scholarly journals Hypertrophic cardiomyopathy in infant newborns of diabetic mother: a heterogeneous condition, the importance of anamnesis, physical examination and follow-up

2021 ◽  
Vol 47 (1) ◽  
Author(s):  
Alessia Claudia Codazzi ◽  
Rosario Ippolito ◽  
Cecilia Novara ◽  
Enrico Tondina ◽  
Rosa Maria Cerbo ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Glycemic Control ◽  
Physical Examination ◽  
Pediatric Population ◽  
First Case ◽  
Pediatric Cardiomyopathy ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Abstract Background Hypertrophic cardiomyopathy (HCM) in neonates is a rare and heterogeneous disorder. HCM accounts for 25 to 40% of all pediatric cardiomyopathy cases and the highest incidence in pediatric population is reported in children < 1 year. Case presentation we report two clinical cases of neonates, born to mothers respectively with a pre-pregnancy insulin-dependent diabetic mellitus type 2 and a suspected diabetes, with inadequate prenatal glycemic control for the first and underestimated glycemic control for the second case, with a different evolution. In the first case, a slow evidence of improvement of the HCM was observed, persuading us to the diagnosis of a diabetes-related HCM; In the second case the progressive worsening of the HCM during follow-up in association with further investigations, resulted in the diagnosis of Pompe disease. Conclusions Hypertrophic cardiomyopathy in newborns can be the clinical expression of different underlying disorders. We aim to show the importance both to reassess maternal and family history and critically evaluate the physical examination in order to address the correct differential diagnosis. Furthermore it is important to continue a regular cardiologic follow-up for this pathology with neonatal onset to prevent a poor prognosis.

scholarly journals A controlled trial of a high fibre, low fat and low sodium diet for mild hypertension in type 2 (non-insulin-dependent) diabetic patients

Diabetologia ◽  
1984 ◽  
Vol 27 (5) ◽  
pp. 522-526 ◽  
Author(s):  
P. M. Dodson ◽  
P. J. Pacy ◽  
P. Bal ◽  
A. J. Kubicki ◽  
R. F. Fletcher ◽  
...  
Keyword(s):  
Mild Hypertension ◽  
Controlled Trial ◽  
Diabetic Patients ◽  
Low Fat ◽  
Low Sodium Diet ◽  
Low Sodium ◽  
High Fibre ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Bone Modeling Indexes at Onset and During the First Year of Follow-Up in Insulin-Dependent Diabetic Children

1997 ◽  
Vol 60 (5) ◽  
pp. 397-400 ◽  
Author(s):  
R. Bonfanti ◽  
S. Mora ◽  
C. Prinster ◽  
E. Bognetti ◽  
F. Meschi ◽  
...  
Keyword(s):  
First Year ◽  
Bone Modeling ◽  
Diabetic Children ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Sporadic unilateral vestibular schwannoma in the pediatric population

2009 ◽  
Vol 4 (2) ◽  
pp. 125-129 ◽  
Author(s):  
Brian P. Walcott ◽  
Ganesh Sivarajan ◽  
Bronislava Bashinskaya ◽  
Douglas E. Anderson ◽  
John P. Leonetti ◽  
...  
Keyword(s):  
Facial Nerve ◽  
Tumor Size ◽  
Pediatric Population ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
Nerve Function ◽  
Facial Nerve Function ◽  
Duration Of Symptoms

Object Vestibular schwannomas (VSs) are rare in the pediatric population. Most often, these lesions manifest as a bilateral disease process in the setting of neurofibromatosis Type 2. Even in the absence of additional clinical diagnostic criteria, the presentation of a unilateral VS in a young patient may be a harbinger of future penetrance for this hereditary tumor syndrome. Methods The authors retrospectively reviewed the charts of a cohort of 7 patients who presented with apparently sporadic, unilateral VSs. These patients had previously undergone surgery via translabyrinthine, retrosigmoid, or combined approaches. Clinical outcomes were reviewed with emphasis on facial nerve function and follow-up for signs and symptoms of a heritable disorder. Results All patients underwent microsurgical resection in a multidisciplinary effort by the senior authors. The average tumor size was 4.57 cm, with an average duration of symptoms prior to definitive diagnosis of 31.2 months. The tumor size at the time of presentation followed a trend different from reports in adults, while the duration of symptoms did not. At a follow-up average of 6.3 years (range 1–12 years), 100% of patients demonstrated good facial function (House-Brackmann Grade I or II). No patient in this cohort demonstrated symptoms, objective signs, or genetic analysis indicating the presence of neurofibromatosis Type 2. Conclusions Diagnosis and management of sporadic, unilateral VSs in children is complicated by clinical presentations and surgical challenges unique from their adult counterparts. Careful consideration should be given to a heritable genetic basis for sporadic unilateral VS in the pediatric population. Results of genetic testing do not preclude the necessity for long-term follow-up and systemic investigation. In patients who present with large tumors, preliminary experience leads the authors to suggest that a combined retrosigmoid-translabyrinthine approach offers the greatest opportunity for preservation of facial nerve function.

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