scholarly journals A balanced game: chicken macrophage response to ALV-J infection

2019 ◽  
Vol 50 (1) ◽  
Author(s):  
Min Feng ◽  
Tingting Xie ◽  
Yuanfang Li ◽  
Nan Zhang ◽  
Qiuyuan Lu ◽  
...  
Keyword(s):  
Macrophage Response ◽  
Balanced Game ◽  
Chicken Macrophage

scholarly journals The immunomodulatory effect of cathelicidin-B1 on chicken macrophages

2020 ◽  
Vol 51 (1) ◽  
Author(s):  
Lianci Peng ◽  
Maaike R. Scheenstra ◽  
Roel M. van Harten ◽  
Henk P. Haagsman ◽  
Edwin J. A. Veldhuizen
Keyword(s):  
Gene Expression ◽  
Immune Response ◽  
Inflammatory Cytokines ◽  
Culture Conditions ◽  
Titration Calorimetry ◽  
Macrophage Response ◽  
Microbial Infections ◽  
Chicken Macrophage ◽  
Inflammatory Profile ◽  
Pro Inflammatory Cytokines

Abstract Cathelicidins (CATHs) play an important role in the innate immune response against microbial infections. Among the four chicken cathelicidins, CATH-B1 is studied the least. In this study, the effect of CATH-B1 on the macrophage response towards avian pathogenic E. coli (APEC) and bacterial ligands was investigated. Our results show that APEC induced CATH-B1 gene expression in both a chicken macrophage cell line (HD11 cells) and primary macrophages, while expression of the other three CATHs was virtually unaffected. While the antimicrobial activity of CATH-B1 is very low under cell culture conditions, it enhanced bacterial phagocytosis by macrophages. Interestingly, CATH-B1 downregulated APEC-induced gene expression of pro-inflammatory cytokines (IFN-β, IL-1β, IL-6 and IL-8) in primary macrophages. In addition, CATH-B1 pre-incubated macrophages showed a significantly higher gene expression of IL-10 after APEC challenge, indicating an overall anti-inflammatory profile for CATH-B1. Using isothermal titration calorimetry (ITC), CATH-B1 was shown to bind LPS. This suggests that CATH-B1 reduces toll like receptor (TLR) 4 dependent activation by APEC which may partly explain the decreased production of pro-inflammatory cytokines by macrophages. On the contrary, direct binding of CATH-B1 to ODN-2006 enhanced the TLR21 dependent activation of macrophages as measured by nitric oxide production. In conclusion, our results show for the first time that CATH-B1 has several immunomodulatory activities and thereby could be an important factor in the chicken immune response.

scholarly journals Dual RNA-Seq transcriptome analysis of chicken macrophage-like cells (HD11) infected in vitro with Eimeria tenella

Parasitology ◽  
2021 ◽  
Vol 148 (6) ◽  
pp. 712-725
Author(s):  
Arnar K. S. Sandholt ◽  
Feifei Xu ◽  
Robert Söderlund ◽  
Anna Lundén ◽  
Karin Troell ◽  
...  
Keyword(s):  
Transcriptome Analysis ◽  
Eimeria Tenella ◽  
Rna Seq ◽  
Chicken Macrophage

Abstract

Age-associated differences in macrophage response in a vaginal wound healing rat model

2020 ◽  
Author(s):  
Ofra Ben Menachem-Zidon ◽  
Ilana Parkes ◽  
Henry H. Chill ◽  
Benjamin Reubinoff ◽  
Kathryn Sandberg ◽  
...  
Keyword(s):  
Wound Healing ◽  
Rat Model ◽  
Macrophage Response

MiR-375 silencing attenuates pro-inflammatory macrophage response and foam cell formation by targeting KLF4

2021 ◽  
Vol 400 (1) ◽  
pp. 112507
Author(s):  
Yanyan Qiu ◽  
Jinyi Xu ◽  
Lihong Yang ◽  
Guihua Zhao ◽  
Jing Ding ◽  
...  
Keyword(s):  
Foam Cell ◽  
Cell Formation ◽  
Foam Cell Formation ◽  
Macrophage Response ◽  
Inflammatory Macrophage

scholarly journals Monocyte/macrophage response to β2-microglobulin modified with advanced glycation end products

1996 ◽  
Vol 49 (2) ◽  
pp. 538-550 ◽  
Author(s):  
Toshio Miyata ◽  
Yoshiyasu Iida ◽  
Yasuhiko Ueda ◽  
Toru Shinzato ◽  
Hisao Seo ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Macrophage Response ◽  
Β2 Microglobulin ◽  
Glycation End Products ◽  
End Products

9. Topical high molecular weight hyaluronan application post laminectomy decreases the acute cytokine and macrophage response

2004 ◽  
Vol 4 (5) ◽  
pp. S7
Author(s):  
Aimee Schimizzi ◽  
Jennifer Massie ◽  
Monika Polewski ◽  
Andrew Perry ◽  
Choll Kim ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Macrophage Response

Surfactant-dependent macrophage response to polypyrrole-based coatings electrodeposited on Ti6Al7Nb alloy

2013 ◽  
Vol 33 (6) ◽  
pp. 3353-3361 ◽  
Author(s):  
Mihaela Mindroiu ◽  
Raluca Ion ◽  
Cristian Pirvu ◽  
Anisoara Cimpean
Keyword(s):  
Macrophage Response

scholarly journals Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection

PLoS Genetics ◽  
2015 ◽  
Vol 11 (10) ◽  
pp. e1005619 ◽  
Author(s):  
Musa A. Hassan ◽  
Kirk D. Jensen ◽  
Vincent Butty ◽  
Kenneth Hu ◽  
Erwan Boedec ◽  
...  
Keyword(s):  
Macrophage Response ◽  
Linkage Analyses ◽  
Inflammatory Stimuli
Sign in / Sign up

Export Citation Format

Share Document