Calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application

Carbonate apatite (CO3Ap) cement is a biocompatible material with the ability to induce osteogenesis and is widely studied as the bone substitute material. The similarity of bone to tooth structure in their organic and inorganic composition offers a good prospect of the application of CO3Ap for regeneration of dentin and pulp tissue repair. This study is a sequel of the previous study in the development of CO3Ap cement for dental application, particularly in pulp capping treatment. In this study, the CO3Ap cement is used to cover an exposed dental pulp in rats and histological evaluation was carried out to evaluate the formation of reparative dentin, which is one of the signs of positive pulp capping treatment outcome. The CO3Ap cement was made by combining 60% dicalcium phosphate anhydrous (DCPA) and 40% vaterite with 1 mol/L Na2HPO4 aqueous solution at liquid to powder ratio of 0.5 and conventional calcium hydroxide [Ca(OH)2], which is the golden standard for pulp capping material was used for control. The coronal part of dental pulp in Wistar Rat was exposed with a small dental bur until bleeding were visible. The CO3Ap cement was applied to the exposed pulp and covered with light cured glass ionomer cement. The same protocol was applied to the control groups using Ca(OH)2. The Evaluation of formation of reparative dentin was done in 3 weeks after application by histological observation. Reparative dentin was histologically visible for all samples in CO3Ap group, as well as in the Ca(OH)2 groups. None of the dental pulps were necrotic and the pulp showed no heavy chronic inflammation. The CO3Ap cement was able to maintain the vitality of the pulp with no sign of chronic inflammation. The formation of reparative dentin was observable in 3 weeks of evaluation. Investigation on other properties and in vivo studies in different types of perforation and animal are to be carried out for further development of this material in dental application.

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Physical properties of different Pulp Capping Materials and Histological Analysis of their effect on Dogs’Dental Pulp Tissue Healing

Egyptian Dental Journal ◽

10.21608/edj.2018.77260 ◽

2018 ◽

Vol 64 (3) ◽

pp. 2657-2667

Author(s):

Mai Hamdy ◽

Dalia Fayyad ◽

Mohamed Eldaharawy ◽

Enas Hegazy

Keyword(s):

Physical Properties ◽

Histological Analysis ◽

Pulp Tissue ◽

Pulp Capping ◽

Tissue Healing

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BiodentineTM Full Pulpotomy in Mature Permanent Teeth with Irreversible Pulpitis and Apical Periodontitis

Healthcare ◽

10.3390/healthcare9060720 ◽

2021 ◽

Vol 9 (6) ◽

pp. 720

Author(s):

Xuan Vinh Tran ◽

Lan Thi Quynh Ngo ◽

Tchilalo Boukpessi

Keyword(s):

Root Canal ◽

Periodontal Ligament ◽

Clinical Signs ◽

Apical Periodontitis ◽

Permanent Teeth ◽

Definitive Treatment ◽

Capping Agent ◽

Root Canal Therapy ◽

Pulp Capping ◽

Irreversible Pulpitis

Vital pulp therapy, including direct pulp capping and partial and full pulpotomy, is primarily indicated for immature or mature permanent teeth with reversible pulpitis. Mature permanent teeth with irreversible pulpitis are frequently treated with root canal therapy. This report presents two cases of full pulpotomy using BiodentineTM in mature permanent teeth with irreversible pulpitis and acute apical periodontitis. The periapical radiograph illustrated a deep carious lesion extended to the pulp with apical radiolucency lesion or widened periodontal ligament space. Full pulpotomy with a tricalcium silicate-based cement was chosen as the definitive treatment. After decayed tissue excavation under a rubber dam, the exposed pulp tissue was amputated to the level of the canal orifice with a new sterile bur. BiodentineTM was applied as the pulp capping agent after hemostasis was obtained and for temporary restoration. The clinical signs disappeared quickly after the treatment. After one month, the coronal part of the temporary restoration was removed, and a composite resin was placed over the capping agent as a final restoration. At two-year follow-ups, the teeth were asymptomatic. Radiographs showed healing of the periapical lesion and periodontal ligament. BiodentineTM full pulpotomy of mature permanent teeth with irreversible pulpitis and apical periodontitis can be an alternative option to root canal therapy.

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Zinc Oxide–Eugenol Pulpotomy in Primary Teeth: A 24-Month Follow-up

Journal of Clinical Pediatric Dentistry ◽

10.17796/1053-4628-40.2.107 ◽

2016 ◽

Vol 40 (2) ◽

pp. 107-112 ◽

Cited By ~ 7

Author(s):

Adriana Gonzalez-Lara ◽

M Socorro Ruiz-Rodriguez ◽

Mauricio Pierdant-Perez ◽

J Arturo Garrocho-Rangel ◽

Amaury J Pozos-Guillen

Keyword(s):

Zinc Oxide ◽

Primary Teeth ◽

Saline Solution ◽

Primary Molars ◽

Minimal Amount ◽

Capping Agent ◽

Pulp Capping ◽

Histopathologic Study ◽

Zinc Oxide Eugenol

Objective: The purpose of the present study was to evaluate the clinical and radiographic effectiveness of zinc oxide–eugenol (ZOE) as the only pulp capping agent in pulpotomies carried out on decayed primary molars after a follow-up period of 24 months. Study design: In total, 60 pulpotomies were performed on 38 patients aged 3 to 11 years. Pulpotomy treatment consisted of the removal of the coronal pup tissue, subsequent hemostasis, irrigation with saline solution, drying and pressure with sterile cotton pellets, and placement of a thick regular ZOE base with a minimal amount of eugenol directly over the vital radicular pulp. Additionally, a histopathologic study was carried out on some of the molars treated. Results: After a 24-month follow-up, we considered 51 procedures to be successful and 9 failures using clinical and radiographic criteria; most of the failures occurred between the 12th and 18th month. Conclusions: Results suggest that the proposed pulpotomy treatment with ZOE as the only capping agent may be considered as an alternative technique in the pulp treatment of primary molars.

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SUCCESS RATE OF MEDCEM PORTLAND CEMENT AS A PULP CAPPING AGENT IN PULPOTOMIES OF PRIMARY TEETH

Journal of IMAB - Annual Proceeding (Scientific Papers) ◽

10.5272/jimab.2018241.1866 ◽

2018 ◽

Vol 24 (1) ◽

pp. 1866-1871 ◽

Cited By ~ 1

Author(s):

Veronika Marie Vilimek ◽

◽

Natalia Gateva ◽

Boris S. Christof ◽

◽

...

Keyword(s):

Portland Cement ◽

Success Rate ◽

Primary Teeth ◽

Capping Agent ◽

Pulp Capping

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Basic Properties of Carbonate Apatite Cement Consisting of Vaterite and Dicalcium Phosphate Anhydrous

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.529-530.192 ◽

2012 ◽

Vol 529-530 ◽

pp. 192-196 ◽

Cited By ~ 11

Author(s):

Arief Cahyanto ◽

Michito Maruta ◽

Kanji Tsuru ◽

Shigeki Matsuya ◽

Ishikawa Kunio

Keyword(s):

Body Temperature ◽

Xrd Analysis ◽

Dicalcium Phosphate ◽

Carbonate Content ◽

Carbonate Apatite ◽

Steel Mold ◽

Apatite Cement ◽

Ft Ir ◽

Bone Apatite ◽

Diametral Tensile Strength

The aim of the present study is to fabricate bone cement that could transform to carbonate apatite (CO3Ap) completely at body temperature. The powder phase of vaterite and dicalcium phosphate anhydrous (DCPA) was mixed with 0.8 mol/L of NaH2PO4, Na2HPO4, and Na3PO4 aqueous solution, respectively, with liquid to powder ratio (L/P ratio) of 0.45, 0.55, and 0.65. The paste was packed into split stainless steel mold, covered with the glass slide and kept at 37°C and 100% relative humidity for up to 96 hours (h). XRD analysis revealed that the cement became pure CO3Ap within 24 h for Na3PO4, 72 h for Na2HPO4, and 96 h for NaH2PO4, respectively. FT-IR results showed that all of the obtained specimens could be assigned to B-type CO3Ap. CHN analysis showed the carbonate content of the specimen were 10.4 ± 0.3% for NaH2PO4, 11.3 ± 0.7% for Na2HPO4, and 11.8 ± 0.4% for Na3PO4, respectively. Diametral tensile strength of the set CO3Ap cement was 1.95 ± 0.42 MPa for NaH2PO4, 2.53 ± 0.53 MPa for Na2HPO4, and 3.45 ± 1.53 MPa for Na3PO4, respectively. The set CO3Ap cement had low crystallinity similar to bone apatite since it was synthesized at body temperature. We concluded, therefore, that CO3Ap cement prepared from the present method has higher possibility to be used as an ideal bone replacement.

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