meta Analysis ◽  
Serum Zinc ◽  
Zinc Levels ◽  
Serum Zinc Levels

scholarly journals Correlation between Serum Zinc Levels and Levodopa in Parkinson’s Disease

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4114
Author(s):  
Hirofumi Matsuyama ◽  
Keita Matsuura ◽  
Hidehiro Ishikawa ◽  
Yoshinori Hirata ◽  
Natsuko Kato ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Zinc Deficiency ◽  
Clinical Symptoms ◽  
Psychiatric Symptoms ◽  
Serum Zinc ◽  
Dosing Frequency ◽  
The Mean ◽  
Zinc Levels ◽  
Serum Zinc Levels

Long-term intake of potential zinc-chelating drugs may cause zinc deficiency. We postulated that zinc deficiency in Parkinson’s disease (PD) patients was related to the intake of drugs such as levodopa. We investigated the relationship between zinc levels and levodopa administration period, dosage, and symptoms of zinc deficiency in PD patients. We measured serum zinc levels and analyzed correlations between serum zinc levels, the levodopa oral administration period, dosage, dosing frequency, and zinc deficiency symptoms including taste disorders. Data analyses were performed using Spearman’s rank correlation coefficient. The mean serum zinc level was 60.5 ± 11.6 μg/dL. The mean administration period for levodopa was 8.0 ± 5.5 years, mean administration frequency 3.4 ± 0.9 times/d, and mean administration dose 420.6 ± 237.1 mg/d. Negative correlations between zinc levels and levodopa dosage and dosing frequency were found. Multiple regression analysis showed a significant correlation with the frequency of levodopa (β = −0.360, p = 0.007). No significant change in clinical symptoms was observed after zinc administration, but anxiety tended to improve. Our results indicated that frequent levodopa administration strongly influenced serum zinc levels which may have alleviating effects on psychiatric symptoms; therefore, preventing zinc deficiency can be important during PD treatment.

scholarly journals Higher serum zinc levels may reduce the risk of cervical cancer in Asian women: A meta-analysis

2018 ◽  
Vol 46 (12) ◽  
pp. 4898-4906 ◽  
Author(s):  
Yueying Xie ◽  
Junjie Wang ◽  
Xiaoya Zhao ◽  
Xuli Zhou ◽  
Xiaohui Nie ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Protective Factor ◽  
Meta Analysis ◽  
Serum Zinc ◽  
Asian Women ◽  
China National Knowledge Infrastructure ◽  
Cervical Cancer Risk ◽  
Zinc Levels ◽  
Serum Zinc Levels

Objective This meta-analysis was conducted to examine the possible association between serum zinc concentration and cervical cancer risk. Methods PubMed, WanFang, China National Knowledge Infrastructure, and SinoMed databases were searched for relevant articles published between January 1980 and September 2017. Results were combined using a random-effects model, and pooled standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated to compare serum zinc levels in patients with cervical cancer versus controls. Publication bias was evaluated using Begg’s funnel plot and Egger’s regression asymmetry test. Results Twelve articles regarding serum zinc levels and cervical cancer were included in this meta-analysis. Combined results showed that serum zinc levels in cervical cancer cases were significantly lower than in controls without cervical cancer (summary SMD –1.379, 95% CI –1.527, –1.231), with high heterogeneity ( I2 = 98.8%). Analysis of data stratified by geographic location showed a significant association between serum zinc levels and cervical cancer risk in Asian populations (summary SMD –1.391, 95% CI –1.543, –1.239). Conclusions Higher serum zinc levels may be a protective factor for cervical cancer in Asian women.

Association between serum zinc levels and recurrent aphthous stomatitis: a meta-analysis with trial sequential analysis

2021 ◽  
Vol 25 (2) ◽  
pp. 407-415
Author(s):  
Sadeq A. Al-Maweri ◽  
Esam Halboub ◽  
Hesham Mohammed Al-Sharani ◽  
Anas Shamala ◽  
Ahlam Al-Kamel ◽  
...  
Keyword(s):  
Sequential Analysis ◽  
Meta Analysis ◽  
Serum Zinc ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Trial Sequential Analysis ◽  
Zinc Levels ◽  
Serum Zinc Levels

Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta‐analysis

2020 ◽  
Vol 33 (6) ◽  
Author(s):  
Brittany E. Yee ◽  
Phillip Richards ◽  
Jennifer Y. Sui ◽  
Amanda Fleming Marsch
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Acne Vulgaris ◽  
Serum Zinc ◽  
Zinc Treatment ◽  
Zinc Levels ◽  
Serum Zinc Levels

scholarly journals Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Ling-Jun Wang ◽  
Ming-Qing Wang ◽  
Rong Hu ◽  
Yi Yang ◽  
Yu-Sheng Huang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Nutritional Status ◽  
Subgroup Analysis ◽  
Zinc Supplementation ◽  
Meta Analysis ◽  
Serum Zinc ◽  
Maintenance Hemodialysis ◽  
Randomized Controlled ◽  
Zinc Levels ◽  
Serum Zinc Levels

We aimed to examine the effects of zinc supplementation on nutritional status, lipid profile, and antioxidant and anti-inflammatory therapies in maintenance hemodialysis (MHD) patients. We performed a systematic review and meta-analysis of randomized, controlled clinical trials of zinc supplementation. Metaregression analyses were utilized to determine the cause of discrepancy. Begg and Egger tests were performed to assess publication bias. Subgroup analysis was utilized to investigate the effects of zinc supplementation in certain conditions. In the crude pooled results, we found that zinc supplementation resulted in higher serum zinc levels (weighted mean difference [WMD] = 28.489;P<0.001), higher dietary protein intake (WMD = 8.012;P<0.001), higher superoxide dismutase levels (WMD = 357.568;P=0.001), and lower levels of C-reactive protein (WMD = −8.618;P=0.015) and malondialdehyde (WMD = −1.275;P<0.001). The results showed no differences in lipid profile. In the metaregression analysis, we found that serum zinc levels correlated positively with intervention time (β=0.272;P=0.042) and varied greatly by ethnicity (P=0.023). Results from Begg and Egger tests showed that there was no significant bias in our meta-analysis (P>0.1). Results of subgroup analysis supported the above results. Our analysis shows that zinc supplementation may benefit the nutritional status of MHD patients and show a time-effect relationship.

scholarly journals RPL6: A Key Molecule Regulating Zinc- and Magnesium-Bound Metalloproteins of Parkinson’s Disease

2021 ◽  
Vol 15 ◽  
Author(s):  
Athira Anirudhan ◽  
Paola Isabel Angulo-Bejarano ◽  
Prabu Paramasivam ◽  
Kalaivani Manokaran ◽  
S. Manjunath Kamath ◽  
...  
Keyword(s):  
Gene Expression ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Meta Analysis ◽  
Trace Element Analysis ◽  
Serum Zinc ◽  
Metal Exposure ◽  
Pcr Analysis ◽  
Element Analysis ◽  
Peripheral Blood Mononuclear

Parkinson’s disease (PD) is a progressive neurodegenerative disease with no definite molecular markers for diagnosis. Metal exposure may alter cellular proteins that contribute to PD. Exploring the cross-talk between metal and its binding proteins in PD could reveal a new strategy for PD diagnosis. We performed a meta-analysis from different PD tissue microarray datasets to identify differentially expressed genes (DEGs) common to the blood and brain. Among common DEGs, we extracted 280 metalloprotein-encoding genes to construct protein networks describing the regulation of metalloproteins in the PD blood and brain. From the metalloprotein network, we identified three important functional hubs. Further analysis shows 60S ribosomal protein L6 (RPL6), a novel intermediary molecule connecting the three hubs of the metalloproteins network. Quantitative real-time PCR analysis showed that RPL6 was downregulated in PD peripheral blood mononuclear cell (PBMC) samples. Simultaneously, trace element analysis revealed altered serum zinc and magnesium concentrations in PD samples. The Pearson’s correlation analysis shows that serum zinc and magnesium regulate the RPL6 gene expression in PBMC. Thus, metal-regulating RPL6 acts as an intermediary molecule connecting the three hubs that are functionally associated with PD. Overall our study explores the understanding of metal-mediated pathogenesis in PD, which provides a serum metal environment regulating the cellular gene expression that may light toward metal and gene expression-based biomarkers for PD diagnosis.

scholarly journals The Relationship between Serum Zinc Level and Heart Failure: A Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Xuefang Yu ◽  
Lei Huang ◽  
Jinyan Zhao ◽  
Zhuoqun Wang ◽  
Wei Yao ◽  
...  
Keyword(s):  
Heart Failure ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Serum Zinc ◽  
Idiopathic Dilated Cardiomyopathy ◽  
Case Control Studies ◽  
Control Subjects ◽  
Zinc Levels ◽  
The Relationship ◽  
Serum Zinc Levels

Zinc is essential for the maintenance of normal cellular structure and functions. Zinc dyshomeostasis can lead to many diseases, such as cardiovascular disease. However, there are conflicting reports on the relationship between serum zinc levels and heart failure (HF). The purpose of the present study is to explore the relationship between serum zinc levels and HF by using a meta-analysis approach. PubMed, Web of Science, and OVID databases were searched for reports on the association between serum zinc levels and HF until June 2016. 12 reports with 1453 subjects from 27 case-control studies were chosen for the meta-analysis. Overall, the pooled analysis indicated that patients with HF had lower zinc levels than the control subjects. Further subgroup analysis stratified by different geographic locations also showed that HF patients had lower zinc levels than the control subjects. In addition, subgroup analysis stratified by HF subgroups found that patients with idiopathic dilated cardiomyopathy (IDCM) had lower zinc levels than the control subjects, except for patients with ischemic cardiomyopathy (ICM). In conclusion, the results of the meta-analysis indicate that there is a significant association between low serum zinc levels and HF.

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