A rare case of meningeal carcinomatosis and internal auditory canal metastasis presenting with the deafness for gastric cancer

Abstract Background Meningeal carcinomatosis is a very rare metastatic site of gastric cancer and meningeal carcinomatosis without other metastatic sites is much extremely rare. Herein, we report our experience with a very rare case of meningeal carcinomatosis which was difficult to diagnose the recurrence by general systemic examination and was found due to the deafness despite the sustained high tumor markers. Case presentation A 68-year-old man consulted a hospital with vomiting and hematemesis. Laboratory tests revealed severe anemia. He was referred to our hospital and underwent an emergency gastroscopy, which revealed Borrman type 3 tumor and oozing of blood. Biopsy specimen showed gastric cancer. After several examinations, total gastrectomy was performed and tegafur-gimeracil-oteracil potassium (S-1) was initiated as adjuvant chemotherapy one month after surgery. Tumor marker levels (CEA and CA19-9) remained high for three months after surgery. S-1 was continued while shortening the imaging study follow-up period. Nine months after surgery, he noticed difficulty in hearing with facial paralysis, dizziness, tinnitus, and appetite loss. He was diagnosed with meningeal carcinomatosis and bilateral internal auditory canal metastasis. He died approximately two months later. Conclusion Meningeal carcinomatosis should be considered if bilateral deafness and vestibulopathy develop after gastrectomy, even if no recurrence is apparent in the abdominal cavity.

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Jugular bulb and skull base pathologies: proposal for a novel classification system for jugular bulb positions and microsurgical implications

Neurosurgical FOCUS ◽

10.3171/2018.5.focus18106 ◽

2018 ◽

Vol 45 (1) ◽

pp. E5 ◽

Cited By ~ 8

Author(s):

Sunil Manjila ◽

Timothy Bazil ◽

Matthew Kay ◽

Unni K. Udayasankar ◽

Maroun Semaan

Keyword(s):

Skull Base ◽

Middle Ear ◽

Classification System ◽

Internal Auditory Canal ◽

Imaging Study ◽

Jugular Bulb ◽

Anatomical Location ◽

Inferior Margin ◽

Consensus Classification ◽

Type 3

OBJECTIVEThere is no definitive or consensus classification system for the jugular bulb position that can be uniformly communicated between a radiologist, neurootologist, and neurosurgeon. A high-riding jugular bulb (HRJB) has been variably defined as a jugular bulb that rises to or above the level of the basal turn of the cochlea, within 2 mm of the internal auditory canal (IAC), or to the level of the superior tympanic annulus. Overall, there is a seeming lack of consensus, especially when MRI and/or CT are used for jugular bulb evaluation without a dedicated imaging study of the venous anatomy such as digital subtraction angiography or CT or MR venography.METHODSA PubMed analysis of “jugular bulb” comprised of 1264 relevant articles were selected and analyzed specifically for an HRJB. A novel classification system based on preliminary skull base imaging using CT is proposed by the authors for conveying the anatomical location of the jugular bulb. This new classification includes the following types: type 1, no bulb; type 2, below the inferior margin of the posterior semicircular canal (SCC), subclassified as type 2a (without dehiscence into the middle ear) or type 2b (with dehiscence into the middle ear); type 3, between the inferior margin of the posterior SCC and the inferior margin of the IAC, subclassified as type 3a (without dehiscence into the middle ear) and type 3b (with dehiscence into the middle ear); type 4, above the inferior margin of the IAC, subclassified as type 4a (without dehiscence into the IAC) and type 4b (with dehiscence into the IAC); and type 5, combination of dehiscences. Appropriate CT and MR images of the skull base were selected to validate the criteria and further demonstrated using 3D reconstruction of DICOM files. The microsurgical significance of the proposed classification is evaluated with reference to specific skull base/posterior fossa pathologies.RESULTSThe authors validated the role of a novel classification of jugular bulb location that can help effective communication between providers treating skull base lesions. Effective utilization of the above grading system can help plan surgical procedures and anticipate complications.CONCLUSIONSThe authors have proposed a novel anatomical/radiological classification system for jugular bulb location with respect to surgical implications. This classification can help surgeons in complication avoidance and management when addressing HRJBs.

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A RARE CASE OF METASTASIS OF GASTRIC CANCER IN THE SPLEEN

Problems in oncology ◽

10.37469/0507-3758-2017-63-1-153-154 ◽

2017 ◽

Vol 63 (1) ◽

pp. 153-154

Author(s):

Oleg Kit ◽

Yevgeniy Kolesnikov ◽

Mikhail Kozhushko ◽

Aleksandr Snezhko

Keyword(s):

Gastric Cancer ◽

Rare Case ◽

Clinical Observation ◽

Malignant Tumors

The spleen’s damage by metastases of malignant tumors is occasional. There is presented a clinical observation of rare isolated metastasis of gastric cancer in the spleen without concomitant dissemination that is interesting.

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Mixed adenoneuroendocrine carcinoma with loss of HER2 positivity after trastuzumab-based chemotherapy for HER2-positive gastric cancer: a case report

Surgical Case Reports ◽

10.1186/s40792-020-0774-7 ◽

2020 ◽

Vol 6 (1) ◽

Author(s):

Hiromi Nagata ◽

Hironori Tsujimoto ◽

Yoshihisa Yaguchi ◽

Keita Kouzu ◽

Yujiro Itazaki ◽

...

Keyword(s):

Gastric Cancer ◽

Rare Case ◽

Metastatic Tumor ◽

Endoscopic Biopsy ◽

Her2 Status ◽

Resected Specimen ◽

Her2 Positive ◽

Standard Regimen ◽

Mixed Adenoneuroendocrine Carcinoma ◽

Her2 Positivity

Abstract Background Trastuzumab (T-mab)-based chemotherapy is a standard regimen for human epithelial growth factor 2 (HER2)-positive gastric cancer. However, some patients have demonstrated a change in HER2 status after T-mab-based treatment of breast cancer. We report a rare case of mixed adenoneuroendocrine carcinoma with loss of HER2 positivity after T-mab-based chemotherapy for HER2-positive gastric cancer. Case presentation A 60-year-old man presented with a mass of the upper abdomen, which was diagnosed as adenocarcinoma with a HER2 score of 3+ by endoscopic biopsy. He received seven cycles of combination chemotherapy with capecitabine, cisplatin, and T-mab. Subsequently, he underwent open total gastrectomy, distal pancreatosplenectomy, and extended left hepatic lobectomy as a conversion surgery. The surgically resected specimen demonstrated both adenocarcinoma and neuroendocrine components; therefore, it was diagnosed as HER2-negative mixed adenoneuroendocrine carcinoma. Although the patient received additional chemotherapy, multiple liver metastases appeared at 3 months postoperatively and he died at 6 months postoperatively because of the rapidly progressing metastatic tumor. Conclusions We encountered a rare case of rapidly progressive mixed adenoneuroendocrine carcinoma that was negative for HER2 expression after T-mab treatment combined with chemotherapy.

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A Rare Case Report of Skin Metastasis in Gastric Cancer

Journal of Gastrointestinal Cancer ◽

10.1007/s12029-021-00603-3 ◽

2021 ◽

Author(s):

Mustafa Şahin ◽

Ferhat Ekinci ◽

Cumali Çelik ◽

Peyker Temiz ◽

Atike Pınar Erdoğan ◽

...

Keyword(s):

Gastric Cancer ◽

Case Report ◽

Rare Case ◽

Skin Metastasis ◽

Rare Case Report

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Metastatic meningeal carcinomatosis from lung cancer: Report of a rare case

Thoracic Cancer ◽

10.1111/1759-7714.13243 ◽

2019 ◽

Vol 11 (1) ◽

pp. 173-175

Author(s):

Hui Liu ◽

Li Liu ◽

Xiaochen Zhang ◽

Song Jin

Keyword(s):

Lung Cancer ◽

Rare Case ◽

Meningeal Carcinomatosis

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A Rare Case of Gastric Crohn’s Disease Complicated by Gastric Carcinoma

POJ Clinical Case Reports ◽

10.32648/2639-3298/2/1/001 ◽

2018 ◽

pp. 1-6

Author(s):

Marwah Sami M Hussain ◽

Bandar Idrees Ali ◽

Abdullah Alzahrani

Keyword(s):

Gastric Cancer ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Inflammatory Bowel Diseases ◽

Rare Case ◽

Small Bowel Adenocarcinoma ◽

Disease Case ◽

Bowel Diseases ◽

Inflammatory Bowel ◽

Upper Gastrointestinal

Background: Inflammatory bowel diseases are strongly associated with colorectal cancer. In addition, a few cases reported with gastric and small bowel adenocarcinoma in gastroduodenal Crohn’s disease. Case report: We reported a case of a 47-Year-old female, who was referred to our surgical department and after a routine gastroscopy which revealed a lesion. Biopsy confirmed gastric well-differentiated adenocarcinoma of limited gastric Crohn’s disease, for a patient on regular anti Crohn’s medication. The patient underwent varying laparoscopic distal gastrectomy. She received adjuvant chemotherapy treatment and thereafter, she was cancer free within the period of 3- years of regular follow up. Conclusion: The only way to diagnose such lesions of a rare case of gastric cancer in a patient with Crohn’s disease is to regularly carry out upper gastrointestinal examinations. Keywords: Inflammatory bowel diseases, Crohn’s disease, Upper gastrointestinal tract Crohn’s disease, Gastric cancer

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Gastric Cancer with Meningeal Carcinomatosis eport of Four Cases

Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons) ◽

10.4030/jjcs1979.25.4_657 ◽

2000 ◽

Vol 25 (4) ◽

pp. 657-662

Author(s):

Kazuyoshi SUZUMURA ◽

Akihiko KOIKE ◽

Takashi KOJIMA ◽

Yutaka TOKUNAGA ◽

Taiseki KANEMITSU ◽

...

Keyword(s):

Gastric Cancer ◽

Meningeal Carcinomatosis

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PAPILLARY CARCINOMA, A METASTASIS OF THE BRAIN AND BONE: A RARE CASE

Wiadomości Lekarskie ◽

10.36740/wlek202010138 ◽

2020 ◽

Vol 73 (10) ◽

pp. 2306-2308

Author(s):

Volodymyr B. Dobrorodniy ◽

Anatoliy D. Bedenyuk ◽

Viktoria G. Khoperiia ◽

Andriy V. Dobrorodniy

Keyword(s):

Papillary Carcinoma ◽

Rare Case ◽

Cerebral Metastases ◽

Papillary Thyroid ◽

Rare Presentation ◽

Large Size ◽

Multiple Metastases ◽

Uncommon Condition ◽

Metastatic Sites ◽

The Brain

Cerebral metastases from papillary carcinoma of the thyroid are a very uncommon condition. These metastases almost always involve concomitant lung or bone metastases which may be the first metastatic sites. In a 59-year-old woman found metastases of papillary thyroid cancer (PTC) in the frontal sinus, scapula, multiple bones of the skeleton and lungs. Evaluation confirmed that it is multiple metastases from PTC. This is a very rare presentation with such a large size of metastasis. We present this rare clinical case of massive distal lesions in PTC.

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