scholarly journals Idiopathic myelitis presenting as Brown-Séquard syndrome: two case reports and a review of the literature

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Xi Peng ◽  
Liang Wang

Abstract Background Brown-Séquard syndrome often occurs in spinal cord injury, and few myelitis patients present with Brown-Séquard syndrome. Case presentation A 33-year-old Han man was admitted with neck pain plus numbness in the right limbs for 2 days and weakness in the left limbs for 1 day. Examination was significant for left limbs with grade 4 muscle power, positive left Babinski sign, diminished vibration sensation in the left limbs and decreased pain below the right clavicle dermatome. The cerebrospinal fluid (CSF) cell count was 24 × 106/L, and the protein count was 185 mg/L. Cervical magnetic resonance imaging (MRI) indicated abnormal swelling signals in the medulla-cervical cord long segment and enhanced signals in the C2-3 region. In the second case, a 47-year-old Han woman was admitted with weakness in the right lower limb and numbness in the left lower limb for more than 20 days. Examination was significant for the right lower limb with grade 4 muscle power, left knee hyperreflexia, positive left Babinski sign, diminished vibration sensation in the right lower limb and decreased pain below the right T2 dermatome. Cervical MRI indicated hyperintense and enhanced signals in the C7-T2 region. In these two cases, CSF culture, oligoclonal band (OB) and aquaporin 4 (AQP4) antibody were negative. Brain MRI was normal. Their symptoms and MRI results improved after treatment with methylprednisolone. Conclusions Myelitis can present as Brown-Séquard syndrome, providing an extended reference in terms of the differential diagnosis for clinical physicians.

2018 ◽  
Vol 6 (6_suppl3) ◽  
pp. 2325967118S0004
Author(s):  
Ana Costa Pinheiro ◽  
Carolina Oliveira ◽  
Margarida Areias ◽  
Bruno Pombo ◽  
Filomena Ferreira ◽  
...  

INTRODUCTION: Fractures-detached is an injury in the place where the tendon or the ligament is inserted in the bear, in the plates of growth. Thus, in the offspring, or tendons or proximal ligaments of a growth plate, may provide sufficient force to cause a growth plate fracture. Single fractures of the apophysis are rare and rarely known lesions. In this article we present 3 clinical cases of patients with indirect trauma, such as the anterior fracture of the anterior tibial tuberosity, the anterior superior iliac spine fracture, and the small fracture of the femoral trochanter. METHOD: Retrospective descriptive of 3 clinical cases based on patients’ electronic clinical processes. CASE 1: Male of 16 years old, victim of fracture-avulsion of the anterior tuberosity of the tibia (ATT). The injury occurred during football practice, immediately feeling intense knee pain associated with functional impairment of the left lower limb. The Emergency Service was used, with pain in the palpation of the left knee, edema, joint effusion, high patella and incapacity of active extension of the affected limb. The left knee radiograph showed a fracture of the ATT. Computed tomography (CT) revealed an extensive metaphyseal-epiphyseal vein, corresponding to a fracture-avulsion type IIIC in a context of previous Osgood-Schlatter disease. It was subjected to open reduction and internal fixation of the fracture with two cannulated screws, without complications. After surgery, the affected lower limb was immobilized for about 1 month, after which the patient started physiotherapy. After 3 months, the patient initiated complaints of contralateral knee pain related to ATT, with improvement after 3 months of conservative treatment. The patient restarted the sport activity at 6 months postoperatively, without complaints or limitations. After 2 years of follow-up, the patient did not present complaints or limitations of mobility bilaterally and resumed the activity level before the injury. CASE 2: The adolescent male, an occasional physical exercise student at school, turned to the US for pain on the right side of the basin, 4 days after a jump during a basketball game. The objective test revealed gait claudication, palpation of the right anterior superior iliac spine (ASIS) and limitation of right movements. The radiograph and CT of the basin, to diagnose a fracture-avulsion of right ASIS, with deviation less than 3 cm. Treatment of pain, relative rest and taking oral anti-inflammatories and discharge of the affected member for 4 weeks. X-ray and CT, at 6 weeks, did not show fracture healing. However, the patient recovers from physical activity after 8 weeks, remains asymptomatic and unrestricted in the practice of physical exercise. CASE 3: An 11-year-old male, he used the Urgency Service with pain at the level of the anterior inner side of the right thigh and functional impotence of the ipsilateral lower limb, after indirect trauma with hyperextension movement in soccer game. The radiographic examination revealed a fracture of the isolated aversion of the small trochanter of the right femur with deviation of less than 2 cm. However, the patient recovers from physical activity after 8 weeks, remains asymptomatic and unrestricted in the practice of physical exercise. DISCUSSION: Or diagnosis of clinical substrate, treatment of low energy trauma rarely caused by trauma. In general, conservative treatment with conventional analgesics and restoration of the load is opted for. According to the degree of deviation (> 3 cm), it can opt for surgical treatment, or it prevents functional deficits and deformities, more frequently in the anterior tibial tuberosity fracture. CONCLUSIONS: After a harvest of the clinical history, a careful analysis of the imaging, were identified as 3 different single fractures, tended in 2 of the cases, non-surgical treatment with analgesia and load restriction (single fracture of the anterior iliac spine And the single fracture of the small trochanter of the femur). In the fracture of the anterior tuberosity of the tibia, after the fracture classification, an open reduction and osteosynthesis were performed with 2 cannulated screws. These case reports are important for the determination of vulnerability to low energy trauma, as well as guiding treatment and preventing functional deficits and deformities. REFERENCES: McKinney B, Nelson C, Carrion W. Apophyseal Avulsion Fractures of the Hip and Pelvis. Orthopedics. 2009; 32(1):42. Kameyama O, Ogawa R. Avulsion fracture of the iliac spine during sporting activity: Report of 30 fractures and their outcome. Journal of Orthopaedic Science .1996; 1(6): 356-362. Rosenberg N, Noiman M, Edelson G. Avulsion fractures of the anterior superior iliac spine in adolescents. J Orthop Trauma. 1996; 10:440–3. Veselko M, Smrkolj V. Avulsion of the anterior superior iliac spine in athletes: case reports. J Trauma. 1994; 36:444–6. T. Pesl, P. Havran. Acute tibial tubercle avulsion fractures in children: selective use of the closed reduction and internal fixation method.J Child Orthop., 2 (5) (2008), pp. 353–356. R.P. Albuquerque, V. Giordano, A.C.P. Carvalho, T. Puell, M.I.P. Albuquerque, N.P. Amaral. Fratura avulsão bilateral e simultânea da tuberosidade tibial em uma adolescente: relato de caso e terapêutica adotada.Rev Bras Ortop., 47 (3) (2012), pp. 56–60. L.H. Carvalho Júnior, W.A. Benevides, F.C.S. Nogueira, W.V. Fonseca, R.P. Andrade. Fraturas da tuberosidade tibial anterior em adolescentes. Relato de casos e revisão da literatura. Rev Bras Ortop., 30 (1) (1995), pp. 70–73. Avulsões apofisárias da bacia e do fémur proximal no jovem desportista. Revista de Medicina Desportiva Informa,2011.2(2), pp 13-15. 


2009 ◽  
Vol 120 (1) ◽  
pp. 204-209 ◽  
Author(s):  
Robert A. Boland ◽  
Hugh Bostock ◽  
Matthew C. Kiernan

2018 ◽  
Vol 89 (10) ◽  
pp. A1.2-A1
Author(s):  
Yoganathan Katie ◽  
Stevenson Alexander ◽  
Khoylou Sanam ◽  
Pearce Ronald

70-year-old female receptionist presented with acute onset lower back pain whilst sitting down. She tried to weight bear but felt her left leg ‘gave way’. There were no sensory complaints and no sphincter disturbance. Positive examination findings in her left lower limb include reduced tone, power 2/5 throughout, and left extensor plantar. In addition, she had absent knee and ankle reflexes bilaterally and loss of pinprick and temperature sensation on the right side up to L1 dermatome, with preservation of vibration and proprioception. She had a normal sensory examination of her left lower limb and rectal examination was unremarkable. Clinically, she has an atypical form of Brown-Séquard syndrome with weakness in the left lower limb and sensory loss in the right lower limb with a sensory level. MRI lumbar/sacral spine showed L3 slipped anteriorly with L3/4 disc bulge resulting in cauda equina syndrome. She was re-scanned five days later including thoracic spine and found to have an acute left hemi-cord infarct at T8/9. This case demonstrates the importance of scanning the relevant sections of the cord and to keep a broad differential in mind, as there can be two aetiologies at work which might misguide the clinician at first glance.


2016 ◽  
Vol 13 (3) ◽  
pp. 5269 ◽  
Author(s):  
Ayşegül Yapıcı ◽  
Barış Maden ◽  
Gülin Fındıkoğlu

The aim of this study is to investigate the effect of a 6-week land and resistance training of 13-16 year old swimmers groups to lower limb isokinetic strength values and to swimming performance. 22 swimmers participated in this study. The subjects were divided into three groups (A-B-C) according to their 50m swimming degrees. 25m underwater,25m,50m,75m and 100m freestyle swimming degrees of swimmers were recorded. As isokinetic measurements was applied at 60°/s,180°/s and 240°/s speed and the right and left knee. Kruskal-Wallis is used the differences between groups, the Mann-Whitney U test is used for which group the difference is caused and group differences were analyzed with the Wilcoxon test. Statistically significant difference was found between pre-test and post-test of 25m underwater,25m,50m,75m and 100m freestyle swimming values (p<0.05). In all groups, at 60°/s,180°/s,240°/s, for the right and left knee flexors and extensor, and freestyle swimming degrees positive development is observed. After 6-weeks training, isokinetic strength and swimming degrees of the group C increased 9.25%, whereas B has increased 8.35%. The pre-test and post-test results in 25m underwater,25m,50m,75m and 100m freestyle swimming values were statistically significant between the groups (p<0.05). In this study, it is possible to say that the land and resistance training can make a significant contribution to the performance of the force in this age group swimmer. ÖzetBu çalışmanın amacı; 13-16 yaş grubu yüzücülerde 6 haftalık kara ve direnç antrenmanlarının alt ekstremite izokinetik kuvvet değerlerine ve yüzme performansına etkisini araştırmaktır. Çalışmaya 22 yüzücü katılmıştır. Denekler 50m yüzme derecelerine göre üç gruba (A-B-C) ayrılmıştır. Yüzücülerin 25m sualtı, 25m, 50m, 75m ve 100m serbest stildeki yüzme dereceleri kayıt edilmiştir. İzokinetik ölçümler 60°/s, 180°/s ve 240°/s hızda sağ ve sol diz için uygulanmıştır. Gruplar arası farka Kruskal Wallis, farkın hangi gruptan kaynaklandığına Mann Whitney U testi, grup içi farklara ise Wilcoxon testi ile bakılmıştır. Ön test ve son test 25m sualtı, 25m, 50m, 75m ve 100m serbest yüzme değerlerinde istatistiksel olarak anlamlı fark bulunmuştur (p<0.05). Tüm grupların, 60º/s, 180º/s ve 240º/s hızda sağ ve sol diz için fleksör ve ektensörlerin tepe tork değerlerinde ve serbest yüzme derecelerinde sayısal olarak pozitif bir gelişim görülmüştür. 6 haftalık antrenman sonunda, C grubunun izokinetik kuvvet ve yüzme derecelerindeki artış (%9.25) iken, B grubunda bu değer (%8.35) çıkmıştır. Yapılan istatistiksel analiz sonucu ön test ve son test 25m sualtı, 25m, 50m, 75m ve 100m serbest yüzme değerlerinde gruplar arasında istatistiksel olarak anlamlı fark bulunmuştur (p<0.05). Bu çalışmada, bu yaş grubu yüzücülerde yapılan kara ve direnç antrenmanlarının kuvvet performansına önemli bir katkı sağlayabileceği söylenebilir.


2019 ◽  
Vol 90 (e7) ◽  
pp. A18.1-A18
Author(s):  
Allycia MacDonald ◽  
Jason Dyke ◽  
Simon Khangure ◽  
Andrew Kelly

IntroductionApproximately 10% of amyotrophic lateral sclerosis (ALS) cases are inherited, of which 20% are due to mutations in the superoxide dismutase-1 gene (SOD1). MRI abnormalities are not uncommon in ALS, and there have been previous case reports of peripheral nerve enhancement in patients with SOD1 mutations, typically attributed to rapid neuronal degeneration.CaseA 31-year-old previously well Malaysian woman presented with a 3 month history of progressive lower limb weakness, initially involving the right lower limb but progressing to involve the left, requiring the use of a walking aid. Initial examination demonstrated asymmetric upper and lower motor neuron signs in bilateral upper and lower limbs. EMG findings were of a severe pure motor axonal process. CSF examination revealed elevated protein without significant elevation of white cells. MRI brain and spine demonstrated smooth cauda-equina ventral nerve root thickening and enhancement. Treatment with intravenous immunoglobulin and high dose corticosteroid was commenced for a presumed inflammatory process, with no clinical improvement. A cauda-equina nerve root biopsy was performed, demonstrating features consistent with an immune-mediated demyelinating neuropathy. The patient continued to deteriorate, developing flaccid upper limb weakness and facial involvement. Plasma exchange, azathioprine, cyclophosphamide, and rituximab were sequentially administered over the following two months without altering the rate of disease progression. Genetic testing returned a positive SOD1 heterozygous gene mutation, confirming the diagnosis of ALS.ConclusionsWe present a case of SOD1-ALS with atypical features on imaging and histopathology suggesting an underlying demyelinating process, expanding the known clinical spectrum of this mutation.


Brain ◽  
2020 ◽  
Author(s):  
Samineh Mesbah ◽  
Tyler Ball ◽  
Claudia Angeli ◽  
Enrico Rejc ◽  
Nicholas Dietz ◽  
...  

Abstract Spinal cord epidural stimulation (scES) has enabled volitional lower extremity movements in individuals with chronic and clinically motor complete spinal cord injury and no clinically detectable brain influence. The aim of this study was to understand whether the individuals’ neuroanatomical characteristics or positioning of the scES electrode were important factors influencing the extent of initial recovery of lower limb voluntary movements in those with clinically motor complete paralysis. We hypothesized that there would be significant correlations between the number of joints moved during attempts with scES prior to any training interventions and the amount of cervical cord atrophy above the injury, length of post-traumatic myelomalacia and the amount of volume coverage of lumbosacral enlargement by the stimulation electrode array. The clinical and imaging records of 20 individuals with chronic and clinically motor complete spinal cord injury who underwent scES implantation were reviewed and analysed using MRI and X-ray integration, image segmentation and spinal cord volumetric reconstruction techniques. All individuals that participated in the scES study (n = 20) achieved, to some extent, lower extremity voluntary movements post scES implant and prior to any locomotor, voluntary movement or cardiovascular training. The correlation results showed that neither the cross-section area of spinal cord at C3 (n = 19, r = 0.33, P = 0.16) nor the length of severe myelomalacia (n = 18, r = −0.02, P = 0.93) correlated significantly with volitional lower limb movement ability. However, there was a significant, moderate correlation (n = 20, r = 0.59, P = 0.006) between the estimated percentage of the lumbosacral enlargement coverage by the paddle electrode as well as the position of the paddle relative to the maximal lumbosacral enlargement and the conus tip (n = 20, r = 0.50, P = 0.026) with the number of joints moved volitionally. These results suggest that greater coverage of the lumbosacral enlargement by scES may improve motor recovery prior to any training, possibly because of direct modulatory effects on the spinal networks that control lower extremity movements indicating the significant role of motor control at the level of the spinal cord.


Author(s):  
Lap Nam Wong ◽  
Yue Zhen Hong ◽  
Jian Feng Sui ◽  
Rui Xu ◽  
Lin Hong Ji

Mobility is the urgent requisite of post spinal cord injury (SCI) patient. Since the alternative and compensatory approach is considered as the major function of mobility assistive device for post-SCI patients, the device should possess capability to acclimate to the ‘abnormal’ gait generate by the patients who usually undergo alternative and compensatory rehabilitation in their neural circuit. The functional ability of individual should be taking into account. Yet according to the requirement of neuro-protective treatment in post-SCI rehabilitation processing, locomotor-like activity is still an essential factor to patient. This study presents a novel concept and prototype of assistive technology base on foot control strategy to take an equilibrium between mobility and gait realization. To demonstrate that foot-induced over-ground locomotor assistive method is capable of achieving locomotor-like activity (dragging step), simulation analysis and prototype preliminary experiment have been conducted. Simulation analysis show that foot-induced assistance can allow more volitional activity compare to the hip-knee-induced assistive device. Yet the input and disturbance act on such kind of device may be increased. Surface electromyography (sEMG) from muscles of lower limb (right rectus femoris, right biceps femoris and right gluteus maximus) have been recorded during the preliminary experiment, and the mean of integrated EMG (iEMG) was used as evaluation of muscle activity. The result of the testing show that the mean of iEMG in the right gluteus maximus was reduced in the swing phase when the subject moving ahead with the prototype, but no significant change in the right rectus femoris. It may imply that foot-induced over-ground locomotor assistive device can reduce the muscle activity when patient complete locomotor-like movement and retain some amount of residual recruitment of lower limb, instead of substituting arbitrarily.


Pulse ◽  
2015 ◽  
Vol 7 (1) ◽  
pp. 50-52
Author(s):  
FA Ruby ◽  
S Ahsan ◽  
Q Hassan ◽  
M Chandy ◽  
A Parvin

3 months old boy presented with inablility to move upper limb and cries on touching the upper limb from 1 week of age. On examination reflexes were absent in upper limb but hyper reflexia was found in lower limb. Cervical and brain MRI revealed expansion of the cervical spinal canal with smoothly marginated mass within the cervical cord which is hyperintense in T1WI, T2WI and completely loses its signal intensity in FS and gradient weighted sequences. There was no diffusion restriction and appears mostly intramedullary. MRI features were consistent with intramedullary lipoma in cervical spinal cord.Pulse Vol.7 January-December 2014 p.50-52


Author(s):  
Helton Magalhães Dias ◽  
◽  
Marcelo Zanetti ◽  
Tiago de Santos ◽  
Carlos Alexandre Falconi ◽  
...  

Investigation about influences between stretching training and muscle strength performance can contribute to the understanding of training. The aim of the present study was to verify the effect of three weeks of stretching training on muscle torque and power. Ten adults, divided into Stretching Group (GA, N = 5) and Control Group (CG, N = 5) were evaluated pre and post intervention. The intervention was performed by GA and consisted of a passive static stretching protocol for the posterior thigh muscles, performed three times a week and during three weeks. The torque and power of the knee extension and flexion were evaluated using an isokinetic dynamometer at three speeds (60, 180 and 360º/s). Range of motion (ROM) was assessed using the sit and reach test. There was an increase in ROM (pre: 23.0 ± 5.6 cm; post: 30.1 ± 6.58 cm; p = 0.033) of GA, but there were no differences between and within groups for the other variables (p> 0.05). There were correlations of the ROM only for the flexion torque (r = 0.664; p = 0.036) and power of the extension (r = 0.638; p = 0.047) of the left knee at 60º/s. It was concluded that three weeks of static stretching training promoted significant gains in ROM, but did not allow increases in torque and power.


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