scholarly journals Dynamic alteration of serum testosterone with aging: a cross-sectional study from Shanghai, China

2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Zhangshun Liu ◽  
Jie Liu ◽  
Xiaohong Shi ◽  
Lihong Wang ◽  
Yan Yang ◽  
...  
Keyword(s):  
Serum Testosterone ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Dynamic Alteration

scholarly journals Testosterone substitution of hypogonadal men prevents the age-dependent increases in body mass index, body fat and leptin seen in healthy ageing men: results of a cross-sectional study

2002 ◽  
pp. 505-511 ◽  
Author(s):  
C Rolf ◽  
S von Eckardstein ◽  
U Koken ◽  
E Nieschlag
Keyword(s):  
Fat Mass ◽  
Serum Testosterone ◽  
Cross Sectional Study ◽  
Fat Content ◽  
Sectional Study ◽  
Cross Sectional ◽  
Serum Leptin ◽  
Testosterone Substitution ◽  
Age Dependent ◽  
Total Fat

INTRODUCTION: In healthy men, body weight and total fat content increase with advancing age, while serum testosterone levels decrease. In order to elucidate whether a causal relationship between these phenomena exists, we investigated the influence of testosterone or human chorionic gonadotrophin substitution on body mass index (BMI), total fat mass and serum leptin in testosterone-treated and untreated hypogonadal patients in comparison with ageing eugonadal men. METHODS: In a cross-sectional study, the inter-relationships of body weight, total fat mass, serum sex hormones and leptin were analysed in untreated hypogonadal men (n=24; age 19-65 years), treated hypogonadal men (n=61; age 20-67 years) and healthy eugonadal men (n=60; age 24-78 years). Total fat mass was assessed by bioimpedance measurement. Univariate and multiple linear regression analysis was used to detect possible differences. RESULTS: In eugonadal men, serum testosterone levels decreased with advancing age (correlation coefficients: r=-0.71; P<0.0001), while BMI (r=0.39; P=0.002), total fat content (r=0.51; P<0.0001) and leptin (r=0.48; P<0.0001) increased significantly. In untreated hypogonadal patients, an increase in BMI (r=0.50; P=0.013) and total fat mass (r=0.41; P=0.044) was also observed with advancing age. However, in substituted hypogonadal patients, no age-dependent change in BMI (r=0.067; P=0.606), body fat content (r=-0.083; P=0.522), serum testosterone (r=-0,071; P=0.59) or serum leptin (r=-0.23; P=0.176) was found. CONCLUSION: Since testosterone-substituted older hypogonadal men show BMI and fat mass similar to those of younger eugonadal men and since non-treated hypogonadal men are similar to normal ageing men, testosterone appears to be an important factor contributing to these changes. Thus ageing men should benefit from testosterone substitution as far as body composition is concerned.

scholarly journals Comparison of Plasma Neurosteroid and Prolactin Levels in Patients with Schizophrenia and Healthy Individuals

Scientifica ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Forough Riahi ◽  
Maryam Izadi-mazidi ◽  
Ali Ghaffari ◽  
Elham Yousefi ◽  
Shahram Khademvatan
Keyword(s):  
Analysis Of Variance ◽  
Serum Testosterone ◽  
Cross Sectional Study ◽  
Serum Testosterone Level ◽  
First Episode ◽  
Healthy Individuals ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hormone Levels ◽  
First Episode Schizophrenia

Background.The present study aimed to compare plasma levels of cortisol, testosterone, dehydroepiandrosterone (DHEA), and prolactin in patients with schizophrenia and healthy individuals.Method.A total of 100 patients with schizophrenia disorder (69 men and 31 women) and 190 healthy individuals (94 men and 96 women) participated in this cross-sectional study. They were tested for hormone levels and completed demographic questionnaires. Data were analyzed using multivariate analysis of variance (MANOVA) and one-way analysis of variance.Results.Serum testosterone level was significantly higher in men with schizophrenia than in healthy men. Women with schizophrenia had a significantly higher level of testosterone and lower level of prolactin compared to healthy women. There were no significant differences in hormone levels across various subtypes of schizophrenia. No significant differences also were observed in hormones levels in patients with first-episode schizophrenia disorder compared to those in patients with recurrent episodes.Conclusion.This study indicated that abnormal testosterone and prolactin levels might be associated with pathophysiology of schizophrenia disorder.

scholarly journals Serum Testosterone Level in Type 2 Diabetes Mellitus

2021 ◽  
pp. 517-522
Author(s):  
Mubeena Laghari ◽  
Shazia Murtaza ◽  
Zuha Talpur ◽  
Khalil Ahmed Memon ◽  
Aneela Tehzeen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Testosterone ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Male Type ◽  
Type 2 Diabetics

Aim: To determine the serum testosterone levels in the type 2 diabetes mellitus and its correlation with biochemical parameters of glycemic and lipid metabolism. Methodology: A cross sectional study was conducted at Department of Biochemistry and Department of Medicine, A cross sectional study was conducted at the Department of Biochemistry, Diabetic outpatient department and Department of Medicine, Liaquat University Hospital. Male type 2 diabetics (n=100) and age matched male (n=100) were included as cases and control for study purpose. Diagnosed cases of type 2 DM, male gender and 40 – 60 years of age were included in the study protocol. Physical examination of male type 2 diabetics was performed by a consultant physician. Sera were separated from blood and stored in refrigerators at – 200C. Blood glucose, A1C, and blood lipids (cholesterol, triglycerides, LDLc and HDLc) were detected by standard laboratory methods. Serum testosterone was measured by ELISA (competitive immuno- assay) assay commercial kit. Data was entered in Statistical software SPSS 21.0 version (IBM, Incorp, USA) for statistical analysis (P≤0.05). Results: Mean±SD age of male type 2 diabetics was 53.2 ± 11.1 years compared to 54.5±10.4 years in control (P=0.056). Serum Testosterone in cases was 10.85±4.7 mmol/L compared to 13.39±3.8mmol/L in control (P=0.0001). Low testosterone level was noted in 46% male.Serum Testosterone shows inverse correlation with RBG (r= -0.31, P=0.003), A1C (r= -0.23, P=0.014), Cholesterol (r= -0.24, P=0.014), TAGs (r= --0.78, P=0.0001) and HDLc(r= -0.70, P=0.0001). Serum testosterone proved positively correlated with LDLc(r= 0.670, P=0.0001). Conclusion: The present study finds low serum testosterone in male type 2 diabetes mellitus patients

Serum Testosterone Levels Are Positively Associated With Serum Anti-mullerian Hormone Levels in Infertile Women

2021 ◽  
Author(s):  
Li-Te Lin ◽  
Chia-Jung Li ◽  
Kuan-Hao Tsui
Keyword(s):  
Ovarian Reserve ◽  
Binary Logistic Regression ◽  
Serum Testosterone ◽  
Cross Sectional Study ◽  
Regression Analyses ◽  
Sectional Study ◽  
Androgen Excess ◽  
Cross Sectional ◽  
Infertile Women ◽  
The Relationship

Abstract Anti-Mullerian hormone (AMH) and testosterone (T) both play distinct roles in the early stages of folliculogenesis. However, the relationship between serum T and AMH levels is poorly understood. This study aimed to investigate the association between serum T and AMH levels in infertile women. A total of 1,935 infertile women aged 20 to 46 years were included in the cross-sectional study and divided into four quartile groups (Q1 to Q4) based on serum T levels. Compared to the subjects in the highest T quartile (Q4), those in the lowest T quartile (Q1) showed significantly lower AMH levels. After adjustment for age, body weight, body mass index and FSH, increasing T quartile categories were associated with higher AMH levels. Binary logistic regression analyses revealed that the odds for the risk of diminished ovarian reserve (DOR) were 11.44-fold higher in Q1 than in Q4 and the odds for the risk of excess ovarian reserve (EOR) were 10.41-fold higher in Q4 than in Q1. Our data show that serum T levels are positively associated with serum AMH levels and suggest that androgen insufficiency may be a potential risk factor for DOR; androgen excess may lead to EOR in infertile women.

scholarly journals Serum testosterone levels are positively associated with serum anti-mullerian hormone levels in infertile women

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Li-Te Lin ◽  
Chia-Jung Li ◽  
Kuan-Hao Tsui
Keyword(s):  
Ovarian Reserve ◽  
Binary Logistic Regression ◽  
Serum Testosterone ◽  
Cross Sectional Study ◽  
Regression Analyses ◽  
Sectional Study ◽  
Androgen Excess ◽  
Cross Sectional ◽  
Infertile Women ◽  
The Relationship

AbstractAnti-Mullerian hormone (AMH) and testosterone (T) both play distinct roles in the early stages of folliculogenesis. However, the relationship between serum T and AMH levels is poorly understood. This study aimed to investigate the association between serum T and AMH levels in infertile women. A total of 1935 infertile women aged 20–46 years were included in the cross-sectional study and divided into four quartile groups (Q1 to Q4) based on serum T levels. Compared to the subjects in the highest T quartile (Q4), those in the lowest T quartile (Q1) showed significantly lower AMH levels. After adjustment for age, body weight, body mass index and FSH, increasing T quartile categories were associated with higher AMH levels. Binary logistic regression analyses revealed that the odds for the risk of diminished ovarian reserve (DOR) were 11.44-fold higher in Q1 than in Q4 and the odds for the risk of excess ovarian reserve (EOR) were 10.41-fold higher in Q4 than in Q1. Our data show that serum T levels are positively associated with serum AMH levels and suggest that androgen insufficiency may be a potential risk factor for DOR; androgen excess may lead to EOR in infertile women.

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