scholarly journals Solid component ratio influences prognosis of GGO-featured IA stage invasive lung adenocarcinoma

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Fenghao Sun ◽  
Yiwei Huang ◽  
Xiaodong Yang ◽  
Cheng Zhan ◽  
Junjie Xi ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Prognostic Value ◽  
Disease Free Survival ◽  
Ground Glass Opacity ◽  
Solid Component ◽  
Component Ratio ◽  
Tumor Diameter ◽  
Cox Proportional Hazard ◽  
Cox Proportional Hazard Models ◽  
Invasive Lung Adenocarcinoma

Abstract Background The computed tomography (CT) characteristic of ground glass opacity (GGO) were shown to be associated with clinical significance in lung adenocarcinoma. We evaluated the prognostic value of the solid component ratio of GGO IA invasive lung adenocarcinoma. Methods We retrospectively analyzed the records of GGO IA patients who received surgical resection from April 2012 to December 2015. The solid component ratio was calculated based on thin-slice CT scans. Baseline features were compared stratified by the ratio. Cox proportional hazard models and survival analyses were adopted to explore potential prognostic value regarding overall survival (OS) and disease-free survival (DFS). Results Four hundred fifteen patients were included. The higher ratio was significantly associated with larger tumor diameter, pathological subtypes and choice of surgical type. There was a significantly worse DFS with a > 50% ratio. The subgroups of 0% and ≤ 50% ratio showed close survival curves of DFS. Similar trends were observed in OS. Multivariate analyses revealed that the ratio was a significant predictor for DFS, but not for OS. No significant prognostic difference was observed between lobectomy and limited resections. Conclusion A higher solid component ratio may help to predict a significantly worse prognosis of GGO IA lung adenocarcinoma.

scholarly journals A Proposal for Restaging of Invasive Lung Adenocarcinoma Manifesting as Pure Ground Glass Opacity

2019 ◽  
Vol 107 (5) ◽  
pp. 1523-1531 ◽  
Author(s):  
Rui Mao ◽  
Yunlang She ◽  
Erjia Zhu ◽  
Donglai Chen ◽  
Chenyang Dai ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Ground Glass Opacity ◽  
Ground Glass ◽  
Invasive Lung Adenocarcinoma

Comparison between diameters of the whole nodule and solid area and the proportion of GGO in the tumor shadow on HRCT in predicting less-invasive lung cancer and recurrence after complete resection in patients with clinical N0 NSCLC.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 7021-7021
Author(s):  
Haruhisa Matsuguma ◽  
Rie Nakahara ◽  
Haruko Suzuki ◽  
Takashi Kasai ◽  
Yukari Kamiyama ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Adenocarcinoma ◽  
Roc Analysis ◽  
Area Under The Curve ◽  
Ground Glass Opacity ◽  
Prognostic Indicator ◽  
Complete Resection ◽  
Less Invasive ◽  
Invasive Lung Adenocarcinoma ◽  
Solid Area

7021 Background: Prediction of less-invasive lung cancer is important in selecting candidates for limited surgical resection. A greater proportion of ground-glass opacity (%GGO) is well-known to be strongly associated with less-invasive lung adenocarcinoma. Recently, the diameter of the solid area (SolidØ) has been reported to also be a simple and better marker for the same purpose compared to the diameter of the whole nodule (NoduleØ). The aim of this study was to confirm that SolidØ can completely replace %GGO in predicting less-invasive lung cancer. Methods: From 1987 to 2009, 433 patients with clinical T1a-2bN0 NSCLC underwent complete resection, and their preoperative HRCT images were preserved in DICOM format. NoduleØ and SolidØ were precisely measured using software. %GGO was calculated using the method we previously published (Eur J Cardiothorac Surg 25:1102-6, 2004). Less-invasive lung cancer was defined as having no vascular, lymphatic, nor pleural invasion. We compared the three parameters with regard to predicting less-invasive lung cancer and recurrence. Results: Among the 433 patients, 220 were male, 367 had an adenocarcinoma histology, and 58 experienced recurrence. Table shows percentages and numbers of non-less-invasive lung cancer cases. Among each category of SolidØ, greater %GGO is associated with less-invasive lung cancer. ROC analysis also showed that the area under the curve of %GGO was the highest (0.859, 95% CI 0.824 – 0.893), followed by SolidØ (0.806, 0.767 – 0.846), and NoduleØ (0.671, 0.620 – 0.721). Regardless of SolidØ, no patient with a greater %GGO (> 50%) experienced recurrence. Conclusions: Although SolidØ is a better prognostic indicator of non-invasiveness compared to NoduleØ, %GGO remains important. [Table: see text]

Comparison of Current Staging Systems for Sinonasal Inverted Papilloma

2020 ◽  
Vol 35 (1) ◽  
pp. 64-71
Author(s):  
Tsuguhisa Nakayama ◽  
Yasuhiro Tsunemi ◽  
Takashi Kashiwagi ◽  
Akihito Kuboki ◽  
Shuchi Yamakawa ◽  
...  
Keyword(s):  
Disease Free Survival ◽  
Staging System ◽  
Inverted Papilloma ◽  
Machine Learning Algorithms ◽  
Recurrence Rates ◽  
Cox Proportional Hazard ◽  
Sinonasal Inverted Papilloma ◽  
Staging Systems ◽  
Cox Proportional Hazard Models

Background A staging system is essential for determining the optimal surgical approach and predicting postoperative outcomes for inverted papilloma (IP). Although staging systems based on the extent to which the location is occupied by an IP have been widely used, an origin site-based classification of IP using unsupervised machine learning algorithms has recently been reported. Objective To determine the most appropriate of five staging systems for sinonasal IP by comparing recurrence rates for each stage according to each of those systems. Methods Eighty-seven patients with sinonasal IP were enrolled in the study. Their tumors were retrospectively categorized according to the Krouse, Oikawa, Cannady, and Han staging systems, which are based on the extent of IP, and the Meng system, which is based on the site of origin. The rates of recurrence for each stage of the five systems were compared. Results Seven of the 87 patients (8.0%) had recurrences during an average 45.5 months (12–138 months) of follow-up. There were significant differences in disease-free survival between the stages specified by Han and Meng (p = 0.027 and p < 0.001, respectively), but not between the stages specified by Krouse, Oikawa, and Cannady (p = 0.236, 0.062, and 0.130, respectively). Cox proportional hazard models revealed that Meng system (adjusted hazard ratio [aHR] 4.32, 95% confidence interval [CI] 1.10–17.04) and presence of dysplasia (aHR 7.42, 95% CI 1.15–47.85) were significantly associated with recurrence. Conclusion The staging systems proposed by Han and Meng were found to be accurate in terms of tumor recurrence. We recommend use of the Han staging system before surgery and the Meng system after intraoperative identification of the origin of the tumor.

Oncological outcomes of intravesical gemcitabine and docetaxel for select patients with high grade recurrent NMIBC.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 4546-4546 ◽  
Author(s):  
Niv Milbar ◽  
Max Kates ◽  
Meera R. Chappidi ◽  
Mark P. Schoenberg ◽  
Trinity Bivalacqua
Keyword(s):  
Disease Free Survival ◽  
Standard Of Care ◽  
Intravesical Therapy ◽  
Johns Hopkins Hospital ◽  
Bladder Preservation ◽  
Free Survival ◽  
Cox Proportional Hazard ◽  
Cox Proportional Hazard Models ◽  
Clinically Meaningful Outcomes ◽  
Muscle Invasive

4546 Background: Bacillus Calmette-Guerin (BCG) unresponsive patients with Non-Muscle Invasive Bladder Cancer (NMIBC) who prefer bladder preservation over Radical Cystectomy (RC) or are poor surgical candidates may be offered intravesical therapies. 2nd line intravesical Gemcitabine (GEM) combined with Docetaxel (DOCE) has been offered at Johns Hopkins Hospital (JHH). Our objective was to evaluate JHH experience with GEM/DOCE, and specifically to address appropriate endpoints for 2nd-line therapies in NMIBC. Methods: 33 patients who received full induction courses of GEM/DOCE since 2011, per the protocol adapted from Michael O’Donnell at U. Iowa, were identified in the IRB-approved JHH NMIBC database. Multivariable logistic regression determined factors associated with LG and HG recurrence. Cox proportional hazard models evaluated risk factors for disease free survival (DFS) and HG recurrence-free survival (HG-RFS). Results: Median DFS was 6.5 months with 42% 1-year and 24% 2-year DFS. Median HG-RFS was 17.1 months with 56% 1-year and 42% 2- year HG-RFS. Median HG-RFS among patients who initiated GEM/DOCE with HG pathology was 15.7 months, with 51% 1-year HG-RFS and 34% 2-year HG-RFS. Within initial HG-NMIBC presentation, 46% (13/28) had HG recurrence. 80% (4/5) of patients with initial LgTa had LG recurrence and 20% (1/5) had HG recurrence. There were no significant predictors for HG-RFS or DFS. There were 5 LG recurrences, and 16 HG recurrences, with 6 progressions among these. 7 patients underwent RC at a median of 14.9 months. Conclusions: GEM/DOCE is a well-tolerated alternative to immediate RC for highly selected patients with HG-NMIBC. As anticipated, including LG recurrence as an endpoint made GEM/DOCE appear less efficacious. However, since standard of care for LG recurrence is further intravesical therapy and recurrence does not result in worse cancer outcomes, it may not be an appropriate endpoint. Future studies of 2nd line therapies for NMIBC should identify endpoints based on clinically meaningful outcomes of interest.

scholarly journals The Effect of Tegafur-Uracil on Survival in T Categories as Defined in the Eighth Edition of the TNM Classification: An Exploratory Analysis of Postoperative Adjuvant Tegafur-Uracil on Survival in Patients with Adenocarcinoma of the Lung

Chemotherapy ◽  
2017 ◽  
Vol 62 (6) ◽  
pp. 357-360
Author(s):  
Masahiro Tsuboi ◽  
Chikuma Hamada ◽  
Harubumi Kato ◽  
Mitsuo Ohta
Keyword(s):  
Tnm Classification ◽  
Tumor Diameter ◽  
Proportional Hazard ◽  
Adenocarcinoma Of The Lung ◽  
Proportional Hazard Models ◽  
Cox Proportional Hazard ◽  
Hazard Ratios ◽  
Cox Proportional Hazard Models ◽  
Eighth Edition ◽  
T Category

Background: Tegafur-uracil (UFT) improves survival in patients with stage I adenocarcinoma of the lung. We evaluated the effect of UFT on survival in maximum primary tumor diameter (T) categories as defined in the eighth edition of the TNM Classification (TNM8). Methods: Tumors were subgrouped on the basis of T category (TNM8) as follows: T1a, T ≤1 cm; T1b, 1 < T ≤2 cm; T1c, 2 < T ≤3 cm; T2a, 3 < T ≤4 cm; T2b , 4 < T ≤5 cm; T3, 5 < T ≤7 cm. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated by Cox proportional hazard models. Results: UFT was associated with improved survival. The adjusted HRs were as follows: for T1a, 0.79 (95% CI 0.14-4.50); for T1b, 1.16 (95% CI 0.63-2.12); for T1c, 0.74 (95% CI 0.43-1.27); for T2a, 0.45 (95% CI 0.21-0.96); for T2b, 0.55 (95% CI 0.10-3.07), and for T3, 0.70 (95% CI 0.20-2.50). Conclusions: The adjuvant chemotherapy with UFT tended to improve survival in patients with adenocarcinoma of the lung of each T category based on TNM8, except T1b.

Sign in / Sign up

Export Citation Format

Share Document