scholarly journals Predictors of all-cause and cardiovascular disease mortality in type 2 diabetes: Diabetes Heart Study

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Laura M. Raffield ◽  
Fang-Chi Hsu ◽  
Amanda J. Cox ◽  
J. Jeffrey Carr ◽  
Barry I. Freedman ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Cardiovascular Disease Mortality ◽  
Disease Mortality ◽  
Heart Study ◽  
Diabetes Heart Study

scholarly journals Dietary fats and mortality among patients with type 2 diabetes: analysis in two population based cohort studies

BMJ ◽  
2019 ◽  
pp. l4009 ◽  
Author(s):  
Jingjing Jiao ◽  
Gang Liu ◽  
Hyun Joon Shin ◽  
Frank B Hu ◽  
Eric B Rimm ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Fatty Acids ◽  
Linoleic Acid ◽  
Saturated Fatty Acids ◽  
Total Mortality ◽  
Cardiovascular Disease Mortality ◽  
Disease Mortality

AbstractObjectiveTo assess the association of dietary fatty acids with cardiovascular disease mortality and total mortality among patients with type 2 diabetes.DesignProspective, longitudinal cohort study.SettingHealth professionals in the United States.Participants11 264 participants with type 2 diabetes in the Nurses’ Health Study (1980-2014) and Health Professionals Follow-Up Study (1986-2014).ExposuresDietary fat intake assessed using validated food frequency questionnaires and updated every two to four years.Main outcome measureTotal and cardiovascular disease mortality during follow-up.ResultsDuring follow-up, 2502 deaths including 646 deaths due to cardiovascular disease were documented. After multivariate adjustment, intake of polyunsaturated fatty acids (PUFAs) was associated with a lower cardiovascular disease mortality, compared with total carbohydrates: hazard ratios comparing the highest with the lowest quarter were 0.76 (95% confidence interval 0.58 to 0.99; P for trend=0.03) for total PUFAs, 0.69 (0.52 to 0.90; P=0.007) for marine n-3 PUFAs, 1.13 (0.85 to 1.51) for α-linolenic acid, and 0.75 (0.56 to 1.01) for linoleic acid. Inverse associations with total mortality were also observed for intakes of total PUFAs, n-3 PUFAs, and linoleic acid, whereas monounsaturated fatty acids of animal, but not plant, origin were associated with a higher total mortality. In models that examined the theoretical effects of substituting PUFAs for other fats, isocalorically replacing 2% of energy from saturated fatty acids with total PUFAs or linoleic acid was associated with 13% (hazard ratio 0.87, 0.77 to 0.99) or 15% (0.85, 0.73 to 0.99) lower cardiovascular disease mortality, respectively. A 2% replacement of energy from saturated fatty acids with total PUFAs was associated with 12% (hazard ratio 0.88, 0.83 to 0.94) lower total mortality.ConclusionsIn patients with type 2 diabetes, higher intake of PUFAs, in comparison with carbohydrates or saturated fatty acids, is associated with lower total mortality and cardiovascular disease mortality. These findings highlight the important role of quality of dietary fat in the prevention of cardiovascular disease and total mortality among adults with type 2 diabetes.

scholarly journals Coincident Linkage of Type 2 Diabetes, Metabolic Syndrome, and Measures of Cardiovascular Disease in a Genome Scan of the Diabetes Heart Study

Diabetes ◽  
2006 ◽  
Vol 55 (7) ◽  
pp. 1985-1994 ◽  
Author(s):  
D. W. Bowden ◽  
M. Rudock ◽  
J. Ziegler ◽  
A. B. Lehtinen ◽  
J. Xu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Genome Scan ◽  
Heart Study ◽  
A Genome ◽  
Diabetes Heart Study

scholarly journals Hepatic Steatosis and Subclinical Cardiovascular Disease in a Cohort Enriched for Type 2 Diabetes: The Diabetes Heart Study

2008 ◽  
Vol 103 (12) ◽  
pp. 3029-3035 ◽  
Author(s):  
Ryan L. McKimmie ◽  
Kurt R. Daniel ◽  
J. Jeffrey Carr ◽  
Donald W. Bowden ◽  
Barry I. Freedman ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Hepatic Steatosis ◽  
Heart Study ◽  
Subclinical Cardiovascular Disease ◽  
Diabetes Heart Study

scholarly journals Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the diabetes heart study

2013 ◽  
Vol 12 (1) ◽  
pp. 31 ◽  
Author(s):  
Jeremy N Adams ◽  
Amanda J Cox ◽  
Barry I Freedman ◽  
Carl D Langefeld ◽  
J Jeffrey Carr ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Genetic Analysis ◽  
Heart Study ◽  
Diabetes Heart Study

scholarly journals Physical Activity, High-Sensitivity C-Reactive Protein, and Total and Cardiovascular Disease Mortality in Type 2 Diabetes

Diabetes Care ◽  
2011 ◽  
Vol 34 (7) ◽  
pp. 1492-1496 ◽  
Author(s):  
T. Vepsalainen ◽  
M. Soinio ◽  
J. Marniemi ◽  
S. Lehto ◽  
A. Juutilainen ◽  
...  
Keyword(s):  
Physical Activity ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Cardiovascular Disease Mortality ◽  
Reactive Protein ◽  
Disease Mortality

Abstract P038: Cadmium Exposure is Prospectively Associated to Cardiovascular Risk in the Strong Heart Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Maria Tellez-Plaza ◽  
Eliseo Guallar ◽  
Barbara Howard ◽  
Jason Umans ◽  
Kevin Francesconi ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Events ◽  
Cadmium Exposure ◽  
Cardiovascular Disease Mortality ◽  
Hazard Ratios ◽  
Disease Mortality ◽  
Heart Study ◽  
Urine Cadmium

Introduction: Cadmium is a widespread toxic metal with potential cardiovascular effects, but establishing cadmium as a cardiovascular risk factor has been limited by the lack of data on its association with incident cardiovascular events. Hypothesis: We tested the hypothesis that urine cadmium concentrations would be associated with cardiovascular disease mortality and incidence. Methods: Prospective cohort study of 3,347 American Indian adults 45-74 years old without prevalent cardiovascular disease from Arizona, Oklahoma and North and South Dakota who participated in the Strong Heart Study (SHS) in 1989-91 and had urine cadmium measures available. Urine cadmium was measured using inductively coupled plasma mass spectrometry. Follow-up extended through December 30 th 2007. Results: We identified 1,028 cardiovascular events, including 372 deaths. After adjustment for known cardiovascular risk factors, the hazard ratios (95% CI) for cardiovascular and coronary heart disease mortality, comparing the 80 th to the 20 th percentiles of urine cadmium concentrations, were 1.43 (1.21, 1.69) and 1.33 (1.09, 1.62), respectively. The corresponding hazard ratios for incident cardiovascular disease, coronary heart disease, stroke, and heart failure were 1.16 (1.04, 1.29), 1.11 (0.98, 1.27), 1.50 (1.01, 2.22) and 1.22 (1.01, 1.47), respectively. The associations were similar in different study subgroups, including never-smokers. The figure shows increasing dose-response relations between urine cadmium concentrations and all cardiovascular disease mortality and incidence endpoints except for incident stroke. Conclusions: Urine cadmium, a biomarker of long-term exposure, was positively and consistently associated with cardiovascular disease mortality and incidence, overall and across subgroups. These findings support that cadmium exposure is a cardiovascular risk factor irrespective of the source of exposure. Efforts to reduce cadmium exposure in the population are needed.

Sign in / Sign up

Export Citation Format

Share Document