scholarly journals Reproducibility of left ventricular blood flow kinetic energy measured by four-dimensional flow CMR

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Ciaran Grafton-Clarke ◽  
Saul Crandon ◽  
Jos J. M. Westenberg ◽  
Peter P. Swoboda ◽  
John P. Greenwood ◽  
...  
Keyword(s):  
Blood Flow ◽  
Kinetic Energy ◽  
Healthy Volunteers ◽  
Statistical Power ◽  
Left Ventricular ◽  
Diastolic Filling ◽  
4D Flow ◽  
Energy Data ◽  
Dimensional Flow ◽  
4D Flow Cmr

Abstract Objectives Four-dimensional flow CMR allows for a comprehensive assessment of the blood flow kinetic energy of the ventricles of the heart. In comparison to standard two-dimensional image acquisition, 4D flow CMR is felt to offer superior reproducibility, which is important when repeated examinations may be required. The objective was to evaluate the inter-observer and intra-observer reproducibility of blood flow kinetic energy assessment using 4D flow of the left ventricle in 20 healthy volunteers across two centres in the United Kingdom and the Netherlands. Data description This dataset contains 4D flow CMR blood flow kinetic energy data for 20 healthy volunteers with no known cardiovascular disease. Presented is kinetic energy data for the entire cardiac cycle (global), the systolic and diastolic components, in addition to blood flow kinetic energy for both early and late diastolic filling. This data is available for reuse and would be valuable in supporting other research, such as allowing for larger sample sizes with more statistical power for further analysis of these variables.

scholarly journals Impact of Age and Diastolic Function on Novel, 4D flow CMR Biomarkers of Left Ventricular Blood Flow Kinetic Energy

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Saul Crandon ◽  
Jos J. M. Westenberg ◽  
Peter P. Swoboda ◽  
Graham J. Fent ◽  
James R. J. Foley ◽  
...  
Keyword(s):  
Blood Flow ◽  
Kinetic Energy ◽  
Diastolic Function ◽  
Left Ventricular ◽  
4D Flow ◽  
4D Flow Cmr

Abstract 13435: Deranged Intra-Cardiac Blood Flow Components and Kinetic Energy in Dilated Cardiomyopathy Are an Additional Marker of Disease Severity and Correlate With Established Markers of Prognosis

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Victoria Stoll ◽  
Aaron Hess ◽  
Eylem Levelt ◽  
Jonatan Eriksson ◽  
Petter Dyverfeldt ◽  
...  
Keyword(s):  
Blood Flow ◽  
Kinetic Energy ◽  
Dilated Cardiomyopathy ◽  
Disease Severity ◽  
Myocardial Strain ◽  
Flow Patterns ◽  
Left Ventricular ◽  
4D Flow ◽  
Flow Components ◽  
Functional Components

Introduction: Heart failure (HF) due to dilated cardiomyopathy (DCM) is a complex syndrome in which numerous cellular, mechanical and flow processes/interactions become deranged. Insights into derangement of left ventricular intra-cardiac flow patterns and kinetic energy (KE) are now afforded by the use of 4D flow CMR. Previous studies have found derangements of intra-ventricular flow components and KE within DCM patients compared to healthy volunteers. Hypothesis: We hypothesised that increasing derangement in 4D flow measures would relate to: 1) decreased mechanical cardiac function, as assessed by myocardial strain, 2) increased levels of biochemical remodelling markers and 3) worsening patient symptoms and functional capacity. Methods: 26 idiopathic DCM patients (69% male, mean age 55±2 yr, LVEF 35±2%) and 10 controls (70% male, mean age 57±4yr, LVEF 68±1.2%) were assessed with 3T CMR. Results: The LV volume was divided into 4 functional components; direct flow (DF), delayed ejection flow (DEF), retained inflow (RI) and residual volume (RV). Compared to controls DCM’s had significantly decreased DF (11±1% vs 38±2%) and increased RV (51±2% vs 31±1%) (fig a). The KE at end diastole differed significantly for all flow components between groups (fig b). Circumferential strain was significantly impaired in DCM’s vs controls (-9.9±0.8% vs -19.7±0.5%, p<0.0001). DF KE correlated positively to the 6 minute walk test (6MWT) and strain, and negatively to the Minnesota HF questionnaire and BNP (fig c). Conclusions: DCM patients demonstrated less efficient blood flow patterns and deranged KE profiles. The greater the derangement of flow parameters from normal, the worse the myocardial strain, BNP, 6MWT and patient symptoms. This study suggests that flow parameter derangements are novel biomarkers of disease severity in DCM, correlating with established markers of prognosis such as BNP and 6MWT and may become useful in monitoring novel therapies and predicting prognosis.

scholarly journals Left ventricular kinetic energy as a marker of mechanical dyssynchrony in failing hearts with LBBB: a 4D flow CMR study

2016 ◽  
Vol 18 (S1) ◽  
Author(s):  
Jakub Zajac ◽  
Jonatan Eriksson ◽  
Petter Dyverfeldt ◽  
Urban Alehagen ◽  
Tino Ebbers ◽  
...  
Keyword(s):  
Kinetic Energy ◽  
Mechanical Dyssynchrony ◽  
Left Ventricular ◽  
4D Flow ◽  
4D Flow Cmr

scholarly journals Age-associated changes in 4D flow CMR derived Tricuspid Valvular Flow and Right Ventricular Blood Flow Kinetic Energy

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Natasha Barker ◽  
Hamza Zafar ◽  
Benjamin Fidock ◽  
Alaa Elhawaz ◽  
Abdallah Al-Mohammad ◽  
...  
Keyword(s):  
Blood Flow ◽  
Kinetic Energy ◽  
Right Ventricular ◽  
4D Flow ◽  
4D Flow Cmr

scholarly journals Left Ventricular Blood Flow Kinetic Energy Assessment by 4D Flow Cardiovascular Magnetic Resonance: A Systematic Review of the Clinical Relevance

2020 ◽  
Vol 7 (3) ◽  
pp. 37
Author(s):  
Harjinder Kaur ◽  
Hosamadin Assadi ◽  
Samer Alabed ◽  
Donnie Cameron ◽  
Vassilios S. Vassiliou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Flow ◽  
Cardiovascular Magnetic Resonance ◽  
Heart Disease ◽  
Magnetic Resonance ◽  
Kinetic Energy ◽  
Left Ventricular ◽  
4D Flow ◽  
Hemodynamic Assessment ◽  
Lv Diastolic Function

Background: There is an emerging body of evidence that supports the potential clinical value of left ventricular (LV) intracavity blood flow kinetic energy (KE) assessment using four-dimensional flow cardiovascular magnetic resonance imaging (4D flow CMR). The aim of this systematic review is to summarize studies evaluating LV intracavity blood flow KE quantification methods and its potential clinical significance. Methods: A systematic review search was carried out on Medline, Pubmed, EMBASE and CINAHL. Results: Of the 677 articles screened, 16 studies met eligibility. These included six (37%) studies on LV diastolic function, another six (37%) studies on heart failure or cardiomyopathies, three (19%) studies on ischemic heart disease or myocardial infarction and finally, one (6%) study on valvular heart disease, namely, mitral regurgitation. One of the main strengths identified by these studies is high reproducibility of LV blood flow KE hemodynamic assessment (mean coefficient of variability = 6 ±  2%) for the evaluation of LV diastolic function. Conclusions: The evidence gathered in this systematic review suggests that LV blood flow KE has great promise for LV hemodynamic assessment. Studies showed increased diagnostic confidence at no cost of additional time. Results were highly reproducible with low intraobserver variability.

scholarly journals Four-dimensional flow cardiovascular magnetic resonance in tetralogy of Fallot: a systematic review

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Ayah Elsayed ◽  
Kathleen Gilbert ◽  
Miriam Scadeng ◽  
Brett R. Cowan ◽  
Kuberan Pushparajah ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cardiovascular Magnetic Resonance ◽  
Magnetic Resonance ◽  
Kinetic Energy ◽  
Tetralogy Of Fallot ◽  
4D Flow ◽  
Pilot Studies ◽  
Systolic Volume ◽  
Dimensional Flow ◽  
4D Flow Cmr

Abstract Background Patients with repaired Tetralogy of Fallot (rTOF) often develop cardiovascular dysfunction and require regular imaging to evaluate deterioration and time interventions such as pulmonary valve replacement. Four-dimensional flow cardiovascular magnetic resonance (4D flow CMR) enables detailed assessment of flow characteristics in all chambers and great vessels. We performed a systematic review of intra-cardiac 4D flow applications in rTOF patients, to examine clinical utility and highlight optimal methods for evaluating rTOF patients. Methods A comprehensive literature search was undertaken in March 2020 on Google Scholar and Scopus. A modified version of the Critical Appraisal Skills Programme (CASP) tool was used to assess and score the applicability of each study. Important clinical outcomes were assessed including similarities and differences. Results Of the 635 articles identified, 26 studies met eligibility for systematic review. None of these were below 59% applicability on the modified CASP score. Studies could be broadly classified into four groups: (i) pilot studies, (ii) development of new acquisition methods, (iii) validation and (vi) identification of novel flow features. Quantitative comparison with other modalities included 2D phase contrast CMR (13 studies) and echocardiography (4 studies). The 4D flow study applications included stroke volume (18/26;69%), regurgitant fraction (16/26;62%), relative branch pulmonary artery flow(4/26;15%), systolic peak velocity (9/26;35%), systemic/pulmonary total flow ratio (6/26;23%), end diastolic and end systolic volume (5/26;19%), kinetic energy (5/26;19%) and vorticity (2/26;8%). Conclusions 4D flow CMR shows potential in rTOF assessment, particularly in retrospective valve tracking for flow evaluation, velocity profiling, intra-cardiac kinetic energy quantification, and vortex visualization. Protocols should be targeted to pathology. Prospective, randomized, multi-centered studies are required to validate these new characteristics and establish their clinical use.

scholarly journals Four-Dimensional Flow MRI of Abdominal Veins: A Systematic Review

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 767
Author(s):  
Simon O. Haarbye ◽  
Michael B. Nielsen ◽  
Adam E. Hansen ◽  
Carsten A. Lauridsen
Keyword(s):  
Systematic Review ◽  
Blood Flow ◽  
Portal Hypertension ◽  
Healthy Subjects ◽  
Visual Quality ◽  
Sampling Strategies ◽  
4D Flow Mri ◽  
4D Flow ◽  
Dimensional Flow ◽  
Flow Mri

The aim of this systematic review is to provide an overview of the use of Four-Dimensional Magnetic Resonance Imaging of vector blood flow (4D Flow MRI) in the abdominal veins. This study was composed according to the PRISMA guidelines 2009. The literature search was conducted in MEDLINE, Cochrane Library, EMBASE, and Web of Science. Quality assessment of the included studies was performed using the QUADAS-2 tool. The initial search yielded 781 studies and 21 studies were included. All studies successfully applied 4D Flow MRI in abdominal veins. Four-Dimensional Flow MRI was capable of discerning between healthy subjects and patients with cirrhosis and/or portal hypertension. The visual quality and inter-observer agreement of 4D Flow MRI were rated as excellent and good to excellent, respectively, and the studies utilized several different MRI data sampling strategies. By applying spiral sampling with compressed sensing to 4D Flow MRI, the blood flow of several abdominal veins could be imaged simultaneously in 18–25 s, without a significant loss of visual quality. Four-Dimensional Flow MRI might be a useful alternative to Doppler sonography for the diagnosis of cirrhosis and portal hypertension. Further clinical studies need to establish consensus regarding MRI sampling strategies in patients and healthy subjects.

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