scholarly journals Epinephrine auto-injector needle length

2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Sten Dreborg ◽  
Gina Tsai ◽  
Harold Kim
Keyword(s):  
Drug Delivery ◽  
High Pressure ◽  
Children And Adolescents ◽  
Subcutaneous Injection ◽  
Low Pressure ◽  
Ultrasound Probe ◽  
Needle Length ◽  
Upper Limits ◽  
Auto Injector ◽  
Intramuscular Delivery

Abstract Background Epinephrine auto-injectors are expected to deliver the drug intramuscularly. Objective To study whether injection through clothing influences the frequency of subcutaneous and intraosseous/periosteal deposition of epinephrine. Methods Skin to muscle and skin to bone distances were measured for 303 children and adolescents and 99 adults. Distance was determined by ultrasound, with high or low pressure on the ultrasound probe. The risk/percentage of subcutaneous and intraosseous/periosteal injections was calculated using the lower and upper limits for the authority-approved length of EAI needles as provided by two high pressure EAI manufacturers and one low pressure EAI manufacturer. The addition winter clothing on the delivery of epinephrine was illustrated by comparing drug delivery fissue depth with no clothes. Furthermore, the riof non-intramuscular delivery for the shortest and longest approved needle length was calculated. Results When using EpipenJr® in children < 15 kg the risk of intraosseous/periostal injection was reduced from 1% and 59% for the shortest and longest approved needle length to 0 and 15% with winter clothes. The Auvi-Q® 0.1 mg had no risk of intraosseous/periosteal injection. However, the subcutaneous deposition risk increased from 94% and 28% to 100% and 99% with winter clothes. The risk of subcutaneous injection using EpipenJr® in the youngest children increased from 13% and 0% to 81% and 1% with winter clothes, and with Epipen® in adults from 45% and 17% to 60% and 38%. Emerade®, had a risk of subcutaneous injection in adults increasing from 14% and 10% to 28% and 21% adding winter clothes. Conclusion The risk of intraosseous/periosteal injections decreases and the risk of subcutaneous injection increases when injecting through winter clothes for all EAIs.

scholarly journals Epinephrine Auto-Injector Needle Length (Does Height or BMI add Valuable Information in Adults?)

2019 ◽  
Vol 7 (1) ◽  
pp. 6-19
Author(s):  
Sten Dreborg ◽  
◽  
Gina Tsai ◽  
Harold Kim
Keyword(s):  
High Pressure ◽  
High Risk ◽  
Predictive Value ◽  
Subcutaneous Injection ◽  
Obese Women ◽  
Obese Adults ◽  
Overweight Women ◽  
Increased Risk ◽  
Injection Methods ◽  
Auto Injector

Background: Some overweight and obese adults have an increased risk of subcutaneous injection using epinephrine auto injectors (EAIs). Needle lengths of EAIs vary between brands and lots. Objective: To study if BMI or height adds information to define adults at risk of having intraosseous or subcutaneous injection. Methods: Ninety-nine (99) food allergic adult patients, 32 men and 67 women, 18 – 72 years of age, prescribed EAIs were included. The skin to muscle and skin to bone distances were measured by ultrasonography. The effect of injection on naked skin or through thick clothing was analyzed. High and minimal pressure was applied to the ultrasound probe. Results: Two of three men and 1/5 women with BMI <20 had a risk of intraosseous/periosteal injection using the high pressure auto injector Epipen® , thick clothing, 5/8. Injecting through naked skin using the shortest needle, 14/17 obese women had a high risk of subcutaneous injection (overweight 14/23), through thick clothing all 17 obese women would have a risk of subcutaneous injection (overweight 20/23). Injecting with LPEAIs through naked skin, using the shortest needle 8/17 obese and 4/23 overweight women would have a risk of subcutaneous injection, wearing thick clothing, 10/17 obese and 7/23 overweight women. Height had no predictive value. Conclusion: Using high pressure EAIs, high BMI predicted a very high risk for subcutaneous injection in women and in some men. Even injection with low pressure EAIs had some risk of subcutaneous injection, especially when injected through thick clothing. Height had no predictive value. Keywords: Auto-injector; epinephrine; intramuscular; subcutaneous; intraosseous; skin to bone distance; skin to muscle distance; clothing; overweight; obese; adults; women; men.

Fouling Is the Beginning: Upcycling Biopolymer-Fouled Substrates for Fabricating High-Permeance Thin-Film Composite Polyamide Membranes

2020 ◽  
Author(s):  
Ruobin Dai ◽  
Hongyi Han ◽  
Tianlin Wang ◽  
Jiayi Li ◽  
Chuyang Y. Tang ◽  
...  
Keyword(s):  
Thin Film ◽  
High Pressure ◽  
End Of Life ◽  
Water Purification ◽  
Low Pressure ◽  
Polymeric Membranes ◽  
Membrane Recycling ◽  
Film Composite ◽  
Thin Film Composite ◽  
First Time

Commercial polymeric membranes are generally recognized to have low sustainability as membranes need to be replaced and abandoned after reaching the end of their life. At present, only techniques for downcycling end-of-life high-pressure membranes are available. For the first time, this study paves the way for upcycling fouled/end-of-life low-pressure membranes to fabricate new high-pressure membranes for water purification, forming a closed eco-loop of membrane recycling with significantly improved sustainability.

scholarly journals High-Pressure Spectroscopy Study of Zn(IO3)2 Using Far-Infrared Synchrotron Radiation

Crystals ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 34
Author(s):  
Akun Liang ◽  
Robin Turnbull ◽  
Enrico Bandiello ◽  
Ibraheem Yousef ◽  
Catalin Popescu ◽  
...  
Keyword(s):  
High Pressure ◽  
Phase Transitions ◽  
Synchrotron Radiation ◽  
Infrared Radiation ◽  
Room Temperature ◽  
Far Infrared ◽  
Low Pressure ◽  
Pressure Response ◽  
Spectroscopy Study ◽  
Far Infrared Radiation

We report the first high-pressure spectroscopy study on Zn(IO3)2 using synchrotron far-infrared radiation. Spectroscopy was conducted up to pressures of 17 GPa at room temperature. Twenty-five phonons were identified below 600 cm−1 for the initial monoclinic low-pressure polymorph of Zn(IO3)2. The pressure response of the modes with wavenumbers above 150 cm−1 has been characterized, with modes exhibiting non-linear responses and frequency discontinuities that have been proposed to be related to the existence of phase transitions. Analysis of the high-pressure spectra acquired on compression indicates that Zn(IO3)2 undergoes subtle phase transitions around 3 and 8 GPa, followed by a more drastic transition around 13 GPa.

scholarly journals Crystal and electronic structure engineering of tin monoxide by external pressure

2021 ◽  
Author(s):  
Kun Li ◽  
Junjie Wang ◽  
Vladislav A. Blatov ◽  
Yutong Gong ◽  
Naoto Umezawa ◽  
...  
Keyword(s):  
Phase Transition ◽  
High Pressure ◽  
Band Gap ◽  
High Pressures ◽  
Low Pressure ◽  
Widespread Application ◽  
Space Group ◽  
Tin Monoxide ◽  
High Possibility ◽  
Pressure Phase

AbstractAlthough tin monoxide (SnO) is an interesting compound due to its p-type conductivity, a widespread application of SnO has been limited by its narrow band gap of 0.7 eV. In this work, we theoretically investigate the structural and electronic properties of several SnO phases under high pressures through employing van der Waals (vdW) functionals. Our calculations reveal that a metastable SnO (β-SnO), which possesses space group P21/c and a wide band gap of 1.9 eV, is more stable than α-SnO at pressures higher than 80 GPa. Moreover, a stable (space group P2/c) and a metastable (space group Pnma) phases of SnO appear at pressures higher than 120 GPa. Energy and topological analyses show that P2/c-SnO has a high possibility to directly transform to β-SnO at around 120 GPa. Our work also reveals that β-SnO is a necessary intermediate state between high-pressure phase Pnma-SnO and low-pressure phase α-SnO for the phase transition path Pnma-SnO →β-SnO → α-SnO. Two phase transition analyses indicate that there is a high possibility to synthesize β-SnO under high-pressure conditions and have it remain stable under normal pressure. Finally, our study reveals that the conductive property of β-SnO can be engineered in a low-pressure range (0–9 GPa) through a semiconductor-to-metal transition, while maintaining transparency in the visible light range.

scholarly journals Investigation of Vorticity during Prevalent Winter Precipitation in Iran

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Iman Rousta ◽  
Farshad Javadizadeh ◽  
Fatemeh Dargahian ◽  
Haraldur Ólafsson ◽  
Amin Shiri-Karimvandi ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
High Pressure ◽  
Persian Gulf ◽  
Low Pressure ◽  
Winter Precipitation ◽  
Central Iran ◽  
Precipitation Data ◽  
East Europe ◽  
Precipitation Threshold ◽  
Dual Core

In this study, precipitation data for 483 synoptic stations, and the U&V component of wind and HGT data for 4 atmospheric levels were respectively obtained from IRIMO and NCEP/NCAR databases (1961–2013). The precipitation threshold of 1 mm and a minimum prevalence of 50% were the criteria based on which the prevalent precipitation of Iran was identified. Then, vorticity of days corresponding to prevalent winter precipitation was calculated and, by performing cluster analysis, the representative days of vorticity were specified. The results showed that prevalent winter precipitation vorticity in Iran is related to the vorticity patterns of low pressure of Mediterranean-low pressure of Persian Gulf dual-core, low pressure closed of central Iran-high pressure of East Europe, Ural low pressure-Middle East High pressure, Saudi Arabia low pressure-Europe high pressure, and high-pressure belt of Siberia-low pressure of central Iran. At the same time, the most intense vorticity occurred when the climate of Iran was influenced by a massive belt pattern of Siberian high pressure-low pressure of central Iran. However, at the time of prevalent winter precipitation in Iran, an intense vorticity is drawn with the direction of Northeast and Northwest from the center of Iraq to the south of Iran.

Influence of Hot Streak Temperature Ratio on Low Pressure Stage of a Vaneless Counter-Rotating Turbine

2007 ◽  
Author(s):  
Qingjun Zhao ◽  
Fei Tang ◽  
Huishe Wang ◽  
Jianyi Du ◽  
Xiaolu Zhao ◽  
...  
Keyword(s):  
Shock Wave ◽  
High Pressure ◽  
Secondary Flow ◽  
Low Pressure ◽  
Turbine Rotor ◽  
Temperature Ratio ◽  
High Pressure Turbine ◽  
Pressure Stage ◽  
Low Pressure Turbine ◽  
Hot Streak

In order to explore the influence of hot streak temperature ratio on low pressure stage of a Vaneless Counter-Rotating Turbine, three-dimensional multiblade row unsteady Navier-Stokes simulations have been performed. The predicted results show that hot streaks are not mixed out by the time they reach the exit of the high pressure turbine rotor. The separation of colder and hotter fluids is observed at the inlet of the low pressure turbine rotor. After making interactions with the inner-extending shock wave and outer-extending shock wave in the high pressure turbine rotor, the hotter fluid migrates towards the pressure surface of the low pressure turbine rotor, and the most of colder fluid migrates to the suction surface of the low pressure turbine rotor. The migrating characteristics of the hot streaks are predominated by the secondary flow in the low pressure turbine rotor. The effect of buoyancy on the hotter fluid is very weak in the low pressure turbine rotor. The results also indicate that the secondary flow intensifies in the low pressure turbine rotor when the hot streak temperature ratio is increased. The effects of the hot streak temperature ratio on the relative Mach number and the relative flow angle at the inlet of the low pressure turbine rotor are very remarkable. The isentropic efficiency of the Vaneless Counter-Rotating Turbine decreases as the hot streak temperature ratio is increased.

Design of an Intermediate Turbine Duct Downstream of a High Pressure Turbine

2016 ◽  
Author(s):  
Chaoshan Hou ◽  
Hu Wu
Keyword(s):  
High Pressure ◽  
Three Dimensional ◽  
Low Pressure ◽  
Aerodynamic Load ◽  
Duct Flow ◽  
Original Design ◽  
High Pressure Turbine ◽  
Intermediate Turbine Duct ◽  
Low Pressure Turbine ◽  
Inlet Conditions

The flow leaving the high pressure turbine should be guided to the low pressure turbine by an annular diffuser, which is called as the intermediate turbine duct. Flow separation, which would result in secondary flow and cause great flow loss, is easily induced by the negative pressure gradient inside the duct. And such non-uniform flow field would also affect the inlet conditions of the low pressure turbine, resulting in efficiency reduction of low pressure turbine. Highly efficient intermediate turbine duct cannot be designed without considering the effects of the rotating row of the high pressure turbine. A typical turbine model is simulated by commercial computational fluid dynamics method. This model is used to validate the accuracy and reliability of the selected numerical method by comparing the numerical results with the experimental results. An intermediate turbine duct with eight struts has been designed initially downstream of an existing high pressure turbine. On the basis of the original design, the main purpose of this paper is to reduce the net aerodynamic load on the strut surface and thus minimize the overall duct loss. Full three-dimensional inverse method is applied to the redesign of the struts. It is revealed that the duct with new struts after inverse design has an improved performance as compared with the original one.

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