scholarly journals Collagen triple helix repeat containing-1 negatively regulated by microRNA-30c promotes cell proliferation and metastasis and indicates poor prognosis in breast cancer

2017 ◽  
Vol 36 (1) ◽  
Author(s):  
Yuan-hui Lai ◽  
Jian Chen ◽  
Xiao-ping Wang ◽  
Yan-qing Wu ◽  
Hai-tao Peng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Poor Prognosis ◽  
Triple Helix ◽  
Collagen Triple Helix ◽  
Proliferation And Metastasis ◽  
Cell Proliferation And Metastasis

microRNA-30e-5p Up-Regulation Subdues Osteosarcoma Cell Proliferation and Metastasis via Regulating Collagen Triple Helix Repeat Containing 1

2021 ◽  
Vol 11 (9) ◽  
pp. 1683-1690
Author(s):  
Yong Duan ◽  
Jin Hai Tan ◽  
Sheng Xiang Tao ◽  
SiYi Liu ◽  
Qian Jin Zheng
Keyword(s):  
Cell Proliferation ◽  
Distant Metastasis ◽  
Poor Prognosis ◽  
Triple Helix ◽  
Osteosarcoma Cell ◽  
Clinical Indicators ◽  
Qrt Pcr ◽  
Collagen Triple Helix ◽  
Proliferation And Metastasis ◽  
Cell Proliferation And Metastasis

The cancerous and matched para-carcinoma tissues were gained from total of 40 patients with OS, miR-30e-5p level was monitored through qRT-PCR, and the relevance between abnormal expressed miR-30e-5p and clinical indicators was uncovered. Simultaneously, miR-30e-5p expressive level in common-applied OS cells was detected by qRT-PCR. Additionally, miR-30e-5p suppression and overexpression models were constructed, and CCK-8 and transwell procedures were subsequently executed to analyze the influences of miR-30e-5p in OS cells. Further, relation between miR-30e-5p and CTHRC1 was forecased, meanwhile CTHRC1 function in miR-30e-5p-modulated OS cells was explored. Low expressed miR-30e-5p is linked to the distant metastasis and poor prognosis, which may restrain the malignant progression of OS by targeting CTHRC1.

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