scholarly journals Protective effects of Zingiber officinale extract on myocardium and placenta against labetalol-induced histopathological, immune-histochemical, and ultrastructural alterations in pregnant rats

2021 ◽  
Vol 82 (1) ◽  
Author(s):  
Hend T. El-Borm ◽  
Marwa N. Atallah
Keyword(s):  
Caspase 3 ◽  
Zingiber Officinale ◽  
Term Treatment ◽  
Control Group ◽  
Acute Management ◽  
Protective Effects ◽  
Pregnant Rats ◽  
Long Term Treatment ◽  
Maternal Hypertension

Abstract Background Labetalol is an antihypertensive drug commonly used in obstetrics for both long-term treatment and the acute management of severe maternal hypertension. However, there have not been published articles about the effects of labetalol on the myocardium and the placenta. This study aimed to estimate the histological, immune-histochemical, and ultrastructural cardio- and placental-toxicity of labetalol administration and the effectiveness of ginger against this toxicity in pregnant rats. Labetalol was daily administrated orally with or without ginger at a dose of 300 mg/kg and 200 mg/kg, respectively, during the gestation days 6 to 20. Results In the labetalol-administrated group, the myocardium displayed histological and ultrastructure destructive changes and a significant increase in caspase-3 expression. Labetalol also decreased the placental weight compared with the control group, caused marked degeneration and disorganization of their architecture, and increased caspase-3 expression. Co-administration of ginger after labetalol highly ameliorates the adverse effect of labetalol on both cardiac and placental tissues. Conclusions It is concluded that ginger can mitigate cardiac and placental toxicity induced by labetalol administration into pregnant rats.

scholarly journals Administration of ziprasidone for 10 days increases cocaine toxicity in mice

2008 ◽  
Vol 27 (6) ◽  
pp. 499-503 ◽  
Author(s):  
K Heard ◽  
S Krier ◽  
NR Zahniser
Keyword(s):  
Atypical Antipsychotic ◽  
Term Treatment ◽  
Toxic Effects ◽  
Neurotransmitter Receptors ◽  
Control Group ◽  
Long Term Treatment ◽  
Significant Difference ◽  
Group Survival ◽  
Cocaine Toxicity

Long-term treatment with antipsychotic medications alters the regional density of several of the neurotransmitter receptors that mediate cocaine toxicity. However, the effect of either up- or down-regulation of the neurotransmitter receptors on cocaine toxicity is unknown. In this study, we determined if subacute administration of the atypical antipsychotic ziprasidone altered the toxic effects of cocaine in mice. Ziprasidone (4 mg/kg) or placebo was administered to the first two groups of CF-1 mice for 10 days and, then on day 10, an estimated LD50 dose of cocaine (102 mg/kg) was given to these mice. In a third group, in order to produce a ziprasidone withdrawal state, we administered ziprasidone for 10 days, followed by no treatment for 2 days before cocaine administration. There was no significant difference among the three groups in overall survival: 63% in the treatment group, 60% in the withdrawal group, and 80% in the placebo group. Survival time was significantly shorter for the withdrawal group than for the control group. Our study may have been limited by lower than expected serum ziprasidone concentrations and lower than expected lethality from cocaine. However, our findings suggest that administration of an atypical antipsychotic for 10 days may increase the toxic effects of cocaine.

Current clinical evidence on endovenous laser ablation (EVLA) from randomised trials

Phlebologie ◽  
2016 ◽  
Vol 45 (04) ◽  
pp. 201-206 ◽  
Author(s):  
K. Rass
Keyword(s):  
Laser Ablation ◽  
Saphenous Vein ◽  
Term Treatment ◽  
High Ligation ◽  
Control Group ◽  
Foam Sclerotherapy ◽  
Endovenous Laser Ablation ◽  
Treatment Approaches ◽  
Long Term Treatment

SummaryBackground Endovenous laser ablation (EVLA) is globally counted among the most frequently administered methods to treat saphenous vein incompetence. Technical development proceeded in three particular steps: EVLA #1 – Diode lasers linearly emitting wavelengths from 810 to 980 nm through optical bare fibres; EVLA #2 – Diode or Nd:YAG lasers emitting wavelengths from 1064 to 1500 nm; EVLA #3 – Modified optical fibres warranting an optimised emission geometry by centralisation of the fibre tip (Tulip-fibre, Jacket-tip) or radial emission of the laser beam. Due to the number of different EVLA techniques their value compared with standard surgery (high ligation and stripping, HLS) and other endovascular approaches has to be questioned.Methods Selective literature analysis based on a systematic PubMed search focussed on randomised controlled trials (RCT) comparing EVLA with HLS and other thermal or nonthermal ablation techniques – radiofrequency ablation (RFA), ultrasound guided foam sclerotherapy (UGFS), endothermal steam ablation (EStA).Results The search terms “endovenous”, “laser”, “varicose vein” resulted in 509 publications, hereof 57 RCTs, hereof 24 randomised studies comparing EVLA with other treatment approaches: 15 studies comprise comparisons with standard surgery and further 9 studies with other endovenous techniques. 6 RCTs contain long-term followup data on EVLA #1 vs. HLS suggesting superiority of HLS in terms of same site clinical and duplex detected recurrence from the groin. 15 RCTs are reporting short-term results clearly demonstrating inferiority of EVLA #1 against EVLA #2, EVLA #3, and RFA with respect to postoperative complaints and patients’ quality of life.Conclusions The first generation endovenous laser systems are disadvantageous or even harmful as compared with more advanced EVLA techniques and RFA in terms of patients’ complaints and side effects. Furthermore, evidence is rising that EVLA #1 is inferior to standard surgery regarding long-term treatment efficacy. Therefore, the application of EVLA #1 in the treatment of saphenous vein incompetence cannot be recommended any longer. In view of the more recently published RCTs reporting long-term superiority of standard surgery, HLS should still be implemented as control group in studies investigating endovenous treatment approaches.

scholarly journals Long-term indapamide retard therapy in adolescents with Stage I arterial hypertension

2011 ◽  
Vol 10 (2) ◽  
pp. 6-12
Author(s):  
I. V. Logacheva ◽  
E. A. Gunicheva
Keyword(s):  
Endothelial Dysfunction ◽  
Arterial Hypertension ◽  
Reactive Hyperemia ◽  
Intima Media Thickness ◽  
Term Treatment ◽  
Stage I ◽  
Control Group ◽  
Large Artery ◽  
Long Term Treatment

Aim. To study the dynamics of office blood pressure (BP) levels, autonomic balance, endothelial dysfunction, and vascular remodelling in adolescents with Stage I arterial hypertension (AH), treated with indapamide retard (IR). Material and methods. In total, the study included 41 adolescent boys, aged 16-18 years, with Stage I AH (main group, MG), and 27 healthy adolescents (control group, CG). The MG participants received, IR (1,5 mg/day) for 6 months. At baseline and in the end of the study, all participants underwent office BP measurement, echocardiography, veloergometry, and the assessment of heart rate variability (HRV), endothelial dysfunction (reactive hyperemia test, endotelin-1 levels), microalbuminuria (MAU), and vascular parameters, such as large artery rigidity and intima-media thickness. Results. Target BP levels were achieved in all MG patients by Week 4 of the treatment, with normal BP values registered throughout the follow-up period. Indapamide therapy was associated with decreased hemodynamic cardiovascular load, normalized endothelial function, and MAU disappearance. IR monotherapy had beneficial effects on HRV, due to moderate parasympathetic stimulation. Conclusion. IR is an effective and safe medication for long-term treatment of adolescents with Stage I AH.

Reactor Neutrons in Multimodality Treatment of Locally Advanced Breast Carcinoma

2015 ◽  
Vol 1084 ◽  
pp. 464-466
Author(s):  
Yury S. Mardynsky ◽  
Igor A. Gulidov ◽  
Gamzat G. Aminov ◽  
Yury A. Ragulin ◽  
Igor I. Kotuchov ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
High Efficiency ◽  
Locally Advanced ◽  
Multimodality Treatment ◽  
Term Treatment ◽  
Control Group ◽  
Neutron Therapy ◽  
Long Term Treatment ◽  
Stage Iii Breast Cancer

We present long-term treatment outcomes of 201 patients with breast carcinoma who received a radical course of radiation therapy as a component of multimodality treatment. Ninety five of them received mixed photon-neutron therapy (the study group), and 106 patients received photon therapy (control group). All patients had stage III breast cancer. The presented data on the mixed photon-neutron therapy prove feasibility of achievement of high efficiency of treatment and satisfactory level of quality of patient’s life. This approach opens additional opportunities for expansion of a scope of neutrons in oncology.

Plasma progesterone levels during long-term treatment with levonorgestrel silastic implants

1982 ◽  
Vol 101 (2) ◽  
pp. 307-311 ◽  
Author(s):  
Horacio B. Croxatto ◽  
Soledad Diaz ◽  
Margarita Pavez ◽  
Patricia Miranda ◽  
Astrid Brandeis
Keyword(s):  
Normal Values ◽  
Significant Proportion ◽  
Term Treatment ◽  
Control Group ◽  
First Year ◽  
Continuous Administration ◽  
Plasma Progesterone ◽  
Luteal Function ◽  
Long Term Treatment

Abstract. Plasma progesterone levels were measured in 113 women using a subdermal implant containing 200 mg levonorgestrel (NORPLANT™*) in an attempt to assess the roles of anovulation and inadequate luteal function in the contraceptive action of this method. Twenty-two women using an IUD (Copper T 200) served as a control group. Blood samples were taken twice a week for 6 consecutive weeks. This was done one to four times in each subject during the first 7 years after insertion of NORPLANT. Plasma progesterone was measured by a specific RIA and criteria based upon normal values in this laboratory were used to define each set of samples as ovulatory, uncertain or anovulatory. The rate of anovulation varied between 25 and 80% throughout the 7 years. The highest rate was observed during the first year of treatment. The rate of anovulation was significantly correlated with the plasma levels of levonorgestrel. Varying degrees of inadequate corpus luteum function were detected among NORPLANT users. All sets of samples in the control group were ovulatory and compatible with normal luteal function. These results clearly show that continuous administration of levonorgestrel by means of NORPLANT interferes with ovulation and/or luteal function in a significant proportion of cycles throughout the first 7 years of use.

scholarly journals Lack of direct involvement of a diazepam long-term treatment in the occurrence of irreversible cognitive impairment: a pre-clinical approach

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Louise Carton ◽  
Candice Niot ◽  
Maéva Kyheng ◽  
Maud Petrault ◽  
Charlotte Laloux ◽  
...  
Keyword(s):  
Working Memory ◽  
Cognitive Impairment ◽  
Cognitive Functions ◽  
Term Treatment ◽  
Post Treatment ◽  
Control Group ◽  
Clinical Approach ◽  
Maze Test ◽  
Long Term Treatment

AbstractSeveral observational studies have found a link between the long-term use of benzodiazepines and dementia, which remains controversial. Our study was designed to assess (i) whether the long-term use of benzodiazepines, at two different doses, has an irreversible effect on cognition, (ii) and whether there is an age-dependent effect. One hundred and five C57Bl/6 male mice were randomly assigned to the 15 mg/kg/day, the 30 mg/kg/day diazepam-supplemented pellets, or the control group. Each group comprised mice aged 6 or 12 months at the beginning of the experiments and treated for 16 weeks. Two sessions of behavioral assessment were conducted: after 8 weeks of treatment and after treatment completion following a 1-week wash-out period. The mid-treatment test battery included the elevated plus maze test, the Y maze spontaneous alternation test, and the open field test. The post-treatment battery was upgraded with three additional tests: the novel object recognition task, the Barnes maze test, and the touchscreen-based paired-associated learning task. At mid-treatment, working memory was impaired in the 15 mg/kg diazepam group compared to the control group (p = 0.005). No age effect was evidenced. The post-treatment assessment of cognitive functions (working memory, visual recognition memory, spatial reference learning and memory, and visuospatial memory) did not significantly differ between groups. Despite a cognitive impact during treatment, the lack of cognitive impairment after long-term treatment discontinuation suggests that benzodiazepines alone do not cause irreversible deleterious effects on cognitive functions and supports the interest of discontinuation in chronically treated patients.

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