scholarly journals Bone mineral density and microarchitecture among Chinese patients with rheumatoid arthritis: a cross-sectional study with HRpQCT

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Shangyi Jin ◽  
Mengtao Li ◽  
Qian Wang ◽  
Xiaofeng Zeng ◽  
Weibo Xia ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bone Microarchitecture ◽  
Fragility Fractures ◽  
Cross Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
X Ray ◽  
Increased Risk

Abstract Background Patients with rheumatoid arthritis (RA) are at increased risk of fractures. Although their decline in bone mineral density (BMD) is well-established, data regarding the alterations in bone microarchitecture are limited. In this study, we aimed to evaluate bone microarchitecture, geometry, and volumetric BMD among patients with RA in mainland China using high-resolution peripheral quantitative computed tomography (HRpQCT). Methods In this cross-sectional study, patients with RA were recruited from the Peking Union Medical College Hospital site of the Chinese Registry of rhEumatoiD arthrITis (CREDIT). Each participant underwent HRpQCT scanning (Scanco XtremeCT II), thoracolumbar X-ray and dual-energy X-ray absorptiometry. The primary outcomes were HRpQCT-related measures at distal radius and tibia. Data regarding demographic features, RA-related characteristics, and history of fragility fractures were collected. Correlation between HRpQCT parameters and potentially related factors were analyzed using linear regression analysis. A group of age- and sex-matched healthy controls was included for comparison. Results A total of 81 patients with RA [69 women, aged 57.9 ± 8.7 years, disease duration 5.7 (IQR 1.4–11.2) years] and 81 matched healthy controls were included. Compared with controls, patients with RA had significantly larger bone area and lower total and trabecular vBMD at both the distal radius and tibia. Lower cortical bone thickness was also shown at the distal tibia. Among patients with RA, advanced age, low BMI, female sex, disease duration, and activity were associated with decreased vBMD and impaired bone microstructure. Female reproductive factors including menopause, late menarche, breast feeding, and early childbirth also showed negative correlation with these parameters. Compared to patients with RA without fractures, patients with fragility fractures (n = 11) showed lower trabecular and cortical vBMD, thinner cortical bone, impaired trabecular microstructure, and a trend of declined bone strength. Current glucocorticoid intake was related to decreased vBMD, trabecular number, increased trabecular separation, and inhomogeneity. Conclusions In this study, we observed alterations in bone mineral density, geometry, and microarchitecture among patients with RA compared to healthy individuals, which may impair bone strength and lead to increased risk of fractures. Both traditional risk factors for osteoporosis and RA-associated factors need to be considered in the assessment of the bone quality.

scholarly journals DXA parameters, Trabecular Bone Score (TBS) and Bone Mineral Density (BMD), in fracture risk prediction in endocrine-mediated secondary osteoporosis

Endocrine ◽  
2021 ◽  
Author(s):  
Enisa Shevroja ◽  
Francesco Pio Cafarelli ◽  
Giuseppe Guglielmi ◽  
Didier Hans
Keyword(s):  
Bone Mineral Density ◽  
Trabecular Bone ◽  
Bone Mineral ◽  
Trabecular Bone Score ◽  
Bone Microarchitecture ◽  
Fragility Fractures ◽  
Endocrine Disorders ◽  
Mineral Density ◽  
Increased Risk

AbstractOsteoporosis, a disease characterized by low bone mass and alterations of bone microarchitecture, leading to an increased risk for fragility fractures and, eventually, to fracture; is associated with an excess of mortality, a decrease in quality of life, and co-morbidities. Bone mineral density (BMD), measured by dual X-ray absorptiometry (DXA), has been the gold standard for the diagnosis of osteoporosis. Trabecular bone score (TBS), a textural analysis of the lumbar spine DXA images, is an index of bone microarchitecture. TBS has been robustly shown to predict fractures independently of BMD. In this review, while reporting also results on BMD, we mainly focus on the TBS role in the assessment of bone health in endocrine disorders known to be reflected in bone.

Circulating Leptin and Bone Mineral Density in Rheumatoid Arthritis

2009 ◽  
Vol 36 (3) ◽  
pp. 512-516 ◽  
Author(s):  
ERIKA A. AGUILAR-CHAVEZ ◽  
JORGE I. GAMEZ-NAVA ◽  
MARIA A. LOPEZ-OLIVO ◽  
SILVIA GALVAN-MELENDRES ◽  
ESTHER G. CORONA-SANCHEZ ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Correlation Coefficients ◽  
Cross Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
Serum Leptin ◽  
Total Hip

Objective.To evaluate the association between circulating leptin and bone mineral density (BMD) in patients with rheumatoid arthritis (RA).Methods.One-hundred thirty postmenopausal women with RA were assessed for body mass index (BMI), disease characteristics, history of drug use, rheumatoid factor, and erythrocyte sedimentation rate (ESR). BMD (g/cm2) was determined in the hip and spine by DEXA. Serum leptin concentrations were measured by ELISA. Spearman’s correlation coefficients (rho) were determined between BMD and leptin and other variables. A multiple regression analysis was used to adjust for confounders.Results.Patients’ serum leptin levels varied widely (range 2–128 ng/ml). Thirty-three patients (25%) had osteoporosis. Higher levels of leptin correlated significantly with BMD in the lumbar spine (rho = 0.17, p = 0.04) and total hip (rho = 0.21, p = 0.01). The variables that were negatively correlated with BMD were age, duration of menopause, and ESR. After adjustment for confounders, leptin was no longer associated with BMD. In the multivariate model, factors that remained associated with BMD in the total hip were age (p = 0.021) and BMI (p = 0.003); and the factors that remained associated with BMD in the lumbar spine were BMI (p = 0.03) and ESR (p = 0.01).Conclusion.No relevant association was found between circulating leptin levels and BMD in patients with RA in this cross-sectional study. Followup studies are needed to evaluate whether abnormal leptin levels confer a risk for fractures due to osteoporosis.

Possible relationships of selected food items to osteoporosis among a group of Iraqi women

2022 ◽  
Vol 63 (4) ◽  
pp. 171-175
Author(s):  
May fawzi Saleh ◽  
Jawad Aldiwan ◽  
Ammar H. Ahmed
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Coffee Consumption ◽  
Total Sample ◽  
Cross Sectional Study ◽  
Mineral Density ◽  
Daily Consumption ◽  
Cross Sectional ◽  
Increased Risk ◽  
Iraqi Women

Background: Osteoporosis is a global health problem which is estimated to affect more than 200 million people worldwide, especially postmenopausal women. It is characterized by decreased bone mineral density leading to fragility and increased risk of fractures.  Objective: This study was conducted to explore the consumption of inappropriate foods related to osteoporosis among a group of Iraqi women. JFac Med Baghdad 2021; Vol.63, No. 4 Received: Sep., 2021 Accepted: Nov., 2021 Published: Jan., 2021   Patients and methods: A cross sectional study of 140 females aged ≥ 40 years attending polyclinics in Al-Dora sector in Baghdad city from 18th January to 24th April 2021. The bone mineral density was measured by portable quantitative calcaneal ultrasound machine (osteosystem) and the bone was assessed for osteoporosis by T-score. Food frequency questionnaire was used for collecting data related to food consumption. Results: Out of the total sample, 74 (52.9%) were found to be osteoporotic. There was a significant association with high salt and coffee consumption with the occurrence of osteoporosis (77.3% and 83.3%, respectively, p = 0.001), compared to those who did not consume caffeinated drinks. Participants with daily consumption of caffeinated drinks had a highly significant association with osteoporosis (21.8% vs 100%, p = 0.001). Conclusion: Excessive consumption of salty foods and caffeinated beverages appears to exert a negative effect on bone mineral density and the occurrence of osteoporosis among the studied group of Iraqi women.

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